{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:17:18Z","timestamp":1778008638642,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Gulf War Illness Research","award":["W81XWH-13-2-0072"],"award-info":[{"award-number":["W81XWH-13-2-0072"]}]},{"DOI":"10.13039\/https:\/\/doi.org\/10.13039\/100011410","name":"University of South Carolina School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/https:\/\/doi.org\/10.13039\/100011410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/https:\/\/doi.org\/10.13039\/100011119","name":"University of Georgia college of veterinary medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/https:\/\/doi.org\/10.13039\/100011119","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/https:\/\/doi.org\/10.13039\/100008899","name":"University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/https:\/\/doi.org\/10.13039\/100008899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.taap.2018.05.006","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T04:22:32Z","timestamp":1525839752000},"page":"64-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness"],"prefix":"10.1016","volume":"350","author":[{"given":"Ratanesh Kumar","family":"Seth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Kimono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas","family":"Alhasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sutapa","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muayad","family":"Albadrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K.","family":"Lasley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnie","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Janulewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitzi","family":"Nagarkatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Nagarkatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-7149","authenticated-orcid":false,"given":"Saurabh","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.05.006_bb0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2016.10.012","article-title":"Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness","volume":"372","author":"Abdullah","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2018.05.006_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172914","article-title":"Altered gut microbiome in a mouse model of Gulf War illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation","volume":"12","author":"Alhasson","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.05.006_bb0015","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1161\/ATVBAHA.112.250142","article-title":"Stearic acid accumulation in macrophages induces toll-like receptor 4\/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis","volume":"32","author":"Anderson","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2018.05.006_bb0020","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2018.05.006_bb0025","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2018.05.006_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biochi.2015.06.020","article-title":"Metabolic endotoxemia with obesity: is it real and is it relevant?","volume":"124","author":"Boutagy","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.taap.2018.05.006_bb0035","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0140-6736(15)00154-3","article-title":"Primary biliary cirrhosis","volume":"386","author":"Carey","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2018.05.006_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbadis.2015.10.009","article-title":"Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis","volume":"1862","author":"Chandrashekaran","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2018.05.006_bb0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.05.005","article-title":"HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease","volume":"13","author":"Chandrashekaran","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2018.05.006_bb0050","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2018.05.006_bb0055","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jhep.2012.11.035","article-title":"Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis","volume":"58","author":"Chatterjee","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2018.05.006_bb0060","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.115","article-title":"Hedgehog controls hepatic stellate cell fate by regulating metabolism","volume":"143","author":"Chen","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2018.05.006_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu9111220","article-title":"Nonalcoholic fatty liver disease is exacerbated in high-fat diet-fed Gnotobiotic mice by colonization with the gut microbiota from patients with nonalcoholic Steatohepatitis","volume":"9","author":"Chiu","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2018.05.006_bb0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/jrnms-82-141","article-title":"A review of Gulf War illness","volume":"82","author":"Coker","year":"1996","journal-title":"J. R. Nav. Med. Serv."},{"key":"10.1016\/j.taap.2018.05.006_bb0075","series-title":"Update of Health Effects of Serving in the Gulf War, 2016","article-title":"Gulf war and health","volume":"vol. 10","year":"2016"},{"key":"10.1016\/j.taap.2018.05.006_bb0080","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1874297101104010140","article-title":"Selected health conditions among overweight, obese, and non-obese veterans of the 1991 Gulf War: results from a survey conducted in 2003-2005","volume":"4","author":"Coughlin","year":"2011","journal-title":"Open Epidemiol. J."