{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:37:45Z","timestamp":1793968665663,"version":"4.8.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012155","name":"NIMAD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.taap.2021.115573","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T21:57:09Z","timestamp":1620856629000},"page":"115573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2"],"prefix":"10.1016","volume":"423","author":[{"given":"Alireza","family":"Hashemzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forouzan","family":"Amerizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Asgharzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Darroudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Avan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mahdi","family":"Hassanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Landarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Khazaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115573_bb0005","doi-asserted-by":"crossref","first-page":"31146","DOI":"10.1021\/acsami.8b11652","article-title":"Surface-functionalization of Zr-fumarate MOF for selective cytotoxicity and immune system compatibility in nanoscale drug delivery","volume":"10","author":"Ab\u00e1nades L\u00e1zaro","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0010","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1021\/acsami.7b17756","article-title":"Mechanistic investigation into the selective anticancer cytotoxicity and immune system response of surface-functionalized, dichloroacetate-loaded, UiO-66 nanoparticles","volume":"10","author":"Ab\u00e1nades L\u00e1zaro","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0015","doi-asserted-by":"crossref","first-page":"31146","DOI":"10.1021\/acsami.8b11652","article-title":"Surface-functionalization of Zr-fumarate MOF for selective cytotoxicity and immune system compatibility in nanoscale drug delivery","volume":"10","author":"Ab\u00e1nades","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0020","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jff.2019.04.037","article-title":"Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-\u043aB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells","volume":"57","author":"Afrin","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.taap.2021.115573_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.molstruc.2016.12.053","article-title":"Synthesis, characterization and crystal structure of Cu (II) complex of trans-cyclohexane-1, 2-diamine: Application in synthesis of symmetrical biaryls","volume":"1134","author":"Agrahari","year":"2017","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.taap.2021.115573_bb0030","series-title":"Antioxidants as a Double-Edged Sword in the Treatment of Cancer, Antioxidants","author":"Asadi-Samani","year":"2019"},{"key":"10.1016\/j.taap.2021.115573_bb0035","first-page":"502","article-title":"Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats","volume":"7","author":"Asgharzadeh","year":"2017","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.taap.2021.115573_bb0040","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biomaterials.2015.12.018","article-title":"Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic","volume":"82","author":"Au","year":"2016","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.taap.2021.115573_bb6000","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1002\/jcp.26041","article-title":"Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress","volume":"233","author":"Bahrami","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.taap.2021.115573_bb0045","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1039\/C5CS00837A","article-title":"Zr-based metal\u2013organic frameworks: design, synthesis, structure, and applications","volume":"45","author":"Bai","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0050","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijbiomac.2015.09.052","article-title":"Development of liposomes entrapped in alginate beads for the treatment of colorectal cancer","volume":"82","author":"Bansal","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2021.115573_bb0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cyto.2017.04.015","article-title":"The effects of thymoquinone on hippocampal cytokine level, brain oxidative stress status and memory deficits induced by lipopolysaccharide in rats","volume":"96","author":"Bargi","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2021.115573_bb0060","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1021\/la5012555","article-title":"Understanding the colloidal stability of the mesoporous MIL-100 (Fe) nanoparticles in physiological media","volume":"30","author":"Bellido","year":"2014","journal-title":"Langmuir"},{"key":"10.1016\/j.taap.2021.115573_bb0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4172\/2161-0444.1000117","article-title":"Preparation and characterization of folate conjugated nanoparticles of doxorubicin using PLGA-PEG-FOL polymer","volume":"2","author":"Boddu","year":"2012","journal-title":"Med. Chem."},{"key":"10.1016\/j.taap.2021.115573_bb0070","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1021\/ja908117a","article-title":"Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin","volume":"132","author":"Brown","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.taap.2021.115573_bb0075","doi-asserted-by":"crossref","first-page":"1801526","DOI":"10.1002\/advs.201801526","article-title":"Metal\u2013Organic Framework-Based Stimuli-Responsive Systems for Drug Delivery","volume":"6","author":"Cai","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.taap.2021.115573_bb0080","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/21691401.2018.1436553","article-title":"Recent progress in synergistic chemotherapy and phototherapy by targeted drug delivery systems for cancer treatment","volume":"46","author":"Cao","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.taap.2021.115573_bb0085","series-title":"UiO-66-NH2\/GO Composite: Synthesis, Characterization and CO2 Adsorption