{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:37:22Z","timestamp":1791326242185,"version":"4.3.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.taap.2021.115653","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T18:42:35Z","timestamp":1626892955000},"page":"115653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio"],"prefix":"10.1016","volume":"426","author":[{"given":"Olivia","family":"Venezia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia R.","family":"Timme-Laragy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karilyn E.","family":"Sant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115653_bb0005","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1073\/pnas.012610299","article-title":"Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer","volume":"99","author":"Barak","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2021.115653_bb0015","doi-asserted-by":"crossref","first-page":"104700","DOI":"10.1016\/j.tiv.2019.104700","article-title":"Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)","volume":"62","author":"Behr","year":"2020","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.taap.2021.115653_bb0020","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00394-016-1359-x","article-title":"Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPAR\u03b3) and vitamin D receptor (VDR) in lean male mice offspring","volume":"57","author":"Belenchia","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.taap.2021.115653_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2016.05.021","article-title":"Interleukin 6 modulates PPAR\u03b1 and PGC-1\u03b1 and is involved in high-fat diet induced cardiac lipotoxicity in mouse","volume":"219","author":"Bonda","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2021.115653_bb0030","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.139.6.6049","article-title":"Differential expression of peroxisome proliferator-activated receptor-\u03b1, \u2212\u03b2, and -\u03b3 during rat embryonic development*","volume":"139","author":"Braissant","year":"1998","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.taap.2021.115653_bb0035","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/bdr2.1215","article-title":"Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio)","volume":"110","author":"Brown","year":"2018","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.taap.2021.115653_bb0040","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8054","article-title":"Ciglitazone-a human PPAR\u03b3 agonist-disrupts dorsoventral patterning in zebrafish","volume":"7","author":"Cheng","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.taap.2021.115653_bb0045","doi-asserted-by":"crossref","first-page":"7508026","DOI":"10.1155\/2016\/7508026","article-title":"The correlation of PPAR\u03b1 activity and cardiomyocyte metabolism and structure in idiopathic dilated cardiomyopathy during heart failure progression","volume":"2016","author":"Czarnowska","year":"2016","journal-title":"PPAR Res."},{"key":"10.1016\/j.taap.2021.115653_bb0050","doi-asserted-by":"crossref","first-page":"358029","DOI":"10.1155\/2015\/358029","article-title":"Zebrafish as a model to study the role of peroxisome proliferating-activated receptors in adipogenesis and obesity","volume":"2015","author":"Den Broeder","year":"2015","journal-title":"PPAR Res."},{"key":"10.1016\/j.taap.2021.115653_bb0060","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1017\/S2040174415001440","article-title":"Programmed regulation of rat offspring adipogenic transcription factor (PPAR\u03b3) by maternal nutrition","volume":"6","author":"Desai","year":"2015","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.taap.2021.115653_bb0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/dbio.2002.0573","article-title":"Sonic hedgehog is required early in pancreatic islet development","volume":"244","author":"diIorio","year":"2002","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.taap.2021.115653_bb0070","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.RES.0000179226.34112.6d","article-title":"Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice","volume":"97","author":"Duan","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115653_bb0075","first-page":"E1702","article-title":"Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat","volume":"292","author":"Erhuma","year":"2007","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.taap.2021.115653_bb0080","doi-asserted-by":"crossref","first-page":"137579","DOI":"10.1155\/2013\/137579","article-title":"Lipotoxicity: effects of dietary saturated and transfatty acids","volume":"2013","author":"Estadella","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.taap.2021.115653_bb0085","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.celrep.2016.01.016","article-title":"Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid","volume":"14","author":"Fraher","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.taap.2021.115653_bb0090","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1242\/dev.02075","article-title":"Targeting of amacrine cell neurites to appropriate synaptic laminae in the developing zebrafish retina","volume":"132","author":"Godinho","year":"2005","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.taap.2021.115653_bb9073","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/molehr\/gal104","article-title":"PPARdelta and its activator PGI2 are reduced in diabetic embryopathy: involvement of PPARdelta activation in lipid metabolic and signalling pathways in rat embryo early organogenesis","volume":"13","author":"Higa","year":"2007","journal-title":"Mol Hum Reprod"},{"issue":"12","key":"10.1016\/j.taap.2021.115653_bb0095","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/dvdy.24683","article-title":"Ppar\u03b1 deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system","volume":"247","author":"Hsieh","year":"2018","journal-title":"Dev. Dynam."