{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:35:50Z","timestamp":1775338550235,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.taap.2019.114688","type":"journal-article","created":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T17:00:53Z","timestamp":1563728453000},"page":"114688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice"],"prefix":"10.1016","volume":"379","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-7156","authenticated-orcid":false,"given":"Ji","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-3905","authenticated-orcid":false,"given":"Wenjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2019.114688_bb0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.taap.2019.114688_bb0010","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1007\/s12035-015-9408-7","article-title":"Stress-induced depressive behaviors require a functional NLRP3 inflammasome","volume":"53","author":"Alcocer-G\u00f3mez","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.taap.2019.114688_bb0015","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2018.11.037","article-title":"On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress","volume":"66","author":"Amini-Khoei","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2019.114688_bb0020","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.exger.2007.01.011","article-title":"Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age","volume":"42","author":"van den Biggelaar","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.taap.2019.114688_bb0025","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.febslet.2010.01.011","article-title":"Regulation of autophagy by phosphatidylinositol 3-phosphate","volume":"584","author":"Burman","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2019.114688_bb0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1139\/jpn.0441","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"Campbell","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.taap.2019.114688_bb0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1476-5381.2010.00906.x","article-title":"Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia","volume":"161","author":"Chan","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2019.114688_bb0040","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1055\/s-0030-1271019","article-title":"Andrographolide inhibits PI3K\/AKT-dependent NOX2 and iNOS expression protecting mice against hypoxia\/ischemia-induced oxidative brain injury","volume":"77","author":"Chern","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.taap.2019.114688_bb0045","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.brainresbull.2008.03.005","article-title":"Antidepressive-like effects of rapamycin in animal models: implications for mTOR inhibition as a new target for treatment of affective disorders","volume":"76","author":"Cleary","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.taap.2019.114688_bb0050","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/ijc.25477","article-title":"The antidepressants maprotiline and fluoxetine induce type II autophagic cell death in drug-resistant Burkitt\u2019s lymphoma","volume":"128","author":"Cloonan","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2019.114688_bb0055","doi-asserted-by":"crossref","first-page":"e7061","DOI":"10.1590\/1414-431x20177061","article-title":"Andrographolide protects mouse astrocytes against hypoxia injury by promoting autophagy and S100B expression","volume":"51","author":"Du","year":"2018","journal-title":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"key":"10.1016\/j.taap.2019.114688_bb0060","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0031-9384(96)00305-8","article-title":"Chronic mild stress and sucrose consumption: validity as a model of depression","volume":"60","author":"Forbes","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.taap.2019.114688_bb0065","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/15548627.2015.1017224","article-title":"FKBP5\/FKBP51 enhances autophagy to synergize with antidepressant action","volume":"11","author":"Gassen","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2019.114688_bb0070","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.biopha.2017.11.039","article-title":"Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP\/PS1 transgenic mice","volume":"97","author":"Geng","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.taap.2019.114688_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jpsychires.2019.05.001","article-title":"Maternal deprivation increases microglial activation and neuroinflammatory markers in the prefrontal cortex and hippocampus of infant rats","volume":"115","author":"Giridharan","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.taap.2019.114688_bb0080","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.mp.4002055","article-title":"Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression","volume":"13","author":"Goshen","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.taap.2019.114688_bb0085","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.intimp.2012.09.002","article-title":"Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-kappaB pathways","volume":"14","author":"Guo","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2019.114688_bb0090","doi-asserted-by":"crossref","first-page":"972","DOI":"10.4161\/auto.28374","article-title":"Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer","volume":"10","author":"Guo","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2019.114688_bb0095","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.taap.2019.114688_bb0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.brainresbull.2017.01.018","article-title":"Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress","volume":"130","author":"Haj-Mirzaian","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.taap.2019.114688_bb0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2018.01.074","article-title":"Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer","volume":"420","author":"Islam","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2019.114688_bb0110","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1091\/mbc.e08-12-1249","article-title":"ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery","volume":"20","author":"Jung","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.taap.2019.114688_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2019.114688_bb0120","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2014.03.008","article-title":"mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T-and