{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:07:45Z","timestamp":1782522465774,"version":"3.54.5"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.taap.2020.115380","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T18:18:29Z","timestamp":1608833909000},"page":"115380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment"],"prefix":"10.1016","volume":"411","author":[{"given":"Solomon E.","family":"Owumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah O.","family":"Nwozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uche O.","family":"Arunsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adegboyega K.","family":"Oyelere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyeronke A.","family":"Odunola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2020.115380_bb0005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.pharep.2019.03.009","article-title":"Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin","volume":"71","author":"Abu-Elsaad","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0010","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1177\/1535370220947387","article-title":"Calliandra portoricensis ameliorates ovarian and uterine oxido-inflammatory responses in N-methyl-N-nitrosourea and benzo[a]pyrene-treated rats","volume":"245","author":"Adefisan","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.taap.2020.115380_bb0015","series-title":"Catalase Estimation","author":"Aebi","year":"1974"},{"key":"10.1016\/j.taap.2020.115380_bb0020","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12944-019-1051-2","article-title":"Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats","volume":"18","author":"Afsar","year":"2019","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.taap.2020.115380_bb0025","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.2147\/DDDT.S222127","article-title":"Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats","volume":"13","author":"Ahmed","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.taap.2020.115380_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22502","article-title":"Protocatechuic acid ameliorates testosterone-induced benign prostatic hyperplasia through the regulation of inflammation and oxidative stress in castrated rats","volume":"34","author":"Akanni","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.taap.2020.115380_bb0035","first-page":"11350","article-title":"Varenicline enhances the survival of doxorubicin-treated mice","volume":"24","author":"Alhowail","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.taap.2020.115380_bb0040","first-page":"31","article-title":"Biochemical studies on the protective effect of honey against doxorubicin-induced toxicity in BALB\/C mice","volume":"14","author":"Alhumaydhi","year":"2020","journal-title":"Int J Health Sci"},{"key":"10.1016\/j.taap.2020.115380_bb0045","article-title":"Antagonistic efficacy of luteolin against Lead acetate exposure-associated with hepatotoxicity is mediated via antioxidant, anti-inflammatory, and anti-apoptotic activities","volume":"9","author":"Al-Megrin","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.taap.2020.115380_bb0050","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.biopha.2018.09.171","article-title":"Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats","volume":"108","author":"Altinkaynak","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115380_bb0055","first-page":"e22623","article-title":"Rutin ameliorates copper sulfate-induced brain damage via antioxidative and anti-inflammatory activities in rats","author":"Arowoogun","year":"2020","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.taap.2020.115380_bb0060","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2008.11.059","article-title":"Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs","volume":"378","author":"Ashley","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2020.115380_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188050","article-title":"Expression of toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model","volume":"12","author":"Bakopoulos","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115380_bb0070","series-title":"Theory and Practise of Histological Techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.taap.2020.115380_bb0075","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1177\/0960327120913094","article-title":"Neuroprotective role of luteolin against lead acetate-induced cortical damage in rats","volume":"39","author":"Baty","year":"2020","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.taap.2020.115380_bb0080","series-title":"Methods of Enzymatic Analysis","author":"Bergmeyer","year":"1974"},{"key":"10.1016\/j.taap.2020.115380_bb0085","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/febs.14606","article-title":"Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases","volume":"286","author":"Bissinger","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.taap.2020.115380_bb0090","doi-asserted-by":"crossref","first-page":"5730395","DOI":"10.1155\/2018\/5730395","article-title":"Reactive oxygen species in chronic obstructive pulmonary disease","volume":"2018","author":"Boukhenouna","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2020.115380_bb0095","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.taap.2020.115380_bb0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13063-019-3963-6","volume":"21","author":"Carrasco","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.taap.2020.115380_bb0105","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: the good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.taap.2020.115380_bb0110","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3892\/or.2015.4431","article-title":"Luteolin