{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:32:32Z","timestamp":1773405152236,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670221"],"award-info":[{"award-number":["81670221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974227"],"award-info":[{"award-number":["81974227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.taap.2021.115654","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T09:12:00Z","timestamp":1627031520000},"page":"115654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["KLF15 negatively regulates cardiac fibrosis by which SDF-1\u03b2 attenuates cardiac fibrosis in type 2 diabetic mice"],"prefix":"10.1016","volume":"427","author":[{"given":"Yuanyuan","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavi","family":"Rane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115654_bb0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1097-2765(05)00014-6","article-title":"Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development","volume":"6","author":"Adams","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2021.115654_bb0010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1084\/jem.191.5.859","article-title":"Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells","volume":"191","author":"Allen","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11892-019-1239-x","article-title":"Diabetes and cardiovascular disease: an update","volume":"19","author":"Almourani","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.taap.2021.115654_bb0020","doi-asserted-by":"crossref","first-page":"8140","DOI":"10.1128\/JVI.00268-07","article-title":"A naturally occurring splice variant of CXCL12\/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities","volume":"81","author":"Altenburg","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.taap.2021.115654_bb0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yjmcc.2013.01.008","article-title":"Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation","volume":"57","author":"Bai","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2021.115654_bb0030","doi-asserted-by":"crossref","first-page":"35760","DOI":"10.1074\/jbc.M508234200","article-title":"The chemokine SDF-1\/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes","volume":"280","author":"Balabanian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115654_bb0035","doi-asserted-by":"crossref","first-page":"E1104","DOI":"10.1152\/ajpendo.2000.279.5.E1104","article-title":"Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db\/db) mice","volume":"279","author":"Belke","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.taap.2021.115654_bb0040","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.2337\/diabetes.53.12.3201","article-title":"Decreased sarcoplasmic reticulum activity and contractility in diabetic db\/db mouse heart","volume":"53","author":"Belke","year":"2004","journal-title":"Diabetes."},{"key":"10.1016\/j.taap.2021.115654_bb0045","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jvs.2010.10.056","article-title":"Inhibition of stromal cell-derived factor-1\u03b1 further impairs diabetic wound healing","volume":"53","author":"Bermudez","year":"2011","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.taap.2021.115654_bb0050","doi-asserted-by":"crossref","first-page":"34355","DOI":"10.1074\/jbc.R100043200","article-title":"Kr\u00fcppel-like factors: three fingers in many pies","volume":"276","author":"Bieker","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115654_bb0055","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1084\/jem.20052144","article-title":"A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development","volume":"203","author":"Burns","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0060","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s002400000134","article-title":"Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism","volume":"28","author":"Cai","year":"2000","journal-title":"Urol. Res."},{"key":"10.1016\/j.taap.2021.115654_bb0065","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00125-004-1403-x","article-title":"Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness","volume":"47","author":"Carey","year":"2004","journal-title":"Diabetologia."},{"key":"10.1016\/j.taap.2021.115654_bb0070","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1038\/srep16813","article-title":"Crosstalk between SDF-1\/CXCR4 and SDF-1\/CXCR7 in cardiac stem cell migration","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2021.115654_bb0075","doi-asserted-by":"crossref","first-page":"23814","DOI":"10.1074\/jbc.M909695199","article-title":"p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system","volume":"275","author":"Craig","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115654_bb0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2021.115654_bb0085","first-page":"1358","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"2007","author":"Cuenda","year":"1773","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2021.115654_bb0090","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1582-4934.2011.01301.x","article-title":"The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells","volume":"15","author":"Dai","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0095","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1582-4934.2011.01301.x","article-title":"The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells","volume":"15","author":"Dai","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0100","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1182\/blood-2003-08-2857","article-title":"Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity","volume":"103","author":"De La Luz","year":"2004","journal-title":"Blood."