{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:36:31Z","timestamp":1785908191689,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES009649"],"award-info":[{"award-number":["ES009649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES029280"],"award-info":[{"award-number":["ES029280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK092069"],"award-info":[{"award-number":["DK092069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.taap.2020.115136","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T12:19:17Z","timestamp":1594815557000},"page":"115136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice"],"prefix":"10.1016","volume":"403","author":[{"given":"Iv\u00e1n L.","family":"Csanaky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lickteig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115136_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0005-2736(00)00355-2","article-title":"Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump","volume":"1511","author":"Akita","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2020.115136_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchromb.2008.08.018","article-title":"Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS\/MS","volume":"873","author":"Alnouti","year":"2008","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.taap.2020.115136_bb0015","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.1016\/S0021-9258(18)68482-0","article-title":"Identification of the hepatocyte Na+\u2212dependent bile acid transport protein using monoclonal antibodies","volume":"263","author":"Ananthanarayanan","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115136_bb0020","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1073\/pnas.89.17.8185","article-title":"Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor","volume":"89","author":"Burbach","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2020.115136_bb0025","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0014-5793(00)01596-9","article-title":"Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver","volume":"474","author":"Cattori","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2020.115136_bb0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.taap.2018.02.005","article-title":"Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice","volume":"343","author":"Csanaky","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0035","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/hep.23984","article-title":"Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: studies in Oatp1b2-null mice","volume":"53","author":"Csanaky","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115136_bb0040","doi-asserted-by":"crossref","first-page":"33920","DOI":"10.1074\/jbc.M306370200","article-title":"Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice","volume":"278","author":"Dawson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115136_bb0045","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1074\/jbc.M412752200","article-title":"The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter","volume":"280","author":"Dawson","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115136_bb0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.1996.0210","article-title":"Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity","volume":"140","author":"Fernandez-Salguero","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0055","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2020.115136_bb0060","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.taap.2013.06.024","article-title":"Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice","volume":"272","author":"Harrill","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0065","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1124\/mol.105.020107","article-title":"Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development","volume":"69","author":"Harstad","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0070","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1001\/archinte.159.22.2647","article-title":"The continuing importance of bile acids in liver and intestinal disease","volume":"159","author":"Hofmann","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.taap.2020.115136_bb0075","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-2952(82)90213-1","article-title":"Uptake of bile acids by isolated rat hepatocytes","volume":"31","author":"Iga","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2020.115136_bb0085","first-page":"18","article-title":"The interaction between hepatic arterial and portal venous blood flows; simultaneous measurement by transit time ultrasonic volume flowmetry","volume":"42","author":"Jakab","year":"1995","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.taap.2020.115136_bb0090","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0065-2571(98)00015-6","article-title":"Export pumps for anionic conjugates encoded by MRP genes","volume":"39","author":"Keppler","year":"1999","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.taap.2020.115136_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0301-2115(98)00323-6","article-title":"Hemodynamics of the ductus venosus","volume":"84","author":"Kiserud","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.taap.2020.115136_bb0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1515\/JPM.2000.011","article-title":"Fetal venous circulation--an update on hemodynamics","volume":"28","author":"Kiserud","year":"2000","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.taap.2020.115136_bb0105","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep.25740","article-title":"Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115136_bb0110","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1073\/pnas.190256997","article-title":"Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice","volume":"97","author":"Lahvis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2020.115136_bb0115","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/mol.104.008888","article-title":"The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse","volume":"67","author":"Lahvis","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2020.115136_bb0120","first-page":"1662","article-title":"Relationship between hepatic blood flow and overall metabolism: the hepatic arterial buffer response","volume":"42","author":"Lautt","year":"1983","journal-title":"Fed. Proc."},{"key":"10.1016\/j.taap.2020.115136_bb0125","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/0016-5085(90)90029-Z","article-title":"Quantitation of the hepatic arterial buffer response to graded changes in portal blood flow","volume":"98","author":"Lautt","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.taap.2020.115136_bb0130","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/toxsci\/kfw054","article-title":"Activation of constitutive androstane receptor (CAR) in mice results in maintained biliary excretion of bile acids despite a marked decrease of bile acids in liver","volume":"151","author":"Lickteig","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115136_bb0135","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.1997.1490345.x","article-title":"Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor","volume":"2","author":"Mimura","year":"1997","journal-title":"Genes Cells"},{"key":"10.1016\/j.taap.2020.115136_bb0140","doi-asserted-by":"crossref","first-page":"F175","DOI":"10.1136\/adc.2005.079822","article-title":"Significant correlations between the flow volume of patent ductus venosus and early neonatal liver function: possible involvement of patent ductus venosus in postnatal liver function","volume":"91","author":"Murayama","year":"2006","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.taap.2020.115136_bb0145","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3846","article-title":"Aryl hydrocarbon receptor ligands in cancer: friend and foe","volume":"14","author":"Murray","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.taap.2020.115136_bb0150","first-page":"1","article-title":"Hepatic blood flow: morphologic aspects and physiologic regulation","volume":"21","author":"Rappaport","year":"1980","journal-title":"Int Rev Physiol"},{"key":"10.1016\/j.taap.2020.115136_bb0155","first-page":"734","article-title":"Uptake of bile acids by perfused rat liver","volume":"231","author":"Reichen","year":"1976","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.taap.2020.115136_bb0160","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1124\/dmd.115.064766","article-title":"Calorie restriction increases P-glycoprotein and decreases intestinal absorption of digoxin in mice","volume":"44","author":"Renaud","year":"2016","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2020.115136_bb0165","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1073\/pnas.93.13.6731","article-title":"Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development","volume":"93","author":"Schmidt","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2020.115136_bb0170","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32213-6","article-title":"Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding","volume":"42","author":"Schwarz","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2020.115136_bb0175","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.27694","article-title":"Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice","volume":"62","author":"Slijepcevic","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2020.115136_bb0180","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00424-006-0152-8","article-title":"The bile salt export pump","volume":"453","author":"Stieger","year":"2007","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.taap.2020.115136_bb0185","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1073\/pnas.98.4.2011","article-title":"Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis","volume":"98","author":"Wang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2020.115136_bb0190","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1194\/jlr.M007641","article-title":"Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice","volume":"51","author":"Zhang","year":"2010","journal-title":"J. Lipid Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20302623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20302623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:53:28Z","timestamp":1758574408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20302623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":38,"alternative-id":["S0041008X20302623"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115136","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115136"}}