{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:07:58Z","timestamp":1786997278414,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.taap.2017.02.001","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T08:45:16Z","timestamp":1486197916000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Identification of sperm mRNA biomarkers associated with testis injury during preclinical testing of pharmaceutical compounds"],"prefix":"10.1016","volume":"320","author":[{"given":"Edward","family":"Dere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Spade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee","family":"Altemus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Moffit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry T.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Boekelheide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2017.02.001_bb0005","doi-asserted-by":"crossref","first-page":"12851","DOI":"10.1074\/jbc.M800403200","article-title":"Clusterin activates survival through the phosphatidylinositol 3-kinase\/Akt pathway","volume":"283","author":"Ammar","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.02.001_bb0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gah258","article-title":"A novel mechanism of protamine expression deregulation highlighted by abnormal protamine transcript retention in infertile human males with sperm protamine deficiency","volume":"12","author":"Aoki","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.taap.2017.02.001_bb0015","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1095\/biolreprod66.4.1042","article-title":"Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin\/ApoJ knock-out mice","volume":"66","author":"Bailey","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2017.02.001_bb0020","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0192623308317426","article-title":"Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat","volume":"36","author":"Bryant","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2017.02.001_bb0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.reprotox.2013.06.061","article-title":"Sensitivity of male reproductive endpoints in nonhuman primate toxicity studies: a statistical power analysis","volume":"41","author":"Cappon","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2017.02.001_bb0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/bdrb.20320","article-title":"Whither the resolution of testicular toxicity?","volume":"92","author":"Chapin","year":"2011","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.taap.2017.02.001_bb0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/bdrb.21041","article-title":"Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat","volume":"98","author":"Chapin","year":"2013","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.taap.2017.02.001_bb0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2164\/jandrol.106.001487","article-title":"Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity","volume":"28","author":"Delb\u00e8s","year":"2007","journal-title":"J. Androl."},{"key":"10.1016\/j.taap.2017.02.001_bb0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/toxsci\/kft207","article-title":"SOT symposium highlight: translatable indicators of testicular toxicity: inhibin B, microRNAs, and sperm signatures","volume":"136","author":"Dere","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.02.001_bb0050","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/toxsci\/kfw137","article-title":"Sperm molecular biomarkers are sensitive indicators of testicular injury following subchronic model toxicant exposure","volume":"153","author":"Dere","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.02.001_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1379\/1466-1268(2002)007<0023:OOAJIH>2.0.CO;2","article-title":"Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide","volume":"7","author":"Dumont","year":"2002","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.taap.2017.02.001_bb0060","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1242\/dev.113.3.779","article-title":"Human acrosome biogenesis: immunodetection of proacrosin in primary spermatocytes and of its partitioning pattern during meiosis","volume":"113","author":"Escalier","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.taap.2017.02.001_bb0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/icb.2014.86","article-title":"Tubulin- and actin-associating GIMAP4 is required for IFN-\u03b3 secretion during Th cell differentiation","volume":"93","author":"Heinonen","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.taap.2017.02.001_bb0070","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/humupd\/7.4.363","article-title":"Testicular function following chemotherapy","volume":"7","author":"Howell","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.taap.2017.02.001_bb0075","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.anireprosci.2007.11.021","article-title":"Saga of a sperm fertility biomarker","volume":"105","author":"Klinefelter","year":"2008","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.taap.2017.02.001_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1200\/JCO.1997.15.1.239","article-title":"Fertility after chemotherapy for testicular germ cell cancers","volume":"15","author":"Lampe","year":"1997","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.taap.2017.02.001_bb0085","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/humupd\/dml037","article-title":"Towards a better understanding of RNA carriage by ejaculate spermatozoa","volume":"12","author":"Miller","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.taap.2017.02.001_bb0090","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/pros.20087","article-title":"Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen","volume":"61","author":"Miyake","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.taap.2017.02.001_bb0095","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/01926230701481931","article-title":"Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis","volume":"35","author":"Moffit","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2017.02.001_bb0100","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(02)09899-9","article-title":"Spermatozoal RNA profiles of normal fertile men","volume":"360","author":"Ostermeier","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2017.02.001_bb0105","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2164\/jandrol.111.015131","article-title":"Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting","volume":"33","author":"Pacheco","year":"2012","journal-title":"J. Androl."},{"key":"10.1016\/j.taap.2017.02.001_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044280","article-title":"Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat","volume":"7","author":"Pacheco","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2017.02.001_bb0115","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/humu.22231","article-title":"Unilateral cryptorchidism in mice mutant for Ptgds","volume":"34","author":"Philibert","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.taap.2017.02.001_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tox.2007.09.029","article-title":"Lindane alters the levels of HSP70 and clusterin in adult rat testis","volume":"243","author":"Saradha","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2017.02.001_bb0125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bdrb.20338","article-title":"Incidence and nature of testicular toxicity findings in pharmaceutical development","volume":"92","author":"Sasaki","year":"2011","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.taap.2017.02.001_bb0130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1182\/blood-2005-11-4616","article-title":"Gimap4 accelerates T-cell death","volume":"108","author":"Schnell","year":"2006","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.taap.2017.02.001_bb0135","doi-asserted-by":"crossref","first-page":"6219","DOI":"10.1007\/s11033-011-1441-7","article-title":"Circulating microRNAs involved in multiple sclerosis","volume":"39","author":"Siegel","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.taap.2017.02.001_bb0140","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2217\/bmm.11.52","article-title":"Promise of new translational safety biomarkers in drug development and challenges to regulatory qualification","volume":"5","author":"Sistare","year":"2011","journal-title":"Biomark. Med"},{"key":"10.1016\/j.taap.2017.02.001_bb0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/humrep\/dem363","article-title":"Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men","volume":"23","author":"Steger","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2017.02.001_bb0150","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1200\/JCO.1995.13.9.2278","article-title":"Evaluation of reproductive capacity in germ cell tumor patients following treatment with cisplatin, etoposide, and bleomycin","volume":"13","author":"Stephenson","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.taap.2017.02.001_bb0155","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.freeradbiomed.2004.10.038","article-title":"Differential effects of clusterin\/apolipoprotein J on cellular growth and survival","volume":"38","author":"Trougakos","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2017.02.001_bb0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbt.20262","article-title":"Methoxychlor-induced alteration in the levels of HSP70 and clusterin is accompanied with oxidative stress in adult rat testis","volume":"23","author":"Vaithinathan","year":"2009","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.taap.2017.02.001_bb0165","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00109-004-0526-3","article-title":"A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications","volume":"82","author":"Wang","year":"2004","journal-title":"J. Mol. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17300583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17300583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T09:44:45Z","timestamp":1658569485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X17300583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":33,"alternative-id":["S0041008X17300583"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2017.02.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of sperm mRNA biomarkers associated with testis injury during preclinical testing of pharmaceutical compounds","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2017.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}