{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T23:50:34Z","timestamp":1773532234974,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.taap.2018.09.043","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:28:21Z","timestamp":1538371701000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination of trichloroethylene and 1,1,1-trichloroethane"],"prefix":"10.1016","volume":"360","author":[{"given":"Tanzir","family":"Mortuza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasa","family":"Muralidhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carey","family":"Hines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.09.043_bb0005","series-title":"Drinking Water and Health","first-page":"172","article-title":"Dose route extrapolations: Using inhalation toxicity data to set drinking water limits","volume":"Vol. 6","author":"Andersen","year":"1986"},{"key":"10.1016\/j.taap.2018.09.043_bb0010","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1080\/10934529.2015.1064275","article-title":"Relationship between vapor intrusion and human exposure to trichloroethylene","volume":"50","author":"Archer","year":"2015","journal-title":"J. Environ. Sci. Health Part A"},{"key":"10.1016\/j.taap.2018.09.043_bb0015","series-title":"Toxicological Profile for 1,1,1-Trichloroethane. Agency for Toxic Substances and Disease Registry","author":"ATSDR","year":"2007"},{"key":"10.1016\/j.taap.2018.09.043_bb0020","unstructured":"ATSDR, 2014. Toxicological Profile for Trichloroethylene. Agency for Toxic Substances and Disease Registry, U.S. Dept. Health and Human Services, Atlanta, GA."},{"key":"10.1016\/j.taap.2018.09.043_bb0025","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jchromb.2006.01.019","article-title":"Quantitation of volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry","volume":"832","author":"Blount","year":"2006","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.taap.2018.09.043_bb0030","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/60.2.363","article-title":"Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats","volume":"60","author":"Bruckner","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2018.09.043_bb0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0041-008X(85)90310-2","article-title":"Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study","volume":"78","author":"Buben","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0040","first-page":"36","article-title":"Community exposures to chemicals through vapor intrusion: a review of past Agency of Toxic Substances and Disease Registry public health evaluations","volume":"75","author":"Burk","year":"2013","journal-title":"J. Environ. Health"},{"key":"10.1016\/j.taap.2018.09.043_bb0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/00039890109604068","article-title":"Recent chemical exposures and blood volatile organic compound levels in a large population-based sample","volume":"56","author":"Churchill","year":"2001","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.taap.2018.09.043_bb0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.116.232629","article-title":"Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: Key similarities, differences, and data gaps","volume":"359","author":"Cichocki","year":"2016","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"10.1016\/j.taap.2018.09.043_bb0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0041-008X(89)90168-3","article-title":"The uptake and elimination of 1,1,1-trichloroethane during and following inhalation exposures in rats","volume":"98","author":"Dallas","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0060","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/15287398509530688","article-title":"Oral and intravenous trichloroethylene pharmacokinetics in the rat","volume":"15","author":"D'Souza","year":"1985","journal-title":"J. Toxicol. Environ. Helath"},{"key":"10.1016\/j.taap.2018.09.043_bb0065","first-page":"779","article-title":"Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rats, and human liver microsomes","volume":"26","author":"Elfarra","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2018.09.043_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0041-008X(89)90137-3","article-title":"Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues","volume":"98","author":"Gargas","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0075","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0045-6535(99)00279-9","article-title":"Relative lipid content as the sole mechanistic determinant of the adipose tissue:blood partition coefficients of highly lipophilic organic chemicals","volume":"40","author":"Haddad","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2018.09.043_bb0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5271\/sjweh.2791","article-title":"A study on the distribution of methylchloroform and n-octane in the mouse during and after inhalation","volume":"3","author":"Holmberg","year":"1977","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.taap.2018.09.043_bb0085","series-title":"Trichloroethylene, Tetrachloroethylene, and some Other Chlorinated