{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:26:35Z","timestamp":1793467595574,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.taap.2021.115530","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T22:23:46Z","timestamp":1618439026000},"page":"115530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation"],"prefix":"10.1016","volume":"420","author":[{"given":"Bingfeng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingdong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115530_bb0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nm.2135","article-title":"Methylation determines fibroblast activation and fibrogenesis in the kidney","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.taap.2021.115530_bb0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/01902148.2018.1536175","article-title":"TSLP promotes asthmatic airway remodeling via p38-STAT3 signaling pathway in human lung fibroblast","volume":"44","author":"Cao","year":"2018","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.taap.2021.115530_bb0015","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41467-017-01236-6","article-title":"Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis","volume":"8","author":"Chakraborty","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2021.115530_bb0020","first-page":"14904","article-title":"A convenient method for quantifying collagen fibers in atherosclerotic lesions by ImageJ software","volume":"10","author":"Chen","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.taap.2021.115530_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fchem.2020.00073","article-title":"Anti-inflammatory Limonoids from cortex Dictamni","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.taap.2021.115530_bb0030","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1101\/gad.308205.117","article-title":"RNA-binding proteins in neurodegeneration: mechanisms in aggregate (vol 31, pg 1509, 2017)","volume":"31","author":"Conlon","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.taap.2021.115530_bb0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jdermsci.2017.08.013","article-title":"FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts","volume":"88","author":"Dolivo","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.taap.2021.115530_bb0040","doi-asserted-by":"crossref","first-page":"341","DOI":"10.18388\/abp.2018_2635","article-title":"Crosstalk between the TGF-beta and WNT signalling pathways during cardiac fibrogenesis","volume":"65","author":"Dzialo","year":"2018","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.taap.2021.115530_bb0045","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nri.2016.129","article-title":"RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins","volume":"17","author":"Fu","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.taap.2021.115530_bb0050","doi-asserted-by":"crossref","first-page":"104927","DOI":"10.1016\/j.archoralbio.2020.104927","article-title":"Fraxinellone alleviates inflammation and promotes osteogenic differentiation in lipopolysaccharide-stimulated periodontal ligament stem cells by regulating the bone morphogenetic protein 2\/Smad pathway","volume":"121","author":"Fu","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.taap.2021.115530_bb0055","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0168-8278(02)00272-6","article-title":"Pirfenidone effectively reverses experimental liver fibrosis","volume":"37","author":"Garcia","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2021.115530_bb0060","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.febslet.2008.03.004","article-title":"RNA-binding proteins and post-transcriptional gene regulation","volume":"582","author":"Glisovic","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2021.115530_bb0065","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3389\/fphys.2017.00829","article-title":"The JNK signaling pathway in renal fibrosis","volume":"8","author":"Grynberg","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2021.115530_bb0070","doi-asserted-by":"crossref","first-page":"16364","DOI":"10.1074\/jbc.RA118.004073","article-title":"Yap\/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis","volume":"293","author":"Gui","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115530_bb0075","doi-asserted-by":"crossref","DOI":"10.1007\/s12032-017-1055-6","article-title":"The role of RNA-binding protein tristetraprolin in cancer and immunity","volume":"34","author":"Guo","year":"2017","journal-title":"Med. Oncol."},{"key":"10.1016\/j.taap.2021.115530_bb0080","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1681\/ASN.2017020130","article-title":"PGC-1 alpha protects from notch-induced kidney fibrosis development","volume":"28","author":"Han","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2021.115530_bb0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of RNA-binding proteins","volume":"19","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2021.115530_bb0090","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.7150\/thno.24821","article-title":"Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma","volume":"8","author":"Hou","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2021.115530_bb0095","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1023\/A:1007068313370","article-title":"Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation","volume":"24","author":"Iyer","year":"2000","journal-title":"Inflammation"},{"key":"10.1016\/j.taap.2021.115530_bb0100","doi-asserted-by":"crossref","first-page":"14085","DOI":"10.1074\/jbc.M115.713289","article-title":"RNA-binding protein Musashi homologue 1 regulates kidney fibrosis by translational inhibition of p21 and numb mRNA","volume":"291","author":"Jadhav","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115530_bb0105","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3389\/fphar.2019.00880","article-title":"Combined blockade of Smad3 and JNK pathways ameliorates progressive fibrosis in folic acid nephropathy","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2021.115530_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2017.07.004","article-title":"Lipopolysaccharides induce Smad2 phosphorylation through PI3K\/Akt and MAPK cascades in HSC-T6 hepatic stellate cells","volume":"184","author":"Kao","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2021.115530_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.intimp.2019.01.043","article-title":"Fraxinellone inhibits inflammatory cell infiltration during acute pancreatitis by suppressing inflammasome