{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:21:33Z","timestamp":1792653693734,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.taap.2020.115255","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T18:39:32Z","timestamp":1601404772000},"page":"115255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial\u2013mesenchymal transition in silicotic mice"],"prefix":"10.1016","volume":"408","author":[{"given":"Shumin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0005","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/1556-4029.14048","article-title":"Silicosis: diagnosis and medicolegal implications","volume":"64","author":"Bukovitz","year":"2019","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.taap.2020.115255_bb0010","doi-asserted-by":"crossref","first-page":"283123","DOI":"10.1155\/2015\/283123","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline alleviates renal fibrosis induced by unilateral ureteric obstruction in BALB\/C mice","volume":"2015","author":"Chan","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0015","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SHK.0b013e3182a6953e","article-title":"Dysregulated renin-angiotensin system contributes to acute lung injury caused by hind-limb ischemia-reperfusion in mice","volume":"40","author":"Chen","year":"2013","journal-title":"Shock."},{"key":"10.1016\/j.taap.2020.115255_bb0025","doi-asserted-by":"crossref","unstructured":"Conte, E., Fagone, E., Gili, E., Fruciano, M., Iemmolo, M., Pistorio, M.P., Impellizzeri, D., Cordaro, M., Cuzzocrea, S., Vancheri, C., 2016. Preventive and therapeutic effects of thymosin \u03b24 N-terminal fragment ac-SDKP in the bleomycin model of pulmonary fibrosis. Oncotarget. 7(23):33841-33854. Doi: 10.18632\/oncotarget.8409.","DOI":"10.18632\/oncotarget.8409"},{"key":"10.1016\/j.taap.2020.115255_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2016.01.010","article-title":"Protective effect of ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-\u03b21\/ROCK1 pathway in silicosis in rat","volume":"294","author":"Deng","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.taap.2020.115255_bb0035","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.7150\/thno.29682","article-title":"Dioscin alleviates crystalline silica-induced pulmonary inflammation and fibrosis through promoting alveolar macrophage autophagy","volume":"9","author":"Du","year":"2019","journal-title":"Theranostics."},{"issue":"10","key":"10.1016\/j.taap.2020.115255_bb0040","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1113\/EP087515","article-title":"Interaction of N-acetyl-seryl-aspartyl-lysyl-proline with the angiotensin-converting enzyme 2-angiotensin-(1-7)-mas axis attenuates pulmonary fibrosis in silicotic rats","volume":"104","author":"Gao","year":"2019","journal-title":"Exp. Physiol."},{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0045","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/HYPERTENSIONAHA.110.167171","article-title":"Angiotensin II binding to angiotensin I-converting enzyme triggers calcium signaling","volume":"57","author":"Guimaraes","year":"2011","journal-title":"Hypertension."},{"issue":"1","key":"10.1016\/j.taap.2020.115255_bb0050","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/HYPERTENSIONAHA.109.141622","article-title":"Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus","volume":"55","author":"Gwathmey","year":"2010","journal-title":"Hypertension."},{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0055","first-page":"R518","article-title":"Novel roles of nuclear angiotensin receptors and signaling mechanisms","volume":"302","author":"Gwathmey","year":"2012","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"11","key":"10.1016\/j.taap.2020.115255_bb0060","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3390\/ijerph15112565","article-title":"Focusing on coal Workers\u2019 lung diseases: a comparative analysis of China, Australia, and the United States","volume":"15","author":"Han","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"11","key":"10.1016\/j.taap.2020.115255_bb0065","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1002\/ptr.6169","article-title":"Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction","volume":"32","author":"Hosseinian","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2020.115255_bb0070","first-page":"1","article-title":"Chronic oestrogen deficiency induced by ovariectomy may cause lung fibrosis through activation of the renin-angiotensin system in rats","volume":"12","author":"Hussien","year":"2019","journal-title":"Arch. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.taap.2020.115255_bb0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/HYPERTENSIONAHA.112.191452","article-title":"Possible involvement of angiotensin-converting enzyme 2 and mas activation in inhibitory effects of angiotensin II type 1 receptor blockade on vascular remodeling","volume":"60","author":"Iwai","year":"2012","journal-title":"Hypertension."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/SHK.0000000000000633","article-title":"Pulmonary angiotensin-converting enzyme 2 (ACE2) and inflammatory lung disease","volume":"46","author":"Jia","year":"2016","journal-title":"Shock."},{"issue":"10174","key":"10.1016\/j.taap.2020.115255_bb0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(19)30478-7","article-title":"Australia reports on audit of silicosis for stonecutters","volume":"393","author":"Kirby","year":"2019","journal-title":"Lancet."},{"key":"10.1016\/j.taap.2020.115255_bb0090","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.2147\/DDDT.S252351","article-title":"ACE2 attenuates epithelial-mesenchymal transition in MLE-12 cells induced by silica","volume":"14","author":"Li","year":"2020","journal-title":"Drug Des Devel Ther."},{"issue":"1","key":"10.1016\/j.taap.2020.115255_bb0100","doi-asserted-by":"crossref","first-page":"L178","DOI":"10.1152\/ajplung.00009.2008","article-title":"Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. American journal of physiology","volume":"295","author":"Li","year":"2008","journal-title":"Lung cellular and molecular physiology."},{"key":"10.1016\/j.taap.2020.115255_bb0105","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/srep00717","article-title":"Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides","volume":"2","author":"Masuyer","year":"2012","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/ars.2013.5818","article-title":"The angiotensin-converting enzyme 2\/angiotensin (1-7)\/mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA\/rho kinase pathway","volume":"22","author":"Meng","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0115","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1165\/rcmb.2017-0284OC","article-title":"Angiotensin-(1-7) attenuated cigarette smoking-related pulmonary fibrosis via improving the impaired autophagy caused by nicotinamide adenine dinucleotide phosphate reduced oxidase 4-dependent reactive oxygen species","volume":"59","author":"Pan","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115255_bb0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejphar.2015.11.009","article-title":"Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists","volume":"769","author":"Pernomian","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2020.115255_bb0125","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/HYPERTENSIONAHA.113.01337","article-title":"Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology","volume":"62","author":"Qi","year":"2013","journal-title":"Hypertension."