},{"issue":"2","key":"10.1016\/j.taap.2021.115653_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115653_bb0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00418-002-0434-y","article-title":"Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio)","volume":"118","author":"Ibabe","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.taap.2021.115653_bb0110","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1172\/JCI42127","article-title":"PPAR\u03b2\/\u03b4 affects pancreatic \u03b2 cell mass and insulin secretion in mice","volume":"122","author":"Iglesias","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2021.115653_bb0115","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.chemosphere.2017.12.094","article-title":"Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio)","volume":"195","author":"Jacobs","year":"2018","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.taap.2021.115653_bb0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/19396368.2014.991881","article-title":"The balancing act - PPAR-\u03b3\u2019s roles at the maternal-fetal interface","volume":"61","author":"Kadam","year":"2015","journal-title":"Syst. Biol. Reprod. Med."},{"issue":"1","key":"10.1016\/j.taap.2021.115653_bb0125","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000492875","article-title":"Targeting peroxisome proliferator activated receptor \u03b1 (PPAR \u03b1) for the prevention of mitochondrial impairment and hypertrophy in cardiomyocytes","volume":"49","author":"Kar","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.taap.2021.115653_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/toxics9030045","article-title":"Perfluoroalkyl acid binding with peroxisome proliferator-activated receptors \u03b1, \u03b3, and \u03b4, and fatty acid binding proteins by equilibrium dialysis with a comparison of methods","volume":"9","author":"Khazaee","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2021.115653_bb0135","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.2337\/diabetes.53.2007.S60","article-title":"Role of peroxisome proliferator-activated receptor-\u03b3 in the glucose-sensing apparatus of liver and \u03b2-cells","volume":"53","author":"Kim","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.taap.2021.115653_bb0140","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/en.2011-1635","article-title":"Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance","volume":"153","author":"Kim","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2021.115653_bb0145","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12862-016-0717-x","article-title":"Subfunctionalization of peroxisome proliferator response elements accounts for retention of duplicated fabp1 genes in zebrafish","volume":"16","author":"Laprairie","year":"2016","journal-title":"BMC Evol. Biol."},{"issue":"6","key":"10.1016\/j.taap.2021.115653_bb0150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1139\/gen-2016-0033","article-title":"Divergent evolution of cis-acting peroxisome proliferator-activated receptor elements that differentially control the tandemly duplicated fatty acid-binding protein genes, fabp1b.1 and fabp1b.2, in zebrafish","volume":"59","author":"Laprairie","year":"2016","journal-title":"Genome"},{"key":"10.1016\/j.taap.2021.115653_bb0155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbpb.2017.08.003","article-title":"Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors","volume":"213","author":"Laprairie","year":"2017","journal-title":"Comp. Biochem. Physiol. B"},{"key":"10.1016\/j.taap.2021.115653_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/954639","article-title":"PPARs and xenobiotic-induced adverse effects: relevance to human health","volume":"2010","author":"Lau","year":"2010","journal-title":"PPAR Res."},{"key":"10.1016\/j.taap.2021.115653_bb0165","doi-asserted-by":"crossref","first-page":"1378175","DOI":"10.1155\/2017\/1378175","article-title":"Collaborative power of Nrf2 and PPAR\u03b3 activators against metabolic and drug-induced oxidative injury","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.taap.2021.115653_bb0170","doi-asserted-by":"crossref","first-page":"19649","DOI":"10.1074\/jbc.M200743200","article-title":"T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115653_bb0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.15283\/ijsc.2009.2.1.28","article-title":"Role of peroxisome proliferator-activated receptor (PPAR)\u03b4 in embryonic stem cell proliferation","volume":"2","author":"Lee","year":"2009","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.taap.2021.115653_bb0180","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)","volume":"270","author":"Lehmann","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115653_bb0185","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1017\/S0007114507894438","article-title":"Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring","volume":"100","author":"Lillycrop","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.taap.2021.115653_bb0190","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ydbio.2004.02.023","article-title":"Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas","volume":"270","author":"Lin","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.taap.2021.115653_bb0195","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.taap.2021.115653_bb0200","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7150\/ijms.40417","article-title":"Circulating fatty acid-binding protein 1 (FABP1) and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus","volume":"17","author":"Lu","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115653_bb0205","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tiv.2012.09.018","article-title":"Assay