{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:42:30Z","timestamp":1792784550848,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences (NIEHS)","doi-asserted-by":"crossref","award":["ES020561-01"],"award-info":[{"award-number":["ES020561-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences (NIEHS)","doi-asserted-by":"crossref","award":["ES025234-01A1"],"award-info":[{"award-number":["ES025234-01A1"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Center for Translational Environmental Health Research","award":["P30ES023512"],"award-info":[{"award-number":["P30ES023512"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.taap.2016.04.016","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T20:16:12Z","timestamp":1461960972000},"page":"65-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol"],"prefix":"10.1016","volume":"303","author":[{"given":"Sakhila K.","family":"Banu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jone A.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthiram K.","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe A.","family":"Arosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-8444","authenticated-orcid":false,"given":"Robert C.","family":"Burghardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2016.04.016_bb0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1749-6632.2010.05850.x","article-title":"Resveratrol and life extension","volume":"1215","author":"Agarwal","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1196\/annals.1299.067","article-title":"Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide\u2014induced apoptosis","volume":"1010","author":"Ahmed","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0015","first-page":"47","article-title":"Environmental exposure to chromium compounds in the valley of Le\u00f3n, M\u00e9xico","volume":"103","author":"Armienta-Hern\u00e1ndez","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.04.016_bb0020","first-page":"537","article-title":"Resveratrol attenuates visfatin and vaspin genes expression in adipose tissue of rats with type 2 diabetes","volume":"18","author":"Asadi","year":"2015","journal-title":"Iran. Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0025","series-title":"Ovarian Toxicology","first-page":"191","article-title":"Heavy metals and the ovary","author":"Banu","year":"2013"},{"key":"10.1016\/j.taap.2016.04.016_bb0030","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.taap.2008.06.002","article-title":"Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats","volume":"232","author":"Banu","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.taap.2011.01.011","article-title":"Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1\/2 and p53","volume":"251","author":"Banu","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1095\/biolreprod.114.125708","article-title":"Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats","volume":"92","author":"Banu","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2016.04.016_bb0045","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2016.04.016_bb0050","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/MCO.0b013e32833ef291","article-title":"Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome?","volume":"13","author":"Beaudeux","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.taap.2016.04.016_bb0055","series-title":"World Worst Pollution Problems","first-page":"1","author":"Blacksmith-Institute","year":"2015"},{"key":"10.1016\/j.taap.2016.04.016_bb0060","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/toxsci\/68.2.473","article-title":"Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse","volume":"68","author":"Borgeest","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0065","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1357-2725(01)00052-8","article-title":"DNA oxidatively damaged by chromium(III) and H(2)O(2) is protected by the antioxidants melatonin, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine, resveratrol and uric acid","volume":"33","author":"Burkhardt","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2016.04.016_bb0070","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1093\/carcin\/bgh183","article-title":"Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells","volume":"25","author":"Chen","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2016.04.016_bb0075","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1139\/O10-012","volume":"88","author":"Chen","year":"2010","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2016.04.016_bb0080","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1182\/blood.V92.3.996","article-title":"Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells","volume":"92","author":"Clement","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.taap.2016.04.016_bb0085","author":"ContaminatedRealty"},{"key":"10.1016\/j.taap.2016.04.016_bb0090","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mi.6.1.7","article-title":"Resveratrol in cardioprotection: a therapeutic promise of alternative medicine","volume":"6","author":"Das","year":"2006","journal-title":"Mol. Interv."},{"key":"10.1016\/j.taap.2016.04.016_bb0095","series-title":"Steroids \u2014 From Physiology to Clinical Medicine","first-page":"45","article-title":"The biological roles of steroid sulfonation","author":"Dawson","year":"2012"},{"key":"10.1016\/j.taap.2016.04.016_bb0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/taap.2002.9502","article-title":"Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide","volume":"184","author":"Devine","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/elsc.200620182","article-title":"Speciation and environmental fate of chromium in rivers contaminated with tannery effluents","volume":"7","author":"Dominik","year":"2007","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0110","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s001280157","article-title":"Chromium (VI) in waters in parts of Sukinda chromite valley and health