{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:23:49Z","timestamp":1788906229568,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Youth Research Fund of Peking Union Medical College","award":["2018ZX09201017-005"],"award-info":[{"award-number":["2018ZX09201017-005"]}]},{"name":"Youth Research Fund of Peking Union Medical College","award":["2017350004"],"award-info":[{"award-number":["2017350004"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.taap.2019.04.016","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T01:49:23Z","timestamp":1556848163000},"page":"48-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish"],"prefix":"10.1016","volume":"373","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-4036","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2019.04.016_bb0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbr.2011.11.020","article-title":"Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds","volume":"228","author":"Ali","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.taap.2019.04.016_bb0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.taap.2019.04.016_bb0015","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jama.297.8.842","article-title":"Mortality in randomized trials of antioxidant supplements for primary and secondary prevention systematic review and meta-analysis","volume":"297","author":"Bjelakovic","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.taap.2019.04.016_bb0020","first-page":"40","article-title":"Antioxidant supplements and mortality","volume":"17","author":"Bjelakovic","year":"2014","journal-title":"Curr Opin. Clin. Nutr. Metab. Care"},{"issue":"Suppl","key":"10.1016\/j.taap.2019.04.016_bb0025","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/nm1067","article-title":"Molecular pathways to neurodegeneration","volume":"10","author":"Bossy-Wetzel","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0030","doi-asserted-by":"crossref","first-page":"23824","DOI":"10.18632\/oncotarget.25323","article-title":"Oxidative stress in female cancers","volume":"9","author":"Calaf","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2019.04.016_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejphar.2009.03.035","article-title":"Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-\u03baB induced oxidative stress and inflammation","volume":"610","author":"Chiang","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejphar.2003.09.067","article-title":"Anti- and prooxidant effects of chronic quercetin administration in rats","volume":"482","author":"Choi","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0045","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.aquatox.2010.03.012","article-title":"Chronic exposure of 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether (PBDE-47) alters locomotion behavior in juvenile zebrafish (Danio rerio)","volume":"98","author":"Chou","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.taap.2019.04.016_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-10-15","article-title":"Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells","volume":"10","author":"Chuang","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2019.04.016_bb0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-3-642-00663-0_9","article-title":"The keap1-nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity","author":"Copple","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0060","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.117.014753","article-title":"Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach","volume":"70","author":"Cuadrado","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.taap.2019.04.016_bb0065","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1021\/es303695f","article-title":"Effect of nanoparticle stabilization and physicochemical properties on exposure outcome: acute toxicity of silver nanoparticle preparations in Zebrafish (Danio rerio)","volume":"47","author":"Cunningham","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.taap.2019.04.016_bb0070","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/152308604771978453","article-title":"Role of redox in fetal development and neonatal diseases","volume":"6","author":"Dennery","year":"2004","journal-title":"Antioxid. Redox Signal."},{"issue":"1245049","key":"10.1016\/j.taap.2019.04.016_bb0075","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2019.04.016_bb0080","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.bcp.2008.06.012","article-title":"Honokiol is a potent scavenger of superoxide and peroxyl radicals","volume":"76","author":"Dikalov","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0301-0082(02)00075-8","article-title":"Development of the locomotor network in zebrafish","volume":"68","author":"Drapeau","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.taap.2019.04.016_bb0090","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.biopha.2018.04.126","article-title":"The promising future of nano-antioxidant therapy against environmental pollutants induced-toxicities","volume":"103","author":"Eftekhari","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2019.04.016_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2019.04.016_bb0100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0300-483X(02)00198-1","article-title":"Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics","volume":"177","author":"Galati","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2019.04.016_bb0105","first-page":"673","article-title":"Anticancer activity of Honokiol against lymphoid malignant cells via activation of ROS-JNK and attenuation of Nrf2 and NF-\u03baB","volume":"21","author":"Gao","year":"2016","journal-title":"J. BUON."},{"key":"10.1016\/j.taap.2019.04.016_bb0110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envint.2013.11.012","article-title":"Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health","volume":"63","author":"Garcia-Reyero","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.taap.2019.04.016_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020562","article-title":"The crosstalk between Nrf2 and inflammasomes","volume":"19","author":"Hennig","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2019.04.016_bb0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1142\/S0192415X00000441","article-title":"Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats","volume":"28","author":"Hou","year":"2000","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0125","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1021\/acschemneuro.8b00290","article-title":"Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2","volume":"9","author":"Hou","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.taap.2019.04.016_bb0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.taap.2005.03.023","article-title":"New models and molecular markers in evaluation of developmental toxicity","volume":"207","author":"Huuskonen","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0135","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","article-title":"Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation","volume":"32","author":"Hybertson","year":"2011","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0140","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ntt.2009.04.066","article-title":"Acute