Agents, Vol","first-page":"106","author":"IARC","year":"2014"},{"key":"10.1016\/j.taap.2018.09.043_bb0090","series-title":"Toxicological Review of 1,1,1-Trichloroethane (CAS No. 71\u201355-6)","author":"IRIS","year":"2009"},{"key":"10.1016\/j.taap.2018.09.043_bb0095","series-title":"Toxicological Review of Trichloroethylene (CAS No. 79\u201301-6)","author":"IRIS","year":"2011"},{"key":"10.1016\/j.taap.2018.09.043_bb0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.scitotenv.2011.12.055","article-title":"Blood\/air distribution of volatile organic compounds in a nationally representative sample","volume":"419","author":"Jia","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2018.09.043_bb0105","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/0272-0590(85)90200-3","article-title":"Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice","volume":"5","author":"Jorgenson","year":"1985","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.taap.2018.09.043_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/toxsci\/kfg212","article-title":"Tissue dosimetry expansion and cross validation of rat and mouse physiologically based pharmacokinetic models for trichloroethylene","volume":"76","author":"Keys","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2018.09.043_bb0115","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1289\/ehp.866989","article-title":"Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice","volume":"69","author":"Klaunig","year":"1986","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2018.09.043_bb0120","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0041-008X(92)90333-N","article-title":"Species differences in metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dicholoroacetate","volume":"115","author":"Larson","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1289\/ehp.00108s2177","article-title":"Metabolism of trichloroethylene","volume":"108","author":"Lash","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2018.09.043_bb0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrrev.2014.04.003","article-title":"Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity","volume":"762","author":"Lash","year":"2014","journal-title":"Mut. Res."},{"key":"10.1016\/j.taap.2018.09.043_bb0135","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1006\/taap.1996.0165","article-title":"Characterization of presystemic elimination of trichloroethylene and its nonlinear kinetics in rats","volume":"139","author":"Lee","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/taap.2000.8892","article-title":"Mechanisms of the dose-dependent kinetics of trichloroethylene: Oral bolus dosing of rats","volume":"164","author":"Lee","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0145","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/taap.1996.8040","article-title":"Cytochrome P450-dependent metabolism of trichloroethylene: Interindividual differences in humans","volume":"142","author":"Lipscomb","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0150","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1124\/dmd.109.028100","article-title":"Presystemic elimination of trichloroethylene in rats following environmentally relevant oral exposures","volume":"37","author":"Liu","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2018.09.043_bb0155","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.yrtph.2007.12.001","article-title":"Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane","volume":"50","author":"Lu","year":"2008","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/bmj.294.6574.727","article-title":"Chronic cardiac toxicity after inhalation of 1, 1, 1-trichloroethane","volume":"294","author":"McLeod","year":"1987","journal-title":"Br. Med. J."},{"key":"10.1016\/j.taap.2018.09.043_bb0165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/es061553y","article-title":"Chlorinated solvents in groundwater of the United States","volume":"41","author":"Moran","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2018.09.043_bb0270","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-4347(99)00282-0","article-title":"A simple method for rapid measurement of trichloroethylene and its major metabolites in biological samples.","volume":"732","author":"Muralidhara","year":"1999","journal-title":"J. Chrom B"},{"key":"10.1016\/j.taap.2018.09.043_bb0170","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0006-2952(93)90252-R","article-title":"Cytochrome P450-related differences in the metabolism of benzene, toluene and trichloroethylene in liver microsomes","volume":"45","author":"Nakajima","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0175","series-title":"Contaminated Water Supplies at Camp Lejeune: Assessing Potential Health Effects. Ch. 3","first-page":"67","author":"NAS","year":"2009"},{"key":"10.1016\/j.taap.2018.09.043_bb0180","article-title":"Report on the Carcinogenesis Bioassay of Chloroform. CAS No. 67\u201366-3","author":"NCI","year":"1976","journal-title":"Technical Report Series. National Cancer Institute, Washington, DC"},{"key":"10.1016\/j.taap.2018.09.043_bb0185","series-title":"Carcinogenesi Bioassay of Trichloroethylene. CAS No. 79\u201301-6. NCI-CG-TR-? Technical Report Series no","first-page":"2","author":"NCI","year":"1976"},{"key":"10.1016\/j.taap.2018.09.043_bb0190","article-title":"Bioassay of Tetrachloroethylene for Possible Carcinogenicity. CAS No. 127\u201318-4. NCI-CG-TR-13","author":"NCI","year":"1977","journal-title":"National Cancer Institute, Washington, DC"},{"key":"10.1016\/j.taap.2018.09.043_bb0195","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0272-0590(84)90057-5","article-title":"Kinetics and metabolism of inhaled methyl chloroform (1,1,1-trichloroethane) in male volunteers","volume":"4","author":"Nolan","year":"1984","journal-title":"Fund. Appl. Toxicol"},{"key":"10.1016\/j.taap.2018.09.043_bb0200","unstructured":"NTP, 2016. 