{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:29:20Z","timestamp":1791386960831,"version":"4.3.3"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1001300"],"award-info":[{"award-number":["2017YFC1001300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430089"],"award-info":[{"award-number":["81430089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671472"],"award-info":[{"award-number":["81671472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Province Health and Family Planning Scientific Research Project","award":["WJ2017C0003"],"award-info":[{"award-number":["WJ2017C0003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.taap.2018.02.017","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T12:43:00Z","timestamp":1519476180000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["nAChRs-ERK1\/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11\u03b2-HSD2"],"prefix":"10.1016","volume":"344","author":[{"given":"Jin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.02.017_bb0005","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2015.05.007","article-title":"Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure","volume":"287","author":"Ao","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0010","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1139\/y06-037","article-title":"The effect of nicotine on in vitro placental perfusion pressure","volume":"84","author":"Bainbridge","year":"2006","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ije\/dyv334","article-title":"Parental smoking during pregnancy and the risk of gestational diabetes in the daughter","volume":"45","author":"Bao","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.taap.2018.02.017_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bcp.2017.01.010","article-title":"Inhibition of 11beta-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole","volume":"130","author":"Beck","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0025","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0022-3565(25)12693-1","article-title":"Intravenous nicotine replacement suppresses nicotine intake from cigarette smoking","volume":"254","author":"Benowitz","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2018.02.017_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnins.2011.00035","article-title":"Elk-1 a transcription factor with multiple facets in the brain","volume":"5","author":"Besnard","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.taap.2018.02.017_bb0035","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/path.4131","article-title":"Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)","volume":"229","author":"Bhattacharyya","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2018.02.017_bb0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0300-483X(94)90029-9","article-title":"Nicotine- or epinephrine-induced uteroplacental vasoconstriction and fetal growth in the rat","volume":"94","author":"Birnbaum","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2018.02.017_bb0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pnpbp.2015.02.010","article-title":"ERK1\/2: function, signaling and implication in pain and pain-related anxio-depressive disorders","volume":"60","author":"Borges","year":"2015","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.taap.2018.02.017_bb0050","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2018.02.017_bb0055","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.17269\/cjph.107.5686","article-title":"Population attributable risk of smoking during pregnancy on obesity in offspring","volume":"107","author":"Chaiton","year":"2016","journal-title":"Can. J. Public health"},{"key":"10.1016\/j.taap.2018.02.017_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.etp.2007.05.007","article-title":"Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat","volume":"59","author":"Chen","year":"2007","journal-title":"Exp. Toxicol. Pathol."},{"issue":"Suppl","key":"10.1016\/j.taap.2018.02.017_bb0065","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.placenta.2009.11.010","article-title":"Review: sex and the human placenta: mediating differential strategies of fetal growth and survival","volume":"31","author":"Clifton","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.taap.2018.02.017_bb0070","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3945\/jn.112.172148","article-title":"Expression of the placental transcriptome in maternal nutrient reduction in baboons is dependent on fetal sex","volume":"143","author":"Cox","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.taap.2018.02.017_bb0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/17455057.2.3.389","article-title":"Pregnancy, smoking and birth outcomes","volume":"2","author":"Delpisheh","year":"2006","journal-title":"Women Health"},{"key":"10.1016\/j.taap.2018.02.017_bb0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejogrb.2012.08.009","article-title":"Abnormal fetomaternal glucocorticoid metabolism in the background of premature delivery: placental expression patterns of the 11 beta-hydroxysteroid dehydrogenase 2 gene","volume":"165","author":"Demendi","year":"2012","journal-title":"Eur. J. Obstet. Gyn. R. B"},{"key":"10.1016\/j.taap.2018.02.017_bb0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/molehr\/7.4.357","article-title":"Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies","volume":"7","author":"Driver","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.taap.2018.02.017_bb0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.amepre.2015.01.015","article-title":"Nicotine and the developing human: a neglected element in the electronic cigarette debate","volume":"49","author":"England","year":"2015","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.taap.2018.02.017_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mce.2014.06.016","article-title":"Maternal and fetal metabonomic alterations in prenatal nicotine exposure-induced rat intrauterine growth retardation","volume":"394","author":"Feng","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2018.02.017_bb0100","article-title":"Endocrine disrupting effects of Triclosan on the placenta in pregnant rats","volume":"11","author":"Feng","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.02.017_bb0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/cvr\/cvq295","article-title":"Cigarette smoking induces vascular proliferative disease through the activation of