{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:26:36Z","timestamp":1777649196604,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007831","name":"University of Tabriz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.taap.2020.115331","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T10:57:10Z","timestamp":1604746630000},"page":"115331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family"],"prefix":"10.1016","volume":"409","author":[{"given":"Farhad","family":"Eslami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmaeil","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashdar Mahmud","family":"Hussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Mostafavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Shahbazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazha Jamal","family":"Hidayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115331_bb0005","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejmech.2013.08.040","article-title":"Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase i and II inhibitory activity","volume":"69","author":"Abdel-Aziz","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2017.03.005","article-title":"Enhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: fabrication, in-vitro characterization, and comparative ex-vivo permeation studies","author":"Al-mahallawi","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.taap.2020.115331_bb0015","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1016\/j.bmc.2010.06.098","article-title":"Synthesis and biological evaluation of tetracyclic fluoroquinolones as antibacterial and anticancer agents","volume":"18","author":"Al-Trawneh","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0020","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1182\/blood-2016-01-688796","article-title":"The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism","volume":"127","author":"Anderson","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.taap.2020.115331_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2017.04.025","article-title":"Apoptosis induction activity and molecular docking studies of survivin siRNA carried by Fe3O4-PEG-LAC-chitosan-PEI nanoparticles in MCF-7 human breast cancer cells","volume":"142","author":"Arami","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.taap.2020.115331_bb0030","first-page":"891","article-title":"Ciprofloxacin mediated cell growth inhibition, S\/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line","volume":"6","author":"Aranha","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2020.115331_bb0035","series-title":"HHS Public Access 98","first-page":"529","author":"Azab","year":"2018"},{"key":"10.1016\/j.taap.2020.115331_bb0040","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1016\/j.bmc.2009.06.053","article-title":"7-((4-substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents","volume":"17","author":"Az\u00e9ma","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pharep.2017.07.007","article-title":"Ciprofloxacin-mediated induction of S-phase cell cycle arrest and apoptosis in COLO829 melanoma cells","volume":"70","author":"Beberok","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2020.115331_bb0050","first-page":"1727","article-title":"Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53\/Bax\/Bcl-2 signaling pathway","volume":"52","author":"Beberok","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2020.115331_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104884","article-title":"The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: in silico and in vitro study","volume":"66","author":"Beberok","year":"2020","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2020.115331_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2875-13-339","article-title":"Recent progress in the development of anti-malarial quinolones","author":"Beteck","year":"2014","journal-title":"Malar. J."},{"key":"10.1016\/j.taap.2020.115331_bb0065","author":"Biosciences BD Biosciences-US"},{"key":"10.1016\/j.taap.2020.115331_bb0070","doi-asserted-by":"crossref","DOI":"10.2174\/0929867323666151223095839","article-title":"A \u201cdouble-edged\u201d scaffold: antitumor power within the antibacterial quinolone","author":"Bisacchi","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0075","first-page":"343","article-title":"Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1\/2, JNK, and NF-\u03baB activation in a cystic fibrosis epithelial cell line","volume":"292","author":"Blau","year":"2007","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2020.115331_bb0080","series-title":"Association of p53 Gene Alterations with the Expression of Antiapoptotic Survivin Splice Variants in Breast Cancer 290\u2013297","author":"Boidot","year":"2007"},{"key":"10.1016\/j.taap.2020.115331_bb0085","doi-asserted-by":"crossref","DOI":"10.1158\/1541-7786.MCR-08-0358","article-title":"Mcl-1 is required for melanoma cell resistance to anoikis","author":"Boisvert-Adamo","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.taap.2020.115331_bb0090","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood.V97.9.2784","article-title":"Cytokine-regulated expression of survivin in myeloid leukemia","volume":"97","author":"Carter","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.taap.2020.115331_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4155\/fmc.12.181","article-title":"Medicinal potential of ciprofloxacin and its derivatives","volume":"5","author":"Castro","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0100","author":"cDNA synthesis kits - Takara Bio"},{"key":"10.1016\/j.taap.2020.115331_bb0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.etap.2017.08.014","article-title":"Long non-coding RNAs: the novel diagnostic biomarkers for leukemia","volume":"55","author":"Chen","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2020.115331_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111810","article-title":"Anticancer and antimicrobial effects of novel ciprofloxacin fatty acids