{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:13:34Z","timestamp":1793682814808,"version":"4.5.1"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54AR055073"],"award-info":[{"award-number":["U54AR055073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES004738"],"award-info":[{"award-number":["R01ES004738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES005022"],"award-info":[{"award-number":["P30ES005022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.taap.2020.115272","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T01:34:03Z","timestamp":1601861643000},"page":"115272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms"],"prefix":"10.1016","volume":"409","author":[{"given":"Rama","family":"Malaviya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard M.","family":"Kipen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Businaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115272_bb0005","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.20041393","article-title":"Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis","volume":"201","author":"Abdollahi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/thx.2009.113456","article-title":"NOX4\/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF\u03b21-induced fibroblast differentiation into myofibroblasts","volume":"65","author":"Amara","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.taap.2020.115272_bb0015","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijrobp.2008.02.046","article-title":"Small molecular inhibitor of transforming growth factor-\u03b2 protects against development of radiation-induced lung injury","volume":"71","author":"Anscher","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1164\/rccm.201103-0561OC","article-title":"Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury","volume":"185","author":"Aono","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1165\/rcmb.2003-0374OC","article-title":"Interferon-\u03b2 inhibits bleomycin-induced lung fibrosis by decreasing transforming growth factor-\u03b2 and thrombospondin","volume":"32","author":"Azuma","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0030","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.nano.2017.10.003","article-title":"Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice","volume":"14","author":"Bai","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.taap.2020.115272_bb0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200609-1279OC","article-title":"Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis","volume":"176","author":"Baran","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1465-9921-6-112","article-title":"The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis","volume":"6","author":"Barbarin","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0045","first-page":"L841","article-title":"Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles","volume":"288","author":"Barbarin","year":"2005","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0050","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2222.2004.01885.x","volume":"34","author":"Batra","year":"2004","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.taap.2020.115272_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/09553002.2018.1532619","article-title":"Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation","volume":"96","author":"Beach","year":"2020","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0060","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.4049\/jimmunol.173.7.4692","article-title":"The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis","volume":"173","author":"Belperio","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.taap.2018.04.033","article-title":"Evaluation of the dose-response and fate in the lung and pleura of chrysotile-containing brake dust compared to chrysotile or crocidolite asbestos in a 28-day quantitative inhalation toxicology study","volume":"351","author":"Bernstein","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0070","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1189\/jlb.0313140","article-title":"CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model","volume":"94","author":"Besnard","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0075","first-page":"109","article-title":"Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis","author":"Bickelhaupt","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.taap.2020.115272_bb0080","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.ajpath.2016.03.020","article-title":"CD4+CD25hiFoxp3+ cells exacerbate bleomycin-induced pulmonary fibrosis","volume":"186","author":"Birjandi","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0085","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.4049\/jimmunol.173.3.2099","article-title":"Smad3 null mice develop airspace enlargement and are resistant to TGF-\u03b2-mediated pulmonary fibrosis","volume":"173","author":"Bonniaud","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0090","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-016-0559-z","article-title":"The IL-1 cytokine family and its role in inflammation and fibrosis in the lung","volume":"38","author":"Borthwick","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.taap.2020.115272_bb0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.imbio.2012.05.020","article-title":"Differential role of regulatory T cells in early and late stages of pulmonary fibrosis","volume":"218","author":"Boveda-Ruiz","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.taap.2020.115272_bb0100","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115272_bb0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12989-014-0067-z","article-title":"Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats","volume":"11","author":"van den Brule","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0110","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1038\/s41598-018-28968-9","article-title":"Inhibition of Wnt\/\u03b2-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis","volume":"8","author":"Cao","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0115","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/ars.2010.3829","article-title":"A key role for NOX4 in epithelial cell death during development of lung fibrosis","volume":"15","author":"Carnesecchi","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2020.115272_bb0120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pupt.2018.07.002","article-title":"Use