Performance","author":"Cao","year":"2018"},{"key":"10.1016\/j.taap.2021.115573_bb0090","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.2967\/jnumed.114.146019","article-title":"Theranostic nanoparticles","volume":"55","author":"Chen","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.taap.2021.115573_bb0095","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1039\/C5DT03736K","article-title":"Magnetic nanoscale metal organic frameworks for potential targeted anticancer drug delivery, imaging and as an MRI contrast agent","volume":"45","author":"Chowdhuri","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.taap.2021.115573_bb0100","doi-asserted-by":"crossref","first-page":"18120","DOI":"10.1039\/C6DT03237K","article-title":"One-pot synthesis of folic acid encapsulated upconversion nanoscale metal organic frameworks for targeting, imaging and pH responsive drug release","volume":"45","author":"Chowdhuri","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.taap.2021.115573_bb0105","doi-asserted-by":"crossref","first-page":"16573","DOI":"10.1021\/acsami.6b03988","article-title":"Carbon dots embedded magnetic nanoparticles@ chitosan@ metal organic framework as a nanoprobe for pH sensitive targeted anticancer drug delivery","volume":"8","author":"Chowdhuri","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0110","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/aa57af","article-title":"One-pot synthesis of multifunctional nanoscale metal-organic frameworks as an effective antibacterial agent against multidrug-resistant Staphylococcus aureus","volume":"28","author":"Chowdhuri","year":"2017","journal-title":"Nanotechnology"},{"key":"10.1016\/j.taap.2021.115573_bb0115","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cej.2017.03.008","article-title":"Synthesis of multifunctional upconversion NMOFs for targeted antitumor drug delivery and imaging in triple negative breast cancer cells","volume":"319","author":"Chowdhuri","year":"2017","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.taap.2021.115573_bb0120","doi-asserted-by":"crossref","first-page":"15343","DOI":"10.1021\/acs.langmuir.8b02946","article-title":"Distinction between active and passive targeting of nanoparticles dictate their overall therapeutic efficacy","volume":"34","author":"Clemons","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.taap.2021.115573_bb0125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.canlet.2011.12.030","article-title":"Epigenetic biomarkers of colorectal cancer: focus on DNA methylation","volume":"342","author":"Coppede","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2021.115573_bb0130","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1039\/C6TB01743F","article-title":"Tumor therapy: targeted drug delivery systems","volume":"4","author":"Dai","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.taap.2021.115573_bb0135","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/modpathol.2011.82","article-title":"Folate receptor-\u03b1 expression in resectable hepatic colorectal cancer metastases: patterns and significance","volume":"24","author":"D\u2019angelica","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.taap.2021.115573_bb0140","doi-asserted-by":"crossref","first-page":"17148","DOI":"10.1002\/chem.201804153","article-title":"Folic Acid Functionalized Zirconium-Based Metal\u2013Organic Frameworks as Drug Carriers for Active Tumor-Targeted Drug Delivery","volume":"24","author":"Dong","year":"2018","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.taap.2021.115573_bb0145","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1002\/anie.201203339","article-title":"Photocontrolled targeted drug delivery: photocaged biologically active folic acid as a light-responsive tumor-targeting molecule","volume":"51","author":"Fan","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.taap.2021.115573_bb0150","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nchem.2229","article-title":"Nanomedicine: MOFs deliver","volume":"7","author":"Faust","year":"2015","journal-title":"Nat. Chem."},{"key":"10.1016\/j.taap.2021.115573_bb0155","doi-asserted-by":"crossref","first-page":"37705","DOI":"10.1038\/srep37705","article-title":"Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2021.115573_bb0160","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1021\/acsami.6b14795","article-title":"Controllable synthesis of a smart multifunctional nanoscale metal\u2013organic framework for magnetic resonance\/optical imaging and targeted drug delivery","volume":"9","author":"Gao","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0165","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1039\/C7NR08892B","article-title":"Size and surface controllable metal\u2013organic frameworks (MOFs) for fluorescence imaging and cancer therapy","volume":"10","author":"Gao","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.taap.2021.115573_bb0170","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.ijbiomac.2018.09.119","article-title":"Co-delivery of 5-fluorouracil and oxaliplatin in novel poly (3-hydroxybutyrate-co-3-hydroxyvalerate acid)\/poly (lactic-co-glycolic acid) nanoparticles for colon cancer therapy","volume":"124","author":"Handali","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2021.115573_bb0175","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/ijc.22811","article-title":"Folate receptor overexpression is associated with poor outcome in breast cancer","volume":"121","author":"Hartmann","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2021.115573_bb0180","first-page":"506","article-title":"Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer","volume":"20","author":"Hashemzehi","year":"2021","journal-title":"EXCLI J."