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0130","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/JLB.MA1218-490RR","article-title":"Effect of preventive or therapeutic treatment with angiotensin 1-7 in a model of bleomycin-induced lung fibrosis in mice","volume":"106","author":"Rago","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0135","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/JLB.MA1218-490RR","article-title":"Effect of preventive or therapeutic treatment with angiotensin 1-7 in a model of bleomycin-induced lung fibrosis in mice","volume":"106","author":"Rago","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.taap.2020.115255_bb0140","doi-asserted-by":"crossref","first-page":"F195","DOI":"10.1152\/ajprenal.00270.2018","article-title":"Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney. American journal of physiology","volume":"316","author":"Romero","year":"2019","journal-title":"Renal physiology."},{"issue":"1","key":"10.1016\/j.taap.2020.115255_bb0145","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1038\/s41598-017-03474-6","article-title":"Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system","volume":"7","author":"Shi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115255_bb0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bcp.2016.05.010","article-title":"Diminazene aceturate, an angiotensin-converting enzyme II activator, prevents gastric mucosal damage in mice: role of the angiotensin-(1-7)\/mas receptor axis","volume":"112","author":"Souza","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0155","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126703","article-title":"Angiotensin-converting enzyme inhibitors may affect pulmonary function in lymphangioleiomyomatosis","volume":"4","author":"Steagall","year":"2019","journal-title":"JCI insight."},{"key":"10.1016\/j.taap.2020.115255_bb0160","doi-asserted-by":"crossref","unstructured":"Tetikkurt, C., Yanardag, H., Pehlivan, M., Bilir, M., 2017. Clinical features and prognostic significance of splenic involvement in sarcoidosis. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 87(3), 893. doi:https:\/\/doi.org\/10.4081\/monaldi.2017.893.","DOI":"10.4081\/monaldi.2017.893"},{"issue":"4","key":"10.1016\/j.taap.2020.115255_bb0165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S2213-2600(19)30078-5","article-title":"The world is failing on silicosis","volume":"7","author":"The Lancet Respiratory, M","year":"2019","journal-title":"Lancet Respir. Med."},{"issue":"3","key":"10.1016\/j.taap.2020.115255_bb0170","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.biocel.2011.11.019","article-title":"Angiotensin signalling in pulmonary fibrosis","volume":"44","author":"Uhal","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.taap.2020.115255_bb0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.rmed.2014.11.009","article-title":"ACE and sIL-2R correlate with lung function improvement in sarcoidosis during methotrexate therapy","volume":"109","author":"Vorselaars","year":"2015","journal-title":"Respir. Med."},{"key":"10.1016\/j.taap.2020.115255_bb0180","doi-asserted-by":"crossref","first-page":"15561","DOI":"10.1038\/srep15561","article-title":"Chronic activation of the renin-angiotensin system induces lung fibrosis","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.taap.2020.115255_bb0185","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1159\/000430131","article-title":"Angiotensin-converting enzyme 2 attenuates bleomycin-induced lung fibrosis in mice","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.taap.2020.115255_bb0190","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/jcb.21248","article-title":"Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung","volume":"101","author":"Wiener","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"7","key":"10.1016\/j.taap.2020.115255_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040301","article-title":"A new antifibrotic target of ac-SDKP: inhibition of myofibroblast differentiation in rat lung with silicosis","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.taap.2020.115255_bb0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/01.HYP.0000107777.91185.89","article-title":"Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction","volume":"43","author":"Yang","year":"2004","journal-title":"Hypertension."},{"key":"10.1016\/j.taap.2020.115255_bb0205","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxlet.2019.05.023","article-title":"Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway","volume":"313","author":"Zhang","year":"2019","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.taap.2020.115255_bb0210","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11596-019-2073-8","article-title":"Dynamic variation of RAS on Silicotic fibrosis pathogenesis in rats","volume":"39","author":"Zhang","year":"2019","journal-title":"Curr Med Sci."},{"key":"10.1016\/j.taap.2020.115255_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2018.04.025","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline (ac-SDKP) attenuates silicotic fibrosis by suppressing apoptosis of alveolar type II epithelial cells via mediation of endoplasmic reticulum stress","volume":"350","author":"Zhang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.taap.2020.115255_bb0225","first-page":"7467","article-title":"Influence of the interaction between AcSDKP and Ang II on the pathogenesis and development of silicotic fibrosis","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.taap.2020.115255_bb0230","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-94-007-4549-0_27","article-title":"Angiogenic activity of sera from interstitial lung disease patients in relation to angiotensin-converting enzyme activity","volume":"756","author":"Zielonka","year":"2013","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20303811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20303811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:51:23Z","timestamp":1758574283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20303811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":43,"alternative-id":["S0041008X20303811"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115255","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial\u2013mesenchymal transition in silicotic mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115255"}}