of animal models in IPF research","volume":"51","author":"Carrington","year":"2018","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.taap.2020.115272_bb0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1023\/A:1015967017103","article-title":"Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions","volume":"234-235","author":"Castranova","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.taap.2020.115272_bb0130","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1164\/rccm.200505-717OC","article-title":"Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model","volume":"173","author":"Chaudhary","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2013.11.012","article-title":"Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL\/6 mice","volume":"275","author":"Chen","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0140","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.bbadis.2012.11.021","article-title":"Oxidative stress and pulmonary fibrosis","volume":"1832","author":"Cheresh","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2020.115272_bb0145","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/path.4359","article-title":"Neutrophil extracellular traps promote differentiation and function of fibroblasts","volume":"233","author":"Chrysanthopoulou","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2353\/ajpath.2007.060352","article-title":"Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis","volume":"170","author":"Chua","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0155","doi-asserted-by":"crossref","first-page":"39714","DOI":"10.1038\/srep39714","article-title":"IL-13 is a therapeutic target in radiation lung injury","volume":"6","author":"Chung","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0160","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1055\/s-0028-1101275","article-title":"Lung disease caused by exposure to coal mine and silica dust","volume":"29","author":"Cohen","year":"2008","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0165","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1165\/rcmb.2015-0020TR","article-title":"Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis","volume":"53","author":"Craig","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1465-9921-6-81","article-title":"CD8+ T lymphocytes in lung tissue from patients with idiopathic pulmonary fibrosis","volume":"6","author":"Daniil","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0175","first-page":"L442","article-title":"Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis","volume":"299","author":"Degryse","year":"2010","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fmed.2018.00043","article-title":"The role of immune and inflammatory cells in idiopathic pulmonary fibrosis","volume":"5","author":"Desai","year":"2018","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.taap.2020.115272_bb0190","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12989-017-0198-0","article-title":"Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-\u03b21 activation and myofibroblast differentiation","volume":"14","author":"Dong","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0195","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00204-014-1428-y","article-title":"Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes","volume":"89","author":"Dong","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0200","first-page":"CD006322","article-title":"Pulmonary rehabilitation for interstitial lung disease","author":"Dowman","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.taap.2020.115272_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1498","article-title":"Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective","volume":"10","author":"Duke","year":"2018","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.taap.2020.115272_bb0210","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1091581818779038","article-title":"Similar and differential canonical pathways and biological processes associated with multiwalled carbon nanotube and asbestos-induced pulmonary fibrosis: a 1-Year postexposure study","volume":"37","author":"Dymacek","year":"2018","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tox.2010.11.012","article-title":"Inhalation of alkylating mustard causes long-term T cell-dependent inflammation in airways and growth of connective tissue","volume":"280","author":"Ekstrand-Hammarstrom","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2020.115272_bb0220","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2004.12.001","article-title":"Attenuation of bleomycin-induced lung fibrosis in rats by mesna","volume":"509","author":"El-Medany","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb2000","doi-asserted-by":"crossref","first-page":"L805","DOI":"10.1152\/ajplung.00009.2009","article-title":"N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition","volume":"297","author":"Felton","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.taap.2020.115272_bb0225","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1183\/13993003.01826-2015","article-title":"Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis","volume":"48","author":"Fernandez","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.taap.2020.115272_bb0230","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.4049\/jimmunol.1203551","article-title":"IL-13 immunotoxin accelerates resolution of lung pathological changes triggered by silica particles in mice","volume":"191","author":"Ferreira","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0235","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ijrobp.2009.12.043","article-title":"Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis","volume":"77","author":"Flechsig","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0240","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cyto.2013.12.003","article-title":"Peripheral depletion of NK cells and imbalance of the Treg\/Th17 axis in idiopathic pulmonary fibrosis patients","volume":"66","author":"Galati","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2020.115272_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1165\/rcmb.2012-0198OC","article-title":"Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment","volume":"48","author":"Garibaldi","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0250","first-page":"3786","article-title":"IL-1R1\/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice","volume":"117","author":"Gasse","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2020.115272_bb0255","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1513\/pats.200605-125SF","article-title":"Smad3 