{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:01:17Z","timestamp":1783573277447,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.taap.2016.02.007","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T23:17:39Z","timestamp":1455146259000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator"],"prefix":"10.1016","volume":"296","author":[{"given":"Claire","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Ewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Muthas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Deavall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Clack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Newham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2016.02.007_bb0005","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1139\/y90-047","article-title":"The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity","volume":"68","author":"Andrews","year":"1990","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2016.02.007_bb0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vascn.2011.03.198","article-title":"A potential algorithm for prediciting drug-induced nausea in man","volume":"64","author":"Ewart","year":"2011","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.taap.2016.02.007_bb0020","first-page":"187","article-title":"Cisplatin-induced emesis in the ferret: a new animal model","volume":"66","author":"Florczyk","year":"1982","journal-title":"Cancer Treat. Rep."},{"issue":"3","key":"10.1016\/j.taap.2016.02.007_bb0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vascn.2004.02.008","article-title":"Gastrointestinal-tract models and techniques for use in safety pharmacology","volume":"49","author":"Harrison","year":"2004","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.taap.2016.02.007_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.taap.2010.03.014","article-title":"The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions","volume":"245","author":"Keating","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2016.02.007_bb0035","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1517\/14740338.5.4.585","article-title":"Drug-induced side effects affecting the gastrointestinal tract","volume":"5","author":"Leong","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.taap.2016.02.007_bb0040","first-page":"819","article-title":"Gastrointestinal injury due to medicinal agents","volume":"81","author":"Lewis","year":"1986","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.taap.2016.02.007_bb0045","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1463-1326.2011.01357.x","article-title":"An overview of once-weekly glucagon-like peptide-1 receptor agonists \u2014 available efficacy and safety data and perspectives for the future","volume":"13","author":"Madsbad","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.taap.2016.02.007_bb0050","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0031-9384(76)90171-2","article-title":"Poison induced pica in rats","volume":"17","author":"Mitchell","year":"1976","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.taap.2016.02.007_bb0055","unstructured":"National Archives, UK Animals (Scientific Procedures) Act, 1986. http:\/\/tna.europarchive.org\/20100413151426\/http:\/\/www.archive.official-documents.co.uk\/document\/hoc\/321\/321-xa.htm (last accessed on 2\/10\/2015)."},{"key":"10.1016\/j.taap.2016.02.007_bb0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/toxsci\/kfr334","article-title":"Application of data mining and visulisation techniques for the prediction of drug-induced nausea in man","volume":"126","author":"Parkinson","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"6","key":"10.1016\/j.taap.2016.02.007_bb0065","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1476-5381.2011.01669.x","article-title":"Predicting the emetic liability of novel chemical entities: a comparative study","volume":"165","author":"Percie du Sert","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2016.02.007_bb0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.mpaic.2009.08.012","article-title":"Physiology and pharmacology of nausea nad vomiting","volume":"10","author":"Pleuvry","year":"2009","journal-title":"Anaesth. Intensive Care Med."},{"key":"10.1016\/j.taap.2016.02.007_bb0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/026119291204000209","article-title":"Refinement of the charcoal meal study by reduction of the fasting period","volume":"40","author":"Prior","year":"2012","journal-title":"ATLA Altern. Lab. Anim."},{"issue":"S1","key":"10.1016\/j.taap.2016.02.007_bb0080","first-page":"1081","article-title":"Impact and frequency of different toxicities throughout the pharmaceutical life cycle","volume":"114","author":"Redfern","year":"2010","journal-title":"The Toxicologist"},{"key":"10.1016\/j.taap.2016.02.007_bb0085","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0091-3057(93)90126-E","article-title":"Pica in rats is analgous to emesis: an animal model in emesis research","volume":"45","author":"Takeda","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.taap.2016.02.007_bb0090","first-page":"589","article-title":"Neuropharmacological mechansims of emesis I. Effects of antiemetic drugs on motion- and apomorphinr-induced pica in rats","volume":"17","author":"Takeda","year":"1995","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.taap.2016.02.007_bb0095","first-page":"647","article-title":"Neuropharmacological mechansims of emesis II. Effects of antiemetic drugs on cisplatin-induced pica in rats","volume":"17","author":"Takeda","year":"1995","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.taap.2016.02.007_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vascn.2008.05.007","article-title":"Safety and secondary pharmacology: successes, threats, challenges and opportunities","volume":"58","author":"Valentin","year":"2008","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.taap.2016.02.007_bb0105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.vascn.2010.04.011","article-title":"Time-course anlaysis of pica in rats using anautomatic feeding monitoring system","volume":"63","author":"Yamamoto","year":"2011","journal-title":"J. Pharmacol. Toxicol. Methods"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16300291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16300291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T01:15:23Z","timestamp":1572916523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X16300291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":20,"alternative-id":["S0041008X16300291"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2016.02.007","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2016.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}