{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:02:56Z","timestamp":1789765376973,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.taap.2021.115825","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T01:56:48Z","timestamp":1639101408000},"page":"115825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Microsomal triglyceride transfer protein inhibitor lomitapide-induced liver toxicity is ameliorated by Triiodothyronine treatment following improved bile homeostasis and \u03b2-oxidation"],"prefix":"10.1016","volume":"434","author":[{"given":"Vishal","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Joharapurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samadhan","family":"Kshirsagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulik","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiren","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardikkumar","family":"Savsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.taap.2021.115825_bb0005","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/cen.12538","article-title":"Defending plasma T3 is a biological priority","volume":"81","author":"Abdalla","year":"2014","journal-title":"Clin. Endocrinol."},{"issue":"8","key":"10.1016\/j.taap.2021.115825_bb0010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1043-2760(03)00144-9","article-title":"The molecular actions of thyroid hormone in bone","volume":"14","author":"Bassett","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.taap.2021.115825_bb0015","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/hep.25861","article-title":"Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5\/G8 complex","volume":"56","author":"Bonde","year":"2012","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"25","key":"10.1016\/j.taap.2021.115825_bb0020","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.118.036859","article-title":"Thyroid and cardiovascular disease research agenda for enhancing knowledge, prevention, and treatment","volume":"139","author":"Cappola","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.taap.2021.115825_bb0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1440-1681.2011.05513.x","article-title":"Inhibition of microsomal triglyceride transfer protein improves insulin sensitivity and reduces atherogenic risk in Zucker fatty rats","volume":"38","author":"Dhote","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.taap.2021.115825_bb0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/20469047.2016.1246640","article-title":"Homozygous familial hypercholesterolaemia: update on management","volume":"36","author":"France","year":"2016","journal-title":"Paediat. Int. Child Health"},{"issue":"2\u20133","key":"10.1016\/j.taap.2021.115825_bb0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(02)02611-0","article-title":"Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor","volume":"455","author":"Funatsu","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.taap.2021.115825_bb0040","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1194\/jlr.M084145","article-title":"Thyroid hormone receptor \u03b21 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice","volume":"59","author":"Gautherot","year":"2018","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.taap.2021.115825_bb0045","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0962-8924(00)89054-6","article-title":"Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles","volume":"5","author":"Gordon","year":"1995","journal-title":"Trends Cell Biol."},{"issue":"10213","key":"10.1016\/j.taap.2021.115825_bb0050","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/S0140-6736(19)32517-6","article-title":"Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"394","author":"Harrison","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"29","key":"10.1016\/j.taap.2021.115825_bb0055","doi-asserted-by":"crossref","first-page":"10297","DOI":"10.1073\/pnas.0504379102","article-title":"Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice","volume":"102","author":"Johansson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.taap.2021.115825_bb0060","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1021\/jm2004706","article-title":"Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia","volume":"55","author":"Joharapurkar","year":"2012","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.taap.2021.115825_bb0065","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/ajcn\/66.4.890","article-title":"Longevity in obese and lean male and female rats of the Zucker strain: prevention of hyperphagia","volume":"66","author":"Johnson","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.taap.2021.115825_bb0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1210\/er.2003-0033","article-title":"Thyroid hormone action in the heart","volume":"26","author":"Kahaly","year":"2005","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.taap.2021.115825_bb0075","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1111\/bph.15427","article-title":"Activation of thyroid hormone receptor-\u03b2 improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis","volume":"178","author":"Kannt","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.taap.2021.115825_bb0080","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1021\/jm4019299","volume":"57","author":"Kelly","year":"2014","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.taap.2021.115825_bb0085","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/MOL.0b013e3282f169c6","article-title":"New targets and emerging therapies for reducing LDL cholesterol","volume":"18","author":"Lilly","year":"2007","journal-title":"Curr. Opin. Lipidol."},{"issue":"2","key":"10.1016\/j.taap.2021.115825_bb0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.14797\/mdcj-13-2-60","article-title":"Hyperthyroidism and the heart","volume":"13","author":"Osuna","year":"2017","journal-title":"Methodist DeBakey Cardiovas. J."},{"key":"10.1016\/j.taap.2021.115825_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cbi.2018.01.004","article-title":"Coagonist of GLP-1 and glucagon decreases liver inflammation and atherosclerosis in dyslipidemic condition","volume":"282","author":"Patel","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2021.115825_bb0100","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.biopha.2017.12.068","article-title":"Central administration of coagonist of GLP-1 and glucagon receptors improves dyslipidemia","volume":"98","author":"Patel","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.taap.2021.115825_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/1874467212666190212112402","article-title":"Activation of GLP-1 and glucagon receptors regulates bile homeostasis independent of thyroid hormone","volume":"12","author":"Patel","year":"2019","journal-title":"Curr. Mol. Pharmacol."},{"issue":"8","key":"10.1016\/j.taap.2021.115825_bb0110","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1096\/fj.08-108464","article-title":"Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit\/reverse nonalcoholic fatty liver in rats","volume":"22","author":"Perra","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2021.115825_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100060","article-title":"Existing and emerging therapies for the treatment of familial hypercholesterolemia","volume":"62","author":"Rosenson","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2021.115825_bb0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13578-016-0113-7","article-title":"Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD","volume":"6","author":"Sinha","year":"2016","journal-title":"Cell Biosci."},{"issue":"8","key":"10.1016\/j.taap.2021.115825_bb0125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11883-020-00858-4","article-title":"Lomitapide-a microsomal triglyceride transfer protein inhibitor for homozygous familial hypercholesterolemia","volume":"22","author":"Stefanutti","year":"2020","journal-title":"Curr. Atheroscler. Rep."},{"issue":"3","key":"10.1016\/j.taap.2021.115825_bb0130","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1530\/JOE-16-0428","article-title":"Exogenous thyroxine improves glucose intolerance in insulin-resistant rats","volume":"232","author":"Vazquez-Anaya","year":"2017","journal-title":"J. Endocrinol."},{"issue":"8","key":"10.1016\/j.taap.2021.115825_bb0135","doi-asserted-by":"crossref","first-page":"650","DOI":"10.7326\/0003-4819-140-8-200404200-00013","article-title":"Pharmacologic lipid-lowering therapy in type 2 diabetes mellitus: background paper for the American College of Physicians","volume":"140","author":"Vijan","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.taap.2021.115825_bb0140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12986-016-0123-9","article-title":"Animal models of metabolic syndrome: a review","volume":"13","author":"Wong","year":"2016","journal-title":"Nutr. Metabol."},{"issue":"4","key":"10.1016\/j.taap.2021.115825_bb0145","doi-asserted-by":"crossref","first-page":"390","DOI":"10.5551\/jat.ED069","article-title":"A first-in-class drug, Lomitapide, tailored to patients with homozygous familial hypercholesterolemia is just about meeting with good news to them","volume":"24","author":"Yoshida","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"issue":"6","key":"10.1016\/j.taap.2021.115825_bb0150","first-page":"317","article-title":"Emerging research on MGL-3196 for the treatment of nonalcoholic Steatohepatitis","volume":"15","author":"Younossi","year":"2019","journal-title":"Gastroenterol. Hepatol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21004294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21004294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:17:33Z","timestamp":1789762653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21004294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"alternative-id":["S0041008X21004294"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115825","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microsomal triglyceride transfer protein inhibitor lomitapide-induced liver toxicity is ameliorated by Triiodothyronine treatment following improved bile homeostasis and \u03b2-oxidation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115825","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115825"}}