signaling involved in pulmonary fibrosis and emphysema","volume":"3","author":"Gauldie","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.taap.2020.115272_bb0260","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pupt.2017.03.010","article-title":"FTY720 promotes pulmonary fibrosis when administered during the remodelling phase following a bleomycin-induced lung injury","volume":"44","author":"Gendron","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.taap.2020.115272_bb0265","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0171-2985(00)80084-4","article-title":"Biologic functions and signaling of the interleukin-4 receptor complexes","volume":"201","author":"Gessner","year":"2000","journal-title":"Immunobiology"},{"key":"10.1016\/j.taap.2020.115272_bb0270","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cyto.2003.08.003","article-title":"CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis","volume":"24","author":"Gharaee-Kermani","year":"2003","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2020.115272_bb0275","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fonc.2019.00877","article-title":"Radiation-induced lung injury (RILI)","volume":"9","author":"Giuranno","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2020.115272_bb0280","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cbi.2013.06.013","article-title":"Historical perspective on effects and treatment of sulfur mustard injuries","volume":"206","author":"Graham","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2020.115272_bb0285","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1189\/jlb.3HI1014-493R","article-title":"Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis","volume":"98","author":"Gregory","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0290","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jat.2878","article-title":"Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in rats","volume":"34","author":"Gustafsson","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0295","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.4049\/jimmunol.178.3.1800","article-title":"Airway epithelial NF-\u03baB activation modulates asbestos-induced inflammation and mucin production in vivo","volume":"178","author":"Haegens","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0300","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/bmj.4.5841.635","article-title":"Early clinical experience with bleomycin in the United Kingdom in series of 105 patients","volume":"4","author":"Halnan","year":"1972","journal-title":"Br. Med. J."},{"key":"10.1016\/j.taap.2020.115272_bb0305","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chest.2019.03.033","article-title":"Radiation-induced lung injury: assessment and management","volume":"156","author":"Hanania","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.taap.2020.115272_bb0310","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.jaci.2013.01.015","article-title":"Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis","volume":"131","author":"Hasan","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0315","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2001.114702","article-title":"IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway","volume":"107","author":"Hashimoto","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0320","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2005","article-title":"NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury","volume":"15","author":"Hecker","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0325","doi-asserted-by":"crossref","first-page":"231ra247","DOI":"10.1126\/scitranslmed.3008182","article-title":"Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance","volume":"6","author":"Hecker","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0330","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.exphem.2010.03.004","article-title":"Fibrocytes in health and disease","volume":"38","author":"Herzog","year":"2010","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.taap.2020.115272_bb0335","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12931-018-0798-8","article-title":"Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis","volume":"19","author":"Heukels","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0340","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1165\/rcmb.2008-0182OC","article-title":"Role of proinflammatory cytokines IL-18 and IL-1\u03b2 in bleomycin-induced lung injury in humans and mice","volume":"41","author":"Hoshino","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0345","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/jcp.26112","article-title":"TNF-\u03b1-induced NF-\u03baB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis","volume":"233","author":"Hou","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2020.115272_bb0350","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1465-9921-15-16","article-title":"Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis","volume":"15","author":"Inomata","year":"2014","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0355","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1183\/09031936.04.00110203","article-title":"CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis","volume":"24","author":"Inoue","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.taap.2020.115272_bb0360","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1096\/fj.201601077R","article-title":"SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis","volume":"31","author":"Jablonski","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2020.115272_bb0365","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jcyt.2015.02.011","article-title":"Intravenous delivery of adipose-derived mesenchymal stromal cells attenuates acute radiation-induced lung injury in rats","volume":"17","author":"Jiang","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.taap.2020.115272_bb0370","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3760\/cma.j.issn.0366-6999.20132749","article-title":"Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung tissue","volume":"127","author":"Jin","year":"2014","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.taap.2020.115272_bb0375","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00109-018-1715-9","article-title":"Identification of molecular signatures involved in radiation-induced lung fibrosis","volume":"97","author":"Jin","year":"2019","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.taap.2020.115272_bb0380","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/dvdy.24541","article-title":"Epithelial-mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease","volume":"247","author":"Jolly","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.taap.2020.115272_bb0385","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.trsl.2009.01.004","article-title":"Asbestos-induced lung diseases: an update","volume":"153","author":"Kamp","year":"2009","journal-title":"Transl. