{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:07:11Z","timestamp":1771643231639,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.taap.2019.114705","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T11:12:07Z","timestamp":1565176327000},"page":"114705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro"],"prefix":"10.1016","volume":"380","author":[{"given":"Yao","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghe","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanqin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuetao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6603","key":"10.1016\/j.taap.2019.114705_bb0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper t lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.taap.2019.114705_bb0010","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","article-title":"Cell type-specific function of tak1 in innate immune signaling","volume":"34","author":"Ajibade","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.taap.2019.114705_bb0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-1-62703-496-8_11","article-title":"Contact hypersensitivity models in mice","volume":"1032","author":"Allen","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.taap.2019.114705_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/424203","article-title":"The llna: a brief review of recent advances and limitations","volume":"2011","author":"Anderson","year":"2011","journal-title":"J. Allergy"},{"issue":"3","key":"10.1016\/j.taap.2019.114705_bb0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jaut.2004.06.007","article-title":"Activation and attenuation of apoptosis of cd4+ t cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid","volume":"23","author":"Blossom","year":"2004","journal-title":"J. Autoimmun."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/15476910701337225","article-title":"Immuno- and hepato-toxicity of dichloroacetic acid in mrl(+\/+) and b(6)c(3)f(1) mice","volume":"4","author":"Cai","year":"2007","journal-title":"J. Immunotoxicol."},{"issue":"5","key":"10.1016\/j.taap.2019.114705_bb0035","first-page":"346","article-title":"Immune responses to trichloroethylene and skin gene expression profiles in Sprague dawley rats","volume":"19","author":"Chen","year":"2006","journal-title":"Biomed. Environ. Sci."},{"issue":"3","key":"10.1016\/j.taap.2019.114705_bb0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.1205879","article-title":"Human health effects of trichloroethylene: key findings and scientific issues","volume":"121","author":"Chiu","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0045","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/jpet.116.232629","article-title":"Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps","volume":"359","author":"Cichocki","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2019.114705_bb0050","series-title":"Immunology-A Short Course","author":"Coico","year":"2003"},{"issue":"5","key":"10.1016\/j.taap.2019.114705_bb0055","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1289\/ehp.11782","article-title":"Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans","volume":"117","author":"Cooper","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/meth.1999.0827","article-title":"Cytokine fingerprinting: characterization of chemical allergens","volume":"19","author":"Dearman","year":"1999","journal-title":"Methods."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/toxsci\/71.2.137","article-title":"Chemical allergy: considerations for the practical application of cytokine profiling","volume":"71","author":"Dearman","year":"2003","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.taap.2019.114705_bb0070","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1182\/blood-2003-03-0727","article-title":"Innate cd4+cd25+ regulatory t cells are required for oral tolerance and inhibition of cd8+ t cells mediating skin inflammation","volume":"102","author":"Dubois","year":"2003","journal-title":"Blood."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1997.8218","article-title":"Selective modulation of t cell memory markers cd62l and cd44 on murine draining lymph node cells following allergen and irritant treatment","volume":"146","author":"Gerberick","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/kfs093","article-title":"Epigenetic alterations may regulate temporary reversal of cd4(+) t cell activation caused by trichloroethylene exposure","volume":"127","author":"Gilbert","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0085","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/toxsci\/57.2.345","article-title":"Cd4(+) t-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in mrl+\/+ mice","volume":"57","author":"Griffin","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00043764-200102000-00012","article-title":"Cancer incidence among danish workers exposed to trichloroethylene","volume":"43","author":"Hansen","year":"2001","journal-title":"J. Occup. Environ. Med."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/187221310791163053","article-title":"The role of regulatory t cells in contact hypersensitivity","volume":"4","author":"Honda","year":"2010","journal-title":"Recent Patents Inflamm. Allergy Drug Discov."