},{"key":"10.1016\/j.taap.2021.115573_bb0185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nmat2608","article-title":"Porous metal\u2013organic-framework nanoscale carriers as a potential platform for drug delivery and imaging","volume":"9","author":"Horcajada","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.taap.2021.115573_bb0190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/0929867323666160926151216","article-title":"Anti-cancer drug delivery using metal organic frameworks (MOFs)","volume":"24","author":"Ibrahim","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.taap.2021.115573_bb0195","doi-asserted-by":"crossref","first-page":"34513","DOI":"10.1021\/acsami.8b13487","article-title":"CuS@ MOF-based well-designed quercetin delivery system for chemo\u2013photothermal therapy","volume":"10","author":"Jiang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0200","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ygyno.2007.11.020","article-title":"Folate receptor alpha as a tumor target in epithelial ovarian cancer","volume":"108","author":"Kalli","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0205","doi-asserted-by":"crossref","first-page":"9449","DOI":"10.1039\/c3cc46105j","article-title":"A facile synthesis of UiO-66, UiO-67 and their derivatives","volume":"49","author":"Katz","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.taap.2021.115573_bb0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1009549127153","article-title":"Study of the structure and reactions of bis (\u03bc-Oxalato) tetramminediplatinum (II) in aqueous chloride solutions","volume":"27","author":"Kazbanov","year":"2001","journal-title":"Russ. J. Coord. Chem."},{"key":"10.1016\/j.taap.2021.115573_bb0215","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1088\/0031-9155\/59\/9\/2249","article-title":"Radiosensitization effect of folate-conjugated gold nanoparticles on HeLa cancer cells under orthovoltage superficial radiotherapy techniques","volume":"59","author":"Khoshgard","year":"2014","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.taap.2021.115573_bb0220","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/med.21387","article-title":"Small molecules for active targeting in cancer","volume":"36","author":"Kue","year":"2016","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0225","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1039\/C8NJ03350A","article-title":"Fabrication of curcumin-loaded folic acid-tagged metal organic framework for triple negative breast cancer therapy in in vitro and in vivo systems","volume":"43","author":"Laha","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.taap.2021.115573_bb0230","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1166\/jbn.2014.2051","article-title":"Anti-tumor immune response of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma","volume":"10","author":"Lai","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.taap.2021.115573_bb0235","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ccr.2018.09.009","article-title":"Application of zirconium MOFs in drug delivery and biomedicine","volume":"380","author":"Lazaro","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0240","doi-asserted-by":"crossref","first-page":"46476","DOI":"10.1039\/C4RA07608G","article-title":"Chemical recycling of waste poly (ethylene terephthalate) fibers into azo disperse dyestuffs","volume":"4","author":"Li","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.taap.2021.115573_bb0245","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.talanta.2016.05.038","article-title":"Fabrication of folic acid-sensitive gold nanoclusters for turn-on fluorescent imaging of overexpression of folate receptor in tumor cells","volume":"158","author":"Li","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.taap.2021.115573_bb0250","doi-asserted-by":"crossref","first-page":"14113","DOI":"10.1039\/C6CC07321B","article-title":"A drug-loaded nanoscale metal\u2013organic framework with a tumor targeting agent for highly effective hepatoma therapy","volume":"52","author":"Li","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.taap.2021.115573_bb0255","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1021\/acsami.6b14446","article-title":"Multifunctional Metal\u2013Organic Framework Nanoprobe for Cathepsin B-Activated Cancer Cell Imaging and Chemo-Photodynamic Therapy","volume":"9","author":"Liu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0260","first-page":"184","article-title":"Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide","volume":"35","author":"Madesh","year":"1998","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.taap.2021.115573_bb0265","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1021\/cr100440g","article-title":"Protein\u2212 nanoparticle interactions: opportunities and challenges","volume":"111","author":"Mahmoudi","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0270","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4614-8993-1_4","article-title":"Pharmacokinetics and pharmacodynamics of nanomaterials","author":"Marcato","year":"2014","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.taap.2021.115573_bb0275","first-page":"3567","article-title":"Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue","volume":"28","author":"Markert","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.taap.2021.115573_bb0280","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2014.12.025","article-title":"Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy","volume":"479","author":"Mehta","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.taap.2021.115573_bb0285","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1039\/c001181a","article-title":"Biodegradable therapeutic MOFs for the delivery of bioactive molecules","volume":"46","author":"Miller","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.taap.2021.115573_bb0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nnano.2010.267","article-title":"Nanobiotechnology: nanoparticle coronas take shape","volume":"6","author":"Monopoli","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.taap.2021.115573_bb0295","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1200\/JCO.2016.69.9538","article-title":"Safety and activity of mirvetuximab soravtansine (IMGN853), a folate receptor alpha\u2013targeting antibody\u2013drug conjugate, in platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer: a phase i expansion