{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:07:56Z","timestamp":1789646876892,"version":"4.0.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573658"],"award-info":[{"award-number":["81573658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102886"],"award-info":[{"award-number":["81102886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Provincial Key Laboratory of Construction Foundation","award":["2011A060901014"],"award-info":[{"award-number":["2011A060901014"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.taap.2017.03.022","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T06:37:01Z","timestamp":1490942221000},"page":"12-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis"],"prefix":"10.1016","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-1405","authenticated-orcid":false,"given":"Xupeng","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuncao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-4685","authenticated-orcid":false,"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2017.03.022_bb0005","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s40268-014-0042-z","article-title":"Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen","volume":"14","author":"Abdel-Dayem","year":"2014","journal-title":"Drugs in R&D"},{"key":"10.1016\/j.taap.2017.03.022_bb0010","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.4254\/wjh.v7.i11.1450","article-title":"Non-alcoholic fatty liver disease in 2015","volume":"7","author":"Ahmed","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.taap.2017.03.022_bb0015","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.annfar.2011.05.019","article-title":"Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine","volume":"30","author":"Alluin","year":"2011","journal-title":"Ann. Fr. Anesth. Reanim."},{"key":"10.1016\/j.taap.2017.03.022_bb0020","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-0034-1375960","article-title":"Drug-induced hepatic steatosis","volume":"34","author":"Amacher","year":"2014","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.taap.2017.03.022_bb0025","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/mol.113.089755","article-title":"Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice","volume":"85","author":"Avery","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2017.03.022_bb0030","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1038\/oby.2009.412","article-title":"Single-nucleotide polymorphism of CD36 locus and obesity in European adolescents","volume":"18","author":"Bokor","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.taap.2017.03.022_bb0035","doi-asserted-by":"publisher","first-page":"G194","DOI":"10.1152\/ajpgi.00413.2005","article-title":"Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis","volume":"290","author":"Bradbury","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2017.03.022_bb0040","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1194\/jlr.M300093-JLR200","article-title":"GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release","volume":"44","author":"Bulotta","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2017.03.022_bb0045","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145626","article-title":"Deregulated lipid sensing by intestinal CD36 in diet-induced hyperinsulinemic obese mouse model","volume":"11","author":"Buttet","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2017.03.022_bb0050","doi-asserted-by":"publisher","first-page":"13018","DOI":"10.1073\/pnas.95.22.13018","article-title":"Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis","volume":"95","author":"Cases","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2017.03.022_bb0055","doi-asserted-by":"publisher","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.03.022_bb0060","first-page":"1","article-title":"Study of valproic acid-enhanced hepatocyte steatosis","volume":"2016","author":"Chang","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2017.03.022_bb0065","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","volume":"2010","author":"Chateauvieux","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.taap.2017.03.022_bb0070","doi-asserted-by":"publisher","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Choi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.03.022_bb0075","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00204-014-1253-3","article-title":"CCR5 knockout mice with C57BL6 background are resistant to acetaminophen-mediated hepatotoxicity due to decreased macrophages migration into the liver","volume":"89","author":"Choi","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2017.03.022_bb0080","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/toxsci\/kfv049","article-title":"Increased hepatic fatty acid uptake and esterification contribute to tetracycline-induced steatosis in mice","volume":"145","author":"Choi","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.03.022_bb0085","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0006-291X(85)91014-9","article-title":"Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid","volume":"132","author":"Dreifuss","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2017.03.022_bb0090","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1212\/WNL.39.2.201","article-title":"Valproic acid hepatic fatalities. II. US experience since 1984","volume":"39","author":"Dreifuss","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2017.03.022_bb0095","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.metabol.2009.09.001","article-title":"Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling","volume":"59","author":"Elam","year":"2010","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.taap.2017.03.022_bb0100","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.4254\/wjh.v7.i9.1251","article-title":"Valproic acid and nonalcoholic fatty liver disease: a possible association?","volume":"7","author":"Farinelli","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.taap.2017.03.022_bb0105","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/S0006-2952(96)00507-2","article-title":"Inhibition of carnitine biosynthesis by valproic acid in rats\u2013the biochemical mechanism of inhibition","volume":"52","author":"Farkas","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2017.03.022_bb0110","first-page":"72","article-title":"SREBP-1c transcription factor and lipid homeostasis clinical perspective","volume":"68","author":"Ferr\u00e9","year":"2007","journal-title":"Horm. Res."