hazards, Orissa, India","volume":"67","author":"Dubey","year":"2001","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.taap.2016.04.016_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103194","article-title":"Genotoxicity of tri- and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro","volume":"9","author":"Fang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2016.04.016_bb0120","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2007.07.021","article-title":"Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones","volume":"43","author":"Gaikwad","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2016.04.016_bb0125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2005.01.031","article-title":"Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo","volume":"231","author":"Garvin","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2016.04.016_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/527209","article-title":"Natural compounds modulating mitochondrial functions","volume":"2015","author":"Gibellini","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2016.04.016_bb0135","series-title":"U. S. Environmental Protection Agency \u2013 Region 2, New York, NY","first-page":"1","article-title":"Documentation of environmental indicator determination \u2014 Interim Final 2\/5\/99","author":"Gordon","year":"2003"},{"key":"10.1016\/j.taap.2016.04.016_bb0140","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/carcin\/18.2.391","article-title":"Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells","volume":"18","author":"Hakkola","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2016.04.016_bb0145","first-page":"1","article-title":"Nutritional influences on estrogen metabolism","volume":"1","author":"Hall","year":"2001","journal-title":"Appl. Nutr. Sci. Rep."},{"key":"10.1016\/j.taap.2016.04.016_bb0150","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.steroids.2008.06.005","article-title":"Effects of endocrine disruptors on genes associated with 17beta-estradiol metabolism and excretion","volume":"73","author":"Hanet","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.taap.2016.04.016_bb0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00378328","article-title":"Spontaneous abortions among women employed in the metal industry in Finland","volume":"47","author":"Hemminki","year":"1980","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.taap.2016.04.016_bb0160","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2105\/AJPH.73.1.32","article-title":"Spontaneous abortions in an industrialized community in Finland","volume":"73","author":"Hemminki","year":"1983","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.taap.2016.04.016_bb0165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.taap.2016.04.016_bb0170","series-title":"The Role of Genetics in Breast and Reproductive Cancers","first-page":"285","article-title":"Estrogen-metabolizing gene polymorphisms, genetic susceptibility, and pharmacogenomics","author":"Huber","year":"2010"},{"key":"10.1016\/j.taap.2016.04.016_bb0175","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1152\/ajpheart.01013.2001","article-title":"Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice","volume":"282","author":"Imamura","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2016.04.016_bb0180","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/j.fct.2011.08.023","article-title":"Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity","volume":"49","author":"Johnson","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2016.04.016_bb0185","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/jn\/135.4.757","article-title":"trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats","volume":"135","author":"Juan","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.taap.2016.04.016_bb0190","doi-asserted-by":"crossref","first-page":"L478","DOI":"10.1152\/ajplung.00361.2007","article-title":"Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells","volume":"294","author":"Kode","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2016.04.016_bb0195","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/ps\/85.5.947","article-title":"Appropriate statistical methods to compare dose responses of methionine sources","volume":"85","author":"Kratzer","year":"2006","journal-title":"Poult. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0200","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/pmic.200500366","article-title":"Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop","volume":"6","author":"Lee","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.taap.2016.04.016_bb0205","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.mce.2011.08.020","article-title":"Early pregnancy induced expression of prostaglandin E2 receptors EP2 and EP4 in the ovine endometrium and regulated by interferon tau through multiple cell signaling pathways","volume":"348","author":"Lee","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2016.04.016_bb0210","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bbrc.2003.08.105","article-title":"Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses","volume":"309","author":"Leonard","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2016.04.016_bb0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxlet.2014.01.022","article-title":"Disrupting androgen production of Leydig cells by resveratrol via direct inhibition of human and rat 3beta-hydroxysteroid dehydrogenase","volume":"226","author":"Li","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2016.04.016_bb0220","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1210\/en.2015-1206","article-title":"Glutamate cysteine ligase modifier subunit (Gclm) null mice have increased ovarian oxidative stress and accelerated age-related ovarian failure","volume":"156","author":"Lim","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2016.04.016_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.123","article-title":"Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death","volume":"5","author":"Lin","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2016.04.016_bb0230","series-title":"Mixed