{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:03:41Z","timestamp":1785128621326,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370337"],"award-info":[{"award-number":["81370337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173089"],"award-info":[{"award-number":["81173089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Key Laboratory of Medical Information Analysis & Tumor Diagnosis and Treatment","award":["PJS140011707"],"award-info":[{"award-number":["PJS140011707"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.taap.2018.05.010","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T21:45:05Z","timestamp":1526420705000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Inhibition of COX-2\/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation"],"prefix":"10.1016","volume":"351","author":[{"given":"Yanzhuo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-2872","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.05.010_bb0005","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/art.27492","article-title":"Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132","volume":"62","author":"Ahmed","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0010","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","article-title":"NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B (4) in a murine model of gout","volume":"64","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0015","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1476-5381.2011.01358.x","article-title":"PGE(2)-EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-\u03baB","volume":"163","author":"Aoki","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.05.010_bb0020","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/jm0613166","article-title":"Structural and functional basis of cyclooxygenase inhibition","volume":"50","author":"Blobaum","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2018.05.010_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03007995.2017.1378502","article-title":"The management of hyperuricemia: back to the pathophysiology of uric acid","volume":"33","author":"Borghi","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.taap.2018.05.010_bb0030","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0304-3959(87)90072-8","article-title":"Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant","volume":"28","author":"Coderre","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.taap.2018.05.010_bb0035","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2018.05.010_bb0040","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2016.06.005","article-title":"Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators","volume":"786","author":"Dhanasekar","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.05.010_bb0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s10067-009-1362-1","article-title":"\u201cClinical features of women with gout arthritis.\u201d A systematic review","volume":"29","author":"Dirken-Heukensfeldt","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.taap.2018.05.010_bb0050","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/BOR.0000000000000143","article-title":"Interleukin-1 as a therapeutic target in gout","volume":"27","author":"Dumusc","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.taap.2018.05.010_bb0055","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.taap.2017.05.016","article-title":"Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1\u03b2 signaling in rheumatoid arthritis synovial fibroblasts","volume":"329","author":"Fechtner","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.05.010_bb0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40264-015-0366-9","article-title":"Hepatotoxicity associated with the use of anti-TNF-\u03b1 agents","volume":"39","author":"French","year":"2016","journal-title":"Drug Saf."},{"key":"10.1016\/j.taap.2018.05.010_bb0065","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1189\/jlb.3MA0915-418R","article-title":"Macrophage migration inhibitory factor drives neutrophil accumulation by facilitating IL-1\u03b2 production in a murine model of acute gout","volume":"99","author":"Galv\u00e3o","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2018.05.010_bb0070","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1039\/c2mb05503a","article-title":"Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network","volume":"8","author":"He","year":"2012","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.taap.2018.05.010_bb0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12974-014-0147-x","article-title":"SCM-198 inhibits microglial overactivation and attenuates A\u03b2 (1-40)-induced cognitive impairments in rats via JNK and NF-\u043aB pathways","volume":"11","author":"Hong","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2018.05.010_bb0080","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1093\/rheumatology\/kex250","article-title":"The British Society for Rheumatology guideline for the management of gout","volume":"56","author":"Hui","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.taap.2018.05.010_bb0085","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1073\/pnas.0802894105","article-title":"Structural basis for induced formation of the inflammatory mediator prostaglandin E2","volume":"105","author":"Jegersch\u00f6ld","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2018.05.010_bb0090","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.phrs.2016.08.035","article-title":"Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2","volume":"113","author":"Joshi","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2018.05.010_bb0095","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.4049\/jimmunol.1400347","article-title":"Crucial role of macrophage selenoproteins in experimental colitis","volume":"193","author":"Kaushal","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2018.05.010_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167058","article-title":"Pro-resolving effects of resolvin D2 in LTD4 and TNF-\u03b1 pre-treated human bronchi","volume":"11","author":"Khaddaj-Mallat","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.05.010_bb0105","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4049\/jimmunol.1303188","article-title":"Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats","volume":"194","author":"Kou","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2018.05.010_bb0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/0717-6287-47-41","article-title":"Ethyl acetate fraction from Angelica sinensis inhibits IL-1\u03b2-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production","volume":"47","author":"Lee","year":"2014","journal-title":"Biol. Res."