{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:12:16Z","timestamp":1778638336796,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["04-02-12-2017RU"],"award-info":[{"award-number":["04-02-12-2017RU"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004530","name":"Universiti Putra Malaysia","doi-asserted-by":"publisher","award":["04-01-09-0713RU"],"award-info":[{"award-number":["04-01-09-0713RU"]}],"id":[{"id":"10.13039\/501100004530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.taap.2021.115605","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T11:38:38Z","timestamp":1622547518000},"page":"115605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines"],"prefix":"10.1016","volume":"425","author":[{"given":"Shun Ying","family":"Quah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charng Choon","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Chyn","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok Lian","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Abdul Manan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pran Kishore","family":"Deb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreenivasa Rao","family":"Sagineedu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnson","family":"Stanslas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115605_bb0005","first-page":"1502","article-title":"Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma","volume":"7","author":"Bao","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.taap.2021.115605_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201621","article-title":"Autophagy mediates epithelial cancer chemoresistance by reducing p62\/SQSTM1 accumulation","volume":"13","author":"Battista","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115605_bb0015","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1186\/s12885-016-2906-9","article-title":"Autophagy is associated with chemoresistance in neuroblastoma","volume":"16","author":"Belounis","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0020","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1158\/1078-0432.CCR-04-2159","article-title":"Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment","volume":"11","author":"Berberat","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0025","doi-asserted-by":"crossref","first-page":"423","DOI":"10.18632\/oncoscience.51","article-title":"Resistance to c-Kit inhibitors in melanoma: insights for future therapies","volume":"1","author":"Carlino","year":"2014","journal-title":"Oncoscience"},{"key":"10.1016\/j.taap.2021.115605_bb0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12885-016-2999-1","article-title":"Molecular chess? Hallmarks of anti-cancer drug resistance","volume":"17","author":"Cree","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0040","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1039\/C4MD00566J","article-title":"Synthesis and evaluation of anticancer activity of novel andrographolide derivatives","volume":"6","author":"Davendar","year":"2015","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.taap.2021.115605_bb0045","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2174\/138920008785821657","article-title":"Medicinal plants and cancer chemoprevention","volume":"9","author":"Desai","year":"2008","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.taap.2021.115605_bb0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.onc.1210623","article-title":"Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models","volume":"27","author":"Desnoyers","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2021.115605_bb0055","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.bmcl.2007.11.054","article-title":"Structural analogs of tylophora alkaloids may not be functional analogs","volume":"18","author":"Gao","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.taap.2021.115605_bb0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13046-016-0478-9","article-title":"FGF19\/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib","volume":"36","author":"Gao","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.95.1.333","article-title":"Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells","volume":"95","author":"Greenburg","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.taap.2021.115605_bb0070","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1158\/1541-7786.MCR-08-0325","article-title":"Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells","volume":"7","author":"Gueron","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0075","first-page":"9","article-title":"Cell cycle perturbation and acquired 5-fluorouracil chemoresistance","volume":"28","author":"Guo","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0080","first-page":"2101","article-title":"The inhibition of heme oxygenase-1 enhances the chemosensitivity and suppresses the proliferation of pancreatic cancer cells through the SHH signaling pathway","volume":"52","author":"Han","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.taap.2021.115605_bb0085","doi-asserted-by":"crossref","first-page":"37298","DOI":"10.1074\/jbc.C700195200","article-title":"The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy","volume":"282","author":"Hanada","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115605_bb0090","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2105-9-S5-S2","article-title":"Gene ontology annotations: what they mean and where they come from","volume":"9","author":"Hill","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.taap.2021.115605_bb0095","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1073\/pnas.1300016110","article-title":"Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function","volume":"110","author":"Hocker","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2021.115605_bb0100","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/cancers6031769","article-title":"Drug resistance in cancer: an overview","volume":"6","author":"Housman","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.taap.2021.115605_bb0105","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.3892\/or.2015.4212","article-title":"Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer","volume":"34","author":"Hu","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.taap.2021.115605_bb0110","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.molmed.2008.09.005","article-title":"Colon cancer stem cells: implications for prevention and therapy","volume":"14","author":"Huang","year":"2008","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.taap.2021.115605_bb0115","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1007\/s10620-013-2609-x","article-title":"Expression of fibroblast growth factor 19 is associated with recurrence and poor prognosis of hepatocellular