{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:40:44Z","timestamp":1790404844297,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.taap.2016.10.012","type":"journal-article","created":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T19:33:38Z","timestamp":1476646418000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Carvedilol suppresses circulating and hepatic IL-6 responsible for hepatocarcinogenesis of chronically damaged liver in rats"],"prefix":"10.1016","volume":"311","author":[{"given":"Mohamed","family":"Balaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Kandeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2016.10.012_bb0005","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4253\/wjge.v7.i5.532","article-title":"Is it time to replace propranolol with carvedilol for portal hypertension?","volume":"7","author":"Abid","year":"2015","journal-title":"World J. Gastrointest. Endosc."},{"key":"10.1016\/j.taap.2016.10.012_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2016.10.012_bb0015","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hep.27016","article-title":"Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer","volume":"60","author":"Aleksandrova","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2016.10.012_bb0020","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1158\/0008-5472.CAN-10-3951","article-title":"Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?","volume":"71","author":"Arzumanyan","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1159\/000459586","article-title":"Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine","volume":"12","author":"Belfield","year":"1971","journal-title":"Enzyme"},{"key":"10.1016\/j.taap.2016.10.012_bb0030","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/hep.23381","article-title":"MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes","volume":"51","author":"Braconi","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2016.10.012_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1158\/1078-0432.CCR-13-3274","article-title":"Activation of IL6\/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4\/NANOG expression","volume":"21","author":"Chang","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0040","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00262-015-1690-8","article-title":"Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model","volume":"64","author":"Chen","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.taap.2016.10.012_bb0045","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1440-1827.2008.02282.x","article-title":"Expression of E-and N-cadherin and clinicopathology in hepatocellular carcinoma","volume":"58","author":"Cho","year":"2008","journal-title":"Pathol. Int."},{"key":"10.1016\/j.taap.2016.10.012_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148868","article-title":"Carvedilol improves inflammatory response, oxidative stress and fibrosis in the alcohol-induced liver injury in rats by regulating Kuppfer cells and hepatic stellate cells","volume":"11","author":"de Ara\u00fajo J\u00fanior","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2016.10.012_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-230X-10-79","article-title":"Mouse model of carbon tetrachloride induced liver fibrosis: histopathological changes and expression of CD133 and epidermal growth factor","volume":"10","author":"Fujii","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.taap.2016.10.012_bb0060","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/17474124.2.6.803","article-title":"Advances in antifibrotic therapy","volume":"2","author":"Ghiassi-Nejad","year":"2008","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2016.10.012_bb0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408449509089886","article-title":"Oxygen and xenobiotic reductase activities of cytochrome P450","volume":"25","author":"Goeptar","year":"1995","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2016.10.012_bb0070","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ctrv.2012.04.007","article-title":"Interleukin-6 signaling pathway in targeted therapy for cancer","volume":"38","author":"Guo","year":"2012","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.taap.2016.10.012_bb0075","first-page":"1117","article-title":"Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas","volume":"15","author":"Gwak","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.taap.2016.10.012_bb0080","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/hepr.12143","article-title":"Carvedilol improves ethanol-induced liver injury via modifying the interaction between oxidative stress and sympathetic hyperactivity in rats","volume":"44","author":"Hakucho","year":"2014","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.04.012","article-title":"New therapeutic aspect for carvedilol: antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage","volume":"261","author":"Hamdy","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2016.10.012_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.590","article-title":"Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model","volume":"6","author":"Hatting","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2016.10.012_bb0095","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cell.2013.09.031","article-title":"Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling","volume":"155","author":"He","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.taap.2016.10.012_bb0100","first-page":"717","article-title":"Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis","volume":"23","author":"Huang","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2016.10.012_bb0105","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hep.23660","article-title":"Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus\u2013related hepatocellular carcinoma by targeting DNA methyltransferase 1","volume":"52","author":"Huang","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2016.10.012_bb0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopha.2016.04.061","article-title":"Artesunate obliterates experimental hepatocellular carcinoma in rats through suppression of IL-6-JAK-STAT signalling","volume":"82","author":"Ilamathi","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2016.10.012_bb0115","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbrc.2011.05.094","article-title":"MAPK\/ERK and Wnt\/beta-catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells","volume":"409","author":"Jin","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2016.10.012_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.taap.2016.10.012_bb0125","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neo.2015.07.005","article-title":"Predominant activation of JAK\/STAT3 pathway by interleukin-6 is implicated in hepatocarcinogenesis","volume":"17","author":"Jung","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.taap.2016.10.012_bb0130","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1097-0215(19970502)71:3<355::AID-IJC8>3.0.CO;2-X","article-title":"The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas","volume":"71","author":"Kanai","year":"1997","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2016.10.012_bb0135","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2165\/00003495-200363160-00006","article-title":"Carvedilol","volume":"63","author":"Keating","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2016.10.012_bb0140","article-title":"Alterations of mast cells and TGF-1 on the silymarin treatment for CCl4-induced hepatic fibrosis","author":"Kim","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2016.10.012_bb0145","first-page":"52","article-title":"Effects of carvedilol on plasma levels of