neuroactive drug exposures alter locomotor activity in larval zebrafish","volume":"32","author":"Irons","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.taap.2019.04.016_bb0145","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1177319","article-title":"Identification of a primary target of thalidomide teratogenicity","volume":"327","author":"Ito","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.taap.2019.04.016_bb0155","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1089\/ars.2005.7.1664","article-title":"Molecular mechanism of Nrf2 activation by oxidative stress","volume":"7","author":"Kang","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2019.04.016_bb0160","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1021\/acschemneuro.7b00071","article-title":"Effect of the biphenyl neolignan honokiol on A\u03b242-induced toxicity in caenorhabditis elegans, A\u03b242 fibrillation, cholinesterase activity, DPPH radicals, and iron(II) chelation","volume":"8","author":"Kantham","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.taap.2019.04.016_bb0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fphar.2018.00140","article-title":"Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-kappaB and Nrf2 signaling","volume":"9","author":"Khalid","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1745-7254.2008.00725.x","article-title":"Anti-inflammatory effect of honokiol is mediated by PI3K\/Akt pathway suppression","volume":"29","author":"Kim","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2019.04.016_bb0175","doi-asserted-by":"crossref","first-page":"809","DOI":"10.4155\/fmc.13.32","article-title":"Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities","volume":"5","author":"Kumar","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.taap.2019.04.016_bb0180","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1126\/science.1059501","article-title":"Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins","volume":"292","author":"Lee","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.taap.2019.04.016_bb0185","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11418-009-0330-z","article-title":"Protective effect of the ethanol extract of magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity","volume":"63","author":"Lee","year":"2009","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pharmthera.2011.01.010","article-title":"Therapeutic applications of compounds in the magnolia family","volume":"130","author":"Lee","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2019.04.016_bb0195","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.biopha.2017.11.063","article-title":"Honokiol protects pancreatic \u03b2 cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2\/ARE pathway in vitro and in vivo","volume":"97","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2019.04.016_bb0200","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2006.03.035","article-title":"Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage","volume":"537","author":"Lin","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2003.08.026","article-title":"Honokiol protects rat brain from focal cerebral ischemia\u2013reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production","volume":"992","author":"Liou","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2019.04.016_bb0210","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0006-2952(94)90187-2","article-title":"Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation","volume":"47","author":"Lo","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0215","series-title":"Lead Exposure and Oxidative Stress: A Systematic Review","first-page":"193","volume":"vol. 236","author":"Lopes","year":"2016"},{"key":"10.1016\/j.taap.2019.04.016_bb0220","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.pharmthera.2009.11.004","article-title":"Transcriptional responses to oxidative stress: pathological and toxicological implications","volume":"125","author":"Ma","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2019.04.016_bb0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2019.04.016_bb0230","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1124\/pr.110.004333","article-title":"Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2","volume":"64","author":"Ma","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.taap.2019.04.016_bb0235","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/j.fct.2010.09.006","article-title":"Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids","volume":"48","author":"Maurya","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.taap.2019.04.016_bb0240","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ana.23780","article-title":"Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model","volume":"73","author":"McGown","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.taap.2019.04.016_bb0245","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defines a physiologically important stress response mechanism","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0250","first-page":"38","article-title":"Dar T:the embryo test with the Zebrafish Danio rerio\u2014a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"ALTEX"},{"key":"10.1016\/j.taap.2019.04.016_bb0255","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0006-291X(75)90710-X","article-title":"Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system","volume":"63","author":"Nishikimi","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2019.04.016_bb0260","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reprotox.2007.04.004","article-title":"Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy","volume":"24","author":"Ornoy","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2019.04.016_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2006.02.006","article-title":"Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells","volume":"161","author":"Ou","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2019.04.016_bb0270","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1159\/000491465","article-title":"Nrf2 pathway in age-related neurological disorders: insights into MicroRNAs","volume":"47","author":"Paladino","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2019.04.016_bb0275","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7656","article-title":"Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3","volume":"6","author":"Pillai","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2019.04.016_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccell.2018.03.022","article-title":"NRF2 and the hallmarks of cancer","volume":"34","author":"Rojo de la Vega","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2019.04.016_bb0285","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0891-5849(00)00224-0","article-title":"Oxidative stress and cell cycle checkpoit