},{"key":"10.1016\/j.taap.2017.03.022_bb0115","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.neurol.2011.02.035","article-title":"Relationship between plasma concentrations of valproic acid and hepatotoxicity in patients receiving high doses","volume":"167","author":"Ghozzi","year":"2011","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.taap.2017.03.022_bb0120","doi-asserted-by":"publisher","first-page":"G1281","DOI":"10.1152\/ajpgi.00074.2008","article-title":"Gene expression in human NAFLD","volume":"294","author":"Greco","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2017.03.022_bb0125","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1080\/15216540400022474","article-title":"Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c","volume":"56","author":"Griffin","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1016\/j.taap.2017.03.022_bb0130","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1146\/annurev.nutr.22.020402.130846","article-title":"Fatty acid transport across membranes: relevance to nutrition and metabolic pathology","volume":"22","author":"Hajri","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.taap.2017.03.022_bb0135","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11306-006-0015-5","article-title":"PNU-91325 increases fatty acid synthesis from glucose and mitochondrial long chain fatty acid degradation: a comparative tracer-based metabolomics study with rosiglitazone and pioglitazone in HepG2 cells","volume":"2","author":"Harrigan","year":"2006","journal-title":"Metabolomics"},{"key":"10.1016\/j.taap.2017.03.022_bb0140","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0387-7604(95)00139-5","article-title":"Hematologic manifestations and impaired liver synthetic function during valproate monotherapy","volume":"18","author":"Hauser","year":"1996","journal-title":"Brain and Development"},{"key":"10.1016\/j.taap.2017.03.022_bb0145","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1258\/ebm.2011.011128","article-title":"The emerging roles of fatty acid translocase\/CD36 and the aryl hydrocarbon receptor in fatty liver disease","volume":"236","author":"He","year":"2011","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.taap.2017.03.022_bb0150","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1111\/j.1872-034X.2008.00382.x","article-title":"Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease","volume":"38","author":"Higuchi","year":"2008","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.taap.2017.03.022_bb0155","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1089\/jmf.2015.3623","article-title":"Water extract of Dolichos lablab attenuates hepatic lipid accumulation in a cellular nonalcoholic fatty liver disease model","volume":"19","author":"Im","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.taap.2017.03.022_bb0160","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.fct.2014.08.009","article-title":"Role of Nrf2 activation and NF-kappaB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice","volume":"73","author":"Jin","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2017.03.022_bb0165","doi-asserted-by":"publisher","first-page":"9114","DOI":"10.1021\/ac202220b","article-title":"Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism","volume":"83","author":"Kamphorst","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2017.03.022_bb0170","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1038\/oby.2011.374","article-title":"Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans","volume":"20","author":"Keller","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.taap.2017.03.022_bb0175","doi-asserted-by":"publisher","first-page":"e31812","DOI":"10.1371\/journal.pone.0031812","article-title":"Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass","volume":"7","author":"Knebel","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2017.03.022_bb0180","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/abio.1995.1197","article-title":"Isotopomer study of lipogenesis in human hepatoma cells in culture: contribution of carbon and hydrogen atoms from glucose","volume":"226","author":"Lee","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2017.03.022_bb0185","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.taap.2007.09.014","article-title":"Subchronic effects of valproic acid on gene expression profiles for lipid metabolism in mouse liver","volume":"226","author":"Lee","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.03.022_bb0190","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1002\/hep.1840020622","article-title":"Valproate-induced hepatic steatogenesis in rats","volume":"2","author":"Lewis","year":"1982","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2017.03.022_bb0195","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/15563650902752376","article-title":"Carnitine in the treatment of valproic acid-induced toxicity","volume":"47","author":"Lheureux","year":"2009","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.taap.2017.03.022_bb0200","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2017.03.022_bb0205","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1093\/hmg\/ddq449","article-title":"Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile","volume":"20","author":"Love-Gregory","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.taap.2017.03.022_bb0210","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.eplepsyres.2009.04.004","article-title":"Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment","volume":"86","author":"Luef","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.taap.2017.03.022_bb0215","first-page":"1299","article-title":"Valproic acid overcomes transforming growth factor-\u03b2-mediated sorafenib resistance in hepatocellular