{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:10:29Z","timestamp":1778505029354,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.taap.2020.115378","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T10:59:47Z","timestamp":1609585187000},"page":"115378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis"],"prefix":"10.1016","volume":"412","author":[{"given":"Wenhan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinghao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lechu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenya","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115378_bb0005","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A simplified, Langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2020.115378_bb0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12013-011-9300-7","article-title":"Cardioprotective efficacy of a novel antioxidant mix VitaePro against ex vivo myocardial ischemia-reperfusion injury","volume":"67","author":"Adluri","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.taap.2020.115378_bb0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/152308603321223630","article-title":"Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice","volume":"5","author":"Aoi","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2020.115378_bb0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pcad.2009.11.004","article-title":"Alcoholic and cocaine-associated cardiomyopathies","volume":"52","author":"Awtry","year":"2010","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.taap.2020.115378_bb0025","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"Bertola","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2020.115378_bb0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12192-013-0443-x","article-title":"Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-\u03baB-mediated inflammation in high fructose and high fat diet-fed mice","volume":"19","author":"Bhuvaneswari","year":"2014","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.taap.2020.115378_bb0035","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.yjmcc.2008.03.018","article-title":"Alcoholic cardiomyopathy: acetaldehyde, insulin insensitization and ER stress","volume":"44","author":"Cai","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4037\/ajcc2014800","article-title":"Holiday heart syndrome","volume":"23","author":"Carey","year":"2014","journal-title":"Am. J. Crit. Care"},{"key":"10.1016\/j.taap.2020.115378_bb0045","doi-asserted-by":"crossref","first-page":"2593742","DOI":"10.1155\/2019\/2593742","article-title":"Acetaldehyde induces neurotoxicity in vitro via oxidative stress- and Ca(2+) imbalance-mediated endoplasmic reticulum stress","volume":"2019","author":"Cui","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2020.115378_bb0050","doi-asserted-by":"crossref","first-page":"7639109","DOI":"10.1155\/2020\/7639109","article-title":"Astaxanthin protects ochratoxin A-induced oxidative stress and apoptosis in the heart via the Nrf2 pathway","volume":"2020","author":"Cui","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2020.115378_bb0055","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/acer.12239","article-title":"Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation","volume":"38","author":"El Hajj","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2020.115378_bb0060","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3389\/fphys.2017.01041","article-title":"Astaxanthin attenuates homocysteine-induced cardiotoxicity in vitro and in vivo by inhibiting mitochondrial dysfunction and oxidative damage","volume":"8","author":"Fan","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2020.115378_bb0065","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2015.91","article-title":"Cardiovascular risks and benefits of moderate and heavy alcohol consumption","volume":"12","author":"Fern\u00e1ndez-Sol\u00e0","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0070","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.humpath.2006.03.022","article-title":"Evidence of apoptosis in alcoholic cardiomyopathy","volume":"37","author":"Fern\u00e1ndez-Sol\u00e0","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.taap.2020.115378_bb0075","first-page":"7722","article-title":"Astaxanthin protecting myocardial cells from hypoxia\/reoxygenation injury by regulating miR-138\/HIF-1\u03b1 axis","volume":"24","author":"Gai","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.taap.2020.115378_bb0080","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.cardfail.2011.05.008","article-title":"Alcoholic cardiomyopathy: A review","volume":"17","author":"George","year":"2011","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.taap.2020.115378_bb0085","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/eurheartj\/ehu514","article-title":"Alcohol consumption and risk of heart failure: The atherosclerosis risk in communities study","volume":"36","author":"Gon\u00e7alves","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.taap.2020.115378_bb0090","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4161\/auto.18997","article-title":"Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts","volume":"8","author":"Guo","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2020.115378_bb0095","doi-asserted-by":"crossref","first-page":"14090","DOI":"10.1038\/s41598-018-32497-w","article-title":"Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115378_bb0100","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2020.115378_bb0105","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00508-017-1235-6","article-title":"Moderate alcohol consumption and atherosclerosis: Meta-analysis of effects on lipids and inflammation","volume":"129","author":"Huang","year":"2017","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.taap.2020.115378_bb0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.taap.2014.02.018","article-title":"Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding","volume":"277","author":"Kaphalia","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2020.115378_bb0115","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2020.115378_bb0120","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3390\/nu12061896","article-title":"Effects of 3-month astaxanthin supplementation on cardiac function in heart failure patients with left ventricular systolic dysfunction-a pilot study","volume":"12","author":"Kato","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2020.115378_bb0125","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.bbrc.2015.12.036","article-title":"Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic \u03b2-cell through JNK signaling","volume":"469","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2020.115378_bb0130","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.yjmcc.2008.02.276","article-title":"Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: Role of insulin signaling and ER stress","volume":"44","author":"Li","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yjmcc.2009.03.017","article-title":"Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress","volume":"47","author":"Li","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0140","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.3390\/md13063368","article-title":"Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS\/MAPK pathway in mice","volume":"13","author":"Li","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.taap.2020.115378_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2017.04.008","article-title":"Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress","volume":"806","author":"Lin","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2020.115378_bb0150","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.jacc.2005.02.075","article-title":"Alcohol and the cardiovascular system: Research challenges and opportunities","volume":"45","author":"Lucas","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0155","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2020.115378_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.014","article-title":"Alcoholic