Model Diagnostics, SAS for Mixed Models","first-page":"413","author":"Littell","year":"2006"},{"key":"10.1016\/j.taap.2016.04.016_bb0235","doi-asserted-by":"crossref","first-page":"762","DOI":"10.7150\/ijbs.11978","article-title":"NQO1 Stabilizes p53 in response to oncogene-induced senescence","volume":"11","author":"Liu","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0240","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1600-079X.2003.00041.x","article-title":"Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions","volume":"34","author":"Lopez-Burillo","year":"2003","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.taap.2016.04.016_bb0245","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF03185932","article-title":"Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet","volume":"65","author":"Macarulla","year":"2009","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.taap.2016.04.016_bb0250","series-title":"US-Environmental-Protection-Agency, (Ed.), EPA Region 6: Congressional District 11","first-page":"1","article-title":"West county road 112: Midland Texas","author":"Malott","year":"2015"},{"key":"10.1016\/j.taap.2016.04.016_bb0255","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.4049\/jimmunol.164.12.6509","article-title":"Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-\u03baB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation","volume":"164","author":"Manna","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2016.04.016_bb0260","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0163-7258(93)90057-K","article-title":"P450 enzymes of estrogen metabolism","volume":"57","author":"Martucci","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2016.04.016_bb0265","doi-asserted-by":"crossref","first-page":"E395","DOI":"10.5942\/jawwa.2012.104.0092","article-title":"Hexavalent Chromium review, part 2: chemistry, occurrence, and treatment","volume":"104","author":"McNeill","year":"2012","journal-title":"J. Am. Water Works Assoc."},{"key":"10.1016\/j.taap.2016.04.016_bb0270","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3390\/nu6020489","article-title":"Protective effect of resveratrol on biomarkers of oxidative stress induced by iron\/ascorbate in mouse spermatozoa","volume":"6","author":"Mojica-Villegas","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2016.04.016_bb0275","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-7827-10-14","article-title":"Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary","volume":"10","author":"Morita","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.taap.2016.04.016_bb0280","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-7827-10-14","article-title":"Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary","volume":"10","author":"Morita","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.taap.2016.04.016_bb0285","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.cbi.2010.04.018","article-title":"Chromium genotoxicity: a double-edged sword","volume":"188","author":"Nickens","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2016.04.016_bb0290","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/nyas.12875","article-title":"Ovarian actions of resveratrol","volume":"1348","author":"Ortega","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2016.04.016_bb0295","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1210\/en.2012-1385","article-title":"Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of AKT\/PKB signaling pathway","volume":"153","author":"Ortega","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2016.04.016_bb0300","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.fertnstert.2012.08.004","article-title":"Effects of resveratrol on growth and function of rat ovarian granulosa cells","volume":"98","author":"Ortega","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.taap.2016.04.016_bb0305","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1757-2215-7-21","article-title":"Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis","volume":"7","author":"Ortega","year":"2014","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.taap.2016.04.016_bb0310","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/jrf.0.0730261","article-title":"Rate and course of atresia during follicular development in the adult cyclic rat","volume":"73","author":"Osman","year":"1985","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.taap.2016.04.016_bb0315","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/oxfordjournals.jncimonographs.a024234","article-title":"Chapter 6: estrogen metabolism by conjugation","volume":"2000","author":"Raftogianis","year":"2000","journal-title":"JNCI Monographs"},{"key":"10.1016\/j.taap.2016.04.016_bb0320","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s10040-011-0771-9","article-title":"Assessment of groundwater contamination from a hazardous dump site in Ranipet, Tamil Nadu, India","volume":"19","author":"Rao","year":"2011","journal-title":"Hydrogeol. J."},{"key":"10.1016\/j.taap.2016.04.016_bb0325","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1755-5949.2008.00045.x","article-title":"Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases","volume":"14","author":"Rocha-Gonzalez","year":"2008","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.taap.2016.04.016_bb0330","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2008.06.067","article-title":"Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes","volume":"591","author":"Rubiolo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0335","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2016.04.016_bb0340","first-page":"2979","article-title":"Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1","volume":"56","author":"Shimada","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2016.04.016_bb0345","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1124\/mol.109.058479","article-title":"Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3\u03b2 inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway","volume":"76","author":"Shin","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0350","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.neurobiolaging.2014.09.024","article-title":"Estrogen receptor-mediated resveratrol actions on blood-brain barrier of ovariectomized mice","volume":"36","author":"Shin","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.taap.2016.04.016_bb0355","first-page":"33","article-title":"Content of hexavalent chromium in the biological substrates of pregnant women and puerperae engaged in the manufacture of chromium compounds","author":"Shmitova","year":"1980","journal-title":"Gig. Tr. Prof. Zabol."