pro-inflammatory cytokines in patients with ischemic and nonischemic dilated cardiomyopathy","volume":"34","author":"Kurum","year":"2007","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.taap.2016.10.012_bb0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial\u2013mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2016.10.012_bb0155","first-page":"1029","article-title":"Diagnostic evaluation of carbon tetrachloride-induced rat hepatic cirrhosis model","volume":"25","author":"Lee","year":"2005","journal-title":"Anticancer Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0160","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1248\/bpb.b12-00494","article-title":"Hepatoprotective effects of the polysaccharide isolated from Tarphochlamys affinis (Acanthaceae) against CCl4-induced hepatic injury","volume":"35","author":"Lin","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.taap.2016.10.012_bb0165","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/j.1530-0277.2012.01773.x","article-title":"Carvedilol attenuates the progression of alcohol fatty liver disease in rats","volume":"36","author":"Liu","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0170","series-title":"Roles of E-cadherin in Hepatocarcinogenesis, Innovative Medicine","first-page":"71","author":"Maeda","year":"2015"},{"key":"10.1016\/j.taap.2016.10.012_bb0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-med-090514-013832","article-title":"Liver cancer: connections with obesity, fatty liver, and cirrhosis","volume":"67","author":"Marengo","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.taap.2016.10.012_bb0180","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1161\/01.HYP.34.6.1197","article-title":"Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding","volume":"34","author":"Massart","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2016.10.012_bb0185","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ni.2865","article-title":"Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin","volume":"15","author":"Mauer","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2016.10.012_bb0190","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/MCG.0b013e3182872f29","article-title":"Epidemiology of HCC: consider the population","volume":"47","author":"Mittal","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.taap.2016.10.012_bb0195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","article-title":"Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production","volume":"317","author":"Naugler","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.taap.2016.10.012_bb0200","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2016.10.012_bb0205","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature07475","article-title":"Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours","volume":"457","author":"Rebouissou","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.taap.2016.10.012_bb0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.taap.2016.10.012_bb0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.taap.2016.10.012_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1179\/135100005X38879","article-title":"Cytoprotective effects of carvedilol against oxygen free radical generation in rat liver","volume":"10","author":"Ronsein","year":"2005","journal-title":"Redox Rep."},{"key":"10.1016\/j.taap.2016.10.012_bb0225","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jhep.2016.02.004","article-title":"IL-6 pathway in the liver: from physiopathology to therapy","volume":"64","author":"Schmidt-Arras","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2016.10.012_bb0230","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/carcin\/bgu109","article-title":"Evidence for a role of E-cadherin in suppressing liver carcinogenesis in mice and men","volume":"35","author":"Schneider","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2016.10.012_bb0235","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.3748\/wjg.v12.i16.2563","article-title":"Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma","volume":"12","author":"Soresi","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2016.10.012_bb0240","first-page":"387","article-title":"Inhibition of proliferation on some neoplastic cell lines-act of carvedilol and captopril","volume":"24","author":"Stanojkovic","year":"2005","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0245","series-title":"Bancroft's Theory and Practice of Histological Techniques","first-page":"104","author":"Suvarna","year":"2013"},{"key":"10.1016\/j.taap.2016.10.012_bb0250","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"Van Roy","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.taap.2016.10.012_bb0255","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0026-265X(70)90045-7","article-title":"An ultramicromethod for the determination of conjugated and total bilirubin in serum or plasma","volume":"15","author":"Walters","year":"1970","journal-title":"Microchem. J."},{"key":"10.1016\/j.taap.2016.10.012_bb0260","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2014.08.039","article-title":"Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells","volume":"147","author":"Wan","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2016.10.012_bb0265","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2016.10.012_bb0270","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0009-8981(74)90357-X","article-title":"An assessment of the suitability of bromocresol green for the determination of serum albumin","volume":"53","author":"Webster","year":"1974","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.taap.2016.10.012_bb0275","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.7150\/ijbs.12118","article-title":"Defective initiation of liver regeneration in osteopontin-deficient mice after partial hepatectomy due to insufficient activation of IL-6\/Stat3 pathway","volume":"11","author":"Wen","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.taap.2016.10.012_bb0280","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/ijc.24281","article-title":"High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B","volume":"124","author":"Wong","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2016.10.012_bb0285","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1158\/1541-7786.MCR-11-0271","article-title":"IL-6 promotes head and neck tumor metastasis by inducing epithelial\u2013mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway","volume":"9","author":"Yadav","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.taap.2016.10.012_bb0290","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/hep.26305","article-title":"MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway","volume":"58","author":"Yang","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2016.10.012_bb0295","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1200\/JCO.2008.20.9908","article-title":"Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study","volume":"27","author":"Zhu","year":"2009","journal-title":"J. Clin. Oncol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16303131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X16303131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T14:33:48Z","timestamp":1749652428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X16303131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":59,"alternative-id":["S0041008X16303131"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2016.10.012","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carvedilol suppresses circulating and hepatic IL-6 responsible for hepatocarcinogenesis of chronically damaged liver in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2016.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}