{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:30:57Z","timestamp":1791469857202,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES013611-S1"],"award-info":[{"award-number":["R01 ES013611-S1"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES027574"],"award-info":[{"award-number":["R01 ES027574"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["K08 HL105537"],"award-info":[{"award-number":["K08 HL105537"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES013611-S1"],"award-info":[{"award-number":["R01 ES013611-S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES027574"],"award-info":[{"award-number":["R01 ES027574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 HL105537"],"award-info":[{"award-number":["K08 HL105537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 ES013611-S1"],"award-info":[{"award-number":["R01 ES013611-S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 ES027574"],"award-info":[{"award-number":["R01 ES027574"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["K08 HL105537"],"award-info":[{"award-number":["K08 HL105537"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.taap.2021.115645","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T11:25:19Z","timestamp":1626175519000},"page":"115645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Wood smoke particle exposure in mice reduces the severity of influenza infection"],"prefix":"10.1016","volume":"426","author":[{"given":"Aaron","family":"Vose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McCravy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya","family":"Birukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta G.","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Tighe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115645_bb0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.matbio.2018.06.006","article-title":"Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis","volume":"80","author":"Bell","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.taap.2021.115645_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1743-8977-9-45","article-title":"Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines","volume":"9","author":"Bolling","year":"2012","journal-title":"Part Fibre Toxicol."},{"issue":"4","key":"10.1016\/j.taap.2021.115645_bb0015","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/IAI.00472-09","article-title":"Inflammatory monocytes but not neutrophils are necessary to control infection with toxoplasma gondii in mice","volume":"78","author":"Dunay","year":"2010","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.taap.2021.115645_bb0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s15010-014-0592-6","article-title":"Particle exposures and infections","volume":"42","author":"Ghio","year":"2014","journal-title":"Infection"},{"issue":"3","key":"10.1016\/j.taap.2021.115645_bb0025","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/oem.2011.065276","article-title":"Exposure to wood smoke particles produces inflammation in healthy volunteers","volume":"69","author":"Ghio","year":"2012","journal-title":"Occup. Environ. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2021.115645_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/08958370701490379","article-title":"Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States","volume":"19","author":"Gilmour","year":"2007","journal-title":"Inhal. Toxicol."},{"issue":"23","key":"10.1016\/j.taap.2021.115645_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00881-18","article-title":"Attenuation of influenza A virus disease severity by viral coinfection in a mouse model","volume":"92","author":"Gonzalez","year":"2018","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.taap.2021.115645_bb0040","doi-asserted-by":"crossref","first-page":"s125","DOI":"10.1007\/s12975-012-0174-9","article-title":"Gr1+ macrophages and dendritic cells dominate the inflammatory infiltrate 12 hours after experimental intracerebral hemorrhage","volume":"3","author":"Hammond","year":"2012","journal-title":"Transl. Stroke Res."},{"issue":"6","key":"10.1016\/j.taap.2021.115645_bb0045","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/08958378.2019.1654046","article-title":"Smoldering and flaming biomass wood smoke inhibit respiratory responses in mice","volume":"31","author":"Hargrove","year":"2019","journal-title":"Inhal. Toxicol."},{"issue":"626","key":"10.1016\/j.taap.2021.115645_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaz3381","article-title":"IFN-kappa suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis","volume":"13","author":"He","year":"2020","journal-title":"Sci. Signal."},{"key":"10.1016\/j.taap.2021.115645_bb0055","first-page":"423","article-title":"The effector T cell response to influenza infection","volume":"386","author":"Hufford","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"5","key":"10.1016\/j.taap.2021.115645_bb0060","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1289\/ehp.1104422","article-title":"Estimated global mortality attributable to smoke from landscape fires","volume":"120","author":"Johnston","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2021.115645_bb0065","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12951-014-0047-3","article-title":"Comparative lung toxicity of engineered nanomaterials utilizing in vitro, ex vivo and in vivo approaches","volume":"12","author":"Kim","year":"2014","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.taap.2021.115645_bb0070","doi-asserted-by":"crossref","first-page":"017011","DOI":"10.1289\/EHP2200","article-title":"Mutagenicity and lung toxicity of smoldering vs. flaming emissions from various biomass fuels: implications for health effects from wildland fires","volume":"126","author":"Kim","year":"2018","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.taap.2021.115645_bb0075","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.taap.2021.115645_bb0080","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.180.4.2562","article-title":"CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality","volume":"180","author":"Lin","year":"2008","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.taap.2021.115645_bb0085","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1111\/gcb.13275","article-title":"A review of the relationships between drought and forest fire in the United States","volume":"22","author":"Littell","year":"2016","journal-title":"Glob. Chang. Biol."