{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:41:31Z","timestamp":1787503291013,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["16ZR1426200"],"award-info":[{"award-number":["16ZR1426200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.taap.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T11:11:19Z","timestamp":1558091479000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase"],"prefix":"10.1016","volume":"376","author":[{"given":"Luyao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-0021","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2019.05.014_bb0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0765.2004.00703.x","article-title":"Mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles","volume":"39","author":"Cao","year":"2004","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.taap.2019.05.014_bb0010","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.18632\/oncotarget.1540","article-title":"Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth","volume":"4","author":"Chen","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2019.05.014_bb0015","first-page":"678","article-title":"Tanshinone prevents cancellous bone loss induced by ovariectomy in rats","volume":"25","author":"Cui","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2019.05.014_bb0020","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2019.05.014_bb0025","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jcp.24792","article-title":"Roles of SATB2 in site-specific stemness, autophagy and senescence of bone marrow mesenchymal stem cells","volume":"230","author":"Dong","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2019.05.014_bb0030","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2217\/epi.13.43","article-title":"DNA methylation and differentiation: silencing, upregulation and modulation of gene expression","volume":"5","author":"Ehrlich","year":"2013","journal-title":"Epigenomics"},{"issue":"738","key":"10.1016\/j.taap.2019.05.014_bb0035","article-title":"A review of the association between osteoporosis and alveolar ridge augmentation","volume":"104","author":"Erdogan","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.taap.2019.05.014_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2018.06.007","article-title":"Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas","volume":"432","author":"Huang","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2019.05.014_bb0045","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00774-003-0433-7","article-title":"Mandible bone loss in osteoporosis rats","volume":"21","author":"Jiang","year":"2003","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.taap.2019.05.014_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/635023","article-title":"The ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women","volume":"2015","author":"Johnston","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2019.05.014_bb0055","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.bcp.2003.12.031","article-title":"Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge","volume":"67","author":"Kim","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2019.05.014_bb0060","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/emm.2006.31","article-title":"Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1","volume":"38","author":"Kwak","year":"2006","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.taap.2019.05.014_bb0065","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2005.08.047","article-title":"Epidemiology, etiology, and diagnosis of osteoporosis","volume":"194","author":"Lane","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.taap.2019.05.014_bb0070","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/BF02973876","article-title":"Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge","volume":"28","author":"Lee","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2019.05.014_bb0075","first-page":"13695","article-title":"Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2019.05.014_bb0080","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00198-013-2494-3","article-title":"Osteoanabolic effect of alendronate and zoledronate on bone marrow stromal cells (BMSCs) isolated from aged female osteoporotic patients and its implications for their mode of action in the treatment of age-related bone loss","volume":"25","author":"Lindtner","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.taap.2019.05.014_bb0085","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1038\/ncomms9570","article-title":"The transcriptional landscape of age in human peripheral blood","volume":"6","author":"Peters","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2019.05.014_bb0090","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/(SICI)1097-4644(19991201)75:3<414::AID-JCB7>3.0.CO;2-C","article-title":"Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics","volume":"75","author":"Rodriguez","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2019.05.014_bb0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1067\/moe.2003.135","article-title":"Long-term changes in trabecular structure of aged rat alveolar bone after ovariectomy","volume":"95","author":"Tanaka","year":"2003","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.taap.2019.05.014_bb0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2019.05.014_bb0105","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/acel.12160","article-title":"Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging","volume":"13","author":"van den Akker","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.taap.2019.05.014_bb0110","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1002\/jcp.26233","article-title":"Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERbeta-SATB2 pathway","volume":"233","author":"Wu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2019.05.014_bb0115","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/art.30420","article-title":"17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner","volume":"63","author":"Xie","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.taap.2019.05.014_bb0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.exger.2016.09.001","article-title":"Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats","volume":"84","author":"Xu","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.taap.2019.05.014_bb0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1259\/dmfr\/12560890","article-title":"Effects of oestrogen deficiency on rat mandibular and tibial microarchitecture","volume":"32","author":"Yang","year":"2003","journal-title":"Dentomaxillofac Radiol."},{"key":"10.1016\/j.taap.2019.05.014_bb0130","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.3892\/or.2016.4669","article-title":"Curcumin inhibits tumor epithelialmesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells","volume":"35","author":"Zhang","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.taap.2019.05.014_bb0135","first-page":"2923","article-title":"Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice","volume":"35","author":"Zhou","year":"2010","journal-title":"Zhongguo Zhong Yao Za Zhi"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19301851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19301851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T18:45:12Z","timestamp":1565117112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X19301851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":27,"alternative-id":["S0041008X19301851"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2019.05.014","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}