suppresses development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats","volume":"35","author":"Cook","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0115","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fphys.2018.00332","article-title":"On the effects of reactive oxygen species and nitric oxide on red blood cell deformability","volume":"9","author":"Diederich","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2020.115380_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.29074\/ascls.30.3.173","article-title":"A methodical approach to interpreting the red blood cell parameters of the complete blood count","volume":"30","author":"Doig","year":"2017","journal-title":"American Society for Clinical Laboratory Science"},{"key":"10.1016\/j.taap.2020.115380_bb0125","first-page":"2","article-title":"Oxidative stress and platelet dysfunction","volume":"2","author":"Eitan","year":"2018","journal-title":"Thrombosis & Haemostasis: Research"},{"key":"10.1016\/j.taap.2020.115380_bb0130","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2020.115380_bb0135","doi-asserted-by":"crossref","first-page":"s11","DOI":"10.1161\/ATVBAHA.107.159178","article-title":"Oxidative stress and platelets","volume":"28","author":"Freedman","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.taap.2020.115380_bb0140","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5152\/eajm.2010.09","article-title":"Acute inhalation injury","volume":"42","author":"Gorguner","year":"2010","journal-title":"Eurasian J Med"},{"key":"10.1016\/j.taap.2020.115380_bb0145","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/01.CCM.0000049948.64660.06","article-title":"Heparin mobilizes xanthine oxidase and induces lung inflammation in acute pancreatitis","volume":"31","author":"Granell","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.taap.2020.115380_bb0150","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000494463","article-title":"The role of toll-like receptors in the production of cytokines by human lung macrophages","volume":"12","author":"Grassin-Delyle","year":"2020","journal-title":"J Innate Immun"},{"key":"10.1016\/j.taap.2020.115380_bb0155","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2020.115380_bb0160","first-page":"126","article-title":"Roles of toll-like receptors: from inflammation to lung cancer progression","volume":"8","author":"Gu","year":"2018","journal-title":"Biomed Rep"},{"key":"10.1016\/j.taap.2020.115380_bb0165","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.taap.2020.115380_bb0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/lungindia.lungindia_225_17","article-title":"Primary cavitary sarcoidosis: a case report, systematic review, and proposal of new diagnostic criteria","volume":"35","author":"Handa","year":"2018","journal-title":"Lung India"},{"key":"10.1016\/j.taap.2020.115380_bb0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1465-9921-5-11","article-title":"Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury","volume":"5","author":"Hesse","year":"2004","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2020.115380_bb0180","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1124\/dmd.32.8.794","article-title":"The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin","volume":"32","author":"Hilmer","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.taap.2020.115380_bb0185","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/0960327114527628","article-title":"Cardioprotective effects of curcumin and nebivolol against doxorubicin-induced cardiac toxicity in rats","volume":"33","author":"Imbaby","year":"2014","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.taap.2020.115380_bb0190","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S1734-1140(09)70041-6","article-title":"Acute doxorubicin pulmotoxicity in rats with malignant neoplasm is effectively treated with fullerenol C60(OH)24 through inhibition of oxidative stress","volume":"61","author":"Injac","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082370","article-title":"The efficacy of amifostine against multiple-dose doxorubicin-induced toxicity in rats","volume":"19","author":"Jacevic","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-3565(25)29664-1","article-title":"Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo","volume":"187","author":"Jollow","year":"1973","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.taap.2020.115380_bb0205","doi-asserted-by":"crossref","first-page":"F132","DOI":"10.1136\/adc.2004.068544","article-title":"Contribution of inflammation to lung injury and development","volume":"91","author":"Kallapur","year":"2006","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.taap.2020.115380_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038912","article-title":"Local oxidative and nitrosative stress increases in the microcirculation during leukocytes-endothelial cell interactions","volume":"7","author":"Kar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115380_bb0215","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-63245-2_8","article-title":"ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)","volume":"967","author":"Kellner","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.taap.2020.115380_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231403","article-title":"Low dose of luteolin activates Nrf2 in the liver of mice at start of the active phase but not that of the inactive phase","volume":"15","author":"Kitakaze","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2020.115380_bb0225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14740\/gr1142","article-title":"The