},{"key":"10.1016\/j.taap.2021.115645_bb0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.envres.2014.10.015","article-title":"A systematic review of the physical health impacts from non-occupational exposure to wildfire smoke","volume":"136","author":"Liu","year":"2015","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.taap.2021.115645_bb0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/08958378.2012.756086","article-title":"Adverse effects of wood smoke PM(2.5) exposure on macrophage functions","volume":"25","author":"Migliaccio","year":"2013","journal-title":"Inhal. Toxicol."},{"issue":"10","key":"10.1016\/j.taap.2021.115645_bb0100","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.4049\/jimmunol.1402295","article-title":"Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice","volume":"194","author":"Milner","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.taap.2021.115645_bb0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/08958370600985875","article-title":"Woodsmoke health effects: a review","volume":"19","author":"Naeher","year":"2007","journal-title":"Inhal. Toxicol."},{"issue":"5","key":"10.1016\/j.taap.2021.115645_bb0110","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.4049\/jimmunol.0904190","article-title":"Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation","volume":"186","author":"Pastva","year":"2011","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.taap.2021.115645_bb0115","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1073\/pnas.1718850115","article-title":"Rapid growth of the US wildland-urban interface raises wildfire risk","volume":"115","author":"Radeloff","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.taap.2021.115645_bb0120","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1164\/rccm.201807-1287OC","article-title":"Wood smoke exposure alters human inflammatory responses to viral infection in a sex-specific manner. A randomized, placebo-controlled study","volume":"199","author":"Rebuli","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.taap.2021.115645_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124047","article-title":"Induction of microglia activation after infection with the non-neurotropic a\/CA\/04\/2009 H1N1 influenza virus","volume":"10","author":"Sadasivan","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.taap.2021.115645_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075005","article-title":"Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection","volume":"8","author":"Seo","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.taap.2021.115645_bb0135","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1165\/rcmb.2013-0201OC","article-title":"Source of biomass cooking fuel determines pulmonary response to household air pollution","volume":"50","author":"Sussan","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4 Pt 1","key":"10.1016\/j.taap.2021.115645_bb0140","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1164\/ajrccm.161.4.9904084","article-title":"The human bone marrow response to acute air pollution caused by forest fires","volume":"161","author":"Tan","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"15","key":"10.1016\/j.taap.2021.115645_bb0145","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/JVI.00291-10","article-title":"Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice","volume":"84","author":"Tate","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.taap.2021.115645_bb0150","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.matbio.2018.01.027","article-title":"Hyaluronan interactions with innate immunity in lung biology","volume":"78-79","author":"Tighe","year":"2019","journal-title":"Matrix Biol."},{"issue":"9","key":"10.1016\/j.taap.2021.115645_bb0155","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.4049\/jimmunol.1101312","article-title":"Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation","volume":"187","author":"Tighe","year":"2011","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.taap.2021.115645_bb0160","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1165\/rcmb.2010-0471OC","article-title":"Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury","volume":"45","author":"Tighe","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2021.115645_bb0165","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12940-016-0093-4","article-title":"Repeating cardiopulmonary health effects in rural North Carolina population during a second large peat wildfire","volume":"15","author":"Tinling","year":"2016","journal-title":"Environ. Health"},{"issue":"6","key":"10.1016\/j.taap.2021.115645_bb0170","first-page":"492","article-title":"Markers for predicting death as an outcome for mice used in infectious disease research","volume":"61","author":"Trammell","year":"2011","journal-title":"Comp. Med."},{"issue":"5","key":"10.1016\/j.taap.2021.115645_bb0175","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1164\/ajrccm.164.5.2010160","article-title":"Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))","volume":"164","author":"van Eeden","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.taap.2021.115645_bb0180","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.1601959","article-title":"Sphingosine 1-phosphate Lyase enhances the activation of IKKepsilon to promote type I IFN-mediated innate immune responses to influenza a virus infection","volume":"199","author":"Vijayan","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2021.115645_bb0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fcimb.2018.00157","article-title":"Gr-1+ cells other than Ly6G+ neutrophils limit virus replication and promote myocardial inflammation and fibrosis following Coxsackievirus B3 infection of mice","volume":"8","author":"Xu","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"11","key":"10.1016\/j.taap.2021.115645_bb0190","doi-asserted-by":"crossref","first-page":"11772","DOI":"10.3390\/ijerph111111772","article-title":"Non-accidental health impacts of wildfire smoke","volume":"11","author":"Youssouf","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:56:32Z","timestamp":1758574592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21002490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":38,"alternative-id":["S0041008X21002490"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115645","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wood smoke particle exposure in mice reduces the severity of influenza infection","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115645"}}