activation","volume":"69","author":"Kim","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.taap.2021.115530_bb0120","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1182\/blood-2018-02-834820","article-title":"The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis","volume":"131","author":"Kramann","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.taap.2021.115530_bb0125","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1172\/JCI74929","article-title":"Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis","volume":"125","author":"Kramann","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.taap.2021.115530_bb0130","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s11684-009-0045-2","article-title":"Effect of pirfenidone on renal tubulointerstitial fibrosis","volume":"3","author":"Li","year":"2009","journal-title":"Front. Med. China"},{"key":"10.1016\/j.taap.2021.115530_bb0135","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbadis.2017.11.011","article-title":"TGF-beta-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis","volume":"1864","author":"Li","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.taap.2021.115530_bb0140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.2015.119","article-title":"Rictor\/mTORC2 signaling mediates TGF beta 1-induced fibroblast activation and kidney fibrosis","volume":"88","author":"Li","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2021.115530_bb0145","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/CIRCULATIONAHA.116.024599","article-title":"Cardiac fibroblast-specific activating transcription factor 3 protects against heart failure by suppressing MAP2K3-p38 signaling","volume":"135","author":"Li","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2021.115530_bb0150","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/nep.12831","article-title":"Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis","volume":"22","author":"Li","year":"2017","journal-title":"Nephrology"},{"key":"10.1016\/j.taap.2021.115530_bb0155","article-title":"Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis","volume":"876","author":"Liu","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2021.115530_bb0160","doi-asserted-by":"crossref","first-page":"172946","DOI":"10.1016\/j.ejphar.2020.172946","article-title":"Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK\/c-JUN signal pathway","volume":"876","author":"Liu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2021.115530_bb0165","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.2017050574","article-title":"Wnt9a promotes renal fibrosis by accelerating cellular senescence in tubular epithelial cells","volume":"29","author":"Luo","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.taap.2021.115530_bb0170","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.taap.2021.115530_bb0175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCULATIONAHA.116.026238","article-title":"Fibroblast-specific genetic manipulation of p38 mitogen-activated protein kinase in vivo reveals its central regulatory role in fibrosis","volume":"136","author":"Molkentin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.taap.2021.115530_bb0180","doi-asserted-by":"crossref","first-page":"F569","DOI":"10.1152\/ajprenal.00270.2013","article-title":"HuR and other turnover- and translation-regulatory RNA-binding proteins: implications for the kidney","volume":"306","author":"Pullmann","year":"2014","journal-title":"Am. J. Physiol. Renal"},{"key":"10.1016\/j.taap.2021.115530_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7113-8_1","article-title":"Human fibrotic diseases: current challenges in fibrosis research","volume":"1627","author":"Rosenbloom","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.taap.2021.115530_bb0190","article-title":"Interplay between Rna-binding protein Hur and Nox4 as novel therapeutic target in diabetic kidney disease","volume":"29","author":"Shi","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.taap.2021.115530_bb0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1523-1755.1998.00962.x","article-title":"Pirfenidone improves renal function and fibrosis in the post-obstructed kidney","volume":"54","author":"Shimizu","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.taap.2021.115530_bb0200","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.bcp.2009.03.002","article-title":"Selective triggering of apoptosis of concanavalin A-activated T cells by fraxinellone for the treatment of T-cell-dependent hepatitis in mice","volume":"77","author":"Sun","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2021.115530_bb0205","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/ptr.6182","article-title":"Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro","volume":"32","author":"Wang","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2021.115530_bb0210","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1038\/ncomms13498","article-title":"CUG-binding protein 1 regulates HSC activation and liver fibrogenesis","volume":"7","author":"Wu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2021.115530_bb0215","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.phrs.2018.08.004","article-title":"Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1 alpha and STAT3","volume":"135","author":"Xing","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2021.115530_bb0220","article-title":"Apigenin alleviates TGF-beta 1-induced nasal mucosa remodeling by inhibiting MAPK\/NF-kappa B signaling pathways in chronic rhinosinusitis","volume":"13","author":"Yang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115530_bb0225","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-981-13-8871-2_12","article-title":"Myofibroblast in kidney fibrosis: origin, activation, and regulation","volume":"1165","author":"Yuan","year":"2019","journal-title":"Renal Fibros. Mech. Therap."},{"key":"10.1016\/j.taap.2021.115530_bb0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0463.2011.02816.x","article-title":"Role of c-Jun N-terminal kinase and p38\/activation protein-1 in interleukin-1 ss-mediated type I collagen synthesis in rat hepatic stellate cells","volume":"120","author":"Zhang","year":"2012","journal-title":"Apmis"},{"key":"10.1016\/j.taap.2021.115530_bb0235","first-page":"818","article-title":"RNA-binding proteins in amyotrophic lateral sclerosis","volume":"41","author":"Zhao","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2021.115530_bb0240","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1016\/j.bbadis.2018.09.007","article-title":"Sphingosine kinase 2 cooperating with Fyn promotes kidney fibroblast activation and fibrosis via STAT3 and AKT","volume":"1864","author":"Zhu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100137X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100137X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:54:24Z","timestamp":1758574464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2100137X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":48,"alternative-id":["S0041008X2100137X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115530","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115530"}}