Y-maze cognitive tests","volume":"266","author":"Lainiola","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.taap.2019.114688_bb0125","first-page":"1","article-title":"Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis","author":"Li","year":"2019","journal-title":"Stress (Amsterdam, Netherlands)"},{"key":"10.1016\/j.taap.2019.114688_bb0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.taap.2019.114688_bb0135","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1159\/000485536","article-title":"Andrographolide induces Autophagic cell death and inhibits invasion and metastasis of human osteosarcoma cells in an autophagy-dependent manner","volume":"44","author":"Liu","year":"2017","journal-title":"Cellular physiology and biochemistry\u202f: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"key":"10.1016\/j.taap.2019.114688_bb0140","doi-asserted-by":"crossref","first-page":"101928","DOI":"10.1016\/j.npep.2019.04.003","article-title":"Implication of NMDA-NO pathway in the antidepressant-like effect of ellagic acid in male mice","volume":"76","author":"Lorigooini","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.taap.2019.114688_bb0145","article-title":"A review for the neuroprotective effects of andrographolide in the central nervous system","volume":"117","author":"Lu","year":"2019","journal-title":"Biomed. Pharmacother. Biomed. & Pharmacother."},{"key":"10.1016\/j.taap.2019.114688_bb0150","first-page":"3","article-title":"Prospect for study on treatment of AIDS with traditional Chinese medicine","volume":"15","author":"L\u00fc","year":"1995","journal-title":"Journal of traditional Chinese medicine= Chung i tsa chih ying wen pan"},{"key":"10.1016\/j.taap.2019.114688_bb0155","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2019.114688_bb0160","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/sj.mp.4001805","article-title":"The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine","volume":"11","author":"M\u00fcller","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.taap.2019.114688_bb0165","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1\u03b2-related inflammation in prefrontal cortex of depressive rats","volume":"41","author":"Pan","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.taap.2019.114688_bb0170","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.taap.2019.114688_bb0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1742-2094-9-75","article-title":"Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress","volume":"9","author":"Peng","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2019.114688_bb0180","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.taap.2019.114688_bb0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA psychiatry"},{"key":"10.1016\/j.taap.2019.114688_bb0190","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychires.2008.02.006","article-title":"Restless legs syndrome as side effect of second generation antidepressants","volume":"43","author":"Rottach","year":"2008","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.taap.2019.114688_bb0195","first-page":"e1958","article-title":"Sucrose preference test to measure anhedonic behaviour in mice","volume":"6","author":"Serchov","year":"2015","journal-title":"BioProtocol"},{"key":"10.1016\/j.taap.2019.114688_bb0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature News"},{"key":"10.1016\/j.taap.2019.114688_bb0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-61779-111-6_2","article-title":"Dissection of rodent brain regions","author":"Spijker","year":"2011","journal-title":"Neuroproteomics"},{"key":"10.1016\/j.taap.2019.114688_bb0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.taap.2019.114688_bb0215","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice","volume":"163","author":"Trivedi","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.taap.2019.114688_bb0220","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2019.114688_bb0225","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bcp.2016.09.024","article-title":"Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression","volume":"121","author":"Wang","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2019.114688_bb0230","first-page":"59","article-title":"The side effect profile and safety of fluoxetine","volume":"46","author":"Wernicke","year":"1985","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.taap.2019.114688_bb0235","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.taap.2019.114688_bb0240","first-page":"e52587","article-title":"The forced swim test as a model of depressive-like behavior","volume":"97","author":"Yankelevitch-Yahav","year":"2015","journal-title":"J. Visual. Exp."},{"key":"10.1016\/j.taap.2019.114688_bb0245","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12974-017-0865-y","article-title":"Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors","volume":"14","author":"Yue","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.taap.2019.114688_bb0250","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/npp.2011.57","article-title":"Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons-dissociation from cholesterol homeostasis","volume":"36","author":"Zschocke","year":"2011","journal-title":"Neuropsychopharmacology"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19302960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19302960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:49:12Z","timestamp":1758574152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X19302960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":50,"alternative-id":["S0041008X19302960"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2019.114688","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2019.114688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114688"}}