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0390","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/08958378.2015.1066905","article-title":"A mechanistic review of silica-induced inhalation toxicity","volume":"27","author":"Kawasaki","year":"2015","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0395","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1378\/chest.07-1948","article-title":"Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis","volume":"133","author":"Kinder","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.taap.2020.115272_bb0400","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2020.115272_bb0405","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1165\/rcmb.2016-0121TR","article-title":"Immune mechanisms in pulmonary fibrosis","volume":"55","author":"Kolahian","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0410","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","article-title":"Transient expression of IL-1\u03b2 induces acute lung injury and chronic repair leading to pulmonary fibrosis","volume":"107","author":"Kolb","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2020.115272_bb0415","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1038\/s41598-017-15022-3","article-title":"Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia","volume":"7","author":"Kotani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0420","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1164\/rccm.200812-1936OC","article-title":"Global impairment of CD4+CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis","volume":"179","author":"Kotsianidis","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: Between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.taap.2020.115272_bb0430","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01902140600817465","article-title":"Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation","volume":"32","author":"Lakatos","year":"2006","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.taap.2020.115272_bb0435","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/toxsci\/kfy309","article-title":"Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants","volume":"168","author":"Laskin","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0440","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/path.4956","article-title":"CCR2+ monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-\u03b21","volume":"243","author":"Lebrun","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0445","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra1705751","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"Lederer","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0450","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00063198-200107000-00001","article-title":"The many faces of transforming growth factor-\u03b2 in pleural diseases","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0455","article-title":"Clarithromycin attenuates radiation-induced lung injury in mice","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115272_bb0460","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125937","article-title":"FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis","volume":"5","author":"Leslie","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.taap.2020.115272_bb0465","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-6-79","article-title":"Small molecule receptor tyrosine kinase inhibitor of platelet-derived growth factor signaling (SU9518) modifies radiation response in fibroblasts and endothelial cells","volume":"6","author":"Li","year":"2006","journal-title":"BMC Cancer"},{"issue":"1422\u20131432","key":"10.1016\/j.taap.2020.115272_bb0470","article-title":"IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice","volume":"134","author":"Li","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0475","first-page":"649","article-title":"Crystalline silica promotes rat fibrocyte differentiation in vitro, and fibrocytes participate in silicosis in vivo","volume":"30","author":"Li","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0480","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/labinvest.2014.145","article-title":"A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis","volume":"95","author":"Liang","year":"2015","journal-title":"Lab. Investig."},{"key":"10.1016\/j.taap.2020.115272_bb0485","doi-asserted-by":"crossref","first-page":"15847","DOI":"10.1038\/s41598-017-14602-7","article-title":"Krupple-like-factor 4 attenuates lung fibrosis via inhibiting epithelial-mesenchymal transition","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0490","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12929-018-0421-9","article-title":"MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts","volume":"25","author":"Lin","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0495","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1755-1536-5-S1-S24","article-title":"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis","volume":"5","author":"Lipson","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.taap.2020.115272_bb0500","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1615\/JEnvironPatholToxicolOncol.v20.i2.30","article-title":"Increased TGF-\u03b21 in the lungs of asbestos-exposed rats and mice: reduced expression in TNF-\u03b1 receptor knockout mice","volume":"20","author":"Liu","year":"2001","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.taap.2020.115272_bb0505","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.4049\/jimmunol.173.5.3425","article-title":"Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4\/IL-13 and mediation via STAT-6","volume":"173","author":"Liu","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0510","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev-pathol-020712-163942","article-title":"Molecular basis of asbestos-induced lung disease","volume":"8","author":"Liu","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0515","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21037\/sci.2019.06.09","article-title":"Cell-based therapy for idiopathic pulmonary fibrosis","volume":"6","author":"Lu","year":"2019","journal-title":"Stem Cell Investig."