{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:42:58Z","timestamp":1789202578609,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.taap.2017.05.036","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T20:31:48Z","timestamp":1500496308000},"page":"158-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Curcumin inhibits adipogenesis induced by benzyl butyl phthalate in 3T3-L1 cells"],"prefix":"10.1016","volume":"329","author":[{"given":"Satoru","family":"Sakuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Endoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Tsukiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2017.05.036_bb0005","doi-asserted-by":"crossref","first-page":"C1510","DOI":"10.1152\/ajpcell.00369.2009","article-title":"Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt\/b-catenin signaling","volume":"298","author":"Ahn","year":"2010","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.taap.2017.05.036_bb0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1467-789X.2007.00394.x","article-title":"The burden of overweight and obesity-related ill health in the UK","volume":"8","author":"Allender","year":"2007","journal-title":"Obes. Rev."},{"key":"10.1016\/j.taap.2017.05.036_bb0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1043-2760(03)00024-9","article-title":"The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones","volume":"14","author":"Arner","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2017.05.036_bb0020","doi-asserted-by":"crossref","first-page":"35361","DOI":"10.1074\/jbc.M504611200","article-title":"JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes","volume":"280","author":"Audrey Nguyen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.05.036_bb0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijheh.2009.08.002","article-title":"GerES IV: phthalate metabolites and bisphenol A in urine of German children","volume":"212","author":"Becker","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.taap.2017.05.036_bb0030","first-page":"91","article-title":"Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972","volume":"28","author":"Bostofte","year":"1983","journal-title":"Int. J. Fertil."},{"key":"10.1016\/j.taap.2017.05.036_bb0035","first-page":"2895","article-title":"Phase 1 clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lessons","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","article-title":"PPAR-mediated activity of phthalates: a link to the obesity epidemic?","volume":"304","author":"Desvergne","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2017.05.036_bb0045","first-page":"4195","article-title":"Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study","volume":"19","author":"Di Pierro","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2017.05.036_bb0050","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1542\/peds.2009-0724","article-title":"Plasma phthalate levels in pubertal gynecomastia","volume":"125","author":"Durmaz","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.taap.2017.05.036_bb0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3945\/jn.108.100966","article-title":"Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57\/BL mice","volume":"139","author":"Ejaz","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.taap.2017.05.036_bb0060","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1021\/pr200765v","article-title":"Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes","volume":"10","author":"Ellero-Simatos","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0065","series-title":"Safety Assessment of di(2-ethylhexyl)phthalate (DEHP) Released from PVC Medical Devices","author":"FDA (Food and Drug Administration)","year":"2001"},{"key":"10.1016\/j.taap.2017.05.036_bb0070","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","author":"Foster","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.taap.2017.05.036_bb0075","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/S0024-3205(01)01538-7","article-title":"The endocrine disruptor nonylphenol preferentially blocks cyclooxygenase-1","volume":"70","author":"Fujimoto","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2017.05.036_bb0080","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0041-008X(03)00095-4","article-title":"Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets","volume":"189","author":"Fujimoto","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2017.05.036_bb0085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.plefa.2005.08.002","article-title":"Effects of endocrine disruptors on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes","volume":"73","author":"Fujimoto","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.taap.2017.05.036_bb0090","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/toxsci\/58.2.350","article-title":"Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat","volume":"58","author":"Gray","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.05.036_bb0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11154-007-9049-x","article-title":"Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis","volume":"8","author":"Grun","year":"2007","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.taap.2017.05.036_bb0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1289\/ehp.94102680","article-title":"Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida","volume":"102","author":"Guillette","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2017.05.036_bb0105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMp068177","article-title":"Obesity and diabetes in the developing world\u2014a growing challenge","volume":"356","author":"Hossain","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2017.05.036_bb0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.2012.06737.x","article-title":"Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue","volume":"1271","author":"Hursting","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.taap.2017.05.036_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bdrc.20197","article-title":"Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity","volume":"93","author":"Janesick","year":"2011","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.taap.2017.05.036_bb0120","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s001090050104","article-title":"Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications","volume":"75","author":"Kelce","year":"1997","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.taap.2017.05.036_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1071\/R98051","article-title":"Antiandrogens as environmental endocrine disruptors","volume":"10","author":"Kelce","year":"1998","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.taap.2017.05.036_bb0130","doi-asserted-by":"crossref","first-page":"69","DOI":"10.6065\/apem.2014.19.2.69","article-title":"Phthalate exposure and childhood obesity","volume":"19","author":"Kim","year":"2014","journal-title":"Ann. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2017.05.036_bb0135","first-page":"41","article-title":"Vitamin E-like molecules potentiate the curcumin-induced suppression of Caco-2 cell proliferation","volume":"6","author":"Kohda","year":"2016","journal-title":"Int. J. Pharmacol. Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/jf802737z","article-title":"Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells","volume":"57","author":"Lee","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2017.05.036_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ajmg.1320210106","article-title":"Hypospadias in British Columbia","volume":"21","author":"Leung","year":"1985","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.taap.2017.05.036_bb0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1097-4644(1999)75:32+<59::AID-JCB8>3.0.CO;2-1","article-title":"Insights into the transcriptional control of adipocyte differentiation","volume":"32-33","author":"Morrison","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2017.05.036_bb0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2009.02.024","article-title":"Environmental estrogens and obesity","volume":"304","author":"Newbold","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2017.05.036_bb0160","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1172\/JCI1235","article-title":"Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats","volume":"101","author":"Okuno","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2017.05.036_bb0165","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ctim.2014.07.006","article-title":"Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial","volume":"22","author":"Panahi","year":"2014","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.taap.2017.05.036_bb0170","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10787-016-0301-4","article-title":"Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial","volume":"25","author":"Panahi","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.taap.2017.05.036_bb0175","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1542\/peds.100.5.831","article-title":"Hypospadias trends in two US surveillance systems","volume":"100","author":"Paulozzi","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.taap.2017.05.036_bb0180","doi-asserted-by":"crossref","first-page":"e77481","DOI":"10.1371\/journal.pone.0077481","article-title":"Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect","volume":"8","author":"Pereira-Fernandes","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2017.05.036_bb0185","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/toxsci\/kfu092","article-title":"Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds","volume":"140","author":"Pereira-Fernandes","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2017.05.036_bb0190","first-page":"567","article-title":"The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial","volume":"6","author":"Rahimi","year":"2016","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.taap.2017.05.036_bb0195","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1101\/gad.14.11.1293","article-title":"Transcriptional regulation of adipogenesis","volume":"14","author":"Rosen","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2017.05.036_bb0200","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.fct.2010.05.051","article-title":"Bisphenol a 3,4-quinone induces the conversion of xanthine dehydrogenase into oxidase in vitro","volume":"48","author":"Sakuma","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2017.05.036_bb0205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3164\/jcbn.10-44","article-title":"cis9, trans11-conjugated linoleic acid differentiates mouse 3T3-L1 preadipocytes into mature small adipocytes through induction of peroxisome proliferator-activated receptor \u03b3","volume":"47","author":"Sakuma","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.taap.2017.05.036_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3177\/jnsv.58.1","article-title":"The involvement of mitogen-activated protein kinases in the 1\u03b1,25-dihydroxy-cholecalciferol-induced inhibition of adipocyte differentiation in vitro","volume":"58","author":"Sakuma","year":"2012","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.taap.2017.05.036_bb0215","first-page":"84","article-title":"Curcumin inhibits the proliferation of a human colorectal cancer cell line Caco-2 partially by both apoptosis and G2\/M cell cycle arrest. Int","volume":"4","author":"Sakuma","year":"2014","journal-title":"J. Pharmacol. Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0220","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0960-0760(98)00027-2","article-title":"An updated review of environmental estrogen and androgen mimics and antagonists","volume":"65","author":"Sonnenschein","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2017.05.036_bb0225","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1289\/ehp.9882","article-title":"Concentrations of urinary phthalatemetabolites are associated with increased waist circumference and insulin resistance in adult U.S. males","volume":"115","author":"Stahlhut","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2017.05.036_bb0230","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2017.05.036_bb0235","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.envres.2011.12.006","article-title":"Associations between phthalate metabolite urinary concentrations and body size measures in New York City children","volume":"112","author":"Teitelbaum","year":"2012","journal-title":"Environ. Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0240","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1289\/ehp.8926","article-title":"Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites","volume":"114","author":"Weuve","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2017.05.036_bb0245","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/humrep\/deu081","article-title":"Phthalate exposure and pubertal development in a longitudinal study of US girls","volume":"29","author":"Wolff","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2017.05.036_bb0250","doi-asserted-by":"crossref","first-page":"41245","DOI":"10.1074\/jbc.M103241200","article-title":"The mechanisms by which both heterozygous peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) deficiency and PPAR\u03b3 agonist improve insulin resistance","volume":"276","author":"Yamauchi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.05.036_bb0255","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/ptr.5197","article-title":"Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial","volume":"28","author":"Yang","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2017.05.036_bb0260","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tiv.2016.01.010","article-title":"Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: a high content cellomics and metabolomics analysis","volume":"32","author":"Yin","year":"2016","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2017.05.036_bb0265","first-page":"429","article-title":"Study on the level of phthalates in human biological samples. Zhonghua yu fang yi xue za zhi","volume":"37","author":"Zhang","year":"2003","journal-title":"Chin. J. Prevent Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17302521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17302521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T05:22:53Z","timestamp":1659244973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X17302521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":53,"alternative-id":["S0041008X17302521"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2017.05.036","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin inhibits adipogenesis induced by benzyl butyl phthalate in 3T3-L1 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2017.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}