function","volume":"28","author":"Shackelford","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0290","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.3390\/molecules15096452","article-title":"Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders","volume":"15","author":"Shen","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2019.04.016_bb0295","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2019.04.016_bb0300","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.1997.sp004024","article-title":"Oxidative stress: oxidants and antioxidants","volume":"82","author":"Sies","year":"1997","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.taap.2019.04.016_bb0305","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1875870","article-title":"Oxidative stress, apoptosis, and mitochondrial function in diabetic nephropathy","volume":"2018","author":"Sifuentes-Franco","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.taap.2019.04.016_bb0310","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.freeradbiomed.2018.05.085","article-title":"Hypertension: focus on autoimmunity and oxidative stress","volume":"125","author":"Small","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2019.04.016_bb0315","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2019.04.016_bb0320","first-page":"7.5.1","article-title":"Measurement of MnSOD and CuZnSOD activity in mammalian tissue homogenates","volume":"2001","author":"Spitz","year":"2001","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.taap.2019.04.016_bb0325","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2014.09.049","article-title":"Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice","volume":"744","author":"Sulakhiya","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0330","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pbb.2015.02.015","article-title":"Beneficial effect of honokiol on lipopolysaccharide induced anxiety-like behavior and liver damage in mice","volume":"132","author":"Sulakhiya","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.taap.2019.04.016_bb0335","first-page":"347","article-title":"Edaravone Mitsubishi-Tokyo","volume":"1","author":"Tabrizchi","year":"2000","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.taap.2019.04.016_bb0340","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/biof.1385","article-title":"Neuroprotective effects of honokiol: from chemistry to medicine","volume":"43","author":"Talarek","year":"2017","journal-title":"Biofactors"},{"key":"10.1016\/j.taap.2019.04.016_bb0345","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1063654","article-title":"Organogenesis\u2014heart and blood formation from the zebrafish point of view","volume":"295","author":"Thisse","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.taap.2019.04.016_bb0350","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/toxsci\/kfp038","article-title":"Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish","volume":"109","author":"Timme-Laragy","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2019.04.016_bb0355","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1089\/ars.2009.3044","article-title":"Redox control in mammalian embryo development","volume":"13","author":"Ufer","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2019.04.016_bb0360","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chemosphere.2017.04.017","article-title":"Diuron and diazinon alter the behavior of zebrafish embryos and larvae in the absence of acute toxicity","volume":"180","author":"Velki","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2019.04.016_bb0365","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.redox.2014.12.017","article-title":"The shifting perception on antioxidants: the case of vitamin E and beta-carotene","volume":"4","author":"Vrolijk","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2019.04.016_bb0370","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.taap.2012.11.010","article-title":"Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish","volume":"266","author":"Wang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0375","doi-asserted-by":"crossref","first-page":"9304091","DOI":"10.1155\/2018\/9304091","article-title":"Nrf2-mediated metabolic reprogramming in cancer","volume":"2018","author":"Wang","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2019.04.016_bb0380","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.taap.2005.01.061","article-title":"Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species","volume":"207","author":"Wells","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0385","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfn263","article-title":"Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer","volume":"108","author":"Wells","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2019.04.016_bb0390","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejphar.2015.04.013","article-title":"Honokiol improves learning and memory impairments induced by scopolamine in mice","volume":"760","author":"Xian","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0395","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.taap.2019.04.016_bb0400","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3892\/mmr.2015.4660","article-title":"Honokiol protects against renal ischemia\/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in rats","volume":"13","author":"Yu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2019.04.016_bb0405","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature12322","article-title":"In vivo cardiac reprogramming contributes to zebrafish heart regeneration","volume":"498","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.taap.2019.04.016_bb0410","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.yrtph.2014.11.007","article-title":"Acute and sub-chronic toxicity studies of honokiol microemulsion","volume":"71","author":"Zhang","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0415","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.yrtph.2015.11.012","article-title":"Embryo-fetal development toxicity of honokiol microemulsion intravenously administered to pregnant rats","volume":"74","author":"Zhang","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2019.04.016_bb0420","doi-asserted-by":"crossref","first-page":"3159801","DOI":"10.1155\/2018\/3159801","article-title":"Honokiol ameliorates myocardial ischemia\/reperfusion injury in type 1 diabetic rats by reducing oxidative stress and apoptosis through activating the SIRT1-Nrf2 signaling pathway","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2019.04.016_bb0425","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/apha.12515","article-title":"Biological and physiological role of reactive oxygen species--the good, the bad and the ugly","volume":"214","author":"Zuo","year":"2015","journal-title":"Acta Physiol (Oxford)"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19301486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19301486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:47:18Z","timestamp":1758574038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X19301486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":84,"alternative-id":["S0041008X19301486"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2019.04.016","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2019.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}