{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:33:03Z","timestamp":1789734783927,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006789","name":"Halogenated Solvents Industry Alliance, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006789","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Chlorinated Solvents Association"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.taap.2017.04.002","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T13:03:16Z","timestamp":1491570196000},"page":"149-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver"],"prefix":"10.1016","volume":"332","author":[{"given":"Melvin E.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-5441","authenticated-orcid":false,"given":"Michael B.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salil N.","family":"Pendse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey J.","family":"Clewell III","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn H.","family":"Pottenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Bus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darol E.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2017.04.002_bb0005","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/0006-2952(78)90061-8","article-title":"Metabolism of dihalomethanes to formaldehyde and inorganic halide\u2014II. Studies on the mechanism of the reaction","volume":"27","author":"Ahmed","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/08958378.2014.905660","article-title":"Inhalation carcinogenicity of dichloromethane in rats and mice","volume":"26","author":"Aiso","year":"2014","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2017.04.002_bb0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0041-008X(87)90281-X","article-title":"Physiologically based pharmacokinetics and the risk assessment process for methylene chloride","volume":"87","author":"Andersen","year":"1987","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0041-008X(91)90264-F","article-title":"Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans","volume":"108","author":"Andersen","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/taap.1994.1193","article-title":"Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo","volume":"128","author":"Andersen","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0030","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfn097","article-title":"Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat","volume":"105","author":"Andersen","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.04.002_bb0035","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/toxsci\/kfq303","article-title":"Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound","volume":"118","author":"Andersen","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.04.002_bb0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF01062666","article-title":"A physiological model for the pharmacokinetics of methylene chloride in B6C3F1 mice following i.v. administrations","volume":"12","author":"Angelo","year":"1984","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.taap.2017.04.002_bb0045","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0278-6915(86)90325-X","article-title":"The pharmacokinetics of dichloromethane. I. Disposition in B6C3F1 mice following intravenous and oral administration","volume":"24","author":"Angelo","year":"1986","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2017.04.002_bb0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B Methodol."},{"key":"10.1016\/j.taap.2017.04.002_bb0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.yrtph.2015.07.017","article-title":"Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens","volume":"73","author":"Black","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/toxsci\/kfr199","article-title":"Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12weeks","volume":"123","author":"Clewell","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.04.002_bb0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2014.06.015","article-title":"Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor","volume":"280","author":"Clewell","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0070","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1172\/JCI105296","article-title":"Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man","volume":"44","author":"Coburn","year":"1965","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2017.04.002_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0041-008X(82)90060-6","article-title":"Metabolism of inhaled brominated hydrocarbons: validation of gas uptake results by determination of a stable metabolite","volume":"66","author":"Gargas","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0041-008X(86)90361-3","article-title":"A physiologically based simulation approach for determining metabolic constants from gas uptake data","volume":"86","author":"Gargas","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0085","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0041-008X(86)90196-1","article-title":"Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways","volume":"82","author":"Gargas","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.taap.2017.04.002_bb0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-1218(83)90211-2","article-title":"The metabolic activation of dichloromethane and chlorofluoromethane in a bacterial mutation assay using Salmonella typhimurium","volume":"118","author":"Green","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2017.04.002_bb0100","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.taap.2017.04.002_bb0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0272-0590(86)90272-1","article-title":"The effect of an unusual workshift on chemical toxicity. I. Studies on the exposure of rats and mice to dichloromethane","volume":"6","author":"Kim","year":"1986","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.taap.2017.04.002_bb0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.pharmtox.46.120604.141053","article-title":"CO as a cellular signaling molecule","volume":"46","author":"Kim","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2017.04.002_bb0115","doi-asserted-by":"crossref","first-page":"R271","DOI":"10.1093\/hmg\/ddl207","article-title":"Molecular components of the mammalian circadian clock","volume":"15","author":"Ko","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.taap.2017.04.002_bb0120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tem.2006.11.005","article-title":"A sense of time: how molecular clocks organize metabolism","volume":"18","author":"Kohsaka","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2017.04.002_bb0125","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/0006-2952(78)90143-0","article-title":"Metabolism of dihalomethanes to carbon monoxide\u2014III. Studies on the mechanism of the reaction","volume":"27","author":"Kubic","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0041-008X(84)90245-X","article-title":"Genotoxicity and carcinogenicity of fluorocarbons: assessment by short-term in vitro tests and chronic exposure in rats","volume":"72","author":"Longstaff","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cbi.2013.11.006","article-title":"A map of the PPARalpha transcription regulatory network for primary human hepatocytes","volume":"209","author":"McMullen","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2017.04.002_bb0140","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-3-642-25950-0_15","article-title":"Mammalian circadian clock: the roles of transcriptional repression and delay","author":"Minami","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000043","article-title":"The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta","volume":"7","author":"Pardee","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.taap.2017.04.002_bb0150","series-title":"Proceedings of the 6th International Conference on Bioinformatics and Computational Biology","article-title":"An interactive visualization tool to interpret transcriptomic data","author":"Pendse","year":"2014"},{"key":"10.1016\/j.taap.2017.04.002_bb0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0041-008X(77)90114-4","article-title":"Effect of dihalogenated methanes on the in vivo production of carbon monoxide and methane by rats","volume":"40","author":"Rodkey","year":"1977","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.04.002_bb0160","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/08958370290084656","article-title":"Comparing respiratory-tract and hepatic exposure-dose relationships for metabolized inhaled vapors: a pharmacokinetic analysis","volume":"14","author":"Sarangapani","year":"2002","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2017.04.002_bb0165","series-title":"Bioinformatics and Computational Biology Solutions using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.taap.2017.04.002_bb0170","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfp233","article-title":"Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals","volume":"112","author":"Thomas","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.04.002_bb0175","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/toxsci\/kfs314","article-title":"Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene","volume":"131","author":"Thomas","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.04.002_bb0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng1504","article-title":"System-level identification of transcriptional circuits underlying mammalian circadian clocks","volume":"37","author":"Ueda","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.taap.2017.04.002_bb0185","series-title":"National Toxicology Program Technical Report Series No. 309","article-title":"Toxicology and carcinogenicity studies of dichloromethane (methylene chloride - CAS No. 75-09-2) in F344\/N rats and B6C3F1 mice (inhalation studies)","author":"US_NTP","year":"1986"},{"key":"10.1016\/j.taap.2017.04.002_bb0190","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/em.21749","article-title":"Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites","volume":"54","author":"Yager","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.taap.2017.04.002_bb0195","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17301515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17301515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T13:32:43Z","timestamp":1719149563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X17301515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":39,"alternative-id":["S0041008X17301515"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2017.04.002","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2017.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}