{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:16:34Z","timestamp":1790738194622,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007189","name":"INRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011255","name":"Cole Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.taap.2018.04.014","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T18:36:42Z","timestamp":1523644602000},"page":"32-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["In vitro study of doxorubicin-induced oxidative stress in spermatogonia and immature Sertoli cells"],"prefix":"10.1016","volume":"348","author":[{"given":"Am\u00e9lie R.","family":"Tremblay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-1075","authenticated-orcid":false,"given":"Geraldine","family":"Delbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"34","key":"10.1016\/j.taap.2018.04.014_bb0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/0973-1296.111265","article-title":"Protective effects of Ficus racemosa stem bark against doxorubucin-induced renal and testicular toxicity","volume":"9","author":"Ahmed","year":"2013","journal-title":"Pharmacogn. Mag."},{"issue":"21","key":"10.1016\/j.taap.2018.04.014_bb0010","first-page":"6101","article-title":"An informatics approach identifying markers of chemosensitivity in human cancer cell lines","volume":"60","author":"Amundson","year":"2000","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0015","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0002-9610(91)90111-P","article-title":"Distribution and metabolism of doxorubicin in rats undergoing testicular circulatory isolation","volume":"162","author":"Arakawa","year":"1991","journal-title":"Am. J. Surg."},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2018.04.014_bb0020","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.fertnstert.2005.11.035","article-title":"Lycopene prevents adriamycin-induced testicular toxicity in rats","volume":"85","author":"Atessahin","year":"2006","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4161\/oxim.3.6.14418","article-title":"Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress","volume":"3","author":"Attia","year":"2010","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0030","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1530\/REP-17-0005","article-title":"Doxorubicin and vincristine affect undifferentiated rat spermatogonia","volume":"153","author":"Beaud","year":"2017","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10565-006-0140-y","article-title":"Adriamycin-induced oxidative mitochondrial cardiotoxicity","volume":"23","author":"Berthiaume","year":"2007","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.taap.2018.04.014_bb0040","doi-asserted-by":"crossref","unstructured":"Den Boer PJ, Mackenbach P & Grootegoed JA (1989) Glutathione metabolism in cultured Sertoli cells and spermatogenic cells from hamsters. J. Reprod. Fertil. 87(1):391\u2013400.","DOI":"10.1530\/jrf.0.0870391"},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0045","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1515\/JPEM.2004.17.6.879","article-title":"Decreased serum inhibin B\/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence","volume":"17","author":"Bordallo","year":"2004","journal-title":"J. Pediatr. Endocrinol. Metabol."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0050","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/1097-0142(19900315)65:6<1298::AID-CNCR2820650607>3.0.CO;2-W","article-title":"The effects of different cumulative doses of chemotherapy on testicular function. Results in 75 patients treated for Hodgkin's disease during childhood or adolescence","volume":"65","author":"Bramswig","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.taap.2018.04.014_bb0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1477-7827-10-79","article-title":"Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats","volume":"10","author":"Brilhante","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0060","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/andr.279","article-title":"Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre-puberty","volume":"2","author":"Cabral","year":"2014","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/andr.12426","article-title":"Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin-treated rats","volume":"6","author":"Cabral","year":"2018","journal-title":"Andrology"},{"key":"10.1016\/j.taap.2018.04.014_bb0070","unstructured":"Canadian Cancer Society's Advisory Committee on Cancer Statistics (2017) Canadian Cancer Statistics 2017. Canadian Cancer Society, Toronto, ON, Available at: cancer.ca\/Canadian-CancerStatistics-2017-EN.pdf (Consult\u00e9 le December 12th)."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0075","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1095\/biolreprod.110.085456","article-title":"BMP4-induced differentiation of a rat spermatogonial stem cell line causes changes in its cell adhesion properties","volume":"83","author":"Carlomagno","year":"2010","journal-title":"Biol. Reprod."