of vtg, ERs and PPARs as endpoint for the rapid in vitro screening of the harmful effect of Di-(2-ethylhexyl)-phthalate (DEHP) and phthalic acid (PA) in zebrafish primary hepatocyte cultures","volume":"27","author":"Maradonna","year":"2013","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2021.115653_bb0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/jcm6030029","article-title":"Oxidative stress: A new target for pancreatic cancer prognosis and treatment","volume":"6","author":"Martinez-Useros","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.taap.2021.115653_bb0215","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/MPA.0000000000000129","article-title":"Pancreatic fat accumulation, fibrosis, and acinar cell injury in the Zucker diabetic fatty rat fed a chronic high-fat diet","volume":"43","author":"Matsuda","year":"2014","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.taap.2021.115653_bb0220","first-page":"105","article-title":"PPAR expression and function during vertebrate development","volume":"46","author":"Michalik","year":"2002","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.taap.2021.115653_bb0225","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0960-894X(01)00672-2","article-title":"Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPAR\u03b1-selective activators","volume":"12","author":"Miyachi","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.taap.2021.115653_bb0230","doi-asserted-by":"crossref","first-page":"549627","DOI":"10.1155\/2013\/549627","article-title":"Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases","volume":"2013","author":"Monsalve","year":"2013","journal-title":"Mediat. Inflamm."},{"issue":"7","key":"10.1016\/j.taap.2021.115653_bb0235","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/2211-5463.12240","article-title":"Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease","volume":"7","author":"Mukai","year":"2017","journal-title":"FEBS Open Bio."},{"issue":"1","key":"10.1016\/j.taap.2021.115653_bb0240","doi-asserted-by":"crossref","first-page":"G307","DOI":"10.1152\/ajpgi.00377.2007","article-title":"Diet-induced obesity and hepatic steatosis in L-Fabp \/ mice is abrogated with SF, but not PUFA, feeding and attenuated after cholesterol supplementation","volume":"294","author":"Newberry","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.taap.2021.115653_bb0245","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2016.01.014","article-title":"Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin","volume":"294","author":"Ouadah-Boussouf","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115653_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.311","article-title":"Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes","volume":"5","author":"Piran","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2021.115653_bb0255","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tig.2004.08.001","article-title":"Subfunction partitioning, the teleost radiation and the annotation of the human genome","volume":"20","author":"Postlethwait","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.taap.2021.115653_bb0260","doi-asserted-by":"crossref","first-page":"459030","DOI":"10.1155\/2008\/459030","article-title":"The roles of PPARs in the fetal origins of metabolic health and disease","volume":"2008","author":"Rees","year":"2008","journal-title":"PPAR Res."},{"key":"10.1016\/j.taap.2021.115653_bb0265","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40572-018-0183-2","article-title":"Zebrafish as a model for toxicological perturbation of yolk and nutrition in the early embryo","volume":"5","author":"Sant","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.taap.2021.115653_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/toxics4030020","article-title":"Assessment of toxicological perturbations and variants of pancreatic islet development in the Zebrafish model","volume":"4","author":"Sant","year":"2016","journal-title":"Toxics"},{"key":"10.1016\/j.taap.2021.115653_bb0275","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.envpol.2016.10.057","article-title":"Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio","volume":"220","author":"Sant","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2021.115653_bb0280","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.aquatox.2018.02.010","article-title":"Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio","volume":"198","author":"Sant","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.taap.2021.115653_bb0285","doi-asserted-by":"crossref","first-page":"116644","DOI":"10.1016\/j.envpol.2021.116644","article-title":"Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio","volume":"275","author":"Sant","year":"2021","journal-title":"Environ Pollut."},{"issue":"1","key":"10.1016\/j.taap.2021.115653_bb0290","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1017\/S2040174420000057","article-title":"Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling","volume":"12","author":"Sant","year":"2021","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.taap.2021.115653_bb0295","first-page":"2021","article-title":"Mathematical modeling of the interaction between yolk utilization and fish growth in zebrafish, Danio rerio","author":"Schwartz","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.taap.2021.115653_bb0300","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.taap.2021.115653_bb0305","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11892-014-0492-2","article-title":"Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?","volume":"14","author":"Sharma","year":"2014","journal-title":"Curr. Diabet. Rep."