flavone luteolin an endocrine disruptor relaxed male Guinea pig gallbladder strips","volume":"12","author":"Kline","year":"2019","journal-title":"Gastroenterology Res"},{"key":"10.1016\/j.taap.2020.115380_bb0230","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00418-018-1747-9","article-title":"The micromechanics of lung alveoli: structure and function of surfactant and tissue components","volume":"150","author":"Knudsen","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.taap.2020.115380_bb0235","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","article-title":"Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis","volume":"107","author":"Kolb","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2020.115380_bb0240","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.intimp.2011.05.013","article-title":"Toll like receptors in diseases of the lung","volume":"11","author":"Kovach","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2020.115380_bb0245","article-title":"Luteolin targets the toll-like receptor signaling pathway in prevention of hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice","volume":"10","author":"Kwon","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2020.115380_bb0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1476-9255-7-57","article-title":"The role of toll-like receptors in acute and chronic lung inflammation","volume":"7","author":"Lafferty","year":"2010","journal-title":"J Inflamm (Lond)"},{"key":"10.1016\/j.taap.2020.115380_bb0255","doi-asserted-by":"crossref","first-page":"R1165","DOI":"10.1152\/ajpregu.2000.279.4.R1165","article-title":"NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes","volume":"279","author":"Li","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.taap.2020.115380_bb0260","first-page":"871","article-title":"Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha","volume":"12","author":"Li","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2020.115380_bb0265","first-page":"2505","article-title":"Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway","volume":"41","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2020.115380_bb0270","doi-asserted-by":"crossref","first-page":"9125601","DOI":"10.1155\/2018\/9125601","article-title":"Neuroprotective effects of dl-3-n-butylphthalide against doxorubicin-induced neuroinflammation, oxidative stress, endoplasmic reticulum stress, and behavioral changes","volume":"2018","author":"Liao","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2020.115380_bb0275","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12967-017-1306-5","article-title":"The pathophysiological role of mitochondrial oxidative stress in lung diseases","volume":"15","author":"Liu","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2020.115380_bb0280","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115380_bb0285","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jpba.2015.11.035","article-title":"A sensitive high performance liquid chromatography assay for the quantification of doxorubicin associated with DNA in tumor and tissues","volume":"119","author":"Lucas","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.taap.2020.115380_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24244587","article-title":"Kleeb Bua Daeng, a Thai traditional herbal formula, ameliorated unpredictable chronic mild stress-induced cognitive impairment in ICR mice","volume":"24","author":"Maneenet","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.taap.2020.115380_bb0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2014.01.065","article-title":"Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis","volume":"728","author":"Mantawy","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2020.115380_bb0300","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.taap.2020.115380_bb0305","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/01612840802203098","article-title":"Activity of antioxidative enzymes in erythrocytes after a single dose administration of doxorubicin in rats pretreated with fullerenol C(60)(OH)(24)","volume":"19","author":"Milic","year":"2009","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.taap.2020.115380_bb0310","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2020.115380_bb0315","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.5114\/aoms.2018.79008","article-title":"Protective effect of nebivolol on doxorubicin-induced cardiotoxicity in rats","volume":"14","author":"Mohamed","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0320","first-page":"1","article-title":"Inflammatory mechanisms in the lung","volume":"2","author":"Moldoveanu","year":"2009","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.taap.2020.115380_bb0325","doi-asserted-by":"crossref","DOI":"10.1515\/jbcpp-2018-0191","article-title":"Protective mechanisms of protocatechuic acid against doxorubicin-induced nephrotoxicity in rat model","volume":"30","author":"Molehin","year":"2019","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2020.115380_bb0330","doi-asserted-by":"crossref","DOI":"10.1515\/ejnm-2014-0019","article-title":"Overcoming the pulmonary barrier: new insights to improve the efficiency of inhaled therapeutics","volume":"6","author":"Murgia","year":"2014","journal-title":"European Journal of Nanomedicine"},{"key":"10.1016\/j.taap.2020.115380_bb0335","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1292\/jvms.17-0497","article-title":"Blood biochemistry and hematological changes in rats after administration of a mixture of three anesthetic