{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:54:16Z","timestamp":1769550856769,"version":"3.49.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.taap.2021.115773","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T07:46:56Z","timestamp":1634888816000},"page":"115773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Inferred inactivation of the Cftr gene in the duodena of mice exposed to hexavalent chromium (Cr(VI)) in drinking water supports its tumor-suppressor status and implies its potential role in Cr(VI)-induced carcinogenesis of the small intestines"],"prefix":"10.1016","volume":"433","author":[{"given":"Roman","family":"Mezencev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott S.","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2 Suppl","key":"10.1016\/j.taap.2021.115773_bb0005","first-page":"P117","article-title":"CFTR modulation by the tobacco smoke toxin Acrolein","volume":"145","author":"Alexander","year":"2011","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0010","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1039\/b903049b","article-title":"Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium","volume":"1","author":"Arita","year":"2009","journal-title":"Metallomics\u202f: integrated biometal science"},{"key":"10.1016\/j.taap.2021.115773_bb0015","series-title":"The NCBI Handbook","first-page":"349","article-title":"Gene expression omnibus (GEO)","author":"Barrett","year":"2013"},{"issue":"21","key":"10.1016\/j.taap.2021.115773_bb0020","doi-asserted-by":"crossref","first-page":"17130","DOI":"10.1074\/jbc.M111.338855","article-title":"Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells","volume":"287","author":"Bomberger","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0025","doi-asserted-by":"crossref","first-page":"G222","DOI":"10.1152\/ajpgi.00405.2006","article-title":"Intestinal phenotype of variable-weight cystic fibrosis knockout mice","volume":"293","author":"Canale-Zambrano","year":"2007","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"issue":"10","key":"10.1016\/j.taap.2021.115773_bb0030","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1164\/rccm.200508-1330OC","article-title":"Cystic Fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers","volume":"173","author":"Cantin","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0035","doi-asserted-by":"crossref","first-page":"C262","DOI":"10.1152\/ajpcell.00070.2005","article-title":"Oxidant stress suppresses CFTR expression","volume":"290","author":"Cantin","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0040","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/ijerph110100202","article-title":"Toxic metal concentrations in cigarettes obtained from US smokers in 2009: results from the international tobacco control (ITC) United States survey cohort","volume":"11","author":"Caruso","year":"2014","journal-title":"Int J Env Res Public Health"},{"key":"10.1016\/j.taap.2021.115773_bb0045","series-title":"Clinical and Functional Translation of CFTR. cftr2.org In., 01-10-2020 edn","author":"CFTR2","year":"2021"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0050","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/toxsci\/kfaa187","article-title":"Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens","volume":"180","author":"Chappell","year":"2021","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1096\/fj.11-192377","article-title":"Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration","volume":"26","author":"Clunes","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2021.115773_bb0060","author":"CFGA"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0065","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1158\/1940-6207.CAPR-17-0130","article-title":"Chemoprevention with cyclooxygenase and epidermal growth factor receptor inhibitors in familial adenomatous polyposis patients: mRNA signatures of duodenal neoplasia","volume":"11","author":"Delker","year":"2018","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.taap.2021.115773_bb0070","first-page":"9(24)","article-title":"The effect of hexavalent chromium on the incidence and mortality of human cancers: a meta-analysis based on published epidemiological cohort studies","author":"Deng","year":"2019","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0075","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1378\/chest.13-0274","article-title":"Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD","volume":"144","author":"Dransfield","year":"2013","journal-title":"Chest"},{"issue":"147","key":"10.1016\/j.taap.2021.115773_bb0080","doi-asserted-by":"crossref","first-page":"170122","DOI":"10.1183\/16000617.0122-2017","article-title":"Cadmium in tobacco smokers: a neglected link to lung disease?","volume":"27","author":"Ganguly","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.taap.2021.115773_bb0085","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.lfs.2016.02.074","article-title":"Weighted gene co-expression network analysis of pneumocytes under exposure to a carcinogenic dose of