},{"key":"10.1016\/j.taap.2021.115654_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12681","article-title":"Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis","volume":"505","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115654_bb0110","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.bbrc.2005.09.174","article-title":"AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK","volume":"337","author":"Du","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2021.115654_bb0115","doi-asserted-by":"crossref","first-page":"13163","DOI":"10.1073\/pnas.0801059105","article-title":"Interleukin-6 regulates pancreatic alpha-cell mass expansion","volume":"105","author":"Ellingsgaard","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2021.115654_bb0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/er.2003-0012","article-title":"Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"25","author":"Fang","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2021.115654_bb0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tcm.2004.06.005","article-title":"An emerging role for Kr\u00fcppel-like factors in vascular biology","volume":"14","author":"Feinberg","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0130","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1073\/pnas.0701981104","article-title":"Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy","volume":"104","author":"Fisch","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2021.115654_bb0135","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/dvg.20387","article-title":"Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice","volume":"46","author":"Gerrits","year":"2008","journal-title":"Genesis"},{"key":"10.1016\/j.taap.2021.115654_bb0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pharmthera.2010.09.011","article-title":"SDF-1\u03b1 as a therapeutic stem cell homing factor in myocardial infarction","volume":"129","author":"Ghadge","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2021.115654_bb0145","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tem.2011.05.001","article-title":"New insights into insulin resistance in the diabetic heart","volume":"22","author":"Gray","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.taap.2021.115654_bb0150","doi-asserted-by":"crossref","first-page":"34322","DOI":"10.1074\/jbc.M201304200","article-title":"The Kr\u00fcppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4","volume":"277","author":"Gray","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115654_bb0155","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1002\/ijc.25245","article-title":"Overlapping and distinct role of CXCR7-SDF-1\/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas","volume":"127","author":"Grymula","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.taap.2021.115654_bb0160","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.1974.03230510023016","article-title":"Diabetic cardiomyopathy","volume":"229","author":"Hamby","year":"1974","journal-title":"Jama."},{"key":"10.1016\/j.taap.2021.115654_bb0165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-5273(00)00411-3","article-title":"Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients","volume":"77","author":"Hirayama","year":"2001","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2021.115654_bb0170","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/CIRCULATIONAHA.106.672451","article-title":"Stromal cell derived factor-1 alpha confers protection against myocardial ischemia\/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis","volume":"116","author":"Hu","year":"2007","journal-title":"Circulation."},{"key":"10.1016\/j.taap.2021.115654_bb0175","series-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2019"},{"key":"10.1016\/j.taap.2021.115654_bb0180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4161\/cam.3.3.8260","article-title":"Functional diversity of SDF-1 splicing variants","volume":"3","author":"Janowski","year":"2009","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.taap.2021.115654_bb0185","doi-asserted-by":"crossref","first-page":"27449","DOI":"10.1074\/jbc.M110.107292","article-title":"Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity","volume":"285","author":"Leenders","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115654_bb0190","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1096\/fj.201801809R","article-title":"Transactivation domain of Kr\u00fcppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis","volume":"33","author":"Lu","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2021.115654_bb0195","first-page":"2033","article-title":"Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress","volume":"43","author":"Luo","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/sctm.17-0172","article-title":"Role of SDF-1:CXCR4 in impaired post-myocardial infarction cardiac repair in diabetes","volume":"7","author":"Mayorga","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.taap.2021.115654_bb0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ebiom.2017.03.036","article-title":"Genetic variation in Kruppel like factor 15 is associated with left ventricular hypertrophy in patients with type 2 diabetes: discovery and replication cohorts","volume":"18","author":"Patel","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.taap.2021.115654_bb0210","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diabetes.55.03.06.db05-1284","article-title":"Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db\/db type 2 diabetic mice","volume":"55","author":"Pereira","year":"2006","journal-title":"Diabetes."