{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:51:23Z","timestamp":1790664683900,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-ES007324"],"award-info":[{"award-number":["T32-ES007324"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31-ES025591"],"award-info":[{"award-number":["F31-ES025591"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01OH010921"],"award-info":[{"award-number":["R01OH010921"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["S10OD019966"],"award-info":[{"award-number":["S10OD019966"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.taap.2020.115041","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:54:04Z","timestamp":1589680444000},"page":"115041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["World Trade Center Dust induces airway inflammation while promoting aortic endothelial dysfunction"],"prefix":"10.1016","volume":"400","author":[{"given":"Michelle","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Galdanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Halzack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianhua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Sebasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morton","family":"Lippmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0005","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1183\/09031936.00005408","article-title":"Pulmonary arterial hypertension masquerading as severe refractory asthma","volume":"32","author":"Achouh","year":"2008","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00204-010-0601-1","article-title":"Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats","volume":"85","author":"Antonini","year":"2011","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00423-006-0073-1","article-title":"Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair","volume":"391","author":"Bartsch","year":"2006","journal-title":"Langenbeck\u2019s Arch. Surg."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0020","first-page":"303","article-title":"Inducible nitric oxide synthase (iNOS): role in asthma pathogenesis","volume":"44","author":"Batra","year":"2007","journal-title":"Indian J. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.taap.2020.115041_bb0025","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/JOM.0b013e31822fff60","article-title":"Lung pathologic findings in a local residential and working community exposed to World Trade Center dust, gas, and fumes","volume":"53","author":"Caplan-Shaw","year":"2011","journal-title":"J. Occup. Environ. Med."},{"issue":"Suppl","key":"10.1016\/j.taap.2020.115041_bb0030","doi-asserted-by":"crossref","first-page":"s37","DOI":"10.1016\/S0140-6736(02)11814-9","article-title":"World trade Center cough","volume":"360","author":"Chen","year":"2002","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/08958370903161232","article-title":"Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium","volume":"22","author":"Cohen","year":"2010","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2020.115041_bb0040","first-page":"1","article-title":"Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung","author":"Cohen","year":"2014","journal-title":"J. Immunotoxicol."},{"issue":"7","key":"10.1016\/j.taap.2020.115041_bb0045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/08958378.2015.1054531","article-title":"Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats","volume":"27","author":"Cohen","year":"2015","journal-title":"Inhal. Toxicol."},{"issue":"1","key":"10.1016\/j.taap.2020.115041_bb0050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/toxsci\/55.1.24","article-title":"Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations","volume":"55","author":"Driscoll","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.taap.2020.115041_bb0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.RES.86.3.347","article-title":"Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide","volume":"86","author":"Drummond","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2020.115041_bb0060","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/1471-2458-11-321","article-title":"9\/11-related experiences and tasks of landfill and barge workers: qualitative analysis from the World Trade Center Health Registry","volume":"11","author":"Ekenga","year":"2011","journal-title":"BMC Public Health"},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1164\/rccm.201011-1909OC","article-title":"Case-control study of lung function in World Trade Center Health Registry area residents and workers","volume":"184","author":"Friedman","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.taap.2020.115041_bb0070","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1289\/ehp.5931","article-title":"World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice","volume":"111","author":"Gavett","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0075","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000431","article-title":"Cardiovascular disease hospitalizations in relation to exposure to the September 11, 2001 World Trade Center disaster and posttraumatic stress disorder","volume":"2","author":"Jordan","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.taap.2020.115041_bb0080","first-page":"676","article-title":"Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo","volume":"101","author":"Kuboki","year":"2000","journal-title":"Spec. Vasc. Act. Insulin"},{"issue":"3","key":"10.1016\/j.taap.2020.115041_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3844\/ojbsci.2009.81.85","article-title":"Indications of potential toxic\/mutagenic effects of World Trade Center Dust on human lung cell cultures","volume":"9","author":"Lambroussis","year":"2009","journal-title":"Online J. Biol. Sci."},{"key":"10.1016\/j.taap.2020.115041_bb0090","doi-asserted-by":"crossref","first-page":"791231","DOI":"10.1155\/2013\/791231","article-title":"Inflammatory signalings involved in airway and pulmonary diseases","volume":"2013","author":"Lee","year":"2013","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.taap.2020.115041_bb0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1179\/oeh.2010.16.1.44","article-title":"Lower respiratory symptoms among residents living near the world trade Center, two and four years after 9\/11","volume":"16","author":"Lin","year":"2010","journal-title":"Int. J. Occup. Environ. Health"},{"key":"10.1016\/j.taap.2020.115041_bb0100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/19338240903390230","article-title":"Respiratory and cardiovascular hospitalizations after the World Trade Center disaster","volume":"65","author":"Lin","year":"2010","journal-title":"Arch. Environ. Occup. Health"},{"key":"10.1016\/j.taap.2020.115041_bb0105","doi-asserted-by":"crossref","first-page":"845037","DOI":"10.1155\/2013\/845037","article-title":"Endothelial progenitor cell dysfunction in cardiovascular diseases: role of reactive oxygen species and