},{"key":"10.1016\/j.taap.2020.115272_bb0520","first-page":"L710","article-title":"Modulation of pulmonary fibrosis by IL-13R\u03b12","volume":"308","author":"Lumsden","year":"2015","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0525","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1189\/jlb.0707504","article-title":"Roles of T lymphocytes in pulmonary fibrosis","volume":"83","author":"Luzina","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0530","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1165\/rcmb.2013-0093OC","article-title":"Interleukin-33 potentiates bleomycin-induced lung injury","volume":"49","author":"Luzina","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0535","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cyto.2014.11.008","article-title":"The cytokines of pulmonary fibrosis: Much learned, much more to learn","volume":"74","author":"Luzina","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2020.115272_bb0540","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.taap.2012.05.005","article-title":"Induction of pulmonary fibrosis by cerium oxide nanoparticles","volume":"262","author":"Ma","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0545","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2017.03.015","article-title":"Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticles-induced lung fibrosis","volume":"323","author":"Ma","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0550","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2010.07.018","article-title":"Inflammatory effects of inhaled sulfur mustard in rat lung","volume":"248","author":"Malaviya","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0555","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.taap.2012.08.027","article-title":"Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor","volume":"265","author":"Malaviya","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0560","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/toxsci\/kfv161","article-title":"Attenuation of nitrogen mustard-induced pulmonary injury and fibrosis by anti-tumor necrosis factor-\u03b1 antibody","volume":"148","author":"Malaviya","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb2525","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfaa150","article-title":"Progressive lung injury, inflammation and fibrosis in rats following inhalation of sulfur mustard","author":"Malaviya","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0565","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pharmthera.2017.06.008","article-title":"Anti-TNF\u03b1 therapy in inflammatory lung diseases","volume":"180","author":"Malaviya","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2020.115272_bb0570","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.toxlet.2019.10.026","article-title":"Long-term respiratory effects of mustard vesicants","volume":"319","author":"Malaviya","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2020.115272_bb0580","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1165\/rcmb.2017-0168OC","article-title":"Bronchiolitis obliterans and pulmonary fibrosis after sulfur mustard inhalation in rats","volume":"58","author":"McGraw","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0585","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.matbio.2018.03.001","article-title":"The impaired proteases and anti-proteases balance in idiopathic pulmonary fibrosis","volume":"68-69","author":"Menou","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0590","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02120-2017","article-title":"CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages","volume":"51","author":"Meziani","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.taap.2020.115272_bb0595","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.4049\/jimmunol.1004081","article-title":"Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-\u03b21-dependent and -independent mechanisms","volume":"187","author":"Mi","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0600","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.intimp.2012.03.010","article-title":"Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: possible role of Th17 cells in chronic lung pathology","volume":"13","author":"Mishra","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0605","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1164\/rccm.200810-1534OC","article-title":"Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis","volume":"179","author":"Moeller","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115272_bb0610","first-page":"L152","article-title":"Murine models of pulmonary fibrosis","volume":"294","author":"Moore","year":"2008","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0615","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/ar200311b","article-title":"Inhalation toxicity assessment of carbon-based nanoparticles","volume":"46","author":"Morimoto","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0620","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/s41598-018-19521-9","article-title":"Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors","volume":"8","author":"Mukherjee","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0625","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1096\/fj.15-271304","article-title":"Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure","volume":"29","author":"Murthy","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2020.115272_bb0630","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12989-017-0218-0","article-title":"Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework","volume":"14","author":"Nikota","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073279","article-title":"Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis","volume":"8","author":"Nkyimbeng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115272_bb0640","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/thoraxjnl-2017-210517","article-title":"CCL2 and T cells in pulmonary fibrosis: an old player