},{"key":"10.1016\/j.taap.2021.115654_bb0215","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.taap.2021.115654_bb0220","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00125-009-1580-8","article-title":"Human IL6 enhances leptin action in mice","volume":"53","author":"Sadagurski","year":"2010","journal-title":"Diabetologia."},{"key":"10.1016\/j.taap.2021.115654_bb0225","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1161\/CIRCULATIONAHA.107.694992","article-title":"Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction","volume":"117","author":"Saxena","year":"2008","journal-title":"Circulation."},{"key":"10.1016\/j.taap.2021.115654_bb0230","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1161\/CIRCULATIONAHA.107.718718","article-title":"Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction","volume":"116","author":"Segers","year":"2007","journal-title":"Circulation."},{"key":"10.1016\/j.taap.2021.115654_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020680","article-title":"CXCR7 protein expression in human adult brain and differentiated neurons","volume":"6","author":"Shimizu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115654_bb0240","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/geno.1995.1180","article-title":"Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene","volume":"28","author":"Shirozu","year":"1995","journal-title":"Genomics."},{"key":"10.1016\/j.taap.2021.115654_bb0245","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/cvr\/cvp044","article-title":"A novel CXCR4 antagonist derived from human SDF-1beta enhances angiogenesis in ischaemic mice","volume":"82","author":"Tan","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.taap.2021.115654_bb0250","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.jacc.2011.12.034","article-title":"Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C\/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner","volume":"59","author":"Tan","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.taap.2021.115654_bb0255","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.4049\/jimmunol.179.8.5483","article-title":"Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway","volume":"179","author":"Tang","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.taap.2021.115654_bb0260","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.8342023","article-title":"Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins","volume":"261","author":"Tashiro","year":"1993","journal-title":"Science."},{"key":"10.1016\/j.taap.2021.115654_bb0265","doi-asserted-by":"crossref","first-page":"H911","DOI":"10.1152\/ajpheart.00124.2009","article-title":"Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus","volume":"297","author":"Thandavarayan","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2021.115654_bb0270","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2337\/diacare.19.10.1083","article-title":"Demonstration of regional sympathetic denervation of the heart in diabetes. Comparison between patients with NIDDM and IDDM","volume":"19","author":"Turpeinen","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.taap.2021.115654_bb0275","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.1128\/MCB.20.19.7319-7331.2000","article-title":"Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kr\u00fcppel-like factor, a novel zinc finger repressor","volume":"20","author":"Uchida","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2021.115654_bb0280","doi-asserted-by":"crossref","first-page":"H2680","DOI":"10.1152\/ajpheart.00395.2006","article-title":"Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27","volume":"291","author":"Venkatakrishnan","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.taap.2021.115654_bb0285","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.yjmcc.2008.05.005","article-title":"The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts","volume":"45","author":"Wang","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2021.115654_bb0290","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00592-020-01551-3","article-title":"Exendin-4 reverses high glucose-induced endothelial progenitor cell dysfunction via SDF-1\u03b2\/CXCR7-AMPK\/p38-MAPK\/IL-6 axis","volume":"57","author":"Yang","year":"2020","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.taap.2021.115654_bb0295","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.gene.2006.02.001","article-title":"Identification and expression of novel isoforms of human stromal cell-derived factor 1","volume":"374","author":"Yu","year":"2006","journal-title":"Gene."},{"key":"10.1016\/j.taap.2021.115654_bb0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000369382","article-title":"KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload","volume":"130","author":"Yu","year":"2015","journal-title":"Cardiology"},{"key":"10.1016\/j.taap.2021.115654_bb0305","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.2337\/db12-1233","article-title":"A novel mechanism by which SDF-1\u03b2 protects cardiac cells from palmitate-induced endoplasmic reticulum stress and apoptosis via CXCR7 and AMPK\/p38 MAPK-mediated interleukin-6 generation","volume":"62","author":"Zhao","year":"2013","journal-title":"Diabetes."},{"key":"10.1016\/j.taap.2021.115654_bb0310","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:55:22Z","timestamp":1758574522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21002581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":62,"alternative-id":["S0041008X21002581"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115654","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KLF15 negatively regulates cardiac fibrosis by which SDF-1\u03b2 attenuates cardiac fibrosis in type 2 diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115654","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115654"}}