},{"issue":"7\u20138","key":"10.1016\/j.taap.2018.04.014_bb0080","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.etp.2011.01.006","article-title":"Impact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages","volume":"64","author":"Ceribasi","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.taap.2018.04.014_bb0085","series-title":"Cancer in Males: Implications for Sperm Quality, Fertility, and Progeny Outcome","first-page":"351","author":"Chan","year":"2011"},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/MPH.0000000000000492","article-title":"Long-term health outcomes in survivors of childhood cancer diagnosed between 1990 and 2000 in a large US integrated health care system","volume":"38","author":"Chao","year":"2016","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.taap.2018.04.014_bb0100","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrfmmm.2008.12.011","article-title":"Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium","volume":"663","author":"Chatterjee","year":"2009","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2605.2001.00260.x","article-title":"Infancy is not a quiescent period of testicular development","volume":"24","author":"Chemes","year":"2001","journal-title":"Int. J. Androl."},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0110","first-page":"166","article-title":"Aluminium-induced Oxidative stress, apoptosis and alterations in testicular tissue and sperm quality in Wistar rats: ameliorative effects of curcumin","volume":"11","author":"Cheraghi","year":"2017","journal-title":"Int. J. Fert. Ster."},{"key":"10.1016\/j.taap.2018.04.014_bb0115","first-page":"254835","article-title":"Pummelo protects doxorubicin-induced cardiac cell death by reducing oxidative stress, modifying glutathione transferase expression, and preventing cellular senescence","volume":"2013","author":"Chularojmontri","year":"2013","journal-title":"Evid. Complemen. Altern. Med."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016938","article-title":"Tolerance of spermatogonia to oxidative stress is due to high levels of Zn and Cu\/Zn superoxide dismutase","volume":"6","author":"Celino","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1095\/biolreprod.112.099887","article-title":"Proliferating spermatogonia are susceptible to reactive oxygen species attack in Japanese eel (Anguilla japonica)","volume":"87","author":"Celino","year":"2012","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0130","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s00726-011-0904-4","article-title":"Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis","volume":"42","author":"Das","year":"2012","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.taap.2018.04.014_bb0135","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/mnfr.201300130","article-title":"Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways","volume":"57","author":"Doggui","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"issue":"9","key":"10.1016\/j.taap.2018.04.014_bb0140","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.gyobfe.2013.07.013","article-title":"Fertility preservation in boys: spermatogonial stem cell transplantation and testicular grafting","volume":"41","author":"Goossens","year":"2013","journal-title":"Gynecologie, Obstetrique & Fertilite"},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0145","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.fct.2010.04.007","article-title":"New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients","volume":"48","author":"Granados-Principal","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1200\/JCO.2009.24.9037","article-title":"Fertility of male survivors of childhood cancer: a report from the childhood cancer survivor study","volume":"28","author":"Green","year":"2010","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0155","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.stem.2017.09.003","article-title":"Chromatin and single-cell RNA-Seq profiling reveal dynamic signaling and metabolic transitions during human spermatogonial stem cell development","volume":"21","author":"Guo","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0160","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2217\/fca.12.44","article-title":"Cardiotoxicity in childhood cancer survivors: strategies for prevention and management","volume":"8","author":"Harake","year":"2012","journal-title":"Futur. Cardiol."},{"issue":"21","key":"10.1016\/j.taap.2018.04.014_bb0165","doi-asserted-by":"crossref","first-page":"9999","DOI":"10.1158\/0008-5472.CAN-05-2004","article-title":"Doxorubicin induces apoptosis in germ line stem cells in the immature rat testis and amifostine cannot protect against this cytotoxicity","volume":"65","author":"Hou","year":"2005","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/MED.0000000000000156","article-title":"Testicular function and fertility preservation after treatment for haematological cancer","volume":"22","author":"Jahnukainen","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diab. Obes."