{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:16:21Z","timestamp":1782850581465,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.taap.2021.115676","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:20:18Z","timestamp":1628598018000},"page":"115676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7"],"prefix":"10.1016","volume":"428","author":[{"given":"Stefanie Nicole","family":"Bothe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Lampert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115676_bb0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.en.41.010196.001115","article-title":"Ion channels as targets for insecticides","volume":"41","author":"Bloomquist","year":"1996","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.taap.2021.115676_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2165\/00139709-200524020-00003","article-title":"Poisoning due to pyrethroids","volume":"24","author":"Bradberry","year":"2005","journal-title":"Toxicol. Rev."},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2021.115676_bb0015","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.neuro.2009.09.002","article-title":"Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides","volume":"30","author":"Breckenridge","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0020","author":"Castle"},{"key":"10.1016\/j.taap.2021.115676_bb0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.taap.2005.06.022","article-title":"Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes","volume":"211","author":"Choi","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0030","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1113\/jphysiol.2009.169409","article-title":"Activation of neurokinin 3 receptor increases Na(v)1.9 current in enteric neurons","volume":"587","author":"Copel","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mcn.2004.01.015","article-title":"Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons","volume":"26","author":"Coste","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.taap.2021.115676_bb0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/15216540701352042","article-title":"DDT, pyrethrins, pyrethroids and insect sodium channels","volume":"59","author":"Davies","year":"2007","journal-title":"IUBMB Life"},{"key":"10.1016\/j.taap.2021.115676_bb0045","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/S0006-3495(96)79504-8","article-title":"Interaction between fast and slow inactivation in Skm1 sodium channels","volume":"71","author":"Featherstone","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.taap.2021.115676_bb0050","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/ps.5300","article-title":"Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I\/II mode of action","volume":"75","author":"Gammon","year":"2019","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.taap.2021.115676_bb0055","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s00424-015-1709-1","article-title":"Heterologous expression of NaV1.9 chimeras in various cell systems","volume":"467","author":"Goral","year":"2015","journal-title":"Pflugers Archiv."},{"key":"10.1016\/j.taap.2021.115676_bb0060","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1038\/srep25974","article-title":"Sodium channel slow inactivation interferes with open channel block","volume":"6","author":"Hampl","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2021.115676_bb0065","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1152\/jn.2001.86.3.1351","article-title":"Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons","volume":"86","author":"Herzog","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.taap.2021.115676_bb0070","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1172\/JCI92373","article-title":"Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability","volume":"127","author":"Huang","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2021.115676_bb0075","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuro.2016.12.005","article-title":"Consequences of acute Nav1.1 exposure to deltamethrin","volume":"60","author":"James","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0080","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuro.2011.02.007","article-title":"A use-dependent sodium current modification induced by type I pyrethroid insecticides in honeybee antennal olfactory receptor neurons","volume":"32","author":"Kadala","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0085","series-title":"Sodium Channels","year":"2011"},{"key":"10.1016\/j.taap.2021.115676_bb0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-3-642-41588-3_5","article-title":"Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents","volume":"221","author":"Lampert","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0095","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ng.2767","article-title":"A de novo gain-of-function mutation in SCN11A causes loss of pain perception","volume":"45","author":"Leipold","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.taap.2021.115676_bb0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1085\/jgp.200709935","article-title":"Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism","volume":"131","author":"Maingret","year":"2008","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00424-004-1315-0","article-title":"Electrophysiological characterization of the tetrodotoxin-resistant Na+ channel, Na(v)1.9, in mouse dorsal root ganglion neurons","volume":"449","author":"Maruyama","year":"2004","journal-title":"Pflugers Archiv."},{"key":"10.1016\/j.taap.2021.115676_bb0110","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/j.pain.0000000000001511","article-title":"The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients","volume":"160","author":"Meents","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.taap.2021.115676_bb0115","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.taap.2014.04.005","article-title":"Persistent modification of Nav1.9 following chronic exposure to insecticides and pyridostigmine bromide","volume":"277","author":"Nutter","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuro.2013.08.006","article-title":"Persistent Na+ and K+ channel dysfunctions after chronic exposure to insecticides and pyridostigmine bromide","volume":"39","author":"Nutter","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0125","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/BJ20051925","article-title":"Modelling insecticide-binding sites in the voltage-gated sodium channel","volume":"396","author":"O'Reilly","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.taap.2021.115676_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041667","article-title":"Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channel","volume":"7","author":"O\u2019Reilly","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115676_bb0135","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ps.3561","article-title":"Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites","volume":"70","author":"O\u2019Reilly","year":"2014","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.taap.2021.115676_bb0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1085\/jgp.201812149","article-title":"Progress in understanding slow inactivation speeds up","volume":"150","author":"Payandeh","year":"2018","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nature11077","article-title":"Crystal structure of a voltage-gated sodium channel in two potentially inactivated