{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:11:58Z","timestamp":1780387918531,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 103-2314-B-039-008"],"award-info":[{"award-number":["MOST 103-2314-B-039-008"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD-TPE-104-53"],"award-info":[{"award-number":["TCRD-TPE-104-53"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008108","name":"Taipei Tzu Chi Hospital","doi-asserted-by":"publisher","award":["TCRD-TPE-105-42"],"award-info":[{"award-number":["TCRD-TPE-105-42"]}],"id":[{"id":"10.13039\/501100008108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.taap.2018.12.016","type":"journal-article","created":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T14:28:32Z","timestamp":1545748112000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Micromolar concentrations of citalopram or escitalopram inhibit glycoprotein VI-mediated and integrin \u03b1IIb\u03b23-mediated signaling in human platelets"],"prefix":"10.1016","volume":"364","author":[{"given":"Yu-Lun","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Pei-Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ling","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yu","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.12.016_bb0005","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1161\/ATVBAHA.112.301165","article-title":"p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear","volume":"33","author":"Aslan","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2018.12.016_bb0010","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1160\/TH10-05-0313","article-title":"Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood","volume":"104","author":"Bampalis","year":"2010","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0015","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1111\/j.1538-7836.2011.04476.x","article-title":"Effect of 5-HT2A receptor antagonists on human platelet activation in blood exposed to physiologic stimuli and atherosclerotic plaque","volume":"9","author":"Bampalis","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jad.2011.08.013","article-title":"Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs","volume":"136","author":"Bismuth-Evenzal","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.taap.2018.12.016_bb0025","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1182\/blood-2008-02-142125","article-title":"Identification of Fc\u03b3RIIa as the ITAM-bearing receptor mediating \u03b1IIb\u03b23 outside-in integrin signaling in human platelets","volume":"112","author":"Boylan","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0030","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI33374","article-title":"Interactions between integrin \u03b1IIb\u03b23 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans","volume":"118","author":"Carneiro","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2018.12.016_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/YIC.0b013e32835d735d","article-title":"Cardiovascular mechanisms of SSRI drugs and their benefits and risks in ischemic heart disease and heart failure","volume":"28","author":"Chittaranjan","year":"2013","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.taap.2018.12.016_bb0040","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1182\/blood-2017-03-773614","article-title":"Integrin \u03b1IIb\u03b23 outside-in signaling","volume":"130","author":"Durrant","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0045","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tips.2012.07.004","article-title":"Platelet GPVI: a target for antithrombotic therapy?!","volume":"33","author":"Dutting","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.taap.2018.12.016_bb0050","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1161\/ATVBAHA.115.306883","article-title":"The novel oral Syk inhibitor, Bl1002494, protects mice from arterial thrombosis and thromboinflammatory brain infraction","volume":"36","author":"van Eeuwijk","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2018.12.016_bb0055","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/j.thromres.2010.04.020","article-title":"Antiplatelet effects of antidepressant treatment: a randomized comparison between escitalopram and nortriptyline","volume":"126","author":"Fl\u00f6ck","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.taap.2018.12.016_bb0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0278-5846(82)80179-6","article-title":"Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity","volume":"6","author":"Hyttel","year":"1982","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.taap.2018.12.016_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vph.2017.07.004","article-title":"Effects of psychopharmacological treatment with antidepressants on the vascular system","volume":"96-98","author":"Kahl","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.016_bb0070","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1503\/cmaj.100912","article-title":"Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infraction","volume":"183","author":"Labos","year":"2011","journal-title":"CMAJ"},{"key":"10.1016\/j.taap.2018.12.016_bb0075","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.4049\/jimmunol.147.8.2652","article-title":"Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII)","volume":"147","author":"Letourneur","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2018.12.016_bb0080","doi-asserted-by":"crossref","first-page":"e87026","DOI":"10.1371\/journal.pone.0087026","article-title":"The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.016_bb0085","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1160\/TH17-04-0288","article-title":"Escitalopram impairs thrombin-induced platelet response, cytoskeleton assembly and activation of associated signalling pathways","volume":"117","author":"Lopez-Vilchez","year":"2017","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0090","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1046\/j.0007-1048.2001.03302.x","article-title":"A novel immunocytochemical assay for the detection of serotonin in platelets","volume":"116","author":"Maurer-Spurej","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.taap.2018.12.016_bb0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1160\/TH03-05-0330","article-title":"The influence of selective serotonin reuptake inhibitors on human platelet serotonin","volume":"91","author":"Maurer-Spurej","year":"2004","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1124\/mi.10.4.6","article-title":"Molecular mechanism of SERT in platelets: Regulation of plasma serotonin levels","volume":"10","author":"Mercado","year":"2010","journal-title":"Mol. Interv."