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/ejh.12683","article-title":"Cardiac function in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study","volume":"97","author":"Jarfelt","year":"2016","journal-title":"Eur. J. Haematol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis: a link between cancer genetics and chemotherapy","volume":"108","author":"Johnstone","year":"2002","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0185","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1046\/j.1432-1033.2002.02809.x","article-title":"The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis","volume":"269","author":"Kaneko","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/spmg.19885","article-title":"Cell lines: valuable tools or useless artifacts","volume":"2","author":"Kaur","year":"2012","journal-title":"Spermatogenesis"},{"issue":"12","key":"10.1016\/j.taap.2018.04.014_bb0195","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/15287390600631144","article-title":"Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors","volume":"69","author":"Kim","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.taap.2018.04.014_bb0200","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2015.07.016","article-title":"Protective effect of cilostazol against doxorubicin-induced cardiomyopathy in mice","volume":"89","author":"Koh","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0205","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00280-016-3174-8","article-title":"Pharmacokinetic and pharmacodynamic study of doxorubicin in children with cancer: results of a \u201cEuropean pediatric oncology off-patents medicines consortium\u201d trial","volume":"78","author":"Krischke","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.taap.2018.04.014_bb0210","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.redox.2013.01.014","article-title":"Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms","volume":"1","author":"Kalyanaraman","year":"2013","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0215","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/sj.bjc.6600779","article-title":"p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection","volume":"88","author":"Lee","year":"2003","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0220","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1095\/biolreprod40.2.317","article-title":"Spermatogenic cell-somatic cell interactions are required for maintenance of spermatogenic cell glutathione","volume":"40","author":"Li","year":"1989","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.taap.2018.04.014_bb0225","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/ar.20693","article-title":"Amifostine protective effect on cisplatin-treated rat testis","volume":"291","author":"Lirdi","year":"2008","journal-title":"Anat. Rec. (Hoboken)"},{"issue":"8","key":"10.1016\/j.taap.2018.04.014_bb0230","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.freeradbiomed.2008.01.011","article-title":"ROS and p53: a versatile partnership","volume":"44","author":"Liu","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0235","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1095\/biolreprod.114.117754","article-title":"Effects of four chemotherapeutic agents, bleomycin, etoposide, cisplatin, and cyclophosphamide, on DNA damage and telomeres in a mouse spermatogonial cell line","volume":"90","author":"Liu","year":"2014","journal-title":"Biol. Reprod."},{"issue":"1\u20132","key":"10.1016\/j.taap.2018.04.014_bb0240","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-011-1059-z","article-title":"Subcellular basis of vitamin C protection against doxorubicin-induced changes in rat cardiomyocytes","volume":"360","author":"Ludke","year":"2012","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.59.1","article-title":"Peritubular myoid cells in the testis: their structure and function","volume":"59","author":"Maekawa","year":"1996","journal-title":"Arch. Histol. Cytol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1095\/biolreprod.110.083568","article-title":"Development of a short-term fluorescence-based assay to assess the toxicity of anticancer drugs on rat stem\/progenitor spermatogonia in vitro","volume":"83","author":"Marcon","year":"2010","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0255","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1530\/REP-12-0497","article-title":"Human testicular peritubular cells: more than meets the eye","volume":"145","author":"Mayerhofer","year":"2013","journal-title":"Reproduction"},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0260","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0006-2952(95)00164-U","article-title":"Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells","volume":"50","author":"Meier","year":"1995","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0265","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.gene.2015.02.015","article-title":"Anti-apoptotic effect of spermatogonial stem cells on doxorubicin-induced testicular toxicity in rats","volume":"561","author":"Mohamed","year":"2015","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0270","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/andr.12191","article-title":"The role of carnitine in male infertility","volume":"4","author":"Mongioi","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.taap.2018.04.014_bb0275","series-title":"Radioprotective effects of amifostine in vitro and in vivo measured with the comet assay. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]","first-page":"517","volume":"180(8)","author":"Muller","year":"2004"},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0280","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.5980\/jpnjurol1989.86.1132","article-title":"[Effects of anti-cancer agents on cultured rat Sertoli cells]. Nihon Hinyokika Gakkai zasshi","volume":"86","author":"Nambu","year":"1995","journal-title":"Jpn. J. Urol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0285","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.reprotox.2008.10.004","article-title":"Functional in vitro model to examine cancer therapy cytotoxicity in maturing rat testis","volume":"27","author":"Nurmio","year":"2009","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0290","article-title":"Pharmacokinetics of adriamycin after intravenous administration in rat","volume":"6","author":"Nwankwoala","year":"2008","journal-title":"Internet J. Oncol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0295","first-page":"31","article-title":"Comparison of viability of B16 and Cl S91 cells in three cytotoxicity tests: cells counting, MTT and flow cytometry after cytostatic drug treatment","volume":"61","author":"Olszewska-Slonina","year":"2004","journal-title":"Acta Pol. Pharm."},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0300","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.bbrc.2010.08.052","article-title":"The ascorbic acid paradox","volume":"400","author":"Osiecki","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0305","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/leu.2017.76","article-title":"Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents","volume":"31","author":"Poganitsch-Korhonen","year":"2017","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.taap.2018.04.014_bb0310","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1023\/A:1007475928452","article-title":"Establishment of a rat Sertoli cell line that displays the morphological and some of the functional characteristics of the native cell","volume":"13","author":"Pognan","year":"1997","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.reprotox.2004.12.005","article-title":"Lipoic acid ameliorates adriamycin-induced testicular mitochondriopathy","volume":"20","author":"Prahalathan","year":"2005","journal-title":"Reprod. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.taap.2018.04.014_bb0320","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cccn.2005.04.025","article-title":"Protective effect of lipoic acid on adriamycin-induced testicular toxicity","volume":"360","author":"Prahalathan","year":"2005","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0325","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.reprotox.2005.07.002","article-title":"Lipoic acid modulates adriamycin-induced testicular toxicity","volume":"21","author":"Prahalathan","year":"2006","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0330","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbi.2005.12.007","article-title":"Modulatory role of lipoic acid on adriamycin-induced testicular injury","volume":"160","author":"Prahalathan","year":"2006","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(13)70010-X","article-title":"Sustaining innovation and improvement in the treatment of childhood cancer: lessons from high-income countries","volume":"14","author":"Pritchard-Jones","year":"2013","journal-title":"Lancet. Oncol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2006.06.025","article-title":"Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets","volume":"545","author":"Ramassamy","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0345","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2605.2010.01058.x","article-title":"High risk of azoospermia in men treated for childhood cancer","volume":"34","author":"Romerius","year":"2011","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.taap.2018.04.014_bb0350","series-title":"The Principles of Humane Experimental Technique","author":"Russell","year":"1959"},{"key":"10.1016\/j.taap.2018.04.014_bb0355","doi-asserted-by":"crossref","unstructured":"Sasso-Cerri E, Oliveira B, de Santi F, Beltrame FL, Caneguim BH & Cerri PS (2017) The antineoplastic busulphan impairs peritubular and Leydig cells, and vitamin B12 stimulates spermatogonia proliferation and prevents busulphan-induced germ cell death. Biomed. Pharmacother. 95:1619\u20131630.","DOI":"10.1016\/j.biopha.2017.08.131"},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0360","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1210\/en.2009-1325","article-title":"15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility","volume":"151","author":"Schell","year":"2010","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.taap.2018.04.014_bb0365","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.taap.2018.04.014_bb0370","doi-asserted-by":"crossref","unstructured":"Skinner R, Mulder RL, Kremer LC, Hudson MM, Constine LS, Bardi E, Boekhout A, Borgmann-Staudt A, Brown MC, Cohn R, Dirksen U, Giwercman A, Ishiguro H, Jahnukainen K, Kenney LB, Loonen JJ, Meacham L, Neggers S, Nussey S, Petersen C, Shnorhavorian M, van den Heuvel-Eibrink MM, van Santen HM, Wallace WH & Green DM (2017) Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the international late effects of childhood cancer guideline harmonization group in collaboration with the PanCareSurFup consortium. Lancet Oncol. 18(2):e75-e90.","DOI":"10.1016\/S1470-2045(17)30026-8"},{"key":"10.1016\/j.taap.2018.04.014_bb0375","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.reprotox.2015.10.010","article-title":"Mono-(2-ethylhexyl) phthalate (MEHP) affects intercellular junctions of Sertoli cell: a potential role of oxidative stress","volume":"58","author":"Sobarzo","year":"2015","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0380","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.gene.2015.08.009","article-title":"Pitfalls of the MTT assay: direct and off-target effects of inhibitors can result in over\/underestimation of cell viability","volume":"574","author":"Stepanenko","year":"2015","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0385","first-page":"66","article-title":"Antioxidant action of carnitine: molecular mechanisms and practical applications","volume":"2","author":"Surai","year":"2015","journal-title":"EC Vet. Sci."