{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:07:58Z","timestamp":1786997278622,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"am","delay-in-days":348,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010843","name":"Guangzhou Science, Technology and Innovation Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.taap.2019.114769","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T19:46:44Z","timestamp":1572896804000},"page":"114769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT"],"prefix":"10.1016","volume":"385","author":[{"given":"Guangxu","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hezhan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peidi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ting","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-2008","authenticated-orcid":false,"given":"Bin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.taap.2019.114769_bb0005","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1242\/dev.037432","article-title":"The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1\/Lhx1","volume":"136","author":"Agrawal","year":"2009","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1042\/BST20110623","article-title":"Regulation of signalling by microRNAs","volume":"40","author":"Avraham","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.taap.2019.114769_bb0015","first-page":"S2","article-title":"Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies and chronic interstitial nephritides","volume":"54","author":"Bohle","year":"1996","journal-title":"Kidney Int. Suppl."},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0020","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.intimp.2015.02.023","article-title":"Leonurine ameliorates kidney fibrosis via suppressing TGF-beta and NF-kappaB signaling pathway in UUO mice","volume":"25","author":"Cheng","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.taap.2019.114769_bb0025","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/s41418-018-0103-x","article-title":"A p53\/miR-30a\/ZEB2 axis controls triple negative breast cancer aggressiveness","volume":"25","author":"di Gennaro","year":"2018","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.taap.2019.114769_bb0030","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.febslet.2009.12.053","article-title":"High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells","volume":"584","author":"Du","year":"2010","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.taap.2019.114769_bb0035","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.febslet.2009.12.053","article-title":"High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells","volume":"584","author":"Du","year":"2010","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.taap.2019.114769_bb0040","doi-asserted-by":"crossref","first-page":"e2987","DOI":"10.1038\/cddis.2017.377","article-title":"MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5","volume":"8","author":"Du","year":"2017","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.taap.2019.114769_bb0045","first-page":"2642","article-title":"MiR-30 suppresses lung cancer cell 95D epithelial mesenchymal transition and invasion through targeted regulating snail","volume":"21","author":"Fan","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2019.114769_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/151724","article-title":"Comparison of two methods of RNA extraction from formalin-fixed paraffin-embedded tissue specimens","volume":"2014","author":"Gouveia","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"9","key":"10.1016\/j.taap.2019.114769_bb0055","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.taap.2019.114769_bb0060","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3109\/0886022X.2015.1077322","article-title":"Dysregulated microRNAs involved in contrast- induced acute kidney injury in rat and human","volume":"37","author":"Gutierrez-Escolano","year":"2015","journal-title":"Ren. Fail."},{"issue":"6","key":"10.1016\/j.taap.2019.114769_bb0065","doi-asserted-by":"crossref","first-page":"F1239","DOI":"10.1152\/ajprenal.90521.2008","article-title":"Renal tubulointerstitial fibrosis: common but never simple","volume":"296","author":"Hewitson","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0070","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ki.2013.80","article-title":"A microRNA-30e\/mitochondrial uncoupling protein 2 axis mediates TGF-beta1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis","volume":"84","author":"Jiang","year":"2013","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ptr.6204","article-title":"Schisandrin B attenuates epidural fibrosis in postlaminectomy rats by inhibiting proliferation and extracellular matrix production of fibroblasts","volume":"33","author":"Jin","year":"2019","journal-title":"Phytother. Res\u202f: PTR"},{"issue":"12","key":"10.1016\/j.taap.2019.114769_bb0080","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.taap.2019.114769_bb0085","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2215\/CJN.00520109","article-title":"MicroRNAs and their role in progressive kidney diseases","volume":"4","author":"Kato","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.taap.2019.114769_bb0090","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v29.i6.20","article-title":"In vivo delivery aspects of miRNA, shRNA and siRNA","volume":"29","author":"Khatri","year":"2012","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"issue":"3","key":"10.1016\/j.taap.2019.114769_bb0095","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/jgh.12425","article-title":"Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice","volume":"29","author":"Li","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"17","key":"10.1016\/j.taap.2019.114769_bb0100","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1007\/s00018-010-0366-y","article-title":"Beta-catenin\/TCF4 transactivates miR-30e during intestinal cell differentiation","volume":"67","author":"Liao","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"10","key":"10.1016\/j.taap.2019.114769_bb0105","first-page":"740","article-title":"Pharmacological actions and clinical use of fructus schizandrae","volume":"102","author":"Liu","year":"1989","journal-title":"Chin. Med. J."},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1681\/ASN.2008121226","article-title":"New insights into epithelial-mesenchymal transition in kidney fibrosis","volume":"21","author":"Liu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.taap.2019.114769_bb0115","first-page":"2108","article-title":"Schizandrin B inhibits the cisDDPinduced apoptosis of HK2 cells by activating ERK\/NFkappaB signaling to regulate the expression of survivin","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbrc.2018.11.128","article-title":"Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress","volume":"508","author":"Mou","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010065","article-title":"Development of novel therapeutic agents by inhibition of oncogenic MicroRNAs","volume":"19","author":"Nguyen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0130","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.intimp.2015.02.014","article-title":"Schizandrin inhibits fibrosis and epithelial-mesenchymal transition in transforming growth factor-beta1-stimulated AML12 cells","volume":"25","author":"Park","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.taap.2019.114769_bb0135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0140","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1039\/C6SC01829G","article-title":"Protecting microRNAs from RNase degradation with steric DNA nanostructures","volume":"8","author":"Qian","year":"2017","journal-title":"Chem. Sci."