14th Report on Carcinogens. National Toxicology Program, U.S. Dept. Health and Human Services, Research Triangle Park, NC."},{"key":"10.1016\/j.taap.2018.09.043_bb0205","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/00984100290071171","article-title":"Comparison of models for the estimation of biological partition coefficients","volume":"65","author":"Payne","year":"2002","journal-title":"J. Toxicol. Environ. Health Part A"},{"key":"10.1016\/j.taap.2018.09.043_bb0210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.taap.2010.09.010","article-title":"A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals","volume":"249","author":"Peyret","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0215","first-page":"283","article-title":"Chemical exposures at hazardous waste sites: Experiences from the United States and Poland","volume":"25","author":"Pohl","year":"2008","journal-title":"Environ. Sci. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0220","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/15287399509532021","article-title":"An algorithm for predicting tissue:blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data","volume":"46","author":"Poulin","year":"1995","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.taap.2018.09.043_bb0225","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.taap.2008.04.020","article-title":"Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1","volume":"231","author":"Ramdhan","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0230","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0041-008X(88)90155-X","article-title":"Physiologically based pharmacokinetic modeling with methylchloroform: Implications for interspecies, high dose\/low dose, and dose route extrapolations","volume":"95","author":"Reitz","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0235","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/jps.20322","article-title":"Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases","volume":"94","author":"Rodgers","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.taap.2018.09.043_bb0240","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2007.09.010","article-title":"General approach for the calculation of tissue to plasma partition coefficients","volume":"22","author":"Schmitt","year":"2008","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2018.09.043_bb0245","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0041-008X(82)90140-5","article-title":"[14C] Methyl chloroform (1,1,1-trichloroethane): Pharmacokinetics in rats and following inhalation exposure","volume":"62","author":"Schumann","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.09.043_bb0255","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4044\/joma1947.98.11-12_1091","article-title":"Experimental study on toxicity of trichloroethane. I. Organ distribution of 1,1,1- and 1,1,2-trichloroethanes in exposed mice","volume":"98","author":"Takahara","year":"1986","journal-title":"Okayama Igakki Zasshi"},{"key":"10.1016\/j.taap.2018.09.043_bb0260","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0892-0362(97)00096-2","article-title":"Schedule-controlled operant behavior of rats during 1,1,1-trichloroethane inhalation: Relationship to blood and brain solvent concentrations","volume":"20","author":"Warren","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.taap.2018.09.043_bb0265","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/toxsci\/56.2.365","article-title":"Biphasic effects of 1,1,1-trichloroethane on the locomotor activity of mice: Relationship to blood and brain solvent concentrations","volume":"56","author":"Warren","year":"2000","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18304575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18304575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T06:37:41Z","timestamp":1543905461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18304575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":53,"alternative-id":["S0041008X18304575"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.09.043","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of dose and exposure protocol on the toxicokinetics and first-pass elimination of trichloroethylene and 1,1,1-trichloroethane","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.09.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}