conjugates","author":"Chrzanowska","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0115","doi-asserted-by":"crossref","DOI":"10.1007\/s10096-014-2296-3","article-title":"Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?","author":"Dalhoff","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.taap.2020.115331_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-016-0326-1","article-title":"Survivin: a unique target for tumor therapy","author":"Garg","year":"2016","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.taap.2020.115331_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-016-0326-1","article-title":"Survivin: a unique target for tumor therapy","volume":"16","author":"Garg","year":"2016","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.taap.2020.115331_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/153765291009877","article-title":"Ciprofloxacin-induced cytotoxicity and apoptosis in HeLa cells","volume":"15","author":"G\u00fcrbay","year":"2005","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.taap.2020.115331_bb0135","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/sj.bjc.6600079","article-title":"Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells","volume":"86","author":"Herold","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2020.115331_bb0140","article-title":"4-quinolone hybrids and their antibacterial activities","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0145","doi-asserted-by":"crossref","DOI":"10.4161\/cbt.4.3.1568","article-title":"Analysis of the Bcl-2 and p53 protein expression in the lymphoproliferative lesions in the upper Egypt","author":"Hussein","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.taap.2020.115331_bb0150","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/AAC.47.3.1161-1164.2003","article-title":"In vitro effects of ciprofloxacin and roxithromycin on apoptosis of Jurkat T lymphocytes","volume":"47","author":"Jun","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.taap.2020.115331_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2016.08.031","article-title":"Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1,2,3-triazole conjugates as potent antibacterial agents","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ejmech.2018.03.026","article-title":"Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity","volume":"150","author":"Kassab","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0165","first-page":"345","article-title":"The influence of ciprofloxacin on hamster ovarian cancer cell line CHO AA8","volume":"67","author":"Kloskowski","year":"2010","journal-title":"Acta Pol. Pharm. Drug Res."},{"issue":"6","key":"10.1016\/j.taap.2020.115331_bb0170","first-page":"859","article-title":"The influence of ciprofloxacin on viability of A549, HepG2, A375.S2, B16 and C6 cell lines in vitro","volume":"68","author":"Kloskowski","year":"2011","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"10.1016\/j.taap.2020.115331_bb0175","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3892\/ijo.2012.1653","article-title":"Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC","volume":"41","author":"Kloskowski","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2020.115331_bb0180","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3892\/ijo.2012.1653","article-title":"Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC","volume":"41","author":"Kloskowski","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2020.115331_bb0185","series-title":"Is ciprofloxacin an Anti-cancer drug? A Minireview Tomas Koltai","author":"Koltai","year":"2016"},{"key":"10.1016\/j.taap.2020.115331_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymeth.2007.12.001","article-title":"Apoptosis and necrosis: detection, discrimination and phagocytosis","author":"Krysko","year":"2008","journal-title":"Methods."},{"key":"10.1016\/j.taap.2020.115331_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103187","article-title":"Ciprofloxacin enhances TRAIL-induced apoptosis in lung cancer cells by upregulating the expression and protein stability of death receptors through CHOP expression","volume":"19","author":"Lim","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2020.115331_bb0200","article-title":"Design, synthesis, biological evaluation, structure-activity relationship, and toxicity of clinafloxacin-azole conjugates as novel antitubercular agents","author":"Liu","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0205","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02977692","article-title":"Gnidilatimonoein from Daphne mucronata induces differentiation and apoptosis in leukemia cell lines","volume":"30","author":"Mahdavi","year":"2007","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2020.115331_bb0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cbi.2016.10.004","article-title":"Evaluation of the cytotoxic, apoptosis inducing activity and molecular docking of spiroquinazolinone benzamide derivatives in MCF-7 breast cancer cells","volume":"260","author":"Mahdavi","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2020.115331_bb0215","article-title":"Safety of fluoroquinolones: an update","author":"Mandell","year":"2002","journal-title":"Can. J. Infect. Dis."},{"key":"10.1016\/j.taap.2020.115331_bb0220","doi-asserted-by":"crossref","DOI":"10.15171\/apb.2016.024","article-title":"Silencing of high mobility group isoform I-C (HMGI-C) enhances paclitaxel chemosensitivity in breast adenocarcinoma cells (MDAMB-468)","author":"Mansoori","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.taap.2020.115331_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/sj.onc.1205353","article-title":"Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway","author":"Mirza","year":"2002","journal-title":"Oncogene."