},{"issue":"3","key":"10.1016\/j.taap.2019.114769_bb0145","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/s10753-018-0943-z","article-title":"Schisandrin B improves the renal function of IgA nephropathy rats through inhibition of the NF-kappaB signalling pathway","volume":"42","author":"Qin","year":"2019","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.taap.2019.114769_bb0150","first-page":"407","article-title":"Epithelial-mesenchymal transition and its implications for the development of renal tubulointerstitial fibrosis","volume":"19","author":"Rastaldi","year":"2006","journal-title":"J. Nephrol"},{"key":"10.1016\/j.taap.2019.114769_bb0155","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.2741\/925","article-title":"Renal fibrosis","volume":"8","author":"Schnaper","year":"2003","journal-title":"Front. Biosci."},{"issue":"9","key":"10.1016\/j.taap.2019.114769_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075572","article-title":"Smad2-dependent downregulation of miR-30 is required for TGF-beta-induced apoptosis in podocytes","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"issue":"1\u20133","key":"10.1016\/j.taap.2019.114769_bb0165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tox.2011.05.005","article-title":"Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro","volume":"286","author":"Stacchiotti","year":"2011","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.taap.2019.114769_bb0170","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jdiacomp.2015.12.011","article-title":"Downregulation of miR-30c promotes renal fibrosis by target CTGF in diabetic nephropathy","volume":"30","author":"Wang","year":"2016","journal-title":"J. Diabetes Complicat."},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1681\/ASN.2012111101","article-title":"Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids","volume":"25","author":"Wu","year":"2014","journal-title":"J. Am. Soc. Nephrol.\u202f: JASN"},{"issue":"1","key":"10.1016\/j.taap.2019.114769_bb0180","article-title":"Small molecule targeting miR-34a for cancer therapy","volume":"2","author":"Xiao","year":"2015","journal-title":"Mol Cell Oncol"},{"key":"10.1016\/j.taap.2019.114769_bb0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-1-4939-6563-2_12","article-title":"Identification of small molecule modulators of MicroRNA by library screening","volume":"1517","author":"Xiao","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"21","key":"10.1016\/j.taap.2019.114769_bb0190","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1158\/0008-5472.CAN-14-0855","article-title":"A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma","volume":"74","author":"Xiao","year":"2014","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.taap.2019.114769_bb0195","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.7150\/jca.25006","article-title":"MicroRNA-30b targets snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells","volume":"9","author":"Xiong","year":"2018","journal-title":"J. Cancer"},{"issue":"6","key":"10.1016\/j.taap.2019.114769_bb0200","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","article-title":"Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis","volume":"14","author":"Yang","year":"2008","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.taap.2019.114769_bb0205","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI0216219","article-title":"Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy","volume":"110","author":"Yang","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.taap.2019.114769_bb0210","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.taap.2019.114769_bb0215","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat. Med."},{"issue":"1\u20133","key":"10.1016\/j.taap.2019.114769_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2012.05.030","article-title":"Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the toll-like receptor 4-dependent MyD88\/IKK\/NF-kappaB signaling pathway in lipopolysaccharide-induced microglia","volume":"692","author":"Zeng","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.taap.2019.114769_bb0225","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbrc.2011.12.121","article-title":"miR-30 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1","volume":"417","author":"Zhang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2019.114769_bb0230","first-page":"2001","article-title":"Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity","volume":"9","author":"Zhang","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.taap.2019.114769_bb0235","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.intimp.2017.04.024","article-title":"Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-beta1\/Smad2 pathways and overexpression of NOX4","volume":"48","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2019.114769_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.05.041","article-title":"Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing","volume":"309","author":"Zhang","year":"2019","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.taap.2019.114769_bb0245","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1002\/jcb.27880","article-title":"A novel agent attenuates cardiotoxicity and improves antitumor activity of doxorubicin in breast cancer cells","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.taap.2019.114769_bb0250","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/JME-17-0083","article-title":"miR-30e targets GLIPR-2 to modulate diabetic nephropathy: in vitro and in vivo experiments","volume":"59","author":"Zhao","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.taap.2019.114769_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/srep37492","article-title":"The coordinated roles of miR-26a and miR-30c in regulating TGFbeta1-induced epithelial-to-mesenchymal transition in diabetic nephropathy","volume":"6","author":"Zheng","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.taap.2019.114769_bb0260","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1142\/S0192415X12500425","article-title":"Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo","volume":"40","author":"Zhu","year":"2012","journal-title":"Am J Chin Med"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19303771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X19303771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:50:25Z","timestamp":1758574225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X19303771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":52,"alternative-id":["S0041008X19303771"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2019.114769","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2019.114769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114769"}}