inflammation","volume":"2013","author":"Lin","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"7","key":"10.1016\/j.taap.2020.115041_bb0110","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1289\/ehp.02110703","article-title":"Characterization of the dust\/smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC 11 September 2001","volume":"110","author":"Lioy","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.taap.2020.115041_bb0115","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3109\/10408444.2015.1044601","article-title":"Health effects of World Trade Center (WTC) dust: an unprecedented disaster\u2019s inadequate risk management","volume":"45","author":"Lippmann","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"issue":"9","key":"10.1016\/j.taap.2020.115041_bb0120","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1096\/fj.02-0024com","article-title":"Periadventitial fat releases a vascular relaxing factor","volume":"16","author":"Lohn","year":"2002","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.taap.2020.115041_bb0125","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1289\/ehp.5930","article-title":"Chemical analysis of world trade Center fine particulate matter for use in toxicologic assessment","volume":"111","author":"McGee","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0130","first-page":"155","article-title":"Pulmonary edema: pathophysiology and diagnosis","volume":"15","author":"Murray","year":"2011","journal-title":"Int. J. Tuberc. Lung Dis"},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1183\/09031936.00202413","article-title":"Exhaled nitric oxide, nitrite\/nitrate levels, allergy, rhinitis and asthma in the EGEA study","volume":"44","author":"Nadif","year":"2014","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0140","first-page":"90","article-title":"Induced sputum nitrite levels correlate with clinical asthma parameters in children aged 7-18 years with mild to moderate persistent asthma","volume":"8","author":"Nandan","year":"2016","journal-title":"J. Lab. Phys."},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0145","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/faat.1997.2390","article-title":"Intratracheal inhalation vs intratracheal instillation: differences in particle effects","volume":"40","author":"Osier","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.taap.2020.115041_bb0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.envpol.2015.12.009","article-title":"Repeated exposures to roadside particulate matter extracts suppresses pulmonary defense mechanisms, resulting in lipid and protein oxidative damage","volume":"210","author":"Pardo","year":"2016","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.taap.2020.115041_bb0155","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3109\/08958371003728057","article-title":"Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction","volume":"22","author":"Quan","year":"2010","journal-title":"Inhal. Toxicol."},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0160","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1513\/pats.200908-092RM","article-title":"Emerging exposures and respiratory health: World Trade Center Dust","volume":"7","author":"Rom","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"issue":"4","key":"10.1016\/j.taap.2020.115041_bb0165","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1183\/09031936.00097109","article-title":"Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?","volume":"35","author":"Said","year":"2010","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2222.1998.00270.x","article-title":"Increased nitric oxide in nasal lavage fluid and nitrotyrosine formation in nasal mucosa--indices for severe perennial nasal allergy","volume":"28","author":"Sato","year":"1998","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.taap.2020.115041_bb0175","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.scitotenv.2012.11.097","article-title":"Associations of world trade Center exposures with pulmonary and cardiometabolic outcomes among children seeking care for health concerns","volume":"444","author":"Trasande","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.taap.2020.115041_bb0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/jes.2013.68","article-title":"A novel system to generate WTC dust particles for inhalation exposures","volume":"24","author":"Vaughan","year":"2014","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"4","key":"10.1016\/j.taap.2020.115041_bb0185","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2006-948288","article-title":"Pathophysiology of acute lung injury and the acute respiratory distress syndrome","volume":"27","author":"Ware","year":"2006","journal-title":"Semin. Respir. Crit. Care. Med."},{"issue":"5","key":"10.1016\/j.taap.2020.115041_bb0190","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1164\/rccm.201512-2434OC","article-title":"Fine particulate matter and emergency room visits for respiratory illness. Effect modification by oxidative potential","volume":"194","author":"Weichenthal","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.taap.2020.115041_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040016","article-title":"Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitro","volume":"7","author":"Weiden","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.taap.2020.115041_bb0200","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1289\/ehp.10248","article-title":"Asthma diagnosed after 11 September 2001 among rescue and recovery workers: findings from the World Trade Center Health Registry","volume":"115","author":"Wheeler","year":"2007","journal-title":"Environ. Health Perspect."},{"issue":"9794","key":"10.1016\/j.taap.2020.115041_bb0205","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0140-6736(11)61180-X","article-title":"Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study","volume":"378","author":"Wisnivesky","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.taap.2020.115041_bb0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/02770900903483808","article-title":"Nitric oxide in both bronchoalveolar lavage fluid and serum is associated with pathogenesis and severity of antigen-induced pulmonary inflammation in rats","volume":"47","author":"Yang","year":"2010","journal-title":"J. Asthma."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20301654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20301654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:05:01Z","timestamp":1778659501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20301654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":42,"alternative-id":["S0041008X20301654"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115041","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"World Trade Center Dust induces airway inflammation while promoting aortic endothelial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115041"}}