{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:07:29Z","timestamp":1793995649310,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170443"],"award-info":[{"award-number":["82170443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800372"],"award-info":[{"award-number":["81800372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004083"],"award-info":[{"award-number":["82004083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770426"],"award-info":[{"award-number":["81770426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700373"],"award-info":[{"award-number":["81700373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021SF-153"],"award-info":[{"award-number":["2021SF-153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.taap.2021.115701","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T10:49:05Z","timestamp":1629888545000},"page":"115701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat"],"prefix":"10.1016","volume":"429","author":[{"given":"Hong-Bao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Lu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Meng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115701_bb0005","doi-asserted-by":"crossref","first-page":"108318","DOI":"10.1016\/j.jnutbio.2019.108318","article-title":"Kefir ameliorates hypertension via gut-brain mechanisms in spontaneously hypertensive rats","volume":"77","author":"de Almeida Silva","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.taap.2021.115701_bb0010","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12967-019-2006-0","article-title":"Adipose afferent reflex is enhanced by TNFalpha in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats","volume":"17","author":"Ding","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.taap.2021.115701_bb0015","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115701_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063061","article-title":"Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases","volume":"22","author":"Gasaly","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2021.115701_bb0025","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","article-title":"Oxidative stress and hypertension","volume":"128","author":"Griendling","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0030","doi-asserted-by":"crossref","first-page":"108212","DOI":"10.1016\/j.jnutbio.2019.07.003","article-title":"Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFkappaB-mediated NLRP3 expression in spontaneously hypertensive rats","volume":"72","author":"Han","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.taap.2021.115701_bb0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/CS20180087","article-title":"Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure","volume":"132","author":"Kim","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2021.115701_bb0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","article-title":"Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.taap.2014.06.004","article-title":"Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension","volume":"279","author":"Li","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115701_bb0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.taap.2016.06.014","article-title":"TLR4\/MyD88\/NF-kappaB signaling and PPAR-gamma within the paraventricular nucleus are involved in the effects of telmisartan in hypertension","volume":"305","author":"Li","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115701_bb0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40168-016-0222-x","article-title":"Gut microbiota dysbiosis contributes to the development of hypertension","volume":"5","author":"Li","year":"2017","journal-title":"Microbiome."},{"key":"10.1016\/j.taap.2021.115701_bb0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2018.12.020","article-title":"Silencing salusin beta ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK\/NF-kappaB pathways in the paraventricular nucleus","volume":"280","author":"Li","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.taap.2021.115701_bb0065","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1161\/HYPERTENSIONAHA.120.14736","article-title":"Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male offspring","volume":"75","author":"Li","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0070","article-title":"Altered gut microbiota is involved in the anti-hypertensive effects of vitamin C in spontaneously hypertensive rat","volume":"65","author":"Li","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2021.115701_bb0075","doi-asserted-by":"crossref","first-page":"412946","DOI":"10.1155\/2015\/412946","article-title":"Neuroprotective effects of clostridium butyricum against vascular dementia in mice via metabolic butyrate","volume":"2015","author":"Liu","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.taap.2021.115701_bb0080","first-page":"631","article-title":"Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies","volume":"31","author":"Montezano","year":"2015","journal-title":"Can. J. Cardiol"},{"key":"10.1016\/j.taap.2021.115701_bb0085","doi-asserted-by":"crossref","first-page":"43259","DOI":"10.1038\/srep43259","article-title":"Silencing salusin-beta attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats","volume":"7","author":"Ren","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2021.115701_bb0090","doi-asserted-by":"crossref","first-page":"13626","DOI":"10.1096\/fj.202001532R","article-title":"Probiotic Bifidobacterium breve prevents DOCA-salt hypertension","volume":"34","author":"Robles-Vera","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2021.115701_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900616","article-title":"Probiotics prevent dysbiosis and the rise in blood pressure in genetic hypertension: role of short-chain fatty acids","volume":"64","author":"Robles-Vera","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2021.115701_bb0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.phrs.2018.03.009","article-title":"Curcumin in heart failure: a choice for complementary therapy?","volume":"131","author":"Saeidinia","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0105","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCRESAHA.116.309006","article-title":"Hypertension-linked