{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:17:09Z","timestamp":1791494229683,"version":"4.3.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.taap.2018.12.020","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T03:13:10Z","timestamp":1545880390000},"page":"120-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":162,"special_numbering":"C","title":["Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NF\u03baB and Nrf-2\/HO-1 signaling crosstalk"],"prefix":"10.1016","volume":"364","author":[{"given":"Sameh","family":"Saber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania M.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walied S.","family":"Abdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Nassif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"El-Ahwany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2018.12.020_bb0005","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"Andaloussi","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2018.12.020_bb0010","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopha.2017.06.074","article-title":"The role of ROS and NF-\u03baB pathway in olmesartan induced-toxicity in HeLa and mcf-7 cell lines","volume":"93","author":"Bakhtiari","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2018.12.020_bb0015","doi-asserted-by":"crossref","first-page":"e54543","DOI":"10.1371\/journal.pone.0054543","article-title":"Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic characterization and correlation to IBD","volume":"8","author":"Brenna","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.020_bb0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40265-016-0676-y","article-title":"Mucosal healing in ulcerative colitis: a comprehensive review","volume":"77","author":"Carvalho","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2018.12.020_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/jpet.107.124891","article-title":"Angiotensin II type 1 receptor-dependent nuclear factor-\u03baB activation-mediated proinflammatory actions in a rat model of obstructive acute pancreatitis","volume":"323","author":"Chan","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2018.12.020_bb0030","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s10620-012-2464-1","article-title":"Grape seed extract reduces the severity of selected disease markers in the proximal colon of dextran sulphate sodium-induced colitis in rats","volume":"58","author":"Cheah","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.taap.2018.12.020_bb0035","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis: Laboratory investigation","volume":"69","author":"Cooper","year":"1993","journal-title":"J. Tech. Methods Pathol."},{"key":"10.1016\/j.taap.2018.12.020_bb0040","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1097\/HJH.0b013e32832be575","article-title":"Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan\/pravastatin","volume":"27","author":"David","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.taap.2018.12.020_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114923","article-title":"Olmesartan decreased levels of IL-1\u03b2 and TNF-\u03b1, down-regulated MMP-2, MMP-9, COX-2, RANK\/RANKL and up-regulated SOCs-1 in an intestinal mucositis model","volume":"9","author":"de Ara\u00fajo J\u00fanior","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.020_bb0050","doi-asserted-by":"crossref","first-page":"e96750","DOI":"10.1371\/journal.pone.0096750","article-title":"Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL\/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model","volume":"9","author":"de Ara\u00fajo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.020_bb0055","first-page":"15670","article-title":"Losartan attenuated lipopolysaccharide-induced lung injury by suppression of lectin-like oxidized low-density lipoprotein receptor-1","volume":"8","author":"Deng","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2018.12.020_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025058","article-title":"Tumor necrosis factor-\u03b1 and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis","volume":"6","author":"Dharmani","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.020_bb0065","first-page":"33","article-title":"63\/EU of the European parliament and of the council of 22 September 2010 on the protection of animals used for scientific purposes","volume":"276","author":"Directive","year":"2010","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.taap.2018.12.020_bb0070","first-page":"100","article-title":"Comparative study between effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on acetic acid-induced ulcerative colitis in rats","volume":"1","author":"El-Medany","year":"2011","journal-title":"Int. Res. J. Pharm. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0075","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.pharep.2017.03.020","article-title":"Anti-inflammatory and anti-arthritic properties of naringenin via attenuation of NF-\u03baB and activation of the heme oxygenase\ufd3e HO\ufd3f-1\/related factor 2 pathway","volume":"69","author":"Fan","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2018.12.020_bb0080","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s40265-017-0755-8","article-title":"Advances in the development of Janus kinase inhibitors in inflammatory bowel disease: future prospects","volume":"77","author":"Flamant","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.taap.2018.12.020_bb0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/hr.2011.176","article-title":"Modulation of renal superoxide dismutase by telmisartan therapy in C57BL\/6-Ins2 Akita diabetic mice","volume":"35","author":"Fujita","year":"2012","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.taap.2018.12.020_bb0090","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10787-012-0147-3","article-title":"Curative effect of Terminalia chebula extract on acetic acid-induced experimental colitis: role of antioxidants, free radicals and acute inflammatory marker","volume":"21","author":"Gautam","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.taap.2018.12.020_bb0095","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1007\/s10620-012-2134-3","article-title":"Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid","volume":"57","author":"Hartmann","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.taap.2018.12.020_bb0100","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.3748\/wjg.14.4028","article-title":"Inflammatory bowel disease in rats: bacterial and chemical interaction","volume":"14","author":"Hussein","year":"2008","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.taap.2018.12.020_bb0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jep.2003.09.042","article-title":"Effect of polyherbal formulation on experimental models of inflammatory bowel diseases","volume":"90","author":"Jagtap","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0110","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/0016-5085(90)91088-N","article-title":"Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis","volume":"98","author":"Jaszewski","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2018.12.020_bb0115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-017-3240-5","article-title":"Muscle proteolytic system modulation through the effect of taurine on mice bearing muscular atrophy","volume":"444","author":"Khalil","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2018.12.020_bb0120","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.exger.2011.02.011","article-title":"Inhibition of NF-\u03baB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney","volume":"46","author":"Kim","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.taap.2018.12.020_bb0130","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NF\u03baB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0135","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.lfs.2005.06.049","article-title":"Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor\/nuclear factor-\u03baB pathway in brain microvascular endothelial cells","volume":"78","author":"Liu","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2018.12.020_bb0140","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-\u03baB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. et