{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:17:22Z","timestamp":1772032642263,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400232"],"award-info":[{"award-number":["81400232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M572572"],"award-info":[{"award-number":["2015M572572"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2016JM8021"],"award-info":[{"award-number":["2016JM8021"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["XJTU2018"],"award-info":[{"award-number":["XJTU2018"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.taap.2018.04.030","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:36:17Z","timestamp":1524659777000},"page":"62-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na + -K + -ATPase, inhibiting Na + -K + -ATPase\/ROS pathway and activating PI3K\/Akt and ERK1\/2"],"prefix":"10.1016","volume":"349","author":[{"given":"Xiaofei","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Litao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.04.030_bb0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yjmcc.2009.04.004","article-title":"NADPH oxidase signaling and cardiac myocyte function","volume":"47","author":"A1","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0010","doi-asserted-by":"crossref","first-page":"H94","DOI":"10.1152\/ajpheart.00374.2012","article-title":"Modulation of cardiac Na+,K+-ATPase cell surface abundance by simulated ischemia-reperfusion and ouabain preconditioning","volume":"304","author":"Belliard","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0015","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1159\/000445561","article-title":"Cardioprotective effects of combined therapy with hyperbaric oxygen and diltiazem pretreatment on myocardial ischemia-reperfusion injury in rats","volume":"38","author":"Chen","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2018.04.030_bb0020","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/HYPERTENSIONAHA.111.180620","article-title":"Testosterone induces vascular smooth muscle cell migration by NADPH oxidase and c-Src-dependent pathways","volume":"59","author":"Chignalia","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2018.04.030_bb0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","article-title":"p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases","volume":"41","author":"E-Benna","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.taap.2018.04.030_bb0030","doi-asserted-by":"crossref","first-page":"H2280","DOI":"10.1152\/ajpheart.01164.2010","article-title":"Enhancement of Na\/K pump activity by chronic intermittent hypobaric hypoxia protected against reperfusion injury","volume":"300","author":"Guo","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0035","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.3892\/mmr.2014.2954","article-title":"Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury","volume":"11","author":"Guo","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"S1","key":"10.1016\/j.taap.2018.04.030_bb0040","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1111\/j.1540-8167.2006.00383.x","article-title":"Molecular control of cardiac sodium homeostasis in health and disease","volume":"17","author":"Hilgemann","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0045","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00424-007-0346-8","article-title":"Cyclooxygenase-2 mediates the delayed cardioprotection induced by hydrogen sulfide preconditioning in isolated rat cardiomyocytes","volume":"455","author":"Hu","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.taap.2018.04.030_bb0050","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1159\/000369716","article-title":"Protective effects of Millettia pulchra flavonoids on myocardial ischemia in vitro and in vivo","volume":"35","author":"Huang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2018.04.030_bb0055","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1007\/s00125-008-1008-x","article-title":"Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets","volume":"51","author":"Kominato","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.taap.2018.04.030_bb0060","doi-asserted-by":"crossref","first-page":"33636","DOI":"10.1038\/srep33636","article-title":"HSPA12B attenuated acute myocardial ischemia\/reperfusion injury via maintaining endothelial integrity in a PI3K\/Akt\/mTOR dependent mechanism","volume":"6","author":"Kong","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2018.04.030_bb0065","article-title":"Rhodiola crenulata and its bioactive components, salidroside and tyrosol, reverse the hypoxia-induced reduction of plasma-membrane-associated Na,K-ATPase expression via inhibition of ROS-AMPK-PKC \u03be pathway","volume":"284150","author":"Lee","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2018.04.030_bb0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pathophys.2007.09.008","article-title":"Regulation of sodium pump endocytosis by cardiotonic steroids: molecular mechanisms and physiological implications","volume":"14","author":"Liu","year":"2007","journal-title":"Pathophysiology"},{"key":"10.1016\/j.taap.2018.04.030_bb0075","doi-asserted-by":"crossref","first-page":"27838","DOI":"10.1074\/jbc.M002950200","article-title":"Ouabain interaction with cardiac Na+\/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations","volume":"275","author":"Liu","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"382","key":"10.1016\/j.taap.2018.04.030_bb0080","article-title":"Regulation of cardiac remodeling by cardiac Na(+)\/K(+)-ATPase isoforms","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.freeradbiomed.2013.04.001","article-title":"Redox signaling in cardiovascular health and disease","volume":"61","author":"Madamanchi","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.taap.2018.04.030_bb0090","doi-asserted-by":"crossref","first-page":"C222","DOI":"10.1152\/ajpcell.00199.2016","article-title":"Src-independent ERK signaling through the rat \u03b13 isoform of Na\/K-ATPase","volume":"312","author":"Madan","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"47","key":"10.1016\/j.taap.2018.04.030_bb0095","doi-asserted-by":"crossref","first-page":"E10178","DOI":"10.1073\/pnas.1713563114","article-title":"HIF and HOIL-1L-mediated PKC\u03b6 degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury","volume":"114","author":"Magnani","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2018.04.030_bb0100","doi-asserted-by":"crossref","first-page":"23241","DOI":"10.1038\/srep23241","article-title":"Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K\/Akt and MEK\/ERK pathways via the Na+\/K+-ATPase","volume":"6","author":"Ono","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2018.04.030_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2015.30","article-title":"NADPH oxidase activation contributes