cardiomyopathy: What is known and what is not known","volume":"43","author":"Mirijello","year":"2017","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.taap.2020.115378_bb0165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.phrs.2010.09.003","article-title":"Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats","volume":"63","author":"Monroy-Ruiz","year":"2011","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2020.115378_bb0170","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1006\/jmcc.2002.2019","article-title":"Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor","volume":"34","author":"M\u00fcller","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0175","first-page":"557","article-title":"Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: Role of endothelin-1","volume":"64","author":"Padilla","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2020.115378_bb0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.amjcard.2008.02.010","article-title":"Astaxanthin: A novel potential treatment for oxidative stress and inflammation in cardiovascular disease","volume":"101","author":"Pashkow","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0185","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12012-014-9252-4","article-title":"Alcoholic cardiomyopathy: Pathophysiologic insights","volume":"14","author":"Piano","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.taap.2020.115378_bb0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11906-019-0984-1","article-title":"Alcohol and hypertension-new insights and lingering controversies","volume":"21","author":"Puddey","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.taap.2020.115378_bb0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.alcohol.2017.01.011","article-title":"Quantifying the contribution of alcohol to cardiomyopathy: A systematic review","volume":"61","author":"Rehm","year":"2017","journal-title":"Alcohol"},{"key":"10.1016\/j.taap.2020.115378_bb0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/ars.2013.5262","article-title":"Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: Potential role in hypertension","volume":"20","author":"Santos","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2020.115378_bb0205","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.alcohol.2009.09.028","article-title":"Alcoholism and alcohol abstinence: N-acetylcysteine to improve energy expenditure, myocardial oxidative stress, and energy metabolism in alcoholic heart disease","volume":"43","author":"Seiva","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.taap.2020.115378_bb0210","doi-asserted-by":"crossref","first-page":"954502","DOI":"10.1155\/2014\/954502","article-title":"Protective effect of astaxanthin on liver fibrosis through modulation of TGF-\u03b21 expression and autophagy","volume":"2014","author":"Shen","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.taap.2020.115378_bb0215","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/acer.13405","article-title":"Alcoholic cardiomyopathy: Disrupted protein balance and impaired cardiomyocyte contractility","volume":"41","author":"Steiner","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.taap.2020.115378_bb0220","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biocel.2017.06.009","article-title":"Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis","volume":"89","author":"Steiner","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.taap.2020.115378_bb0225","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.18632\/aging.102474","article-title":"Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis","volume":"11","author":"Sun","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.taap.2020.115378_bb0230","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jacc.2011.12.034","article-title":"Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C\/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner","volume":"59","author":"Tan","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.taap.2020.115378_bb0235","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/mus.20168","article-title":"Effects of alcohol on skeletal and cardiac muscle","volume":"30","author":"Urbano-M\u00e1rquez","year":"2004","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.taap.2020.115378_bb0240","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM198902163200701","article-title":"The effects of alcoholism on skeletal and cardiac muscle","volume":"320","author":"Urbano-Marquez","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2020.115378_bb0245","article-title":"Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1","volume":"173749","author":"Victor","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2020.115378_bb0250","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.bbamcr.2014.01.012","article-title":"Endoplasmic reticulum stress associated responses in cancer","volume":"1843","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2020.115378_bib296","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1038\/ncomms13997","article-title":"Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115378_bb0255","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.bbrc.2014.12.012","article-title":"High-dose alcohol induces reactive oxygen species-mediated apoptosis via PKC-\u03b2\/p66Shc in mouse primary cardiomyocytes","volume":"456","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2020.115378_bb0260","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00210-018-1595-0","article-title":"Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2\/HO-1 pathway in rats","volume":"392","author":"Xue","year":"2019","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.taap.2020.115378_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/md14030056","article-title":"Astaxanthin inhibits acetaldehyde-induced cytotoxicity in SH-SY5Y cells by modulating Akt\/CREB and p38MAPK\/ERK signaling pathways","volume":"14","author":"Yan","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.taap.2020.115378_bb0270","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/toxsci\/kfx140","article-title":"Alcohol inhibition of the enzymatic activity of glyceraldehyde 3-phosphate dehydrogenase impairs cardiac glucose utilization, contributing to alcoholic cardiomyopathy","volume":"159","author":"Yan","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115378_bb0275","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3390\/biom5042538","article-title":"Endoplasmic reticulum stress and ethanol neurotoxicity","volume":"5","author":"Yang","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.taap.2020.115378_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092563","article-title":"Effects of antioxidants in reducing accumulation of fat in hepatocyte","volume":"19","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2020.115378_bb0285","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41467-017-00171-w","article-title":"A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure","volume":"8","author":"Yao","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115378_bb0290","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fcell.2019.00202","article-title":"NF\u03baB\/Orai1 facilitates endoplasmic reticulum stress by oxidative stress in the pathogenesis of non-alcoholic fatty liver disease","volume":"7","author":"Zhang","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.taap.2020.115378_bb0295","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2018.02.009","article-title":"CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis","volume":"117","author":"Zhou","year":"2018","journal-title":"Free Radic. Biol. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20305007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20305007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:53:20Z","timestamp":1758574400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20305007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":60,"alternative-id":["S0041008X20305007"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115378","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115378"}}