},{"issue":"3","key":"10.1016\/j.taap.2019.114705_bb0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.toxlet.2011.12.012","article-title":"B cell increases and ex vivo il-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry","volume":"209","author":"Jung","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0105","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.4049\/jimmunol.181.2.1143","article-title":"Enterocyte-derived tak1 signaling prevents epithelium apoptosis and the development of ileitis and colitis","volume":"181","author":"Kajino-Sakamoto","year":"2008","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.taap.2019.114705_bb0110","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1539\/joh.L8013","article-title":"Trichloroethylene causes generalized hypersensitivity skin disorders complicated by hepatitis","volume":"50","author":"Kamijima","year":"2008","journal-title":"J. Occup. Health"},{"issue":"3","key":"10.1016\/j.taap.2019.114705_bb0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jdermsci.2013.07.003","article-title":"Occupational trichloroethylene hypersensitivity syndrome: human herpesvirus 6 reactivation and rash phenotypes","volume":"72","author":"Kamijima","year":"2013","journal-title":"J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.taap.2019.114705_bb0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/1099-1263(200011\/12)20:6<471::AID-JAT716>3.0.CO;2-E","article-title":"Immunotoxicity of trichloroethylene: a study with mrl-lpr\/lpr mice","volume":"20","author":"Kaneko","year":"2000","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0125","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2131\/jts.37.381","article-title":"Trichloroethylene enhances tcr-cd3-induced proliferation of cd8(+) rather than cd4(+) t cells","volume":"37","author":"Kobayashi","year":"2012","journal-title":"J. Toxicol. Sci."},{"issue":"12","key":"10.1016\/j.taap.2019.114705_bb0130","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1265","article-title":"Inducing and expanding regulatory t cell populations by foreign antigen","volume":"6","author":"Kretschmer","year":"2005","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1091581818757036","article-title":"Trichloroethylene alters th1\/th2\/th17\/treg paradigm in mice: a novel mechanism for chemically induced autoimmunity","volume":"37","author":"Li","year":"2018","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.taap.2019.114705_bb0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tox.2019.05.014","article-title":"Effect of trichloroacetaldehyde on the activation of cd4+t cells in occupational medicamentosa-like dermatitis: an in vivo and in vitro study","volume":"423","author":"Li","year":"2019","journal-title":"Toxicology."},{"issue":"31","key":"10.1016\/j.taap.2019.114705_bb0145","doi-asserted-by":"crossref","first-page":"11677","DOI":"10.1073\/pnas.0603089103","article-title":"Essential role of tak1 in thymocyte development and activation","volume":"103","author":"Liu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.taap.2019.114705_bb0150","first-page":"1143","article-title":"Application of microrna expression profiles to the study of occupational medicamentosa-like dermatitis induced by trichloroethylene","volume":"24","author":"Liu","year":"2017","journal-title":"Pract. Prev. Med."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0155","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1539\/joh.45.8","article-title":"Generalized skin reactions in relation to trichloroethylene exposure: a review from the viewpoint of drug-metabolizing enzymes","volume":"45","author":"Nakajima","year":"2003","journal-title":"J. Occup. Health"},{"issue":"4","key":"10.1016\/j.taap.2019.114705_bb0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2486\/indhealth.2017-0202","article-title":"Exposure reconstruction of trichloroethylene among patients with occupational trichloroethylene hypersensitivity syndrome","volume":"56","author":"Nakajima","year":"2018","journal-title":"Ind. Health"},{"issue":"20","key":"10.1016\/j.taap.2019.114705_bb0165","doi-asserted-by":"crossref","first-page":"18485","DOI":"10.1074\/jbc.M207453200","article-title":"A resorcylic acid lactone, 5z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of tak1 mapk kinase kinase","volume":"278","author":"Ninomiya-Tsuji","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2019.114705_bb0170","series-title":"OECD Guideline for the Testing of Chemicals No 442B","article-title":"Skin sensitisation: local lymph node assay: Brdu-elisa","author":"OECD","year":"2010"},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0175","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12033","article-title":"Nf-kappab: roles and regulation in different cd4(+) t-cell subsets","volume":"252","author":"Oh","year":"2013","journal-title":"Immunol. Rev."