chloroprene","volume":"151","author":"Guo","year":"2016","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.taap.2021.115773_bb0090","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.taap.2021.115773_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050837","article-title":"MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung","volume":"7","author":"Hassan","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1465-9921-15-69","article-title":"Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels","volume":"15","author":"Hassan","year":"2014","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2021.115773_bb0105","first-page":"21(13)","article-title":"NRF2, a transcription factor for stress response and beyond","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.taap.2021.115773_bb0110","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/jnci\/91.14.1194","article-title":"Tobacco smoke carcinogens and lung Cancer","volume":"91","author":"Hecht","year":"1999","journal-title":"JNCI: Journal of the National Cancer Institute"},{"key":"10.1016\/j.taap.2021.115773_bb0115","doi-asserted-by":"crossref","first-page":"172598","DOI":"10.1016\/j.ejphar.2019.172598","article-title":"Sulfonylurea derivatives and cancer, friend or foe?","volume":"861","author":"Hendriks","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.taap.2021.115773_bb0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/00039896.1994.9937483","article-title":"Contribution of cadmium in cigarettes to lung cancer: an evaluation of risk assessment methodologies","volume":"49","author":"Hertz-Picciotto","year":"1994","journal-title":"Arch. Environ. Health"},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0125","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4251\/wjgo.v8.i3.282","article-title":"Emerging role of cystic fibrosis transmembrane conductance regulator - an epithelial chloride channel in gastrointestinal cancers","volume":"8","author":"Hou","year":"2016","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.taap.2021.115773_bb0135","series-title":"Arsenic, Metals, Fibres and Dusts","volume":"vol. 100C","author":"International Agency for Research on Cancer","year":"2012"},{"key":"10.1016\/j.taap.2021.115773_bb0140","series-title":"GeneReviews\u00ae[Internet]. edn","article-title":"APC-associated polyposis conditions","author":"Jasperson","year":"2017"},{"issue":"9","key":"10.1016\/j.taap.2021.115773_bb0145","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11427-012-4369-9","article-title":"Ion channels\/transporters as epigenetic regulators? \u2014a microRNA perspective","volume":"55","author":"Jiang","year":"2012","journal-title":"Sci. China Life Sci."},{"issue":"12","key":"10.1016\/j.taap.2021.115773_bb0150","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1002\/ijc.24679","article-title":"Cancer risk among patients with cystic fibrosis and their first-degree relatives","volume":"125","author":"Johannesson","year":"2009","journal-title":"Int. J. Cancer"},{"issue":"31","key":"10.1016\/j.taap.2021.115773_bb0155","doi-asserted-by":"crossref","first-page":"27912","DOI":"10.1074\/jbc.M110288200","article-title":"Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator","volume":"277","author":"Jungas","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.taap.2021.115773_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.06.024","article-title":"Nasal polyps and future risk of head and neck cancer: A&#xa0;nationwide population-based cohort study","volume":"144","author":"Kim","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2011.11.012","article-title":"Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water","volume":"259","author":"Kopec","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.taap.2012.04.026","article-title":"Comparative toxicogenomic analysis of oral Cr (VI) exposure effects in rat and mouse small intestinal epithelia","volume":"262","author":"Kopec","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.taap.2021.115773_bb0175","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1289\/ehp.0900911","article-title":"Low-dose arsenic compromises the immune response to influenza a infection in vivo","volume":"117","author":"Kozul","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.taap.2021.115773_bb0180","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1289\/ehp.0800199","article-title":"Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung","volume":"117","author":"Kozul","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.taap.2021.115773_bb0185","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2013","journal-title":"Bioinformatics"},{"issue":"Suppl. 