study","volume":"35","author":"Moore","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0300","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2018.07.017","article-title":"Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FR\u03b1)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancer","volume":"151","author":"Moore","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0305","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.matchemphys.2015.12.065","article-title":"Folate attached, curcumin loaded Fe3O4 nanoparticles: A novel multifunctional drug delivery system for cancer treatment","volume":"172","author":"Nam","year":"2016","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.taap.2021.115573_bb0310","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.msec.2019.02.017","article-title":"Magnetic bio-metal\u2013organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment","volume":"99","author":"Nejadshafiee","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.taap.2021.115573_bb0315","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s10965-019-1779-4","article-title":"Preparation and characterization of oxaliplatin drug delivery vehicle based on PEGylated half-generation PAMAM dendrimer","volume":"26","author":"Nguyen","year":"2019","journal-title":"J. Polym. Res."},{"key":"10.1016\/j.taap.2021.115573_bb0320","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2147\/IJN.S38378","article-title":"Nanodrugs: pharmacokinetics and safety","volume":"9","author":"Onoue","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.taap.2021.115573_bb0325","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1039\/C5CC05237H","article-title":"Amorphous metal\u2013organic frameworks for drug delivery","volume":"51","author":"Orellana-Tavra","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.taap.2021.115573_bb0330","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1039\/C6TB02025A","article-title":"Drug delivery and controlled release from biocompatible metal\u2013organic frameworks using mechanical amorphization","volume":"4","author":"Orellana-Tavra","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.taap.2021.115573_bb0335","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/adhm.201600296","article-title":"Endocytosis mechanism of nano metal-organic frameworks for drug delivery","volume":"5","author":"Orellana-Tavra","year":"2016","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.taap.2021.115573_bb0340","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S1359-6446(05)03698-6","article-title":"Essential properties of drug-targeting delivery systems","volume":"10","author":"Petrak","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.taap.2021.115573_bb0345","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1039\/C5TB02555A","article-title":"Near-infrared triggered generation of reactive oxygen species from upconverting nanoparticles decorated with an organoiridium complex","volume":"4","author":"Raj","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.taap.2021.115573_bb0350","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/kin.20995","article-title":"Kinetic and mechanistic investigations on some N, N-Chelated Pt (II) oxalate complexes with some \u201cS\u201d containing biorelevant ligands at physiological condition","volume":"48","author":"Ray","year":"2016","journal-title":"Int. J. Chem. Kinet."},{"key":"10.1016\/j.taap.2021.115573_bb0355","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1039\/c0nr00156b","article-title":"Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles\u2013opportunities & challenges","volume":"2","author":"Rosenholm","year":"2010","journal-title":"Nanoscale"},{"key":"10.1016\/j.taap.2021.115573_bb0360","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00432-016-2179-3","article-title":"Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy","volume":"142","author":"Samadian","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0365","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1054\/bjoc.1999.1026","article-title":"Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs","volume":"82","author":"Screnci","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2021.115573_bb0370","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.humpath.2007.09.013","article-title":"Immunohistochemical expression of folate receptor \u03b1 in colorectal carcinoma: patterns and biological significance","volume":"39","author":"Shia","year":"2008","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.taap.2021.115573_bb0375","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1070\/RCR4797","article-title":"Towards rational design of metal-organic framework-based drug delivery systems","volume":"87","author":"Simagina","year":"2018","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0380","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/smll.201502730","article-title":"Dose-dependent therapeutic distinction between active and passive targeting revealed using transferrin-coated PGMA nanoparticles","volume":"12","author":"Singh","year":"2016","journal-title":"Small"},{"issue":"2","key":"10.1016\/j.taap.2021.115573_bb0385","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/jcp.29053","article-title":"Novel oral transforming growth factor-\u03b2 signaling inhibitor potently inhibits postsurgical adhesion band formation","volume":"235","author":"Soleimani","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2021.115573_bb0390","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejps.2012.12.006","article-title":"A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics","volume":"48","author":"Steichen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.taap.2021.115573_bb0395","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-409X(99)00062-9","article-title":"Targeted drug delivery via the folate receptor","volume":"41","author":"Sudimack","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0400","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jsps.2015.02.002","article-title":"In vitro and in vivo targeting effect of folate decorated paclitaxel loaded PLA\u2013TPGS nanoparticles","volume":"23","author":"Thu","year":"2015","journal-title":"Saudi Pharmaceut. J."