agents","volume":"80","author":"Ochiai","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0340","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/19390211.2017.1335822","article-title":"Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in Wistar rats through antioxidant defense system","volume":"15","author":"Omobowale TO","year":"2018","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.taap.2020.115380_bb0345","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.toxrep.2019.02.007","article-title":"Manganese suppresses oxidative stress, inflammation and caspase-3 activation in rats exposed to chlorpyrifos","volume":"6","author":"Owumi","year":"2019","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0350","doi-asserted-by":"crossref","DOI":"10.1177\/2397847319874359","article-title":"Biochemical alterations in diclofenac-treated rats: effect of selenium on oxidative stress, inflammation, and hematological changes","volume":"3","author":"Owumi","year":"2019","journal-title":"Toxicology Research and Application"},{"key":"10.1016\/j.taap.2020.115380_bb0355","doi-asserted-by":"crossref","DOI":"10.1177\/2397847319855285","article-title":"Dichloromethane and ethanol co-exposure aggravates oxidative stress indices causing hepatic and renal dysfunction in pubertal rats","volume":"3","author":"Owumi","year":"2019","journal-title":"Toxicology Research and Application"},{"key":"10.1016\/j.taap.2020.115380_bb0360","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22327","article-title":"Fluoride and diethylnitrosamine coexposure enhances oxido-inflammatory responses and caspase-3 activation in liver and kidney of adult rats","volume":"33","author":"Owumi","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.taap.2020.115380_bb0365","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1177\/0960327119871095","article-title":"Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate","volume":"38","author":"Owumi","year":"2019","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.taap.2020.115380_bb0370","doi-asserted-by":"crossref","DOI":"10.1177\/2397847320972040","article-title":"Luteolin abates reproductive toxicity mediated by the oxido-inflammatory response in doxorubicin treated rats","volume":"4","author":"Owumi","year":"2020","journal-title":"Toxicology Research and Application"},{"key":"10.1016\/j.taap.2020.115380_bb0375","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1177\/1535370220917643","article-title":"Gallic acid and omega-3 fatty acids decrease inflammatory and oxidative stress in manganese-treated rats","volume":"245","author":"Owumi","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.taap.2020.115380_bb0380","article-title":"Oxido-inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes","author":"Owumi","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.taap.2020.115380_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13316","article-title":"Gallic acid protects against aflatoxin B1 -induced oxidative and inflammatory stress damage in rats kidneys and liver","volume":"44","author":"Owumi","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.taap.2020.115380_bb0390","doi-asserted-by":"crossref","DOI":"10.1111\/and.13630","article-title":"Gallic acid and omega-3 fatty acids mitigate epididymal and testicular toxicity in manganese-treated rats","volume":"52","author":"Owumi","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.taap.2020.115380_bb0395","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/ncomms2921","article-title":"Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin","volume":"4","author":"Pang","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2020.115380_bb0400","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4162\/nrp.2019.13.6.473","article-title":"Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN\/LPS-induced hepatitic ICR mice","volume":"13","author":"Park","year":"2019","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.taap.2020.115380_bb0405","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrd2153","article-title":"Inhaling medicines: delivering drugs to the body through the lungs","volume":"6","author":"Patton","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.taap.2020.115380_bb0410","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1165\/ajrcmb.26.1.f224","article-title":"Complex regulation of iNOS in lung","volume":"26","author":"Pitt","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2020.115380_bb0415","doi-asserted-by":"crossref","first-page":"4781528","DOI":"10.1155\/2019\/4781528","article-title":"iNOS inhibition reduces lung mechanical alterations and remodeling induced by particulate matter in mice","volume":"2019","author":"Prado","year":"2019","journal-title":"Pulm Med"},{"key":"10.1016\/j.taap.2020.115380_bb0420","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2018.03.023","article-title":"Toxicity of doxorubicin (dox) to different experimental organ systems","volume":"200","author":"Pugazhendhi","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0425","doi-asserted-by":"crossref","first-page":"109547","DOI":"10.1016\/j.biopha.2019.109547","article-title":"Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling","volume":"122","author":"Qi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115380_bb0430","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.taap.2020.115380_bb0435","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/jir.2008.0076","article-title":"IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells","volume":"29","author":"Saperstein","year":"2009","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.taap.2020.115380_bb0440","series-title":"Red Cell