Egr-1","volume":"88","author":"Fukuda","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2018.02.017_bb0110","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1210\/en.2005-0046","article-title":"11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate","volume":"146","author":"Ge","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2018.02.017_bb0115","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1095\/biolreprod.113.110924","article-title":"The ERK1\/2 signaling pathway regulates 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through a transcriptional mechanism","volume":"89","author":"Guan","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2018.02.017_bb0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/CIRCRESAHA.107.155143","article-title":"Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1\/2-Elk-1 and NF-kappaB","volume":"102","author":"Hasan","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2018.02.017_bb0125","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1007\/s00204-017-2039-1","article-title":"Erratum to: prenatal nicotine exposure induces HPA axis-hypersensitivity in offspring rats via the intrauterine programming of up-regulation of hippocampal GAD67","volume":"91","author":"He","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2018.02.017_bb0130","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1007\/s00204-017-1996-8","article-title":"Prenatal nicotine exposure induces HPA axis-hypersensitivity in offspring rats via the intrauterine programming of up-regulation of hippocampal GAD67","volume":"91","author":"He","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2018.02.017_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1014089706107","article-title":"Inhibition of human angiogenesis with heparin and hydrocortisone","volume":"4","author":"Jung","year":"2001","journal-title":"Angiogenesis"},{"key":"10.1016\/j.taap.2018.02.017_bb0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10519-015-9750-6","article-title":"Maternal smoking during pregnancy and offspring birth weight: a genetically-informed approach comparing multiple raters","volume":"46","author":"Knopik","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.taap.2018.02.017_bb0145","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1080\/14767058.2016.1214125","article-title":"Variants of HSD11B2 gene in hypertensive disorders of pregnancy","volume":"30","author":"Kosicka","year":"2017","journal-title":"J. Matern.-fetal Neonatal Med."},{"key":"10.1016\/j.taap.2018.02.017_bb0150","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/dgd.12376","article-title":"Prenatal exposure to dexamethasone in the mouse induces sex-specific differences in placental gene expression","volume":"59","author":"Lee","year":"2017","journal-title":"Develop. Growth Differ."},{"key":"10.1016\/j.taap.2018.02.017_bb0155","doi-asserted-by":"crossref","first-page":"L1297","DOI":"10.1152\/ajplung.00194.2006","article-title":"MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production","volume":"292","author":"Li","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2018.02.017_bb0160","doi-asserted-by":"crossref","first-page":"E899","DOI":"10.1210\/jc.2010-2852","article-title":"The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts","volume":"96","author":"Li","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2018.02.017_bb0165","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1476-5381.2011.01488.x","article-title":"Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring","volume":"164","author":"Lim","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0170","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.placenta.2004.10.009","article-title":"Nicotinic acetylcholine receptors in rat and human placenta","volume":"26","author":"Lips","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.taap.2018.02.017_bb0175","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.toxlet.2012.09.001","article-title":"Prenatal nicotine exposure induced a hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in intrauterine growth retardation offspring rats","volume":"214","author":"Liu","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2018.02.017_bb0180","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2014.02.015","article-title":"Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta","volume":"276","author":"Machaalani","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0185","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1067\/mob.2003.80","article-title":"Relaxin causes proliferation of human amniotic epithelium by stimulation of insulin-like growth factor-II","volume":"188","author":"Millar","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.taap.2018.02.017_bb0190","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.psyneuen.2015.05.004","article-title":"Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: role of obesity and sex","volume":"59","author":"Mina","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.taap.2018.02.017_bb0195","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrendo.2014.73","article-title":"Glucocorticoids and fetal programming part 1: outcomes","volume":"10","author":"Moisiadis","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.taap.2018.02.017_bb0200","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrendo.2014.74","article-title":"Glucocorticoids and fetal programming part 2: mechanisms","volume":"10","author":"Moisiadis","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.taap.2018.02.017_bb0205","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/bmj.324.7328.26","article-title":"Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort","volume":"324","author":"Montgomery","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.taap.2018.02.017_bb0210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.placenta.2017.02.015","article-title":"Effect of glucocorticoids on mechanisms of placental angiogenesis","volume":"52","author":"Ozmen","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.taap.2018.02.017_bb0215","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.taap.2016.06.021","article-title":"Suppressed osteoclast differentiation at the chondro-osseous junction mediates endochondral ossification retardation in long bones of Wistar fetal rats with prenatal ethanol exposure","volume":"305","author":"Pan","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/ntr\/ntw228","article-title":"Maternal active smoking during pregnancy and low birth weight in the americas: a systematic review and meta-analysis","volume":"19","author":"Pereira","year":"2017","journal-title":"Nicotine Tobacco Res."