57","key":"10.1016\/j.taap.2021.115773_bb0190","article-title":"The impact of genotype on clinical course of cystic fibrosis (CF) in adult patients","volume":"42","author":"Krasovskij","year":"2013","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.taap.2021.115773_bb0195","first-page":"L894","article-title":"Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract","volume":"288","author":"Kreindler","year":"2005","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"9","key":"10.1016\/j.taap.2021.115773_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013066","article-title":"Ontology-based Meta-analysis of global collections of high-throughput public data","volume":"5","author":"Kupershmidt","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.taap.2021.115773_bb0205","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.3892\/ijo.2015.2921","article-title":"The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer","volume":"46","author":"Li","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.taap.2021.115773_bb0210","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell systems"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0215","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/19336950.2018.1502585","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR): making an ion channel out of an active transporter structure","volume":"12","author":"Linsdell","year":"2018","journal-title":"Channels"},{"key":"10.1016\/j.taap.2021.115773_bb0220","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.2147\/CMAR.S248539","article-title":"CFTR functions as a tumor suppressor and is regulated by DNA methylation in colorectal Cancer","volume":"12","author":"Liu","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0225","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/jnci\/djs481","article-title":"Cancer risk in cystic Fibrosis: a 20-year Nationwide study from the United States","volume":"105","author":"Maisonneuve","year":"2012","journal-title":"JNCI: Journal of the National Cancer Institute"},{"issue":"12","key":"10.1016\/j.taap.2021.115773_bb0230","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ng.990","article-title":"Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis","volume":"43","author":"March","year":"2011","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0235","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/cncr.24697","article-title":"Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma","volume":"116","author":"McWilliams","year":"2010","journal-title":"Cancer"},{"issue":"11","key":"10.1016\/j.taap.2021.115773_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013984","article-title":"Enrichment map: a network-based method for gene-set enrichment visualization and interpretation","volume":"5","author":"Merico","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.taap.2021.115773_bb0245","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJM199502233320803","article-title":"The risk of cancer among patients with cystic fibrosis","volume":"332","author":"Neglia","year":"1995","journal-title":"New Engl J Med"},{"issue":"6","key":"10.1016\/j.taap.2021.115773_bb0250","doi-asserted-by":"crossref","first-page":"G1032","DOI":"10.1152\/ajpgi.00473.2003","article-title":"Inflammation of the cystic fibrosis mouse small intestine","volume":"286","author":"Norkina","year":"2004","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"issue":"9","key":"10.1016\/j.taap.2021.115773_bb0255","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1136\/gutjnl-2011-300812","article-title":"Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer","volume":"61","author":"Oh","year":"2012","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.taap.2021.115773_bb0260","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/thx.2009.119347","article-title":"A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the health effects of arsenic longitudinal study (HEALS)","volume":"65","author":"Parvez","year":"2010","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0265","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.1152\/physrev.1999.79.1.S215","article-title":"Role of CFTR in airway disease","volume":"79","author":"Pilewski","year":"1999","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.taap.2021.115773_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047405","article-title":"Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90","volume":"7","author":"Prota","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0275","first-page":"L77","article-title":"TGF-\u03b21 downregulates CFTR expression and function in nasal polyps of non-CF patients","volume":"288","author":"Pruli\u00e8re-Escabasse","year":"2005","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0280","doi-asserted-by":"crossref","first-page":"C756","DOI":"10.1152\/ajpcell.00391.2006","article-title":"Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression","volume":"292","author":"Rab","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0285","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/toxsci\/kfx085","article-title":"High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr (VI) exposure","volume":"158","author":"Rager","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0290","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfq101","article-title":"Cadmium regulates the expression of the CFTR chloride channel in human airway epithelial cells","volume":"116","author":"Rennolds","year":"2010","journal-title":"Toxicological sciences\u202f: an official journal of the Society of Toxicology"},{"issue":"5","key":"10.1016\/j.taap.2021.115773_bb0295","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1046\/j.1469-1809.2003.00028.x","article-title":"The phenotypic consequences of CFTR mutations","volume":"67","author":"Rowntree","year":"2003","journal-title":"Ann. Hum. Genet."