{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:35:47Z","timestamp":1770744947901,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.taap.2020.115125","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T02:10:24Z","timestamp":1594433424000},"page":"115125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["LncRNA Mical2\/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis"],"prefix":"10.1016","volume":"403","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhecheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongcheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115125_bb0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1479-5876-8-134","article-title":"Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences","volume":"8","author":"Amit","year":"2010","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2020.115125_bb0015","first-page":"1073","article-title":"Non-coding RNAs as therapeutic targets in hepatocellular cancer","volume":"12","author":"Braconi","year":"2012","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.taap.2020.115125_bb0020","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1089\/ars.2009.2737","article-title":"Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease","volume":"12","author":"Cannito","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2020.115125_bb0025","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/onc.2016.278","article-title":"The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma","volume":"36","author":"Cao","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2020.115125_bb0030","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.1187197","article-title":"Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA","volume":"328","author":"Cazalla","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.taap.2020.115125_bb0035","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.7150\/thno.20942","article-title":"Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression","volume":"7","author":"Chen","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2020.115125_bb0040","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1158\/1078-0432.CCR-17-2376","article-title":"Long noncoding RNA LINC01234 functions as a competing endogenous RNA to regulate CBFB expression by sponging miR-204-5p in gastric cancer","volume":"24","author":"Chen","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2020.115125_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1147535","article-title":"Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430","volume":"318","author":"Choi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.taap.2020.115125_bb0050","first-page":"2179","article-title":"Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride-mediated oxidative hepatocellular damage in rat model","volume":"11","author":"Choudhury","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.taap.2020.115125_bb0055","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.gastro.2008.04.038","article-title":"Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage","volume":"135","author":"Dooley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2020.115125_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2020.115125_bb0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cellsig.2013.11.003","article-title":"MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX","volume":"26","author":"Hamada","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2020.115125_bb0070","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1128\/MCB.00341-14","article-title":"p66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition","volume":"34","author":"Hudson","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2020.115125_bb0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/hep.23765","article-title":"Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes","volume":"52","author":"Kaimori","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115125_bb0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.omtn.2017.06.022","article-title":"Anti-fibrotic effects of synthetic oligodeoxynucleotide for TGF-beta1 and Smad in an animal model of liver cirrhosis","volume":"8","author":"Kim","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.taap.2020.115125_bb0085","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1038\/ncomms8305","article-title":"A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture","volume":"6","author":"Krol","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115125_bb0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.cmet.2015.02.004","article-title":"A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice","volume":"21","author":"Li","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2020.115125_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.74","article-title":"Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells","volume":"6","author":"Li","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2020.115125_bb0100","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/hep.22397","article-title":"Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways","volume":"48","author":"Nitta","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115125_bb0105","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jhep.2011.02.001","article-title":"Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?","volume":"55","author":"Pinzani","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2020.115125_bb0110","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nature09144","article-title":"A coding-independent function of gene and pseudogene mRNAs regulates tumour biology","volume":"465","author":"Poliseno","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.taap.2020.115125_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.07.032","article-title":"Redox processes inform multivariate transdifferentiation trajectories associated with TGF\u03b2-induced epithelial-mesenchymal transition","volume":"76","author":"Prasanphanich","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2020.115125_bb0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.taap.2020.115125_bb0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115125_bb0130","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell."},{"key":"10.1016\/j.taap.2020.115125_bb0135","series-title":"Complexities of Post-transcriptional Regulation and the Modeling of ceRNA Crosstalk","first-page":"231","volume":"53","author":"Smillie","year":"2018"},{"key":"10.1016\/j.taap.2020.115125_bb0140","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice","volume":"51","author":"Taura","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115125_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5010009","article-title":"Controversies over the epithelial-to-mesenchymal transition in liver fibrosis","volume":"5","author":"Taura","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.taap.2020.115125_bb0150","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2011.09.029","article-title":"Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs","volume":"147","author":"Tay","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.taap.2020.115125_bb0155","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jhep.2012.05.013","article-title":"p53\/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice","volume":"57","author":"Tomita","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2020.115125_bb0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/B978-0-12-405881-1.00006-9","article-title":"p66Shc, mitochondria, and the generation of reactive oxygen species","volume":"528","author":"Trinei","year":"2013","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2020.115125_bb0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/ATVBAHA.113.302104","article-title":"MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus","volume":"34","author":"Wang","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2020.115125_bb0170","first-page":"528","article-title":"Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy","volume":"8","author":"Wu","year":"2018","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.taap.2020.115125_bb0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/acel.12176","article-title":"let-7-repressesed Shc translation delays replicative senescence","volume":"13","author":"Xu","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.taap.2020.115125_bb0180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.freeradbiomed.2012.03.015","article-title":"Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells","volume":"53","author":"Yuan","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2020.115125_bb0185","doi-asserted-by":"crossref","first-page":"23337","DOI":"10.1074\/jbc.M700194200","article-title":"Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition","volume":"282","author":"Zeisberg","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115125_bb0190","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.freeradbiomed.2016.07.014","article-title":"Angiotensin(1-7) attenuated angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome\/IL-1beta\/Smad circuit","volume":"97","author":"Zhang","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2020.115125_bb0195","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41467-017-00204-4","article-title":"The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFbeta and Notch pathways","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115125_bb0200","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41419-020-2429-9","article-title":"Imbalance in mitochondrial dynamics induced by low PGC-1\u03b1 expression contributes to hepatocyte EMT and liver fibrosis","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2020.115125_bb0205","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.7150\/thno.29620","article-title":"p66Shc contributes to liver fibrosis through the regulation of mitochondrial reactive oxygen species","volume":"9","author":"Zhao","year":"2019","journal-title":"Theranostics"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20302519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20302519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:50:44Z","timestamp":1758574244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20302519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":40,"alternative-id":["S0041008X20302519"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115125","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA Mical2\/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115125"}}