to native low-density lipoprotein-induced proliferation of human aortic smooth muscle cells","volume":"47","author":"Park","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.taap.2018.04.030_bb0110","doi-asserted-by":"crossref","first-page":"C42","DOI":"10.1152\/ajpcell.00386.2010","article-title":"Modulation of Na-K-ATPase cell surface abundance through structural determinants on the \u03b11-subunit","volume":"300","author":"Pierre","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0115","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1161\/01.CIR.0000132477.32438.03","article-title":"Digitalis therapy for patients in clinical heart failure","volume":"109","author":"Rahimtoola","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2018.04.030_bb0120","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1155\/2013\/974358","article-title":"Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage","volume":"35","author":"Rodrigo","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.taap.2018.04.030_bb0125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.yjmcc.2010.04.013","article-title":"Na+\/K+-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes","volume":"49","author":"Sapia","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2018.04.030_bb0130","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0008-6363(02)00767-8","article-title":"The Na, K-ATPase in the failing human heart","volume":"57","author":"Schwinger","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2018.04.030_bb0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BJ20061903","article-title":"NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation","volume":"406","author":"Serrander","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2018.04.030_bb0140","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500781","article-title":"pNaKtide inhibits Na\/K-ATPase reactive oxygen species amplification and attenuates adipogenesis","volume":"1","author":"Sodhi","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.taap.2018.04.030_bb0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2152\/jmi.60.66","article-title":"Cardioprotective effects of hyperkalemia during simulated ischemia\/reperfusion in neonatal rat cardiomyocyte -preservation of Na(+)\/K(+)-ATPase activity","volume":"60","author":"Takata","year":"2013","journal-title":"J. Med. Investig."},{"key":"10.1016\/j.taap.2018.04.030_bb0150","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1253\/circj.CJ-13-1187","article-title":"Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase","volume":"78","author":"Teshima","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.taap.2018.04.030_bb0155","doi-asserted-by":"crossref","first-page":"17250","DOI":"10.1074\/jbc.M313239200","article-title":"Ouabain assembles signaling cascades through the caveolar Na+\/K+-ATPase","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.04.030_bb0160","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.freeradbiomed.2014.03.036","article-title":"Involvement of Na\/K-ATPase in hydrogen peroxide-induced activation of the Src\/ERK pathway in LLC-PK1 cells","volume":"71","author":"Wang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"50","key":"10.1016\/j.taap.2018.04.030_bb0165","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1021\/bi4011804","article-title":"Cell signaling associated with Na(+)\/K(+)-ATPase: activation of phosphatidylinositide 3-kinase IA\/Akt by ouabain is independent of Src","volume":"52","author":"Wu","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.taap.2018.04.030_bb0170","doi-asserted-by":"crossref","first-page":"19323","DOI":"10.1074\/jbc.274.27.19323","article-title":"Intracellular reactive oxygen species mediate the linkage of Na+\/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes","volume":"274","author":"Xie","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.04.030_bb0175","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.bbrc.2005.10.067","article-title":"Activation of (Na+ + K+)-ATPase","volume":"338","author":"Xu","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2018.04.030_bb0180","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbrc.2006.08.070","article-title":"Activation of (Na+ + K+)-ATPase induces positive inotropy in intact mouse heart in vivo","volume":"349","author":"Xu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2018.04.030_bb0185","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/abbs\/gmw079","article-title":"Activation of Na+-K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities by DRm217","volume":"48","author":"Yan","year":"2016","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.taap.2018.04.030_bb0190","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10495-016-1342-2","article-title":"Activation of Na+-K+-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na+-K+-ATPase\/Src\/Ros amplifier","volume":"22","author":"Yan","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.taap.2018.04.030_bb0195","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/1567202611666140908094517","article-title":"Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91(phox)","volume":"11","author":"Yu","year":"2014","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.taap.2018.04.030_bb0200","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.RES.86.6.692","article-title":"Inhibition of extracellular signal-regulated kinase enhances ischemia\/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart","volume":"86","author":"Yue","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2018.04.030_bb0205","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.3390\/molecules17043805","article-title":"Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats","volume":"17","author":"Zhang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2018.04.030_bb0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/cvr\/cvq263","article-title":"Cardioprotection induced by Na(+)\/K(+)-ATPase activation involves extracellular signal-regulated kinase 1\/2 and phosphoinositide 3-kinase\/Akt pathway","volume":"89","author":"Zheng","year":"2011","journal-title":"Cardiovasc. Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18301741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18301741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T23:46:37Z","timestamp":1661039197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18301741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":42,"alternative-id":["S0041008X18301741"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.04.030","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DRm217 attenuates myocardial ischemia-reperfusion injury via stabilizing plasma membrane Na+-K+-ATPase, inhibiting Na+-K+-ATPase\/ROS pathway and activating PI3K\/Akt and ERK1\/2","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}