},{"key":"10.1016\/j.taap.2018.05.006_bb0085","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s10620-017-4492-3","article-title":"Increasing burden of chronic liver disease among adolescents and young adults in the USA: a silent epidemic","volume":"62","author":"Doycheva","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.taap.2018.05.006_bb0090","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1189\/jlb.1111537","article-title":"Mechanisms of triglyceride accumulation in activated macrophages","volume":"92","author":"Feingold","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2018.05.006_bb0095","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1089\/ars.2015.6383","article-title":"The rapeutic opportunities in damage-associated molecular pattern-driven metabolic diseases","volume":"23","author":"Garcia-Martinez","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2018.05.006_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/nu9091026","article-title":"Insights into the hexose liver metabolism-glucose versus fructose","volume":"9","author":"Geidl-Flueck","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2018.05.006_bb0105","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1007\/s00221-017-5050-0","article-title":"Gulf War illness (GWI) as a neuroimmune disease","volume":"235","author":"Georgopoulos","year":"2017","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.taap.2018.05.006_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40168-016-0171-4","article-title":"Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"4","author":"Giloteaux","year":"2016","journal-title":"Microbiome"},{"key":"10.1016\/j.taap.2018.05.006_bb0115","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2337\/diabetes.52.7.1664","article-title":"Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop","volume":"52","author":"Guilmeau","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2018.05.006_bb0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/jamaneurol.2013.596","article-title":"Cholinergic autonomic dysfunction in veterans with Gulf War illness: confirmation in a population-based sample","volume":"70","author":"Haley","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.taap.2018.05.006_bb0125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.taap.2018.05.006_bb0130","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1507\/endocrj.K07E-110","article-title":"ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome","volume":"55","author":"Iizuka","year":"2008","journal-title":"Endocr. J."},{"key":"10.1016\/j.taap.2018.05.006_bb0135","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/gutjnl-2016-312135","article-title":"Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease","volume":"67","author":"Imhann","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.taap.2018.05.006_bb0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.diabres.2016.11.002","article-title":"Fatigue in type 1 diabetes: a systematic review of observational studies","volume":"123","author":"Jensen","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.taap.2018.05.006_bb0145","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pmrj.2010.04.011","article-title":"Fatigue, endocrinopathies, and metabolic disorders","volume":"2","author":"Kaltsas","year":"2010","journal-title":"PM & R"},{"key":"10.1016\/j.taap.2018.05.006_bb0150","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.3748\/wjg.v18.i46.6771","article-title":"Hepatic expression and cellular distribution of the glucose transporter family","volume":"18","author":"Karim","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2018.05.006_bb0155","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/aje\/kwp238","article-title":"Physical, psychological, and functional comorbidities of multisymptom illness in Australian male veterans of the 1991 Gulf War","volume":"170","author":"Kelsall","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.taap.2018.05.006_bb0160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1515\/reveh-2015-0032","article-title":"Gulf War illness: an overview of events, most prevalent health outcomes, exposures, and clues as to pathogenesis","volume":"30","author":"Kerr","year":"2015","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.taap.2018.05.006_bb0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fct.2014.08.010","article-title":"Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-beta1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats","volume":"73","author":"Khan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2018.05.006_bb0170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2217\/epi.15.20","article-title":"The role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention","volume":"7","author":"Khan","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.taap.2018.05.006_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbi.2017.08.003","article-title":"Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness","volume":"67","author":"Koo","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.taap.2018.05.006_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092887","article-title":"Mitochondrial dysfunction in Gulf War illness revealed by 31Phosphorus magnetic resonance spectroscopy: a case-control study","volume":"9","author":"Koslik","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.05.006_bb0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12934-017-0691-z","article-title":"Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria","volume":"16","author":"LeBlanc","year":"2017","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.taap.2018.05.006_bb0190","doi-asserted-by":"crossref","DOI":"10.4161\/21688370.2014.977176","article-title":"Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation","volume":"3","author":"Luettig","year":"2015","journal-title":"Tissue Barriers"},{"issue":"2","key":"10.1016\/j.taap.2018.05.006_bb0195","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2018.05.006_bb0200","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/ncb2324","article-title":"NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration","volume":"13","author":"Mauro","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2018.05.006_bb0205","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000336669","article-title":"Nonalcoholic fatty liver disease\/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment","volume":"30","author":"Milic","year":"2012","journal-title":"Dig. Dis."},{"key":"10.1016\/j.taap.2018.05.006_bb0210","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.2174\/1381612822666160914182822","article-title":"The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and Neuroimmune processes with an emphasis on inflammatory bowel disease type 1 diabetes and chronic fatigue syndrome","volume":"22","author":"Morris","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.taap.2018.05.006_bb0215","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40168-017-0261-y","article-title":"Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"5","author":"Nagy-Szakal","year":"2017","journal-title":"Microbiome"},{"key":"10.1016\/j.taap.2018.05.006_bb0220","doi-asserted-by":"crossref","first-page":"E5472","DOI":"10.1073\/pnas.1607571113","article-title":"Metabolic features of chronic fatigue syndrome","volume":"113","author":"Naviaux","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2018.05.006_bb0225","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jnc.13088","article-title":"Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness","volume":"133","author":"O'Callaghan","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2018.05.006_bb0230","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ebiom.2016.10.037","article-title":"Supporting