carcinoma","volume":"58","author":"Hyeon","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.taap.2021.115605_bb0120","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/14756360600866714","article-title":"Semisynthesis and cytotoxic activities of andrographolide analogues","volume":"21","author":"Jada","year":"2006","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.taap.2021.115605_bb0125","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.phytochem.2006.11.031","article-title":"Semisynthesis and in vitro anticancer activities of andrographolide analogues","volume":"68","author":"Jada","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.taap.2021.115605_bb0130","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/bjp.2008.368","article-title":"Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 cell cycle arrest and apoptosis","volume":"155","author":"Jada","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2021.115605_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/hep-2017-0008","article-title":"Fibroblast growth factor 19, a double-edged sword","volume":"4","author":"Jansen","year":"2017","journal-title":"Hepat. Oncol."},{"key":"10.1016\/j.taap.2021.115605_bb0140","doi-asserted-by":"crossref","first-page":"846740","DOI":"10.1155\/2013\/846740","article-title":"Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent andrographolide","volume":"2013","author":"Jayakumar","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.taap.2021.115605_bb0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ejphar.2016.06.052","article-title":"Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation","volume":"788","author":"Jo","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.taap.2021.115605_bb0150","first-page":"4559","article-title":"Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds","volume":"26","author":"Kars","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0155","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41416-019-0721-1","article-title":"Cancer as a disease of old age: changing mutational and microenvironment landscapes","volume":"122","author":"Laconi","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/cells8010031","article-title":"Fibroblast growth factor receptor 4 targeting in cancer: new insights into mechanisms and therapeutic strategies","volume":"8","author":"Lang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.taap.2021.115605_bb0165","doi-asserted-by":"crossref","first-page":"29993","DOI":"10.1074\/jbc.M604044200","article-title":"A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras\/ERK pathway downstream of fibroblast growth factor receptor stimulation","volume":"281","author":"Lao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115605_bb0170","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2021.115605_bb0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13045-019-0818-2","article-title":"Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy","volume":"12","author":"Lim","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.taap.2021.115605_bb0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/carcin\/bgp259","article-title":"Cancer stem cells: a reality, a myth, a fuzzy concept or a misnomer? An analysis","volume":"31","author":"Maenhaut","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2021.115605_bb0185","doi-asserted-by":"crossref","first-page":"339","DOI":"10.15171\/apb.2017.041","article-title":"The different mechanisms of cancer drug resistance: a brief review","volume":"7","author":"Mansoori","year":"2017","journal-title":"Adv. Pharm. Bul."},{"key":"10.1016\/j.taap.2021.115605_bb0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fonc.2014.00040","article-title":"In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies","volume":"4","author":"McDermott","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2021.115605_bb0195","first-page":"447","article-title":"Drug-adapted cancer cell lines as preclinical models of acquired resistance","volume":"2","author":"Michaelis","year":"2019","journal-title":"Cancer Drug Resist."},{"key":"10.1016\/j.taap.2021.115605_bb0200","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF02897284","article-title":"Characterization of an etoposide-resistant human small-cell lung cancer cell line","volume":"26","author":"Minato","year":"1990","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.taap.2021.115605_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.taap.2021.115605_bb0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1525-1438.2000.00018.x","article-title":"Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cell line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement","volume":"10","author":"Mujoo","year":"2000","journal-title":"Int. J. Gynecol. Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0215","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/pros.22994","article-title":"FGF19 promotes progression of prostate cancer","volume":"75","author":"Nagamatsu","year":"2015","journal-title":"Prostate"},{"key":"10.1016\/j.taap.2021.115605_bb0220","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1016\/j.bmcl.2004.06.090","article-title":"Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents","volume":"14","author":"Nanduri","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.taap.2021.115605_bb0225","doi-asserted-by":"crossref","first-page":"121826","DOI":"10.1155\/2015\/121826","article-title":"Roles of autophagy induced by natural compounds in prostate cancer","volume":"2015","author":"Naponelli","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2021.115605_bb0230","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature05372","article-title":"A human colon cancer cell capable of initiating tumor growth in immunodeficient mice","volume":"445","author":"O\u2019Brien","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115605_bb0235","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/wdev.176","article-title":"The fibroblast growth factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.taap.2021.115605_bb0240","doi-asserted-by":"crossref","first-page":"859871","DOI":"10.1155\/2014\/859871","article-title":"Tumor initiating cells and chemoresistance: which is the best strategy to target colon cancer stem cells?","volume":"2014","author":"Paldino","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2021.115605_bb0245","first-page":"526","article-title":"New substituted C(14)-andrographolide derivatives with potent cytotoxic activities","volume":"5","author":"Patil","year":"2014","journal-title":"Int. J. Pharm. Bio Sci."