{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:54:45Z","timestamp":1791863685716,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH Common Fund Initiative","award":["3UO1NS038455-13S1"],"award-info":[{"award-number":["3UO1NS038455-13S1"]}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES019776"],"award-info":[{"award-number":["ES019776"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES026560"],"award-info":[{"award-number":["ES026560"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES012870"],"award-info":[{"award-number":["ES012870"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH107205"],"award-info":[{"award-number":["MH107205"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NS038455"],"award-info":[{"award-number":["NS038455"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NS050659"],"award-info":[{"award-number":["NS050659"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.taap.2018.12.001","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T02:26:39Z","timestamp":1543890399000},"page":"122-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Metabolome-wide association study of anti-epileptic drug treatment during pregnancy"],"prefix":"10.1016","volume":"363","author":[{"given":"Douglas I.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Perry-Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Finnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt D.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilinh","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"McElrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimford J.","family":"Meador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Page B.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.12.001_bb0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1472-6483(10)60300-8","article-title":"Early risk factors for miscarriage: a prospective cohort study in pregnant women","volume":"17","author":"Arck","year":"2008","journal-title":"Reprod. BioMed. Online"},{"key":"10.1016\/j.taap.2018.12.001_bb0010","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.biocel.2003.11.016","article-title":"Methylthioadenosine","volume":"36","author":"Avila","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2018.12.001_bb0015","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.taap.2018.12.001_bb0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neuroscience.2005.07.021","article-title":"Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance","volume":"138","author":"Belelli","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.taap.2018.12.001_bb0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc. B"},{"key":"10.1016\/j.taap.2018.12.001_bb0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1001\/jamaneurol.2017.3897","article-title":"Association of folic acid supplementation during pregnancy with the risk of autistic traits in children exposed to antiepileptic drugs in utero","volume":"75","author":"Bjork","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0035","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/ppe.12004","article-title":"Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study","volume":"26","author":"Bobo","year":"2012","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"10.1016\/j.taap.2018.12.001_bb0040","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/archneurol.2009.142","article-title":"Affect of seizures during gestation on pregnancy outcomes in women with epilepsy","volume":"66","author":"Chen","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role","volume":"3","author":"Crider","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.taap.2018.12.001_bb0050","series-title":"Metabolome-Wide Association Study of Phenylalanine in Plasma of Common Marmosets","author":"Go","year":"2014"},{"key":"10.1016\/j.taap.2018.12.001_bb0055","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/toxsci\/kfv198","article-title":"Reference standardization for mass spectrometry and high-resolution metabolomics applications to exposome research","volume":"148","author":"Go","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2018.12.001_bb0060","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1523\/JNEUROSCI.2534-15.2016","article-title":"Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain","volume":"36","author":"Goeden","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.taap.2018.12.001_bb0065","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1474-4422(12)70239-9","article-title":"Neuroendocrine considerations in the treatment of men and women with epilepsy","volume":"12","author":"Harden","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1212\/WNL.0b013e3181a6b312","volume":"73","author":"Harden","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2018.12.001_bb0075","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1212\/WNL.0b013e3182574f39","article-title":"Comparative safety of antiepileptic drugs during pregnancy","volume":"78","author":"Hernandez-Diaz","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2018.12.001_bb0080","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.steroids.2011.07.002","article-title":"The steroid metabolome in lamotrigine-treated women with epilepsy","volume":"76","author":"Hill","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.taap.2018.12.001_bb0085","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/aje\/kwp218","article-title":"Maternal catecholamine levels in midpregnancy and risk of preterm delivery","volume":"170","author":"Holzman","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.taap.2018.12.001_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.taap.2018.12.001_bb0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.toxrep.2015.11.009","article-title":"Sequencing the exposome: a call to action","volume":"3","author":"Jones","year":"2016","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.taap.2018.12.001_bb0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev-nutr-072610-145159","article-title":"Nutritional metabolomics: progress in addressing complexity in diet and health","volume":"32","author":"Jones","year":"2012","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.taap.2018.12.001_bb0105","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkr988","article-title":"KEGG for integration and interpretation of large-scale molecular data sets","volume":"40","author":"Kanehisa","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2018.12.001_bb0110","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.jbi.2011.07.001","article-title":"A review of causal inference for biomedical informatics","volume":"44","author":"Kleinberg","year":"2011","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.taap.2018.12.001_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003123","article-title":"Predicting network activity from high throughput metabolomics","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.taap.2018.12.001_bb0120","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1097\/JOM.0000000000000773","article-title":"High resolution metabolomics assessment of military personnel","volume":"58","author":"Liu","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2018.12.001_bb0125","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/jamaneurol.2015.1017","article-title":"Mortality and morbidity during delivery hospitalization among pregnant women with epilepsy in the United