{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:02:19Z","timestamp":1792065739201,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"am","delay-in-days":331,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0310112"],"award-info":[{"award-number":["JP20fk0310112"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.taap.2021.115659","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T02:37:56Z","timestamp":1627526276000},"page":"115659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Role of respiratory uncoupling in drug-induced mitochondrial permeability transition"],"prefix":"10.1016","volume":"427","author":[{"given":"Tomoyuki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115659_bb0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0005-2728(03)00110-5","article-title":"Rhodamine 123 as a probe of mitochondrial membrane potential: evaluation of proton flux through F(0) during ATP synthesis","volume":"1606","author":"Baracca","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2021.115659_bb0010","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2010.11.006","article-title":"Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver","volume":"54","author":"Begriche","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2021.115659_bb0015","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1016\/j.bbamcr.2016.02.012","article-title":"The mitochondrial permeability transition pore in AD 2016: an update","volume":"1863","author":"Biasutto","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2021.115659_bb0020","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nprot.2016.064","article-title":"Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques","volume":"11","author":"Bonora","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.taap.2021.115659_bb0025","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/1831525a0","article-title":"Inhibition of electron transport and the swelling of isolated mitochondria","volume":"183","author":"Chappell","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115659_bb0030","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jhep.2015.04.016","article-title":"Drug-induced liver injury: interactions between drug properties and host factors","volume":"63","author":"Chen","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2021.115659_bb0035","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1111\/j.1742-4658.2008.06550.x","article-title":"Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation","volume":"275","author":"Chirou","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.taap.2021.115659_bb0040","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1021\/tx7001349","article-title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening","volume":"20","author":"Coe","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2021.115659_bb0045","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0014-5793(97)00741-2","article-title":"Further studies on the recoupling effect of 6-ketocholestanol upon oxidative phosphorylation in uncoupled liver mitochondria","volume":"411","author":"Cuellar","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2021.115659_bb0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.drudis.2007.07.013","article-title":"The significance of mitochondrial toxicity testing in drug development","volume":"12","author":"Dykens","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.taap.2021.115659_bb0055","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1021\/acs.chemrestox.8b00132","article-title":"Development of a decision tree for mitochondrial dysfunction: uncoupling of oxidative phosphorylation","volume":"31","author":"Enoch","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2021.115659_bb0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bpc.2010.08.006","article-title":"A biophysical approach to phospholipase A2 activity and inhibition by anti-inflammatory drugs","volume":"152","author":"Gaspar","year":"2010","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.taap.2021.115659_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bj2680153","volume":"268","author":"Halestrap","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2021.115659_bb0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2014.08.018","article-title":"The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia\/reperfusion injury","volume":"78","author":"Halestrap","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.taap.2021.115659_bb0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.lfs.2011.02.006","article-title":"Protective action of tamoxifen on carboxyatractyloside-induced mitochondrial permeability transition","volume":"88","author":"Hernandez-Esquivel","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0080","doi-asserted-by":"crossref","first-page":"104889","DOI":"10.1016\/j.tiv.2020.104889","article-title":"Hypoxia\/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: possible application for toxicity screening","volume":"67","author":"Ikeyama","year":"2020","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.taap.2021.115659_bb0085","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1073\/pnas.1410104111","article-title":"Identifying the components of the elusive mitochondrial permeability transition pore","volume":"111","author":"Karch","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2021.115659_bb0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1472-8206.2008.00608.x","article-title":"Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies","volume":"22","author":"Labbe","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.taap.2021.115659_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2016.04.010","article-title":"Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes","volume":"302","author":"Liu","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115659_bb0100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/abbi.1997.0288","article-title":"Activation of liver mitochondrial phospholipase A2 by superoxide","volume":"346","author":"Madesh","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.taap.2021.115659_bb0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/toxsci\/kfm052","article-title":"Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants","volume":"97","author":"Marroquin","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0110","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0022-3565(24)35379-0","article-title":"Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs","volume":"292","author":"Masubuchi","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2021.115659_bb0115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.taap.2013.06.019","article-title":"Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes","volume":"272","author":"Nadanaciva","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115659_bb0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/toxsci\/kfs279","article-title":"The development of structure-activity relationships for mitochondrial dysfunction: uncoupling of oxidative phosphorylation","volume":"131","author":"Naven","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/03602532.2011.604086","article-title":"Central role of mitochondria in drug-induced liver injury","volume":"44","author":"Pessayre","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.taap.2021.115659_bb0130","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0021-9258(18)54034-5","article-title":"Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2(+)","volume":"268","author":"Petronilli","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115659_bb0135","doi-asserted-by":"crossref","first-page":"21939","DOI":"10.1016\/S0021-9258(20)80631-0","article-title":"Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria","volume":"268","author":"Petronilli","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115659_bb0140","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-3495(99)77239-5","article-title":"Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence","volume":"76","author":"Petronilli","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.taap.2021.115659_bb0145","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/KFS197","article-title":"Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria","volume":"129","author":"Porceddu","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0150","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1194\/jlr.M043307","article-title":"Regulation of the Ca2(+)-independent phospholipase A2 in liver mitochondria by changes in the energetic state","volume":"55","author":"Rauckhorst","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2021.115659_bb0155","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.febslet.2015.07.016","article-title":"The iPLA(2)gamma is identified as the membrane potential sensitive phospholipase in liver mitochondria","volume":"589","author":"Rauckhorst","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.taap.2021.115659_bb0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2014.05.009","article-title":"Mitochondria: the gateway for tamoxifen-induced liver injury","volume":"323","author":"Ribeiro","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2021.115659_bb0165","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2131\/jts.44.811","article-title":"Mild depolarization is involved in troglitazone-induced liver mitochondrial membrane permeability transition","volume":"44","author":"Sato","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0170","doi-asserted-by":"crossref","first-page":"12295","DOI":"10.1074\/jbc.272.19.12295","article-title":"On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal","volume":"272","author":"Scorrano","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115659_bb0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2131\/jts.43.339","article-title":"Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat","volume":"43","author":"Segawa","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2021.115659_bb0180","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2015.06.018","article-title":"Metabolic activation of hepatotoxic drug (benzbromarone) induced mitochondrial membrane permeability transition","volume":"288","author":"Shirakawa","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115659_bb0185","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1107\/S0907444906003660","article-title":"Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution","volume":"62","author":"Singh","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.taap.2021.115659_bb0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0005-2728(96)00134-X","article-title":"6-ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes","volume":"1318","author":"Starkov","year":"1997","journal-title":"BBA-Bioenergetics"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:56:39Z","timestamp":1758574599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21002635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":38,"alternative-id":["S0041008X21002635"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115659","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of respiratory uncoupling in drug-induced mitochondrial permeability transition","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115659"}}