},{"key":"10.1016\/j.taap.2018.05.010_bb0115","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/rheumatology\/kex142","article-title":"Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis","volume":"56","author":"Li","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.taap.2018.05.010_bb0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-017-0849-y","article-title":"Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression","volume":"14","author":"Liu","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2018.05.010_bb0125","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/imm.12478","article-title":"Leukotriene B\u2084-leukotriene B\u2084 receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8+ T cells","volume":"146","author":"Lv","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.taap.2018.05.010_bb0130","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.30249","article-title":"Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout","volume":"63","author":"Martin","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0135","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1365-2249.2004.02563.x","article-title":"Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies","volume":"137","author":"McNearney","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.taap.2018.05.010_bb0140","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1002\/art.21403","article-title":"Circadian pattern of spontaneous behavior in monarthritic rats: a novel global approach to evaluation of chronic pain and treatment effectiveness","volume":"52","author":"Millecamps","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0145","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbalip.2014.09.016","article-title":"Cyclooxygenase inhibitors: from pharmacology to clinical read-outs","volume":"1851","author":"Patrignani","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2018.05.010_bb0150","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/med.21424","article-title":"Nonsteroidal anti-inflammatory therapy: a journey toward safety","volume":"37","author":"Pereira-Leite","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.taap.2018.05.010_bb0155","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/art.30232","article-title":"Characterization of CCL19 and CCL21 in rheumatoid arthritis","volume":"63","author":"Pickens","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0160","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7326\/M16-0570","article-title":"Management of acute and recurrent gout: a clinical practice guideline from the American College of Physicians","volume":"166","author":"Qaseem","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.taap.2018.05.010_bb0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13023-015-0228-7","article-title":"Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey","volume":"10","author":"Rossi-Semerano","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.taap.2018.05.010_bb0170","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/annrheumdis-2013-203803","article-title":"High-density lipoproteins inhibit urate crystal-induced inflammation in mice","volume":"74","author":"Scanu","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.taap.2018.05.010_bb0175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI43302","article-title":"Leukotriene B4 amplifies NF-\u03baB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression","volume":"121","author":"Serezani","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2018.05.010_bb0180","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.bmc.2014.03.008","article-title":"Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors","volume":"22","author":"Shang","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2018.05.010_bb0185","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1002\/art.38730","article-title":"Brief report: granulocyte-macrophage colony-stimulating factor drives monosodium urate monohydrate crystal-induced inflammatory macrophage differentiation and NLRP3 inflammasome up-regulation in an in vivo mouse model","volume":"66","author":"Shaw","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2018.05.010_bb0190","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.taap.2018.05.010_bb0195","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.taap.2018.05.010_bb0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10753-014-0009-9","article-title":"Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis","volume":"38","author":"Song","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.taap.2018.05.010_bb0205","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/ard.2003.015743","article-title":"Severe gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic option","volume":"63","author":"Tausche","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.taap.2018.05.010_bb0210","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3389\/fimmu.2017.01214","article-title":"Cannabinoid receptor 1 participates in liver inflammation by promoting M1 macrophage polarization via RhoA\/NF-\u03baB p65 and ERK1\/2 pathways, respectively, in mouse liver fibrogenesis","volume":"8","author":"Tian","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2018.05.010_bb0215","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12891-017-1648-4","article-title":"Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-\u03b1 stimulation of synovial cells: an in vitro study","volume":"18","author":"Uchida","year":"2017","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.taap.2018.05.010_bb0220","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.talanta.2016.10.065","article-title":"Targeted profiling of arachidonic acid and eicosanoids in rat tissue by UFLC-MS\/MS: application to identify potential markers for rheumatoid arthritis","volume":"162","author":"Wang","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.taap.2018.05.010_bb0225","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/annrheumdis-2014-206074","article-title":"AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages","volume":"75","author":"Wang","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.taap.2018.05.010_bb0230","first-page":"1","article-title":"TNF-\u03b1 potentiates uric acid-induced interleukin-1\u03b2 (IL-1\u03b2) secretion in human neutrophils","volume":"14","author":"Yokose","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.taap.2018.05.010_bb0235","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2014.07.018","article-title":"Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion","volume":"280","author":"Zheng","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18302096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18302096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T20:07:46Z","timestamp":1720296466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18302096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":47,"alternative-id":["S0041008X18302096"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.05.010","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of COX-2\/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}