carcinoma","volume":"7","author":"Matsuda","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2017.03.022_bb0220","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1136\/gut.2010.222844","article-title":"Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C","volume":"60","author":"Miquilena-Colina","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.taap.2017.03.022_bb0225","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","article-title":"Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2017.03.022_bb0230","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.clinbiochem.2013.06.012","article-title":"Adverse drug reactions induced by valproic acid","volume":"46","author":"Nanau","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.taap.2017.03.022_bb0235","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.atherosclerosis.2010.02.009","article-title":"Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults","volume":"211","author":"Noel","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.taap.2017.03.022_bb0240","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ejps.2014.06.023","article-title":"A physiologically based pharmacokinetic model for valproic acid in adults and children","volume":"63","author":"Ogungbenro","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.taap.2017.03.022_bb0245","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1146\/annurev-nutr-071812-161220","article-title":"Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism","volume":"34","author":"Pepino","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.taap.2017.03.022_bb0250","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1262-3636(08)74599-3","article-title":"The role of the lipogenic pathway in the development of hepatic steatosis","volume":"34","author":"Postic","year":"2008","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.taap.2017.03.022_bb0255","first-page":"381","article-title":"A case of hyperammonaemic encephalopathy due to valproic acid","volume":"69","author":"Prins","year":"2011","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.taap.2017.03.022_bb0260","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1080\/15287397909529766","article-title":"Hepatocyte suspensions and cultures as tools in experimental carcinogenesis","volume":"5","author":"Seglen","year":"1979","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.taap.2017.03.022_bb0265","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1017\/S0007114515004341","article-title":"Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans","volume":"115","author":"Sergeant","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.taap.2017.03.022_bb0270","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1081\/CLT-120014645","article-title":"Valproic acid toxicity: overview and management","volume":"40","author":"Sztajnkrycer","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.taap.2017.03.022_bb0275","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/pds.1736","article-title":"Adverse events with use of antiepileptic drugs: a prescription and event symmetry analysis","volume":"18","author":"Tsiropoulos","year":"2009","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.taap.2017.03.022_bb0280","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1194\/jlr.M007948","article-title":"Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease","volume":"51","author":"Wang","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2017.03.022_bb0285","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1177\/0960327112444477","article-title":"Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium","volume":"31","author":"Wang","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.taap.2017.03.022_bb0290","first-page":"570","article-title":"Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice","volume":"157","author":"Wilson","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.taap.2017.03.022_bb0295","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1210\/en.2015-1866","article-title":"Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice","volume":"157","author":"Wilson","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2017.03.022_bb0300","first-page":"18","article-title":"Evaluation of a rat model of valproate-induced obesity","author":"Wolden-Hanson","year":"1998","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.taap.2017.03.022_bb0305","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/hep.21655","article-title":"Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis","volume":"45","author":"Yamaguchi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2017.03.022_bb0310","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s11306-013-0511-3","article-title":"Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes","volume":"9","author":"Yee","year":"2013","journal-title":"Metabolomics"},{"key":"10.1016\/j.taap.2017.03.022_bb0315","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/hep.20783","article-title":"Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice","volume":"42","author":"Yu","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2017.03.022_bb0320","doi-asserted-by":"publisher","first-page":"15013","DOI":"10.1074\/jbc.M511116200","article-title":"A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.03.022_bb0325","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1053\/j.gastro.2007.11.037","article-title":"Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis","volume":"134","author":"Zhou","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2017.03.022_bb0330","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/hep.1840020513","article-title":"Valproate-induced hepatic injury: analyses of 23 fatal cases","volume":"2","author":"Zimmerman","year":"1982","journal-title":"Hepatology"}],"updated-by":[{"DOI":"10.1016\/j.taap.2023.116413","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000}}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17301369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17301369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,2]],"date-time":"2018-09-02T23:00:41Z","timestamp":1535929241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X17301369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":66,"alternative-id":["S0041008X17301369"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2017.03.022","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.taap.2023.116413","asserted-by":"object"}]},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2017.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}