},{"issue":"28","key":"10.1016\/j.taap.2019.114705_bb0180","doi-asserted-by":"crossref","first-page":"19610","DOI":"10.1074\/jbc.M603384200","article-title":"Tak1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis","volume":"281","author":"Omori","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.taap.2019.114705_bb0185","doi-asserted-by":"crossref","first-page":"10575","DOI":"10.3390\/ijerph120910575","article-title":"Trichloroethylene and its oxidative metabolites enhance the activated state and th1 cytokine gene expression in jurkat cells","volume":"12","author":"Pan","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.taap.2019.114705_bb0190","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1289\/ehp.1002106","article-title":"A case-control study of occupational exposure to trichloroethylene and non-hodgkin lymphoma","volume":"119","author":"Purdue","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.taap.2019.114705_bb0195","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/intimm\/dxl082","article-title":"Tak1 is indispensable for development of t cells and prevention of colitis by the generation of regulatory t cells","volume":"18","author":"Sato","year":"2006","journal-title":"Int. Immunol."},{"issue":"11","key":"10.1016\/j.taap.2019.114705_bb0200","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ni1255","article-title":"Essential function for the kinase tak1 in innate and adaptive immune responses","volume":"6","author":"Sato","year":"2005","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.taap.2019.114705_bb0205","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1084\/jem.20051611","article-title":"Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow","volume":"202","author":"Shapiro-Shelef","year":"2005","journal-title":"J. Exp. Med."},{"issue":"22","key":"10.1016\/j.taap.2019.114705_bb0210","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1101\/gad.1360605","article-title":"Tak1, but not tab1 or tab2, plays an essential role in multiple signaling pathways in vivo","volume":"19","author":"Shim","year":"2005","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.taap.2019.114705_bb0215","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1097-2765(04)00236-9","article-title":"The traf6 ubiquitin ligase and tak1 kinase mediate ikk activation by bcl10 and malt1 in t lymphocytes","volume":"14","author":"Sun","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2019.114705_bb0220","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2017.08.009","article-title":"Gene expression profiles in auricle skin as a possible additional endpoint for determination of sensitizers: a multi-endpoint evaluation of the local lymph node assay","volume":"280","author":"Tsuchiyama","year":"2017","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(02)00742-4","article-title":"Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mrna expression and production in the draining lymph nodes of mice","volume":"188","author":"Vandebriel","year":"2003","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.taap.2019.114705_bb0230","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/embo-reports\/kve064","article-title":"A highly efficient ligand-regulated cre recombinase mouse line shows that loxp recombination is position dependent","volume":"2","author":"Vooijs","year":"2001","journal-title":"EMBO Rep."},{"issue":"8","key":"10.1016\/j.taap.2019.114705_bb0235","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni1355","article-title":"The kinase tak1 integrates antigen and cytokine receptor signaling for t cell development, survival and function","volume":"7","author":"Wan","year":"2006","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0240","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.toxlet.2014.06.841","article-title":"Complement c3a binding to its receptor as a negative modulator of th2 response in liver injury in trichloroethylene-sensitized mice","volume":"229","author":"Wang","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.taap.2019.114705_bb0245","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000290775","article-title":"Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation","volume":"221","author":"Watanabe","year":"2010","journal-title":"Dermatology"},{"key":"10.1016\/j.taap.2019.114705_bb0250","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.toxlet.2018.02.012","article-title":"Cytokine expression and cytokine-based t-cell profiling in occupational medicamentosa-like dermatitis due to trichloroethylene","volume":"288","author":"Xueqin","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2019.114705_bb0255","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.taap.2016.07.019","article-title":"Lack of tak1 in dendritic cells inhibits the contact hypersensitivity response induced by trichloroethylene in local lymph node assay","volume":"307","author":"Yao","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2019.114705_bb0260","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cmi.2011.11","article-title":"An essential role for tak1 in the contact hypersensitivity response","volume":"8","author":"Zhao","year":"2011","journal-title":"Cell. Mol. Immunol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19303138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19303138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:48:16Z","timestamp":1758574096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X19303138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":52,"alternative-id":["S0041008X19303138"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2019.114705","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2019.114705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114705"}}