a Neuroimmune basis of Gulf War Illness","volume":"13","author":"O'Callaghan","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.taap.2018.05.006_bb0235","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cmet.2016.11.009","article-title":"SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism","volume":"25","author":"Oishi","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2018.05.006_bb0240","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/npp.2013.158","article-title":"Mood and memory deficits in a model of Gulf War Illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus","volume":"38","author":"Parihar","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.taap.2018.05.006_bb0245","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1210\/en.2014-1552","article-title":"TLR4 expression in bone marrow-derived cells is both necessary and sufficient to produce the insulin resistance phenotype in diet-induced obesity","volume":"156","author":"Razolli","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2018.05.006_bb0250","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1113\/JP273269","article-title":"Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid- and lipopolysaccharide-induced TLR4 signalling","volume":"595","author":"Reichardt","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.taap.2018.05.006_bb0255","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/gast.2002.35391","article-title":"HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice","volume":"123","author":"Sappington","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2018.05.006_bb0260","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3748\/wjg.14.2474","article-title":"Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment","volume":"14","author":"Schreuder","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2018.05.006_bb0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/gut.47.3.397","article-title":"Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease","volume":"47","author":"Segain","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.taap.2018.05.006_bb0270","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1139\/O07-145","article-title":"Competitive inhibition of histone deacetylase activity by trichostatin a and butyrate","volume":"85","author":"Sekhavat","year":"2007","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2018.05.006_bb0275","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/toxsci\/kft104","article-title":"Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice","volume":"134","author":"Seth","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2018.05.006_bb0280","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/toxsci\/kft104","article-title":"Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice","volume":"134","author":"Seth","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2018.05.006_bb0285","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2018.05.006_bb0290","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/gut.47.2.178","article-title":"Leptin secretion and leptin receptor in the human stomach","volume":"47","author":"Sobhani","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.taap.2018.05.006_bb0295","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2006.05.170","article-title":"Activation of toll-like receptor 4 is associated with insulin resistance in adipocytes","volume":"346","author":"Song","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2018.05.006_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ntt.2017.11.002","article-title":"Neuropsychological functioning in military pesticide applicators from the Gulf War: effects on information processing speed, attention and visual memory","volume":"65","author":"Sullivan","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.taap.2018.05.006_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","article-title":"Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases","volume":"52","author":"Sun","year":"2017","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.taap.2018.05.006_bb0310","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.pop.2017.07.003","article-title":"Nonalcoholic fatty liver disease","volume":"44","author":"Sweet","year":"2017","journal-title":"Prim. Care"},{"key":"10.1016\/j.taap.2018.05.006_bb0315","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1111\/j.1476-5381.2010.00956.x","article-title":"Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase","volume":"161","author":"Tang","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.05.006_bb0320","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.taap.2018.05.006_bb0325","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cortex.2015.08.022","article-title":"Recent research on gulf war illness and other health problems in veterans of the 1991 gulf war: effects of toxicant exposures during deployment","volume":"74","author":"White","year":"2016","journal-title":"Cortex"},{"issue":"3","key":"10.1016\/j.taap.2018.05.006_bb0330","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/liv.13591","article-title":"Complications, symptoms, quality of life and pregnancy in cholestatic liver disease","volume":"38","author":"Zakharia","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.taap.2018.05.006_bb0335","first-page":"71","article-title":"A chronic longitudinal characterization of neurobehavioral and Neuropathological cognitive impairment in a mouse model of gulf war agent exposure","volume":"9","author":"Zakirova","year":"2015","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.taap.2018.05.006_bb0340","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12876-016-0500-x","article-title":"Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.taap.2018.05.006_bb0345","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of Claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J. Immunol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18302059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18302059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T21:32:55Z","timestamp":1661203975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18302059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":69,"alternative-id":["S0041008X18302059"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.05.006","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}