gets a new role","volume":"72","author":"Osafo-Addo","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.taap.2020.115272_bb0645","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S1679-45082015RB3438","article-title":"Chemokines and immunity","volume":"13","author":"Palomino","year":"2015","journal-title":"Einstein (Sao Paulo)"},{"key":"10.1016\/j.taap.2020.115272_bb3000","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3346\/jkms.2009.24.4.614","article-title":"Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function","volume":"24","author":"Park","year":"2009","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0650","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000097133","article-title":"Inflammatory cell phenotyping of the pulmonary interstitium in idiopathic interstitial pneumonia","volume":"74","author":"Parra","year":"2007","journal-title":"Respiration"},{"key":"10.1016\/j.taap.2020.115272_bb0655","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fphar.2014.00080","article-title":"CD4+CD25+FoxP3+ regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-\u03b21 exposed murine lung","volume":"5","author":"Peng","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0660","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2020.115272_bb0665","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cyto.2008.07.469","article-title":"Regulatory T cells in health and disease","volume":"43","author":"Piccirillo","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2020.115272_bb0670","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fimmu.2016.00311","article-title":"Neutrophil extracellular traps in pulmonary diseases: too much of a good thing?","volume":"7","author":"Porto","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0675","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2147\/IJN.S123839","article-title":"Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappaB pathway","volume":"12","author":"Qin","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.taap.2020.115272_bb0680","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11926-006-0055-x","article-title":"The role of circulating fibrocytes in fibrosis","volume":"8","author":"Quan","year":"2006","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0685","article-title":"Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice","volume":"9","author":"Re","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115272_bb0690","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S2213-2600(19)30262-0","article-title":"Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial","volume":"8","author":"Richeldi","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0695","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160107","article-title":"Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis","volume":"36","author":"Robert","year":"2016","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0700","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.ijrobp.2004.12.072","article-title":"The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation","volume":"61","author":"R\u00fcbe","year":"2005","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb3535","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfp253","article-title":"Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure","volume":"114","author":"Shakarjian","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115272_bb0705","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000207617","article-title":"Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis","volume":"78","author":"Shinoda","year":"2009","journal-title":"Respiration"},{"key":"10.1016\/j.taap.2020.115272_bb0710","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1357-2725(02)00315-1","article-title":"Cell signaling and transcription factor activation by asbestos in lung injury and disease","volume":"35","author":"Shukla","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0715","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2353\/ajpath.2007.060381","article-title":"Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-\u03b4 knockout mice","volume":"170","author":"Shukla","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0720","first-page":"L552","article-title":"Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL\/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis","volume":"295","author":"Shvedova","year":"2008","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115272_bb0725","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/15287394.2016.1159635","article-title":"Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: a 1-year postexposure study","volume":"79","author":"Snyder-Talkington","year":"2016","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.taap.2020.115272_bb0730","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1172\/JCI30562","article-title":"The role of CXC chemokines in pulmonary fibrosis","volume":"117","author":"Strieter","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2020.115272_bb0735","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1165\/rcmb.2017-0287OC","article-title":"IL-9 blockade suppresses silica-induced lung inflammation and fibrosis in mice","volume":"60","author":"Sugimoto","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0740","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3892\/mco.2016.993","article-title":"Analysis of blood neutrophil elastase, glutathione levels and pathological findings in postoperative acute exacerbation of idiopathic pulmonary fibrosis associated with lung cancer: two case reports","volume":"5","author":"Sugino","year":"2016","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.taap.2020.115272_bb0745","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1582-4934.2008.00647.x","article-title":"TNF-\u03b1 induces TGF-\u03b21 expression in lung fibroblasts at the transcriptional level via AP-1 activation","volume":"13","author":"Sullivan","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2020.115272_bb1515","doi-asserted-by":"crossref","first-page":"114798","DOI":"10.1016\/j.taap.2019.114798","article-title":"Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard","volume":"387","author":"Sunil","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0750","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1183\/09031936.00127011","article-title":"A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice","volume":"40","author":"Takemasa","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.taap.2020.115272_bb0755","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1038\/s41598-017-03676-y","article-title":"Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice","volume":"7","author":"Tanaka","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0760","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1165\/rcmb.2016-0248PS","article-title":"In