{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:45:10Z","timestamp":1792320310176,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81273119"],"award-info":[{"award-number":["No.81273119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2016YFC0401108"],"award-info":[{"award-number":["2016YFC0401108"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["DUT16LK17"],"award-info":[{"award-number":["DUT16LK17"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.taap.2016.08.001","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T02:02:32Z","timestamp":1470276152000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice"],"prefix":"10.1016","volume":"307","author":[{"given":"Yongan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2016.08.001_bb0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tox.2006.08.020","article-title":"A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): reproductive effects on adult male offspring rats","volume":"228","author":"Andrade","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2016.08.001_bb0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2015.10.021","article-title":"Ovarian development and disease: the known and the unexpected","volume":"45","author":"Biason-Lauber","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2016.08.001_bb0015","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1289\/ehp.00108895","article-title":"Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development","volume":"108","author":"Colon","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/humupd\/8.6.529","article-title":"Inhibins, activins and follistatin in reproduction","volume":"8","author":"de Kretser","year":"2002","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.taap.2016.08.001_bb0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/dbio.2000.9861","article-title":"A role for E-cadherin in mouse primordial germ cell development","volume":"226","author":"Di Carlo","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.taap.2016.08.001_bb0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/toxsci\/kfm049","article-title":"Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone","volume":"97","author":"Gaido","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2016.08.001_bb0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.taap.2009.10.011","article-title":"Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro","volume":"242","author":"Gupta","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.08.001_bb0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.toxlet.2013.03.021","article-title":"In utero phthalate effects in the female rat: a model for MRKH syndrome","volume":"223","author":"Hannas","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2016.08.001_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.114.119032","article-title":"Daily exposure to di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice","volume":"90","author":"Hannon","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2016.08.001_bb0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2015.02.010","article-title":"Di(2-ethylhexyl) phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles","volume":"284","author":"Hannon","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.08.001_bb0055","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1289\/ehp.1509760","article-title":"Urinary phthalate metabolite concentrations and reproductive outcomes among women undergoing in vitro fertilization: results from the EARTH study","volume":"124","author":"Hauser","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0060","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ijheh.2007.07.011","article-title":"Phthalates: toxicology and exposure","volume":"210","author":"Heudorf","year":"2007","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.taap.2016.08.001_bb0065","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1289\/ehp.10788","article-title":"Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations","volume":"116","author":"Hogberg","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.envint.2008.05.012","article-title":"Association between prenatal exposure to phthalates and the health of newborns","volume":"35","author":"Huang","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2016.08.001_bb9000","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fertnstert.2011.04.093","article-title":"The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air","volume":"96","author":"Huang","year":"2011","journal-title":"Fertility & Sterility"},{"key":"10.1016\/j.taap.2016.08.001_bb0075","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/toxsci\/kfr020","article-title":"Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways","volume":"120","author":"Johnson","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2016.08.001_bb0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfs206","article-title":"Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent","volume":"129","author":"Johnson","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2016.08.001_bb0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.reprotox.2006.04.007","article-title":"NTP-CERHR expert panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate","volume":"22","author":"Kavlock","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2016.08.001_bb0090","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/10408444.2013.766149","article-title":"Reproductive and developmental effects of phthalate diesters in females","volume":"43","author":"Kay","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2016.08.001_bb0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/10408444.2013.875983","article-title":"Reproductive and developmental effects of phthalate diesters in males","volume":"44","author":"Kay","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2016.08.001_bb0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0160-4120(02)00058-2","article-title":"Inhibition of oocyte development in Japanese medaka (Oryzias latipes) exposed to di-2-ethylhexyl phthalate","volume":"28","author":"Kim","year":"2002","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2016.08.001_bb0105","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10815-012-9775-1","article-title":"Phthalates and bisphenol do not accumulate in human follicular fluid","volume":"29","author":"Krotz","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.taap.2016.08.001_bb0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000067012","article-title":"Exposure to di(2-ethylhexyl)phthalate in humans during pregnancy. A preliminary report","volume":"83","author":"Latini","year":"2003","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.taap.2016.08.001_bb0115","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1289\/ehp.6202","article-title":"In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy","volume":"111","author":"Latini","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1289\/ehp.5658","article-title":"Mechanisms of phthalate ester toxicity in the female reproductive system","volume":"111","author":"Lovekamp-Swan","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0125","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1289\/ehp.8663","article-title":"Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance","volume":"114","author":"Marsee","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/humrep\/dev292","article-title":"Urinary phthalate metabolites and ovarian reserve among women seeking infertility care","volume":"31","author":"Messerlian","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2016.08.001_bb0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.reprotox.2012.02.006","article-title":"Reproductive effects in F1 adult females exposed in utero to moderate to high doses of mono-2-ethylhexylphthalate (MEHP)","volume":"34","author":"Moyer","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2016.08.001_bb0140","doi-asserted-by":"crossref","first-page":"10651","DOI":"10.1021\/acs.est.5b02617","article-title":"Levels of phthalate metabolites in urine of pregnant women and risk of clinical pregnancy loss","volume":"49","author":"Mu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2016.08.001_bb0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.reprotox.2015.02.013","article-title":"Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice","volume":"53","author":"Niermann","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2016.08.001_bb0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrendo.2012.235","article-title":"Disorders of sex development: new genes, new concepts","volume":"9","author":"Ono","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.taap.2016.08.001_bb9005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.taap.2008.04.001","article-title":"Correlation of phthalate exposures with semen quality","volume":"231","author":"Pant","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.08.001_bb0155","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/en.2003-1141","article-title":"Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene","volume":"145","author":"Pisarska","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2016.08.001_bb0160","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2016.08.001_bb0165","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.6723","article-title":"Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999\u20132000","volume":"112","author":"Silva","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2016.08.001_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000339511","article-title":"Genetic control of ovarian development","volume":"7","author":"Tevosian","year":"2013","journal-title":"Sex. Dev."},{"key":"10.1016\/j.taap.2016.08.001_bb0175","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1262\/jrd.20220","article-title":"Differential effects of flutamide and di-(2-ethylhexyl) phthalate on male reproductive organs in a rat model","volume":"55","author":"Vo","year":"2009","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.taap.2016.08.001_bb0180","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.taap.2011.11.008","article-title":"Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway","volume":"258","author":"Wang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.08.001_bb0185","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1002\/etc.2261","article-title":"Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus)","volume":"32","author":"Wang","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.taap.2016.08.001_bb0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2015.07.009","article-title":"Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring","volume":"336","author":"Wang","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2016.08.001_bb0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/toxsci\/kfw063","article-title":"Di(2-ethylhexyl) phthalate exposure in utero damages sertoli cell differentiation via disturbance of sex determination pathway in fetal and postnatal mice","volume":"152","author":"Wang","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2016.08.001_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00009.2006","article-title":"Sex determination and gonadal development in mammals","volume":"87","author":"Wilhelm","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2016.08.001_bb0205","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2004.11.003","article-title":"The pathway to femaleness: current knowledge on embryonic development of the ovary","volume":"230","author":"Yao","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2016.08.001_bb0210","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tox.2014.04.006","article-title":"Effects of tamoxifen on the sex determination gene and the activation of sex reversal in the developing gonad of mice","volume":"321","author":"Yu","year":"2014","journal-title":"Toxicology"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16302162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16302162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:40:07Z","timestamp":1589668807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X16302162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"alternative-id":["S0041008X16302162"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2016.08.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2016.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}