},{"key":"10.1016\/j.taap.2020.115331_bb0230","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1016\/j.bmc.2016.07.070","article-title":"New antiproliferative 7-(4-(N-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2\/M phase","volume":"24","author":"Mohammed","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ejmech.2004.11.008","article-title":"Benzenesulfonamide analogs of fluoroquinolones. Antibacterial activity and QSAR studies","volume":"40","author":"Nieto","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2434","article-title":"Cytochrome c: functions beyond respiration","author":"Ow","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2020.115331_bb0245","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1046\/j.0022-202x.2001.01409.x","article-title":"The Bax\/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95\/Fas-mediated apoptosis","volume":"117","author":"Raisova","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.taap.2020.115331_bb0250","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","author":"Ruijter","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.taap.2020.115331_bb0255","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ctrv.2009.05.003","article-title":"Survivin: a new target for anti-cancer therapy","volume":"35","author":"Ryan","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.taap.2020.115331_bb0260","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/jm049061o","article-title":"Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line","volume":"48","author":"S\u00e1nchez-Mart\u00edn","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0265","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1074\/jbc.275.10.7337","article-title":"P53 induces apoptosis by caspase activation through mitochondrial cytochrome C release","volume":"275","author":"Schuler","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115331_bb0270","series-title":"Novel N -4-Piperazinyl Cipro fl oxacin-Ester Hybrids: Synthesis, Biological Evaluation, and Molecular Docking Studies 90","first-page":"1558","author":"Shahbazi","year":"2020"},{"key":"10.1016\/j.taap.2020.115331_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2007.08.025","article-title":"Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway","author":"Sheng","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115331_bb0280","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2010.04.068","article-title":"Potent antitumor activities of recombinant human PDCD5 protein in combination with chemotherapy drugs in K562 cells","volume":"396","author":"Shi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2020.115331_bb0285","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/aps.2011.158","article-title":"Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells","volume":"33","author":"Shi","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.taap.2020.115331_bb0290","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jinorgbio.2007.11.013","article-title":"Impact of the carbon chain length of novel platinum complexes derived from N-alkyl-propanediamines on their cytotoxic activity and cellular uptake","volume":"102","author":"Silva","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.taap.2020.115331_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0051251","article-title":"Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic Leukemia cells","volume":"7","author":"Suppipat","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115331_bb0300","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1016\/j.bmcl.2013.09.077","article-title":"Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines","volume":"23","author":"Suresh","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"23","key":"10.1016\/j.taap.2020.115331_bb0305","first-page":"5315","article-title":"IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs","volume":"58","author":"Tamm","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.taap.2020.115331_bb0310","doi-asserted-by":"crossref","DOI":"10.1038\/sj.cdd.4402269","article-title":"Molecular characteristics of immunogenic cancer cell death","author":"Tesniere","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2020.115331_bb0315","doi-asserted-by":"crossref","DOI":"10.1177\/095632029800900504","article-title":"Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12","author":"Witvrouw","year":"1998","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.taap.2020.115331_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2018.12.119","article-title":"Repositioning of fluoroquinolones from antibiotic to anti-cancer agents: an underestimated truth","author":"Yadav","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115331_bb0325","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-015-1560-y","article-title":"Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation","volume":"15","author":"Yadav","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.taap.2020.115331_bb0330","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1055\/s-2005-873165","article-title":"3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells","volume":"71","author":"Yazdanparast","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.taap.2020.115331_bb0335","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.biopha.2018.04.089","article-title":"In vitro anti-leukemia activity of dual PI3K\/mTOR inhibitor Voxtalisib on HL60 and K562 cells, as well as their multidrug resistance counterparts HL60\/ADR and K562\/A02 cells","volume":"103","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115331_bb0340","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.biopha.2018.06.153","article-title":"A novel synthesized 3\u2032 5\u2032-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways","volume":"106","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115331_bb0345","article-title":"OncoTargets and therapy Dovepress mechanisms of drug resistance in acute myeloid leukemia","volume":"12\u20131937","author":"Zhang","year":"2019","journal-title":"Onco. Targets. Ther."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20304531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20304531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:55:56Z","timestamp":1758574556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20304531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":69,"alternative-id":["S0041008X20304531"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115331","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115331"}}