},{"issue":"10","key":"10.1016\/j.taap.2021.115773_bb0300","doi-asserted-by":"crossref","first-page":"e817","DOI":"10.1038\/cddis.2013.355","article-title":"Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity","volume":"4","author":"Rubera","year":"2013","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0305","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/02698590701498084","article-title":"Interpreting causality in the health sciences","volume":"21","author":"Russo","year":"2007","journal-title":"Int. Stud. Philos. Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0310","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-016-2391-y","article-title":"Role of CFTR in epithelial physiology","volume":"74","author":"Saint-Criq","year":"2017","journal-title":"Cellular and molecular life sciences\u202f: CMLS"},{"key":"10.1016\/j.taap.2021.115773_bb0315","first-page":"38","article-title":"Cancer risk in patients with cystic fibrosis: the European data. CF\/CSG Group","volume":"89","author":"Sch\u00f6ni","year":"1996","journal-title":"J R Soc Med"},{"issue":"8","key":"10.1016\/j.taap.2021.115773_bb0320","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.3390\/ijms21082891","article-title":"Cystic Fibrosis, CFTR, and colorectal Cancer","volume":"21","author":"Scott","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2021.115773_bb0325","series-title":"Industry Profile, Exposure Profile, Technological Feasibility Evaluation, and Environmental Impact for Industries Affected by a Proposed OSHA Standard for Hexavalent Chromium","author":"Shaw Environmental Inc","year":"2006"},{"issue":"Pt 2","key":"10.1016\/j.taap.2021.115773_bb0330","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1469-7793.1997.333bh.x","article-title":"Mechanism of glibenclamide inhibition of cystic fibrosis transmembrane conductance regulator cl- channels expressed in a murine cell line","volume":"503","author":"Sheppard","year":"1997","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.taap.2021.115773_bb0335","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/aje\/kwq383","article-title":"Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis","volume":"173","author":"Smith","year":"2011","journal-title":"Am. J. Epidemiol."},{"issue":"5\u20136","key":"10.1016\/j.taap.2021.115773_bb0340","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000094139","article-title":"Arsenic inhibits CFTR-mediated chloride secretion by killifish (Fundulus heteroclitus) Opercular membrane","volume":"17","author":"Stanton","year":"2006","journal-title":"Cell. Physiol. Biochem."},{"issue":"5922","key":"10.1016\/j.taap.2021.115773_bb0345","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1126\/science.1163040","article-title":"A transposon-based genetic screen in mice identifies genes altered in colorectal Cancer","volume":"323","author":"Starr","year":"2009","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.taap.2021.115773_bb0350","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.0800208","article-title":"Hexavalent chromium is carcinogenic to F344\/N rats and B6C3F1 mice after chronic oral exposure","volume":"117","author":"Stout","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0355","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jcmgh.2017.11.013","article-title":"Cftr Modulates Wnt\/&#x3b2;-Catenin Signaling and Stem Cell Proliferation in Murine Intestine","volume":"5","author":"Strubberg","year":"2018","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0360","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jat.3894","article-title":"The NTP report on carcinogens: a valuable resource for public health, a challenge for regulatory science","volume":"40","author":"Suarez-Torres","year":"2020","journal-title":"J. Appl. Toxicol."},{"issue":"43","key":"10.1016\/j.taap.2021.115773_bb0365","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0370","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbamcr.2013.12.013","article-title":"Disrupted interaction between CFTR and AF-6\/afadin aggravates malignant phenotypes of colon cancer","volume":"1843","author":"Sun","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0375","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ng.3175","article-title":"Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression","volume":"47","author":"Takeda","year":"2015","journal-title":"Nat. Genet."},{"issue":"D1","key":"10.1016\/j.taap.2021.115773_bb0380","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"32","key":"10.1016\/j.taap.2021.115773_bb0385","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1038\/onc.2015.483","article-title":"CFTR is a tumor suppressor gene in murine and human intestinal cancer","volume":"35","author":"Than","year":"2016","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0390","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/toxsci\/kfr164","article-title":"Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium","volume":"123","author":"Thompson","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0395","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/toxsci\/kfr164","article-title":"Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium","volume":"123","author":"Thompson","year":"2011","journal-title":"Toxicological sciences\u202f: an official journal of the Society of