{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:09:50Z","timestamp":1789661390252,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Projects of Research and Development","award":["2016YFC0904600"],"award-info":[{"award-number":["2016YFC0904600"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1432248"],"award-info":[{"award-number":["U1432248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11775280"],"award-info":[{"award-number":["11775280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11575262"],"award-info":[{"award-number":["11575262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["31920160048"],"award-info":[{"award-number":["31920160048"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.taap.2018.01.003","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T17:06:19Z","timestamp":1515258379000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice"],"prefix":"10.1016","volume":"341","author":[{"given":"Lu","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancheng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.01.003_bb0005","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1096\/fj.05-3718com","article-title":"Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury","volume":"19","author":"Adlam","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2018.01.003_bb0010","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1089\/ars.2014.5952","article-title":"Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications","volume":"22","author":"Apostolova","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2018.01.003_bb0015","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics--mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2018.01.003_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2015.10.011","article-title":"Mitochondrial fusion\/fission dynamics in neurodegeneration and neuronal plasticity","volume":"90","author":"Bertholet","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.taap.2018.01.003_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/BJ20100308","article-title":"Prevention of diabetic nephropathy in Ins2(+\/)(\u2212)(AkitaJ) mice by the mitochondria-targeted therapy MitoQ","volume":"432","author":"Chacko","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2018.01.003_bb0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-genet-110410-132529","article-title":"Fusion and fission: interlinked processes critical for mitochondrial health","volume":"46","author":"Chan","year":"2012","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.taap.2018.01.003_bb0035","first-page":"491","article-title":"Space radiation: the number one risk to astronaut health beyond low earth orbit","volume":"4","author":"Chancellor","year":"2014","journal-title":"Life (Basel)"},{"key":"10.1016\/j.taap.2018.01.003_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0070-2153(04)59005-1","article-title":"Mitochondrial dynamics in mammals","volume":"59","author":"Chen","year":"2004","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0050","first-page":"v","article-title":"Mitochondrial DNA. Methods and protocols. Introduction","volume":"197","author":"Copeland","year":"2002","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0055","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"D'Autreaux","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0060","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1073\/pnas.0803998105","article-title":"The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and\/or inhibit fusion in drosophila","volume":"105","author":"Deng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2018.01.003_bb0065","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"Detmer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.asr.2004.12.034","article-title":"Ground-based research with heavy ions for space radiation protection","volume":"35","author":"Durante","year":"2005","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0075","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.lfs.2008.01.004","article-title":"Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse","volume":"82","author":"Feng","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2018.01.003_bb0080","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcp.10159","article-title":"H(2)O(2) induces translocation of APE\/Ref-1 to mitochondria in the Raji B-cell line","volume":"193","author":"Frossi","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2018.01.003_bb0085","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1089\/neu.2008.0857","article-title":"Early mitochondrial dysfunction after cortical contusion injury","volume":"26","author":"Gilmer","year":"2009","journal-title":"J. Neurotrauma"},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2018.01.003_bb0090","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.2337\/diabetes.53.2007.S110","article-title":"Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes","volume":"53","author":"Green","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2018.01.003_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/e66bdc4e-2409-4582-b163-7bc182db275e","article-title":"Changes in mouse thymus and spleen after return from the STS-135 mission in space","volume":"8","author":"Gridley","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.01.003_bb0100","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.14037","article-title":"Brain aging and neurodegeneration: from a mitochondrial point of view","volume":"143","author":"Grimm","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2018.01.003_bb0105","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/bph.12516","article-title":"Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease","volume":"171","author":"Hall","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.01.003_bb0110","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2018.01.003_bb0115","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.freeradbiomed.2006.07.017","article-title":"Superoxide dismutase overexpression and cellular oxidative damage in diabetes. A commentary on \"Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress\"","volume":"41","author":"Jain","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2018.01.003_bb0120","doi-asserted-by":"crossref","first-page":"50310","DOI":"10.1074\/jbc.M405600200","article-title":"Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis","volume":"279","author":"Keil","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.01.003_bb0125","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1074\/jbc.M009093200","article-title":"Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties","volume":"276","author":"Kelso","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.01.003_bb0130","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1158\/0008-5472.CAN-05-3036","article-title":"A role for mitochondrial dysfunction in perpetuating radiation-induced genomic instability","volume":"66","author":"Kim","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-079X.2011.00917.x","article-title":"Exogenous melatonin modulates apoptosis in the mouse brain induced by high-LET carbon ion irradiation","volume":"52","author":"Liu","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0140","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/ars.2007.1865","article-title":"Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?","volume":"10","author":"Lu","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2018.01.003_bb0145","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbr.2007.09.033","article-title":"Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid","volume":"187","author":"Manda","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0150","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3233\/JAD-2012-120145","article-title":"Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration","volume":"30","author":"Mathew","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.taap.2018.01.003_bb0155","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neuroscience.2014.10.045","article-title":"Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions","volume":"284","author":"Naumenko","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.taap.2018.01.003_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060953","article-title":"Novel double-hit model of radiation and hyperoxia-induced oxidative cell damage relevant to space travel","volume":"17","author":"Pietrofesa","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2018.01.003_bb0165","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/eji.201343921","article-title":"Circulating mitochondrial DNA increases with age and is a familiar trait: implications for \"inflamm-aging\"","volume":"44","author":"Pinti","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.taap.2018.01.003_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168283","article-title":"Therapeutic targeting of the mitochondria initiates excessive superoxide production and mitochondrial depolarization causing decreased mtDNA integrity","volume":"11","author":"Pokrzywinski","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.01.003_bb0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/0192623309352003","article-title":"Unintended effects of cranial irradiation on cognitive function","volume":"38","author":"Raber","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2018.01.003_bb0180","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0005-2728(94)90062-0","article-title":"Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat","volume":"1188","author":"Rolfe","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2018.01.003_bb0185","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0921-8777(99)00027-0","article-title":"Repair of DNA damage in mitochondria","volume":"434","author":"Sawyer","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0190","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1667\/RR3050","article-title":"Generation of reactive oxygen species and radiation response in lymphocytes and tumor cells","volume":"160","author":"Shankar","year":"2003","journal-title":"Radiat. Res."},{"key":"10.1016\/j.taap.2018.01.003_bb0195","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.molcel.2008.08.002","article-title":"Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release","volume":"31","author":"Sheridan","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2018.01.003_bb0200","doi-asserted-by":"crossref","first-page":"607","DOI":"10.18632\/aging.100587","article-title":"Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production","volume":"5","author":"Suman","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.taap.2018.01.003_bb0205","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuropharm.2011.07.008","article-title":"Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain","volume":"61","author":"Wani","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.taap.2018.01.003_bb0210","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12031-016-0866-9","article-title":"Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents","volume":"61","author":"Yang","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.taap.2018.01.003_bb0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neulet.2012.12.049","article-title":"A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia\/reperfusion injury via an anti-apoptotic pathway in rats","volume":"535","author":"Zhang","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.taap.2018.01.003_bb0220","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.18632\/oncotarget.13954","article-title":"Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18300036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18300036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T08:36:32Z","timestamp":1603614992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18300036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":44,"alternative-id":["S0041008X18300036"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.01.003","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}