States","volume":"72","author":"MacDonald","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0130","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1528-1167.2007.01056.x","article-title":"Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias","volume":"48","author":"Manent","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.taap.2018.12.001_bb0135","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1474-4422(12)70323-X","article-title":"Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study","volume":"12","author":"Meador","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0140","series-title":"American Epilepsy Society Annual Meeting, Houston, TX","article-title":"Antiepileptic drug prescribing patterns in pregnant women with epilepsy: Findings from the MONEAD Study; Abstract #1.211","author":"Meador","year":"2016"},{"key":"10.1016\/j.taap.2018.12.001_bb0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pharmthera.2007.04.011","article-title":"Neurosteroid regulation of central nervous system development","volume":"116","author":"Mellon","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2018.12.001_bb0150","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.taap.2018.12.001_bb0155","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1046\/j.1365-2265.1997.2991136.x","article-title":"Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures","volume":"47","author":"Munoz-Hoyos","year":"1997","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.taap.2018.12.001_bb0160","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1535-7597.2005.05201.x","article-title":"Using current evidence in selecting antiepileptic drugs for use during pregnancy","volume":"5","author":"Pennell","year":"2005","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.taap.2018.12.001_bb0165","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s13311-016-0464-0","article-title":"Use of antiepileptic drugs during pregnancy: evolving concepts","volume":"13","author":"Pennell","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.taap.2018.12.001_bb0170","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/jcem-57-4-760","article-title":"Effects of tyrosine and tryptophan ingestion on plasma catecholamine and 3,4-dihydroxyphenylacetic acid concentrations","volume":"57","author":"Rasmussen","year":"1983","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2018.12.001_bb0175","author":"Registry"},{"key":"10.1016\/j.taap.2018.12.001_bb0180","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/jama.2011.1433","article-title":"Folic acid supplements in pregnancy and severe language delay in children","volume":"306","author":"Roth","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2018.12.001_bb0185","doi-asserted-by":"crossref","first-page":"1295S","DOI":"10.1093\/ajcn\/71.5.1295s","article-title":"Folic acid: influence on the outcome of pregnancy","volume":"71","author":"Scholl","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.taap.2018.12.001_bb0190","series-title":"Targeting the Broadly Pathogenic Kynurenine Pathway","first-page":"205","article-title":"Role of the Kynurenine Pathway in Epilepsy","author":"Sharma","year":"2015"},{"key":"10.1016\/j.taap.2018.12.001_bb0195","doi-asserted-by":"crossref","first-page":"11725","DOI":"10.1021\/ac402503m","article-title":"Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources","volume":"85","author":"Simon-Manso","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2018.12.001_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0813s47","article-title":"Biological network exploration with cytoscape 3","volume":"47","author":"Su","year":"2014","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.taap.2018.12.001_bb0205","first-page":"609","article-title":"Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. The Lancet","volume":"10","author":"Tomson","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.taap.2018.12.001_bb0210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2105-14-15","article-title":"xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data","volume":"14","author":"Uppal","year":"2013","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.taap.2018.12.001_bb0215","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fbioe.2015.00087","article-title":"MetabNet: an R package for metabolic association analysis of high-resolution metabolomics data","volume":"3","author":"Uppal","year":"2015","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.taap.2018.12.001_bb0225","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acs.chemrestox.6b00179","article-title":"Computational metabolomics: a framework for the million metabolome","volume":"29","author":"Uppal","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2018.12.001_bb0230","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1021\/acs.chemrestox.6b00179","article-title":"Computational metabolomics: a framework for the million metabolome","volume":"29","author":"Uppal","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2018.12.001_bb0235","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/acs.analchem.6b01214","article-title":"xMSannotator: an R package for network-based annotation of high-resolution metabolomics data","volume":"89","author":"Uppal","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.taap.2018.12.001_bb0240","article-title":"Diagnosis and management of catamenial seizures: a review","volume":"535","author":"Verrotti Alberto","year":"2012","journal-title":"Int. J. Women's Health"},{"key":"10.1016\/j.taap.2018.12.001_bb0245","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1055\/s-0037-1608932","article-title":"Delivery of a Personalized Treatment Approach to Women with Epilepsy","volume":"37","author":"Voinescu","year":"2017","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.taap.2018.12.001_bb0250","series-title":"Population Screening for Biological and Environmental Properties of the Human Metabolic Phenotype: Implications for Personalized Medicine","year":"2016"},{"key":"10.1016\/j.taap.2018.12.001_bb0255","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/JOM.0000000000000768","article-title":"Deployment-associated exposure surveillance with high-resolution metabolomics","volume":"58","author":"Walker","year":"2016","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.taap.2018.12.001_bb0260","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/ije\/dyw218","article-title":"High-resolution metabolomics of occupational exposure to trichloroethylene","volume":"45","author":"Walker","year":"2016","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.taap.2018.12.001_bb0265","doi-asserted-by":"crossref","first-page":"D801","DOI":"10.1093\/nar\/gks1065","article-title":"HMDB 3.0\u2014the human metabolome database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2018.12.001_bb0270","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/bioinformatics\/btp291","article-title":"apLCMS\u2014adaptive processing of high-resolution LC\/MS data","volume":"25","author":"Yu","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.taap.2018.12.001_bb0275","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1021\/pr301053d","article-title":"Hybrid feature detection and information accumulation using high-resolution LC-MS metabolomics data","volume":"12","author":"Yu","year":"2013","journal-title":"J. Proteome Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T23:56:57Z","timestamp":1720828617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18305374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":54,"alternative-id":["S0041008X18305374"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.001","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolome-wide association study of anti-epileptic drug treatment during pregnancy","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}