{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:31:55Z","timestamp":1790224315700,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-16-00014249"],"award-info":[{"award-number":["G-16-00014249"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["40-1-6000299"],"award-info":[{"award-number":["40-1-6000299"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["G-16-00014249"],"award-info":[{"award-number":["G-16-00014249"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["40-1-6000299"],"award-info":[{"award-number":["40-1-6000299"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.taap.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T15:34:12Z","timestamp":1510155252000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["H2S protects lipopolysaccharide-induced inflammation by blocking NF\u03baB transactivation in endothelial cells"],"prefix":"10.1016","volume":"338","author":[{"given":"Caitlyn","family":"Bourque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Racine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-9249","authenticated-orcid":false,"given":"Adam","family":"Greasley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-3399","authenticated-orcid":false,"given":"Yanxi","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2017.11.004_bb0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2017.11.004_bb0010","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.archoralbio.2014.05.022","article-title":"Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-\u03baB signalling in periodontal fibroblasts","volume":"59","author":"Chi","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.taap.2017.11.004_bb0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/MOH.0b013e3283523e1c","article-title":"Vascular endothelial-cadherin and vascular stability","volume":"19","author":"Dejana","year":"2012","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.taap.2017.11.004_bb0020","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1242\/jcs.017897","article-title":"The role of adherens junctions and VE-cadherin in the control of vascular permeability","volume":"121","author":"Dejana","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.taap.2017.11.004_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/CS20080021","article-title":"Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation","volume":"115","author":"Esechie","year":"2008","journal-title":"Clin. Sci."},{"key":"10.1016\/j.taap.2017.11.004_bb0030","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/npp.2015.46","article-title":"Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT2A receptor system","volume":"40","author":"Fink","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.taap.2017.11.004_bb0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2015.10.407","article-title":"Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts","volume":"89","author":"Fu","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2017.11.004_bb0040","doi-asserted-by":"crossref","first-page":"42127","DOI":"10.1038\/srep42127","article-title":"Method for dual viral vector mediated CRISPR-Cas9 gene disruption in primary human endothelial cells","volume":"7","author":"Gong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2017.11.004_bb0045","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.taap.2017.11.004_bb0050","doi-asserted-by":"crossref","first-page":"22131","DOI":"10.1074\/jbc.M111883200","article-title":"Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression","volume":"277","author":"Hsu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.11.004_bb0055","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2017.11.004_bb0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.vph.2015.04.012","article-title":"Wogonin inhibits LPS-induced vascular permeability via suppressing MLCK\/MLC pathway","volume":"72","author":"Huang","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.taap.2017.11.004_bb0065","doi-asserted-by":"crossref","first-page":"e0132105","DOI":"10.1371\/journal.pone.0132105","article-title":"Capillary isoelectric focusing immunoassay for fat cell differentiation proteomics","author":"Johlfs","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2017.11.004_bb0070","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbagen.2015.08.003","article-title":"H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells","volume":"1850","author":"Ju","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2017.11.004_bb0075","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jcp.24722","article-title":"Hydrogen sulfide epigenetically attenuates homocysteine-induced mitochondrial toxicity mediated through NMDA receptor in mouse brain endothelial (bEnd3) cells","volume":"230","author":"Kamat","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2017.11.004_bb0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.imlet.2011.10.004","article-title":"High concentrations of hydrogen sulphide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients","volume":"141","author":"Kloesch","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.taap.2017.11.004_bb0085","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.2002329","article-title":"H2S-induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response","volume":"4","author":"Krishnan","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/j.taap.2017.11.004_bb0090","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.320.5880.1155","article-title":"Medicine: nothing rotten about hydrogen sulfide's medical promise","volume":"320","author":"Leslie","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.taap.2017.11.004_bb0095","doi-asserted-by":"crossref","first-page":"H711","DOI":"10.1152\/ajpheart.00724.2016","article-title":"Cystathionine \u03b3-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6","volume":"312","author":"Leucker","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2017.11.004_bb0100","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2017.11.004_bb0105","doi-asserted-by":"crossref","first-page":"H406","DOI":"10.1152\/ajpheart.00245.2016","article-title":"The interaction of estrogen and CSE\/H2S pathway in the development of atherosclerosis","volume":"312","author":"Li","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2017.11.004_bb0110","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide modification in Gram-negative bacteria during chronic infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.taap.2017.11.004_bb0115","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2017.11.004_bb0120","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.taap.2017.11.004_bb0125","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2017.11.004_bb0130","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2017.11.004_bb0135","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2017.11.004_bb0140","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.4049\/jimmunol.136.5.1680","article-title":"Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells","volume":"136","author":"Pober","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2017.11.004_bb0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2017.11.004_bb0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000331720","article-title":"NF\u03baB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia","volume":"28","author":"Stone","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2017.11.004_bb0155","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1073\/pnas.1105121108","article-title":"Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function","volume":"108","author":"Suzuki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2017.11.004_bb0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2017.11.004_bb0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/jb\/mvr018","article-title":"Production of H2S by 3-mercaptopyruvate sulphurtransferase","volume":"149","author":"Tanizawa","year":"2011","journal-title":"J. Biochem."},{"key":"10.1016\/j.taap.2017.11.004_bb0170","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/ncomms2623","article-title":"Sulfhydration mediates neuroprotective actions of parkin","volume":"4","author":"Vandiver","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2017.11.004_bb0175","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2017.11.004_bb0180","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1089\/ars.2013.5604","article-title":"Sulfhydration of p66Shc at cysteine59 mediates the anti-oxidant effect of hydrogen sulfide","volume":"21","author":"Xie","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2017.11.004_bb0185","doi-asserted-by":"crossref","first-page":"49199","DOI":"10.1074\/jbc.M408997200","article-title":"Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1\/2 phosphorylation and p21Cip\/WAK-1","volume":"279","author":"Yang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2017.11.004_bb0190","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.taap.2017.11.004_bb0195","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2017.11.004_bb0200","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.redox.2016.08.004","article-title":"Hydrogen sulfide metabolism regulates endothelial solute barrier function","volume":"9","author":"Yuan","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2017.11.004_bb0205","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation","volume":"20","author":"Zanardo","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2017.11.004_bb0210","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00395-008-0733-0","article-title":"The role of inflammatory cytokines in endothelial dysfunction","volume":"103","author":"Zhang","year":"2008","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.taap.2017.11.004_bb0215","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.ajpath.2012.12.008","article-title":"The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma","volume":"182","author":"Zhang","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2017.11.004_bb0220","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2017.11.004_bb0225","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/embr.201338213","article-title":"S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair","volume":"15","author":"Zhao","year":"2014","journal-title":"EMBO Rep."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17304416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X17304416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:21:55Z","timestamp":1693189315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X17304416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":45,"alternative-id":["S0041008X17304416"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2017.11.004","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H2S protects lipopolysaccharide-induced inflammation by blocking NF\u03baB transactivation in endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}