the shadow of fibrosis: innate immune suppression mediated by transforming growth factor-\u03b2","volume":"55","author":"Thomas","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0765","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1755-1536-3-18","article-title":"T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7\u2212\/\u2212 mice","volume":"3","author":"Trujillo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.taap.2020.115272_bb0770","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1165\/rcmb.2015-0120OC","article-title":"Characterization of distinct macrophage subpopulations during nitrogen mustard-induced lung injury and fibrosis","volume":"54","author":"Venosa","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0775","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/08958378.2014.880202","article-title":"IL-33 modulates chronic airway resistance changes induced by multi-walled carbon nanotubes","volume":"26","author":"Wang","year":"2014","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0780","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1667\/RR14708.1","article-title":"Metformin attenuates radiation-induced pulmonary fibrosis in a murine model","volume":"188","author":"Wang","year":"2017","journal-title":"Radiat. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0785","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2016.05.014","article-title":"Mustard vesicant-induced lung injury: advances in therapy","volume":"305","author":"Weinberger","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115272_bb0795","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/08958370802596298","article-title":"Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury","volume":"21","author":"Wigenstam","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2020.115272_bb0800","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/01902148.2014.979516","article-title":"The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis","volume":"41","author":"Williamson","year":"2015","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.taap.2020.115272_bb0805","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20092121","article-title":"Bleomycin and IL-1\u03b2-mediated pulmonary fibrosis is IL-17A dependent","volume":"207","author":"Wilson","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0810","doi-asserted-by":"crossref","first-page":"19755","DOI":"10.1038\/srep19755","article-title":"Non-invasive imaging of idiopathic pulmonary fibrosis using cathepsin protease probes","volume":"6","author":"Withana","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115272_bb0815","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1124\/jpet.113.208223","article-title":"Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis","volume":"349","author":"Wollin","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2020.115272_bb0820","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1183\/09031936.00174914","article-title":"Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis","volume":"45","author":"Wollin","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.taap.2020.115272_bb0825","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the TH1\/TH2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0830","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.taap.2020.115272_bb0835","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2020.115272_bb0840","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2020.115272_bb0845","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/09553000701558977","article-title":"Matrix-Metallo-Proteinases and their tissue inhibitors in radiation-induced lung injury","volume":"83","author":"Yang","year":"2007","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.taap.2020.115272_bb0850","doi-asserted-by":"crossref","first-page":"108851","DOI":"10.1016\/j.biopha.2019.108851","article-title":"Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice","volume":"114","author":"Yang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115272_bb0855","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1465-9921-10-80","article-title":"Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis","volume":"10","author":"Yogo","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0860","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1158\/1078-0432.CCR-07-1894","article-title":"Inhibition of the tumor necrosis factor-\u03b1 pathway is radioprotective for the lung","volume":"14","author":"Zhang","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2020.115272_bb0865","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/cei.12319","article-title":"Enhanced formation and impaired degradation of neutrophil extracellular traps in dermatomyositis and polymyositis: a potential contributor to interstitial lung disease complications","volume":"177","author":"Zhang","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.taap.2020.115272_bb0870","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12931-018-0864-2","article-title":"Macrophages: friend or foe in idiopathic pulmonary fibrosis?","volume":"19","author":"Zhang","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115272_bb0875","article-title":"Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages","volume":"13","author":"Zhao","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115272_bb0880","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3892\/br.2016.832","article-title":"Effect of bosentan is correlated with MMP-9\/TIMP-1 ratio in bleomycin-induced pulmonary fibrosis","volume":"6","author":"Zuo","year":"2017","journal-title":"Biomed. Rep."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20303987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20303987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:52:36Z","timestamp":1758574356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20303987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":179,"alternative-id":["S0041008X20303987"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115272","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115272"}}