},{"key":"10.1016\/j.taap.2018.12.016_bb0105","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK tyrosine kinase: a crucial player in diverse biological functions","volume":"10","author":"Mocsai","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2018.12.016_bb0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: is GPVI the central receptor?","volume":"102","author":"Nieswandt","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0115","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/blood.V97.12.3829","article-title":"Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation","volume":"97","author":"Nieswandt","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1538-7836.2011.04274.x","article-title":"Advances in our understanding of the molecular basis of disorders of platelet function","volume":"9","author":"Nurden","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1083\/jcb.200112113","article-title":"Coordinate interactions of Csk, Src, and Syk kinases with \u03b1IIb\u03b23 initiate integrin signaling to the cytoskeleton","volume":"157","author":"Obergfell","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2018.12.016_bb0130","doi-asserted-by":"crossref","first-page":"20210","DOI":"10.1074\/jbc.M116.736983","article-title":"Loss of serotonin transporter function alters ADP-mediated glycoprotein \u03b1IIb\u03b23 activation through dysregulation of 5-HT2A receptor","volume":"291","author":"Oliver","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.12.016_bb0135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000325216","article-title":"Regulation of serotonin transport in human platelets by tyrosine kinase Syk","volume":"27","author":"Pavanetto","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2018.12.016_bb0140","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/emboj\/16.9.2333","article-title":"The Fc receptor \u03b3-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen","volume":"16","author":"Poole","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.taap.2018.12.016_bb0145","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1182\/blood.V96.13.4246","article-title":"Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway","volume":"96","author":"Quek","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0150","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1755-148X.2008.00481.x","article-title":"The antidepressant sertraline downregulates Akt and has activity against melanoma cells","volume":"21","author":"Reddy","year":"2008","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.taap.2018.12.016_bb0155","doi-asserted-by":"crossref","first-page":"c1468","DOI":"10.1136\/bmj.c1468","article-title":"Long term treatment of depression with selective serotonin reuptake inhibitors and newer antidepressants","volume":"340","author":"Reid","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.taap.2018.12.016_bb0160","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1038\/s41598-018-21348-3","article-title":"Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport","volume":"8","author":"Roweth","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2018.12.016_bb0165","doi-asserted-by":"crossref","first-page":"33610","DOI":"10.1074\/jbc.M500146200","article-title":"A new functional role of fibrinogen RGD motif as the molecular switch that selectively triggers integrin \u03b1IIb\u03b23-dependent RhoA activation during cell spreading","volume":"280","author":"Salsmann","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2018.12.016_bb0170","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood-2014-01-453134","article-title":"Src family kinases: at the forefront of platelet activation","volume":"124","author":"Senis","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.taap.2018.12.016_bb0175","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/2211-5463.12149","article-title":"Central role of PI3K-SYK interaction in fibrinogen-induced lamellipodia and filopodia formation in platelets","volume":"6","author":"Singh","year":"2016","journal-title":"FEBS Open Bio."},{"key":"10.1016\/j.taap.2018.12.016_bb0180","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1538-7836.2009.03451.x","article-title":"The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets","volume":"7","author":"Spalton","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2018.12.016_bb0185","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.pcad.2015.11.003","article-title":"Treatment of depression in patients with concomitant cardiac disease","volume":"58","author":"Teply","year":"2016","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.taap.2018.12.016_bb0190","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.thromres.2010.09.017","article-title":"A selective serotonin reuptake inhibitor, citalopram, inhibits collagen-induced platelet aggregation and activation","volume":"126","author":"Tseng","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.taap.2018.12.016_bb0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.thromres.2013.02.007","article-title":"Selective serotonin reuptake inhibitors reduce P2Y12 receptor-mediated amplification of platelet aggregation","volume":"131","author":"Tseng","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.taap.2018.12.016_bb0200","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0092-8674(03)01014-6","article-title":"Serotonylation of small GTPase is a signal transduction pathway that triggers platelet \u03b1-granule release","volume":"115","author":"Walther","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.taap.2018.12.016_bb0205","doi-asserted-by":"crossref","first-page":"E421","DOI":"10.1208\/aapsj070242","article-title":"Serotonin Transporters: Implications for antidepressant drug development","volume":"7","author":"White","year":"2005","journal-title":"AAPSJ"},{"key":"10.1016\/j.taap.2018.12.016_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147664","article-title":"Partially defective store operated calcium and hem(ITAM) signaling in platelets of serotonin transporter deficient mice","volume":"11","author":"Wolf","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.016_bb0215","doi-asserted-by":"crossref","first-page":"12999","DOI":"10.1074\/jbc.M009344200","article-title":"Expression of the platelet receptor GPVI confers signaling via the Fc receptor \u03b3-Chain in response to the snake venom convulxin but not to collagen","volume":"276","author":"Zheng","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:37:48Z","timestamp":1694522268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18305751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":43,"alternative-id":["S0041008X18305751"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.016","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micromolar concentrations of citalopram or escitalopram inhibit glycoprotein VI-mediated and integrin \u03b1IIb\u03b23-mediated signaling in human platelets","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}