Indices","author":"Sarma","year":"1990"},{"key":"10.1016\/j.taap.2020.115380_bb0445","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3892\/ol.2020.11662","article-title":"Inflammatory cytokines, appetite-regulating hormones, and energy metabolism in patients with gastrointestinal cancer","volume":"20","author":"Shinsyu","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.taap.2020.115380_bb0450","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0971-6580.103656","article-title":"A study on the toxic effects of doxorubicin on the histology of certain organs","volume":"19","author":"Shivakumar","year":"2012","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.taap.2020.115380_bb0455","doi-asserted-by":"crossref","first-page":"C881","DOI":"10.1152\/ajpcell.00467.2004","article-title":"Regulatory effects of estrogen on acute lung inflammation in mice","volume":"288","author":"Speyer","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.taap.2020.115380_bb0460","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3109\/15376516.2010.485622","article-title":"Antioxidant properties of fullerenol C60(OH)24 in rat kidneys, testes, and lungs treated with doxorubicin","volume":"20","author":"Srdjenovic","year":"2010","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.taap.2020.115380_bb0465","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacar","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.taap.2020.115380_bb0470","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3389\/fphar.2019.01551","article-title":"Luteolin exerts neuroprotection via modulation of the p62\/Keap1\/Nrf2 pathway in intracerebral hemorrhage","volume":"10","author":"Tan","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2020.115380_bb0475","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020282","article-title":"A special amino-acid formula tailored to boosting cell respiration prevents mitochondrial dysfunction and oxidative stress caused by doxorubicin in mouse cardiomyocytes","volume":"12","author":"Tedesco","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.taap.2020.115380_bb0480","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-981-13-1435-3_12","article-title":"NF-kB and inflammatory cytokine signalling: role in skeletal muscle atrophy","volume":"1088","author":"Thoma","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.taap.2020.115380_bb0485","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.taap.2020.115380_bb0490","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s42003-020-01440-z","article-title":"Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI","volume":"3","author":"Timm","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.taap.2020.115380_bb0495","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S1734-1140(10)70328-5","article-title":"Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats","volume":"62","author":"Torres","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0500","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s13318-012-0092-y","article-title":"Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine","volume":"37","author":"Vapa","year":"2012","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.taap.2020.115380_bb0505","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/intox-2015-0009","article-title":"Lead toxicity: a review","volume":"8","author":"Wani","year":"2015","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.taap.2020.115380_bb0510","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/59.1.5","article-title":"The toxicology of inhaled nitric oxide","volume":"59","author":"Weinberger","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0515","doi-asserted-by":"crossref","first-page":"2719252","DOI":"10.1155\/2019\/2719252","article-title":"Luteolin attenuates cardiac ischemia\/reperfusion injury in diabetic rats by modulating Nrf2 Antioxidative function","volume":"2019","author":"Xiao","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2020.115380_bb0520","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113658","article-title":"Ginsenoside Rg1 prevents doxorubicin-induced cardiotoxicity through the inhibition of autophagy and endoplasmic reticulum stress in mice","volume":"19","author":"Xu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2020.115380_bb0525","doi-asserted-by":"crossref","first-page":"37157","DOI":"10.1038\/srep37157","article-title":"Regulation of Sirt1\/Nrf2\/TNF-alpha signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2020.115380_bb0530","doi-asserted-by":"crossref","first-page":"110044","DOI":"10.1016\/j.biopha.2020.110044","article-title":"Luteolin alleviates neuroinflammation via downregulating the TLR4\/TRAF6\/NF-kappaB pathway after intracerebral hemorrhage","volume":"126","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2020.115380_bb0535","first-page":"118","article-title":"The two faces of reactive oxygen species","volume":"62","author":"Zablocka","year":"2008","journal-title":"Postepy Hig Med Dosw"},{"key":"10.1016\/j.taap.2020.115380_bb0540","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1159\/000480471","article-title":"Oxymatrine ameliorates doxorubicin-induced cardiotoxicity in rats","volume":"43","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20305020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X20305020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:53:06Z","timestamp":1758574386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X20305020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":108,"alternative-id":["S0041008X20305020"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2020.115380","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2020.115380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115380"}}