pathophysiological alterations in the gut","volume":"120","author":"Santisteban","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0110","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/HYPERTENSIONAHA.118.10934","article-title":"Involvement of neuroinflammation in the pathogenesis of monocrotaline-induced pulmonary hypertension","volume":"71","author":"Sharma","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0115","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCRESAHA.118.313882","article-title":"Microglial cells impact gut microbiota and gut pathology in angiotensin II-induced hypertension","volume":"124","author":"Sharma","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/HYPERTENSIONAHA.120.14931","article-title":"Gut pathology and its rescue by ACE2 (angiotensin-converting enzyme 2) in hypoxia-induced pulmonary hypertension","volume":"76","author":"Sharma","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.taap.2014.02.002","article-title":"Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension","volume":"276","author":"Su","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115701_bb0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2015.12.047","article-title":"Clostridium butyricum pretreatment attenuates cerebral ischemia\/reperfusion injury in mice via anti-oxidation and anti-apoptosis","volume":"613","author":"Sun","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.taap.2021.115701_bb0135","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-immunol-051116-052235","article-title":"Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation","volume":"35","author":"Tan","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.taap.2021.115701_bb0140","doi-asserted-by":"crossref","first-page":"657825","DOI":"10.3389\/fnins.2021.657825","article-title":"beta-Arrestin1 reduces oxidative stress via Nrf2 activation in the rostral ventrolateral medulla in hypertension","volume":"15","author":"Tan","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.taap.2021.115701_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13285","article-title":"Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats","volume":"227","author":"Toral","year":"2019","journal-title":"Acta Physiol (Oxford)"},{"key":"10.1016\/j.taap.2021.115701_bb0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fphys.2019.00231","article-title":"Critical role of the interaction gut microbiota -sympathetic nervous system in the regulation of blood pressure","volume":"10","author":"Toral","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.taap.2021.115701_bb0155","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1161\/CIRCRESAHA.117.310672","article-title":"Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap?","volume":"120","author":"Touyz","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.taap.2021.115701_bb0160","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/C7FO01242J","article-title":"Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives","volume":"9","author":"Tsuda","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.taap.2021.115701_bb0165","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.120.15026","article-title":"2020 international society of hypertension global hypertension practice guidelines","volume":"75","author":"Unger","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0170","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1042\/CS20190171","article-title":"Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.taap.2021.115701_bb0175","doi-asserted-by":"crossref","first-page":"103493","DOI":"10.1016\/j.mcn.2020.103493","article-title":"Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells","volume":"105","author":"Wenzel","year":"2020","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.taap.2021.115701_bb0180","first-page":"e13","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1854642","article-title":"Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat","volume":"13","author":"Xia","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.taap.2021.115701_bb0190","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1161\/HYPERTENSIONAHA.115.05315","article-title":"Gut dysbiosis is linked to hypertension","volume":"65","author":"Yang","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.taap.2021.115701_bb0195","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41581-018-0018-2","article-title":"The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease","volume":"14","author":"Yang","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.taap.2021.115701_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13256","article-title":"Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats","volume":"226","author":"Yang","year":"2019","journal-title":"Acta Physiol (Oxford)"},{"key":"10.1016\/j.taap.2021.115701_bb0205","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.1021\/acs.jafc.9b02083","article-title":"Sodium butyrate improves liver glycogen metabolism in type 2 diabetes mellitus","volume":"67","author":"Zhang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2021.115701_bb0210","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fphar.2018.00472","article-title":"Curcumin, a polyphenolic Curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy","volume":"9","author":"Zheng","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.taap.2021.115701_bb0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1161\/CIRCRESAHA.119.313965","article-title":"Impaired autonomic nervous system-microbiome circuit in hypertension","volume":"125","author":"Zubcevic","year":"2019","journal-title":"Circ. Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21003057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21003057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:58:23Z","timestamp":1778633903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21003057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":43,"alternative-id":["S0041008X21003057"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115701","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115701"}}