},{"key":"10.1016\/j.taap.2016.04.016_bb0360","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jpag.2012.04.001","article-title":"Ameliorative effects of resveratrol on acute ovarian toxicity induced by total body irradiation in young adult rats","volume":"25","author":"Simsek","year":"2012","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"10.1016\/j.taap.2016.04.016_bb0365","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ydbio.2014.02.003","article-title":"Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring","volume":"388","author":"Sivakumar","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.taap.2016.04.016_bb0370","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1093\/carcin\/21.11.1947","article-title":"SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells","volume":"21","author":"Spink","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2016.04.016_bb0375","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.reprotox.2011.05.007","article-title":"Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors","volume":"32","author":"Stanley","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2016.04.016_bb0380","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2013.02.006","article-title":"Postnatal exposure to chromium through mother's milk accelerates follicular atresia in F1 offspring through increased oxidative stress and depletion of antioxidant enzymes","volume":"61C","author":"Stanley","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2016.04.016_bb0385","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1095\/biolreprod.113.113332","article-title":"Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring","volume":"91","author":"Stanley","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2016.04.016_bb0390","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.taap.2015.09.002","article-title":"A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown","volume":"289","author":"Stanley","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.04.016_bb0395","first-page":"280","article-title":"Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase","volume":"64","author":"Supornsilchai","year":"2005","journal-title":"Horm. Res."},{"key":"10.1016\/j.taap.2016.04.016_bb0400","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jat.1456","article-title":"Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro","volume":"29","author":"Svechnikov","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2016.04.016_bb0405","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0065-2571(02)00038-9","article-title":"Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis","volume":"43","author":"Talalay","year":"2003","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.taap.2016.04.016_bb0410","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0753-3322(03)00043-X","article-title":"The importance of glutathione in human disease","volume":"57","author":"Townsend","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2016.04.016_bb0415","doi-asserted-by":"crossref","first-page":"H2417","DOI":"10.1152\/ajpheart.01258.2006","article-title":"Resveratrol increases vascular oxidative stress resistance","volume":"292","author":"Ungvari","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2016.04.016_bb0420","series-title":"In US-Environmental-Protection-Agency, (Ed.), EPA 816-F-09-004","first-page":"1","article-title":"National primary drinking water regulations","author":"USEPA","year":"2009"},{"key":"10.1016\/j.taap.2016.04.016_bb0425","series-title":"Hinkley Groundwater Remediation Project \u2014 IRP Manager Community Briefing No. 5. Project Navigator Ltd","first-page":"1","author":"Webster","year":"2012"},{"key":"10.1016\/j.taap.2016.04.016_bb0430","series-title":"Human, Rat, and Mouse Metabolism of Resveratrol","author":"Yu","year":"2002"},{"key":"10.1016\/j.taap.2016.04.016_bb0435","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/jcb.23431","article-title":"Cellular and molecular effects of resveratrol in health and disease","volume":"113","author":"Yu","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2016.04.016_bb0440","first-page":"262","article-title":"Chromium pollution of soil and water in Jinzhou","volume":"21","author":"Zhang","year":"1987","journal-title":"Zhonghua yu fang yi xue za zhi [Chin. J. prev. Med.]"},{"key":"10.1016\/j.taap.2016.04.016_bb0445","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bbrc.2005.12.124","article-title":"Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms","volume":"340","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2016.04.016_bb0450","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/bjp.2008.81","article-title":"Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo","volume":"154","author":"Zhao","year":"2008","journal-title":"Br. J. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16300977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16300977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T04:06:25Z","timestamp":1600488385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X16300977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":90,"alternative-id":["S0041008X16300977"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2016.04.016","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2016.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}