Toxicology"},{"issue":"15","key":"10.1016\/j.taap.2021.115773_bb0400","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1073\/pnas.88.15.6565","article-title":"Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis","volume":"88","author":"Trapnell","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0405","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/156800909787314002","article-title":"The urokinase plasminogen activator system: a target for anti-cancer therapy","volume":"9","author":"Ulisse","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0410","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2017.12.017","article-title":"Phospholipid remodeling and cholesterol availability regulate intestinal Stemness and tumorigenesis","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0415","first-page":"C793","article-title":"Mercury and zinc differentially inhibit shark and human CFTR orthologues: involvement of shark cysteine 102","volume":"290","author":"Weber","year":"2006","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"3","key":"10.1016\/j.taap.2021.115773_bb0420","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41419-018-0330-6","article-title":"Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer","volume":"9","author":"Wen","year":"2018","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.taap.2021.115773_bb0425","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/gut.2004.062786","article-title":"Patterns of GI disease in adulthood associated with mutations in the CFTR gene","volume":"56","author":"Wilschanski","year":"2007","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0430","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/0192623312469856","article-title":"Mechanistic insights from the NTP studies of chromium","volume":"41","author":"Witt","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.taap.2021.115773_bb0435","doi-asserted-by":"crossref","first-page":"966","DOI":"10.12659\/MSM.899341","article-title":"Lower cystic Fibrosis transmembrane conductance regulator (CFTR) promotes the proliferation and migration of endometrial carcinoma","volume":"23","author":"Xia","year":"2017","journal-title":"Med. Sci. Monit."},{"issue":"18","key":"10.1016\/j.taap.2021.115773_bb0440","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1038\/onc.2012.251","article-title":"CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer","volume":"32","author":"Xie","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2021.115773_bb0445","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddl486","article-title":"TGF-beta signaling alterations and susceptibility to colorectal cancer","volume":"16","author":"Xu","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.taap.2021.115773_bb0450","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/JEnvironPatholToxicolOncol.v27.i2.10","article-title":"Oxidative stress and chromium(VI) carcinogenesis","volume":"27","author":"Yao","year":"2008","journal-title":"Journal of environmental pathology, toxicology and oncology\u202f: official organ of the International Society for Environmental Toxicology and Cancer"},{"issue":"12","key":"10.1016\/j.taap.2021.115773_bb0455","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.bbamcr.2013.07.021","article-title":"Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer","volume":"1833","author":"Zhang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.taap.2021.115773_bb0460","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00018-018-2755-6","article-title":"Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer","volume":"75","author":"Zhang","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.taap.2021.115773_bb0465","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1096\/fj.08-110221","article-title":"Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium","volume":"23","author":"Zheng","year":"2009","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.taap.2021.115773_bb0470","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000029497","article-title":"Genotype and phenotype in cystic fibrosis","volume":"67","author":"Zielenski","year":"2000","journal-title":"Respiration"},{"key":"10.1016\/j.taap.2021.115773_bb0475","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/S1569-1993(20)30338-6","article-title":"P001 thirteen novel and rare mutations causing cystic fibrosis not included in CFTR 2 database","volume":"19","author":"Zybert","year":"2020","journal-title":"J. Cyst. Fibros."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100377X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2100377X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:57:20Z","timestamp":1758574640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2100377X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":94,"alternative-id":["S0041008X2100377X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115773","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inferred inactivation of the Cftr gene in the duodena of mice exposed to hexavalent chromium (Cr(VI)) in drinking water supports its tumor-suppressor status and implies its potential role in Cr(VI)-induced carcinogenesis of the small intestines","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115773"}}