},{"key":"10.1016\/j.taap.2018.02.017_bb0225","doi-asserted-by":"crossref","first-page":"146S","DOI":"10.1097\/01.alc.0000189286.81943.51","article-title":"Ethanol-induced liver injury: potential roles for egr-1","volume":"29","author":"Pritchard","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2018.02.017_bb0230","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2018.02.017_bb0235","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10735-013-9522-7","article-title":"Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy","volume":"44","author":"Rebelato","year":"2013","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.taap.2018.02.017_bb0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphys.2016.00033","article-title":"The programming power of the placenta","volume":"7","author":"Sferruzzi-Perri","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2018.02.017_bb0245","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s00726-011-0907-1","article-title":"Low amino acids affect expression of 11beta-HSD2 in BeWo cells through leptin-activated JAK-STAT and MAPK pathways","volume":"42","author":"Shang","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.taap.2018.02.017_bb0250","doi-asserted-by":"crossref","first-page":"e3157","DOI":"10.1038\/cddis.2017.546","article-title":"Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats","volume":"8","author":"Shangguan","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2018.02.017_bb0255","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/PSY.0000000000000410","article-title":"Prenatal major depressive disorder, placenta glucocorticoid and serotonergic signaling, and infant cortisol response","volume":"78","author":"Stroud","year":"2016","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.taap.2018.02.017_bb0260","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.toxlet.2012.09.007","article-title":"Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation","volume":"214","author":"Tan","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2018.02.017_bb0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ceca.2010.02.005","article-title":"Egr-1-A Ca(2+)-regulated transcription factor","volume":"47","author":"Thiel","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.taap.2018.02.017_bb0270","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1096\/fj.15-274399","article-title":"Intrauterine low-functional programming of IGF1 by prenatal nicotine exposure mediates the susceptibility to osteoarthritis in female adult rat offspring","volume":"30","author":"Tie","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2018.02.017_bb0275","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.lfs.2008.07.005","article-title":"Differential regulation of 11beta-hydroxysteroid dehydrogenase type-1 and -2 gene transcription by proinflammatory cytokines in vascular smooth muscle cells","volume":"83","author":"Tsugita","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2018.02.017_bb0280","doi-asserted-by":"crossref","first-page":"R1615","DOI":"10.1152\/ajpregu.00463.2009","article-title":"Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats","volume":"297","author":"Van Mieghem","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.taap.2018.02.017_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107024","article-title":"Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity","volume":"9","author":"Wen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.02.017_bb0290","first-page":"59","article-title":"The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression. Environmental health: a global access science","volume":"16","author":"Winterbottom","year":"2017","journal-title":"Source"},{"key":"10.1016\/j.taap.2018.02.017_bb0295","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2015.09.007","article-title":"Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism","volume":"289","author":"Wu","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.02.017_bb0300","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1210\/en.2008-1100","article-title":"Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice","volume":"150","author":"Wyrwoll","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2018.02.017_bb0305","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.toxlet.2012.01.006","article-title":"Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic alterations in fetal rats","volume":"209","author":"Xu","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2018.02.017_bb0310","article-title":"Caffeine-induced activated glucocorticoid metabolism in the hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.02.017_bb0315","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/aps.2013.171","article-title":"Prenatal nicotine exposure enhances the susceptibility to metabolic syndrome in adult offspring rats fed high-fat diet via alteration of HPA axis-associated neuroendocrine metabolic programming","volume":"34","author":"Xu","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2018.02.017_bb0320","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1039\/C4TX00092G","article-title":"Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats","volume":"4","author":"Xu","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.taap.2018.02.017_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120267","article-title":"Low dose nicotine attenuates Abeta neurotoxicity through activation early growth response gene 1 pathway","volume":"10","author":"Xue","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.02.017_bb0330","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.cellsig.2012.08.003","article-title":"Regulation of the transcriptional activity of nuclear receptors by the MEK\/ERK1\/2 pathway","volume":"24","author":"Zassadowski","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2018.02.017_bb0335","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1111\/bph.13506","article-title":"Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats","volume":"173","author":"Zhang","year":"2016","journal-title":"Br. J. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.taap.2022.115864","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000}}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18300632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18300632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T20:37:11Z","timestamp":1751402231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18300632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":67,"alternative-id":["S0041008X18300632"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.02.017","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"nAChRs-ERK1\/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11\u03b2-HSD2","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}