},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0390","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0253-7613.91871","article-title":"Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats","volume":"44","author":"Swamy","year":"2012","journal-title":"Indian J. Pharmacol."},{"issue":"9330","key":"10.1016\/j.taap.2018.04.014_bb0395","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(02)09606-X","article-title":"Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study","volume":"360","author":"Thomson","year":"2002","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.taap.2018.04.014_bb0400","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.gofs.2017.09.004","article-title":"Transgenerational impact of chemotherapy: Would the father exposure impact the health of future progeny?","volume":"45","author":"Tremblay","year":"2017","journal-title":"Gynecologie, Obstetrique, Fertilite & Senologie"},{"issue":"2","key":"10.1016\/j.taap.2018.04.014_bb0405","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mrgentox.2010.08.005","article-title":"Evaluation of male germ cell toxicity in rats: correlation between sperm head morphology and sperm comet assay","volume":"703","author":"Trivedi","year":"2010","journal-title":"Mutat. Res."},{"issue":"12","key":"10.1016\/j.taap.2018.04.014_bb0410","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ardp.201400266","article-title":"Mitochondria as a target in the therapeutic properties of curcumin","volume":"347","author":"Trujillo","year":"2014","journal-title":"Arch. Pharm."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0415","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1210\/endo.143.5.8806","article-title":"Establishment of cell lines with rat spermatogonial stem cell characteristics","volume":"143","author":"Van Pelt","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2018.04.014_bb0420","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-7827-8-3","article-title":"Amifostine reduces the seminiferous epithelium damage in doxorubicin-treated prepubertal rats without improving the fertility status","volume":"8","author":"Vendramini","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"8","key":"10.1016\/j.taap.2018.04.014_bb0425","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1093\/humrep\/des159","article-title":"Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest","volume":"27","author":"Vendramini","year":"2012","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.taap.2018.04.014_bb0430","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4103\/0253-7613.84952","article-title":"Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats","volume":"43","author":"Viswanatha Swamy","year":"2011","journal-title":"Indian J. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2018.04.014_bb0435","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.theriogenology.2013.11.007","article-title":"Effect of vitamin C on growth of caprine spermatogonial stem cells in vitro","volume":"81","author":"Wang","year":"2014","journal-title":"Theriogenology"},{"key":"10.1016\/j.taap.2018.04.014_bb0440","article-title":"Triptolide induces Sertoli cell apoptosis in mice via ROS\/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response","author":"Wang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.taap.2018.04.014_bb0445","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11764-014-0354-6","article-title":"Male infertility in long-term survivors of pediatric cancer: a report from the childhood cancer survivor study","volume":"8","author":"Wasilewski-Masker","year":"2014","journal-title":"J. Cancer Survivorship"},{"issue":"1","key":"10.1016\/j.taap.2018.04.014_bb0450","first-page":"84","article-title":"Doxorubicin, DNA torsion, and chromatin dynamics","volume":"1845","author":"Yang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.taap.2018.04.014_bb0455","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bcp.2007.06.031","article-title":"Protection by doxycycline against doxorubicin-induced oxidative stress and apoptosis in mouse testes","volume":"74","author":"Yeh","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2018.04.014_bb0460","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2147\/TCRM.S141738","article-title":"Curcumin inhibits apoptosis by modulating Bax\/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats","volume":"13","author":"Zhao","year":"2017","journal-title":"Ther. Clin. Risk Manag."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18301492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18301492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T13:33:54Z","timestamp":1617716034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18301492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":91,"alternative-id":["S0041008X18301492"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.04.014","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro study of doxorubicin-induced oxidative stress in spermatogonia and immature Sertoli cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}