},{"key":"10.1016\/j.taap.2021.115573_bb0405","first-page":"1399","article-title":"Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges","volume":"10","author":"Toporkiewicz","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.taap.2021.115573_bb0410","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/cm1022882","article-title":"Disclosing the complex structure of UiO-66 metal organic framework: a synergic combination of experiment and theory","volume":"23","author":"Valenzano","year":"2011","journal-title":"Chem. Mater."},{"key":"10.1016\/j.taap.2021.115573_bb0415","first-page":"2014","article-title":"Uptake of etoposide in CT-26 cells of colorectal cancer using folate targeted dextran stearate polymeric micelles","author":"Varshosaz","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2021.115573_bb0420","doi-asserted-by":"crossref","first-page":"8385","DOI":"10.1039\/C7TA01066D","article-title":"A metal\u2013organic framework and conducting polymer based electrochemical sensor for high performance cadmium ion detection","volume":"5","author":"Wang","year":"2017","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.taap.2021.115573_bb0425","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF01052894","article-title":"The folate receptor in central nervous system malignancies of childhood","volume":"21","author":"Weitman","year":"1994","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0430","doi-asserted-by":"crossref","first-page":"1606134","DOI":"10.1002\/adma.201606134","article-title":"Metal\u2013organic framework (MOF)-based drug\/cargo delivery and cancer therapy","volume":"29","author":"Wu","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.taap.2021.115573_bb0435","doi-asserted-by":"crossref","first-page":"322","DOI":"10.7150\/thno.10257","article-title":"Aptamers: active targeting ligands for cancer diagnosis and therapy","volume":"5","author":"Wu","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.taap.2021.115573_bb0440","doi-asserted-by":"crossref","first-page":"34655","DOI":"10.1021\/acsami.8b13758","article-title":"Multifunctional supramolecular materials constructed from polypyrrole@ UiO-66 nanohybrids and pillararene nanovalves for targeted chemophotothermal therapy","volume":"10","author":"Wu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0445","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.theochem.2005.10.032","article-title":"Electronic structure, Raman and infrared spectra, and vibrational assignment of carboplatin, Density functional theory studies","volume":"758","author":"Wysoki\u0144ski","year":"2006","journal-title":"J. Mol. Struct. THEOCHEM"},{"key":"10.1016\/j.taap.2021.115573_bb0450","doi-asserted-by":"crossref","DOI":"10.1615\/JEnvironPatholToxicolOncol.2017025229","article-title":"Dual roles of oxidative stress in metal carcinogenesis","volume":"36","author":"Xu","year":"2017","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.taap.2021.115573_bb0455","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1007\/s11095-017-2253-9","article-title":"Post-synthetic modification nanoscale metal-organic frameworks for targeted drug delivery in cancer cells","volume":"34","author":"Yang","year":"2017","journal-title":"Pharm. Res."},{"key":"10.1016\/j.taap.2021.115573_bb0460","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1002\/jps.23746","article-title":"Utilizing dynamic light scattering as a process analytical technology for protein folding and aggregation monitoring in vaccine manufacturing","volume":"102","author":"Yu","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.taap.2021.115573_bb0465","first-page":"2016","article-title":"Design of nanoparticle-based carriers for targeted drug delivery","author":"Yu","year":"2016","journal-title":"J. Nanomater."},{"key":"10.1016\/j.taap.2021.115573_bb0470","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1039\/C6NR07315H","article-title":"Nanocaged platforms: modification, drug delivery and nanotoxicity, Opening synthetic cages to release the tiger","volume":"9","author":"Zangabad","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.taap.2021.115573_bb0475","first-page":"151","article-title":"A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting","volume":"7","author":"Zhang","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.taap.2021.115573_bb0480","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1021\/acs.langmuir.7b02365","article-title":"Converting metal\u2013organic framework particles from hydrophilic to hydrophobic by an interfacial assembling route","volume":"33","author":"Zhang","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.taap.2021.115573_bb0485","doi-asserted-by":"crossref","first-page":"19687","DOI":"10.1021\/acsami.7b05142","article-title":"Rational design of metal organic framework nanocarrier-based codelivery system of doxorubicin hydrochloride\/verapamil hydrochloride for overcoming multidrug resistance with efficient targeted cancer therapy","volume":"9","author":"Zhang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.taap.2021.115573_bb0490","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1039\/C6CS00898D","article-title":"Supramolecular chemotherapy based on host\u2013guest molecular recognition: a novel strategy in the battle against cancer with a bright future","volume":"46","author":"Zhou","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.taap.2021.115573_bb0495","series-title":"Nanotoxicology: materials, methodologies, and assessments","author":"Zucolotto","year":"2013"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21001800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21001800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:54:51Z","timestamp":1758574491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21001800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":100,"alternative-id":["S0041008X21001800"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115573","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115573"}}