},{"key":"10.1016\/j.taap.2021.115605_bb0250","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-12-387688-1.00009-0","article-title":"Cancer stem cells in tumor heterogeneity","volume":"112","author":"Pietras","year":"2011","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.taap.2021.115605_bb0255","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22146\/ijc.21699","article-title":"Structure modification of andrographolide improve its potency as anticancer","volume":"7","author":"Poerwono","year":"2007","journal-title":"Indo. J. Chem."},{"key":"10.1016\/j.taap.2021.115605_bb0260","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/j.1349-7006.2012.02222.x","article-title":"Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression","volume":"103","author":"Qi","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.taap.2021.115605_bb0265","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1359-4117.2003.01090.x","article-title":"Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata","volume":"3","author":"Rajagopal","year":"2003","journal-title":"J. Exp. Ther. Oncol."},{"key":"10.1016\/j.taap.2021.115605_bb0270","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating-cells","volume":"445","author":"Ricci-Vitiani","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115605_bb0275","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2011.10.014","article-title":"The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis","volume":"44","author":"Rubinstein","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2021.115605_bb0280","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/ijc.28804","article-title":"Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance","volume":"136","author":"Singh","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0285","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bmcl.2011.11.085","article-title":"New substituted C-19-andrographolide analogues with potent cytotoxic activities","volume":"22","author":"Sirion","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.taap.2021.115605_bb0290","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2021.115605_bb0295","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.4161\/auto.7.9.16521","article-title":"Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development","volume":"7","author":"Sun","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2021.115605_bb0300","doi-asserted-by":"crossref","first-page":"57633","DOI":"10.18632\/oncotarget.9328","article-title":"Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival","volume":"7","author":"Tiong","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2021.115605_bb0305","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.10","article-title":"Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer","volume":"5","author":"Turkington","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2021.115605_bb0310","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115605_bb0315","first-page":"141","article-title":"Drug resistance and combating drug resistance in cancer","volume":"2","author":"Wang","year":"2019","journal-title":"Cancer Drug Resist."},{"key":"10.1016\/j.taap.2021.115605_bb0320","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000494454","article-title":"Upregulation of fibroblast growth factor 19 is associated with the initiation of colorectal adenoma","volume":"37","author":"Wang","year":"2019","journal-title":"Dig. Dis."},{"key":"10.1016\/j.taap.2021.115605_bb0325","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.2353\/ajpath.2006.051365","article-title":"Overexpression of heme oxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice","volume":"169","author":"Was","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.taap.2021.115605_bb0330","series-title":"In vitro Growth Inhibition, Molecular Mechanisms of Cell Cycle Arrest and Apoptosis in Prostate Cancer Cells by SRJ23, Master\u2019s thesis","author":"Wong","year":"2013"},{"key":"10.1016\/j.taap.2021.115605_bb0335","series-title":"Elucidation of the Mechanism of Anticancer Activity of 3,19-(2-Bromobenzylidene)andrographolide (SRJ09) in Breast and Colon Cancer Cells, Ph.D. thesis","author":"Wong","year":"2015"},{"key":"10.1016\/j.taap.2021.115605_bb0340","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10565-014-9282-5","article-title":"SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells","volume":"30","author":"Wong","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.taap.2021.115605_bb0345","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.phrs.2016.02.024","article-title":"SRJ09, a promising anticancer drug lead: elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy","volume":"107","author":"Wong","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2021.115605_bb0350","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1006\/cyto.1999.0485","article-title":"FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4","volume":"11","author":"Xie","year":"1999","journal-title":"Cytokine"},{"key":"10.1016\/j.taap.2021.115605_bb0355","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","article-title":"Mammalian autophagy: core molecular machinery and signaling regulation","volume":"22","author":"Yang","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.taap.2021.115605_bb0360","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1158\/2159-8290.CD-19-0015","article-title":"Cellular plasticity in cancer","volume":"9","author":"Yuan","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.taap.2021.115605_bb0365","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1074\/jbc.M601252200","article-title":"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115605_bb0370","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/1759-7714.12504","article-title":"FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas","volume":"8","author":"Zhang","year":"2017","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.taap.2021.115605_bb0375","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1179\/1607845414Y.0000000212","article-title":"Heme oxygenase-1 plays a crucial role in chemoresistance in acute myeloid leukemia","volume":"20","author":"Zhe","year":"2015","journal-title":"Hematology"},{"key":"10.1016\/j.taap.2021.115605_bb0380","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3892\/ol.2015.3735","article-title":"Knockdown of heme oxygenase-1 promotes apoptosis and autophagy and enhances the cytotoxicity of doxorubicin in breast cancer cells","volume":"10","author":"Zhu","year":"2015","journal-title":"Oncol. Lett."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100209X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100209X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:40:03Z","timestamp":1778636403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2100209X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":75,"alternative-id":["S0041008X2100209X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115605","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115605"}}