},{"key":"10.1016\/j.taap.2021.115653_bb0310","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1073\/pnas.052707099","article-title":"The peroxisome proliferator-activated receptor \u03b4, an integrator of transcriptional repression and nuclear receptor signaling","volume":"99","author":"Shi","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.taap.2021.115653_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048777","article-title":"Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults","volume":"7","author":"Shi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115653_bb0320","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12986-015-0012-7","article-title":"E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish","volume":"12","author":"Shimada","year":"2015","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.taap.2021.115653_bb0325","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/jm058056x","article-title":"Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPAR\u03b1 agonists. 1. Discovery of a novel series of potent HDLc raising agents","volume":"50","author":"Sierra","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.taap.2021.115653_bb0330","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/bdrc.20214","article-title":"Zebrafish: as an integrative model for twenty-first century toxicity testing","volume":"93","author":"Sipes","year":"2011","journal-title":"Birth Defects Res. C Embryo Today"},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2021.115653_bb0335","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.2337\/diabetes.53.2007.S71","article-title":"Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion","volume":"53","author":"Sugden","year":"2004","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.taap.2021.115653_bb0340","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/ani10122358","article-title":"mRNA expression and role of PPAR\u03b3 and PPAR\u03b4 in bovine preimplantation embryos depending on the quality and developmental stage","volume":"10","author":"Suwik","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.taap.2021.115653_bb0345","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","article-title":"Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta\/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate","volume":"95","author":"Takacs","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115653_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009797","article-title":"A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery","volume":"5","author":"Tiefenbach","year":"2010","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.taap.2021.115653_bb0355","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2009.04.018","article-title":"Zebrafish pancreas development","volume":"312","author":"Tiso","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.taap.2021.115653_bb0360","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/acs.estlett.5b00123","article-title":"Leveraging embryonic Zebrafish to prioritize ToxCast testing","volume":"2","author":"Volz","year":"2015","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.taap.2021.115653_bb0365","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.pharmthera.2009.12.001","article-title":"Peroxisome proliferator-activated receptor beta\/delta (PPARbeta\/delta) acts as regulator of metabolism linked to multiple cellular functions","volume":"125","author":"Wagner","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2021.115653_bb0370","doi-asserted-by":"crossref","first-page":"1930261","DOI":"10.1155\/2017\/1930261","article-title":"Oxidative stress in pancreatic beta cell regeneration","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"27","key":"10.1016\/j.taap.2021.115653_bb0375","doi-asserted-by":"crossref","first-page":"25279","DOI":"10.1074\/jbc.M101233200","article-title":"Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115653_bb0380","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/415813a","article-title":"Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR\u03b1","volume":"415","author":"Xu","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115653_bb0385","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.apsb.2012.05.003","article-title":"The role of fatty acid metabolism and lipotoxicity in pancreatic \u03b2-cell injury: identification of potential therapeutic targets","volume":"2","author":"Yang","year":"2012","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.taap.2021.115653_bb0390","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11695-019-04307-3","article-title":"Serum FABP1 levels correlate positively with obesity in Chinese patients after laparoscopic sleeve gastrectomy: a 12-month follow-up study","volume":"30","author":"You","year":"2020","journal-title":"Obes. Surg."},{"key":"10.1016\/j.taap.2021.115653_bb0395","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.reprotox.2014.09.015","article-title":"Inhibition of PPAR\u03b1 attenuates vimentin phosphorylation on Ser-83 and collapse of vimentin filaments during exposure of rat Sertoli cells in vitro to DBP","volume":"50","author":"Zhang","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.taap.2021.115653_bb0400","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1038\/srep08554","article-title":"Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100257X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100257X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:57:35Z","timestamp":1758574655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2100257X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":79,"alternative-id":["S0041008X2100257X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115653","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115653"}}