states","volume":"486","author":"Payandeh","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115676_bb0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pharmthera.2005.10.003","article-title":"A reassessment of the neurotoxicity of pyrethroid insecticides","volume":"111","author":"Ray","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.taap.2021.115676_bb0155","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","article-title":"Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons","volume":"86","author":"Renganathan","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.taap.2021.115676_bb0160","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1016\/S0006-3495(98)78001-4","article-title":"Slow inactivation in human cardiac sodium channels","volume":"74","author":"Richmond","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.taap.2021.115676_bb0165","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1111\/bph.15196","article-title":"Uncoupling sodium channel dimers restores the phenotype of a pain-linked Nav 1.7 channel mutation","volume":"177","author":"R\u00fchlmann","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(87)91645-3","article-title":"Increase of sodium current after pyrethroid insecticides in mouse neuroblastoma cells","volume":"437","author":"Ruigt","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2021.115676_bb0175","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/164_2017_91","article-title":"Translational model systems for complex sodium channel pathophysiology in pain","volume":"246","author":"Schrenk-Siemens","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0180","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1113\/jphysiol.2006.127027","article-title":"A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity","volume":"581","author":"Sheets","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0185","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aaw2493","article-title":"Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins","volume":"363","author":"Shen","year":"2019","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.taap.2021.115676_bb0190","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1520-6327(1998)38:3<126::AID-ARCH3>3.0.CO;2-Q","article-title":"Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes","volume":"38","author":"Smith","year":"1998","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0195","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00204-011-0726-x","article-title":"Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances","volume":"86","author":"Soderlund","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2021.115676_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0300-483X(01)00569-8","article-title":"Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment","volume":"171","author":"Soderlund","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0205","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0022-3565(24)37324-0","article-title":"Potent modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by the type II pyrethroid deltamethrin","volume":"284","author":"Tabarean","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2021.115676_bb0210","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0022-3565(24)29221-1","article-title":"Kinetics of modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by tetramethrin and deltamethrin","volume":"299","author":"Tabarean","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.taap.2021.115676_bb0215","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuro.2008.10.008","article-title":"Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin","volume":"30","author":"Tan","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2021.115676_bb0220","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.taap.2010.07.001","article-title":"Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na(v)1.6 sodium channels","volume":"247","author":"Tan","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pestbp.2011.06.001","article-title":"Actions of tefluthrin on rat Na(v)1.7 voltage-gated sodium channels expressed in xenopus oocytes","volume":"101","author":"Tan","year":"2011","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2020.105844","article-title":"Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and \u03b24-peptide on human cardiac Nav1.5 sodium channel gating properties","volume":"31","author":"Thull","year":"2020","journal-title":"Data Brief"},{"key":"10.1016\/j.taap.2021.115676_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115010","article-title":"Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5","volume":"397","author":"Thull","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0240","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1152\/physrev.00024.2004","article-title":"Sodium channel inactivation: molecular determinants and modulation","volume":"85","author":"Ulbricht","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.taap.2021.115676_bb0245","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1085\/jgp.115.3.305","article-title":"Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations","volume":"115","author":"Vais","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0250","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1385\/CBB:35:2:171","article-title":"Slow inactivation in voltage-gated sodium channels: molecular substrates and contributions to channelopathies","volume":"35","author":"Vilin","year":"2001","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.taap.2021.115676_bb0255","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0026-895X(24)12626-0","article-title":"A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action","volume":"60","author":"Wang","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.taap.2021.115676_bb0260","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.110.2.119","article-title":"Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology","volume":"110","author":"Warmke","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.taap.2021.115676_bb0265","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cortex.2015.08.022","article-title":"Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: effects of toxicant exposures during deployment","volume":"74","author":"White","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.taap.2021.115676_bb0270","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2017.06.039","article-title":"Structure of the Nav1.4-\u03b21 complex from electric eel","volume":"170","author":"Yan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.taap.2021.115676_bb0275","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nature11054","article-title":"Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel","volume":"486","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115676_bb0280","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3389\/fphar.2017.00852","article-title":"Electrophysiological and pharmacological analyses of Nav1.9 voltage-gated sodium channel by establishing a heterologous expression system","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21002805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:55:18Z","timestamp":1758574518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21002805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":56,"alternative-id":["S0041008X21002805"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115676","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The insecticide deltamethrin enhances sodium channel slow inactivation of human Nav1.9, Nav1.8 and Nav1.7","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115676"}}