Biophys. Acta (BBA)"},{"key":"10.1016\/j.taap.2018.12.020_bb0145","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3390\/ijms17091455","article-title":"Exogenous ghrelin accelerates the healing of acetic acid-induced colitis in rats","volume":"17","author":"Matuszyk","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2018.12.020_bb0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2249.2003.02268.x","article-title":"Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis","volume":"134","author":"Melgar","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.taap.2018.12.020_bb0155","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.taap.2013.04.026","article-title":"Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats","volume":"271","author":"Nagib","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0160","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/11341","article-title":"Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen","volume":"5","author":"Newberry","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2018.12.020_bb0165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cbi.2015.06.026","article-title":"Protective effect of cavidine on acetic acid-induced murine colitis via regulating antioxidant, cytokine profile and NF-\u03baB signal transduction pathways","volume":"239","author":"Niu","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2018.12.020_bb0170","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4196\/kjpp.2015.19.4.299","article-title":"Effects of local pancreatic renin-angiotensin system on the microcirculation of rat with severe acute pancreatitis","volume":"19","author":"Pan","year":"2015","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0175","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s11605-014-2487-3","article-title":"The impact of peri-operative anti-TNF treatment on anastomosis-related complications in Crohn's disease patients. A critical review","volume":"18","author":"Papaconstantinou","year":"2014","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.taap.2018.12.020_bb0180","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.intimp.2018.09.021","article-title":"Lisinopril inhibits nuclear transcription factor kappa B and augments sensitivity to silymarin in experimental liver fibrosis","volume":"64","author":"Saber","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0185","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3889\/oamjms.2018.167","article-title":"Liver protective effects of renin-angiotensin system inhibition have no survival benefits in hepatocellular carcinoma induced by repetitive administration of diethylnitrosamine in mice","volume":"6","author":"Saber","year":"2018","journal-title":"Open Access Macedonian J. Med. Sci."},{"key":"10.1016\/j.taap.2018.12.020_bb0190","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.toxlet.2018.05.036","article-title":"Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B","volume":"295","author":"Saber","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2018.12.020_bb0195","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1139\/cjpp-2017-0728","article-title":"Renin\u2013angiotensin system inhibition ameliorates CCl4-induced liver fibrosis in mice through the inactivation of nuclear transcription factor kappa B","volume":"96","author":"Saber","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2018.12.020_bb0200","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1681\/ASN.2007020149","article-title":"Angiotensin II\u2013induced reactive oxygen species and the kidney","volume":"18","author":"Sachse","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.taap.2018.12.020_bb0205","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1080\/1744666X.2018.1524754","article-title":"Targeting IL-23 in Crohn's disease","volume":"14","author":"Sedda","year":"2018","journal-title":"Exp. Rev. Clin. Immunol."},{"key":"10.1016\/j.taap.2018.12.020_bb0210","doi-asserted-by":"crossref","first-page":"27552","DOI":"10.1038\/srep27552","article-title":"Activation of the renin-angiotensin system promotes Colitis development","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2018.12.020_bb0215","first-page":"382","article-title":"Risk of cerebrovascular accidents and ischemic heart disease in patients with inflammatory bowel disease: a systematic review and meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the","volume":"12","author":"Singh","year":"2014","journal-title":"Am. Gastroenterol. Assoc."},{"key":"10.1016\/j.taap.2018.12.020_bb0220","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0167-5273(00)00323-5","article-title":"First dose hypotension after angiotensin converting enzyme inhibitor captopril and angiotensin II blocker losartan in patients with acute myocardial infarction","volume":"75","author":"Spinar","year":"2000","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2018.12.020_bb0225","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1155\/2015\/214937","article-title":"Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the patient perspective","volume":"29","author":"Steinhart","year":"2015","journal-title":"Can. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2018.12.020_bb0230","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1128\/MCB.01639-08","article-title":"Acetylation of Nrf2 by p300\/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response","volume":"29","author":"Sun","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2018.12.020_bb0235","article-title":"The effect of NF-\u03baB signalling pathway on expression and regulation of Nacrein in Pearl Oyster, Pinctada fucata","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2018.12.020_bb0240","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2018.12.020_bb0245","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/01.HYP.0000157409.88971.fc","article-title":"Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress","volume":"45","author":"Tsuda","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2018.12.020_bb0250","first-page":"L1245","article-title":"Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction","volume":"277","author":"Wang","year":"1999","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2018.12.020_bb0255","doi-asserted-by":"crossref","first-page":"8308","DOI":"10.3748\/wjg.v23.i47.8308","article-title":"Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis","volume":"23","author":"Wang","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.taap.2018.12.020_bb0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1465-9921-9-43","article-title":"Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice","volume":"9","author":"Waseda","year":"2008","journal-title":"Resp. Res."},{"key":"10.1016\/j.taap.2018.12.020_bb0265","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1524-6175.2007.07805.x","article-title":"The efficacy and safety of initial use of Irbesartan\/hydrochlorothiazide fixed-dose combination in hypertensive patients with and without high cardiovascular risk","volume":"9","author":"Weir","year":"2007","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.taap.2018.12.020_bb0270","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/jpet.104.077883","article-title":"Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats","volume":"313","author":"Yamada","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2018.12.020_bb0275","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.redox.2013.07.005","article-title":"Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-\u03baB pathways in diabetic neuropathy","volume":"1","author":"Yerra","year":"2013","journal-title":"Redox Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X18305799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T22:54:32Z","timestamp":1573599272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X18305799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":55,"alternative-id":["S0041008X18305799"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.020","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NF\u03baB and Nrf-2\/HO-1 signaling crosstalk","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2018.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}