{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:58:25Z","timestamp":1764331105641,"version":"3.44.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.taap.2021.115847","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T09:23:06Z","timestamp":1640424186000},"page":"115847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["CREB\/Sp1-mediated MCL1 expression and NF\u03baB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells"],"prefix":"10.1016","volume":"435","author":[{"given":"Jing-Ting","family":"Chiou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti-Hsiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Chin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long-Sen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2021.115847_bb0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12885-019-5377-y","article-title":"Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia","volume":"19","author":"Al-Aamri","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.taap.2021.115847_bb0010","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","article-title":"Chronic myeloid leukaemia","volume":"385","author":"Apperley","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.taap.2021.115847_bb0015","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3109\/10715762.2010.509399","article-title":"Beneficial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats","volume":"44","author":"Arozal","year":"2010","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.taap.2021.115847_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008719","article-title":"Modulation of Akt and ERK1\/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70","volume":"5","author":"Banerjee Mustafi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115847_bb0025","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.3390\/ijms18112362","article-title":"ABC transporters in cancer stem cells: beyond chemoresistance","volume":"18","author":"Begicevic","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2021.115847_bb0030","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00280-017-3424-4","article-title":"Molecular study of ABCB1 gene and its correlation with imatinib response in chronic myeloid leukemia","volume":"80","author":"Ben Hassine","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.onc.1206056","article-title":"NF-\u03baB transcription factor induces drug resistance through MDR1 expression in cancer cells","volume":"22","author":"Bentires-Alj","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.taap.2021.115847_bb0040","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1158\/1535-7163.MCT-08-0314","article-title":"Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance","volume":"7","author":"Bewry","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.taap.2021.115847_bb0045","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.1074\/jbc.272.20.12952","article-title":"Daunorubicin activates NF\u03baB and induces \u03baB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells","volume":"272","author":"Boland","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115847_bb0050","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ccell.2020.03.006","article-title":"Response and resistance to BCR-ABL1-targeted therapies","volume":"37","author":"Braun","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2021.115847_bb0055","doi-asserted-by":"crossref","first-page":"66287","DOI":"10.18632\/oncotarget.11507","article-title":"The BCR-ABL\/NF-\u03baB signal transduction network: a long lasting relationship in Philadelphia positive leukemias","volume":"7","author":"Carr\u00e0","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2021.115847_bb0060","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.tips.2020.09.004","article-title":"BH3 mimetics in AML therapy: death and beyond?","volume":"41","author":"Cerella","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.taap.2021.115847_bb0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.taap.2018.09.008","article-title":"The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells","volume":"358","author":"Chen","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114544","article-title":"Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells","volume":"188","author":"Chiou","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ijbiomac.2021.07.133","article-title":"Carboxyl group-modified \u03b1-lactalbumin induces TNF-\u03b1-mediated apoptosis in leukemia and breast cancer cells through the NOX4\/p38 MAPK\/PP2A axis","volume":"187","author":"Chiou","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.taap.2021.115847_bb0080","doi-asserted-by":"crossref","first-page":"7356","DOI":"10.1002\/jcp.30407","article-title":"NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells","volume":"236","author":"Chiou","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2021.115847_bb0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.taap.2021.115847_bb0090","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1158\/1078-0432.CCR-10-1613","article-title":"Molecular pathways: BCR-ABL","volume":"18","author":"Cilloni","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.taap.2021.115847_bb0095","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.leukres.2010.11.004","article-title":"The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study)","volume":"35","author":"Deau","year":"2011","journal-title":"Leuk. Res."},{"key":"10.1016\/j.taap.2021.115847_bb0100","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/leu.2014.245","article-title":"Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia","volume":"29","author":"Eiring","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2021.115847_bb0105","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.molcel.2009.06.007","article-title":"CRD-BP protects the coding region of \u03b2TrCP1 mRNA from miR-183-mediated degradation","volume":"35","author":"Elcheva","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.taap.2021.115847_bb0110","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ncb3596","article-title":"Mitochondrial permeabilization engages NF-\u03baB-dependent anti-tumour activity under caspase deficiency","volume":"19","author":"Giampazolias","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.taap.2021.115847_bb0115","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/sj.leu.2401570","article-title":"Molecular effects of topoisomerase II inhibitors in AML cell lines: correlation of apoptosis with topoisomerase II activity but not with DNA damage","volume":"13","author":"Gieseler","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2021.115847_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028491","article-title":"Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells","volume":"6","author":"Han","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115847_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115013","article-title":"Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells","volume":"397","author":"Huang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0130","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/leu.2014.320","article-title":"Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia","volume":"29","author":"Huelsemann","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2021.115847_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191034","article-title":"Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury","volume":"13","author":"Jeong","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115847_bb0140","doi-asserted-by":"crossref","first-page":"33289","DOI":"10.1074\/jbc.M111.249102","article-title":"Forced expression of heat shock protein 27 (Hsp27) reverses P-glycoprotein (ABCB1)-mediated drug efflux and MDR1 gene expression in Adriamycin-resistant human breast cancer cells","volume":"286","author":"Kanagasabai","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115847_bb0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cbi.2014.06.009","article-title":"Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells","volume":"219","author":"Kosztyu","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2021.115847_bb0150","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1182\/blood.V98.4.913","article-title":"Signaling pathways activated by daunorubicin","volume":"98","author":"Laurent","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.taap.2021.115847_bb0155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canlet.2018.06.019","article-title":"ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells","volume":"432","author":"Lee","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2021.115847_bb0160","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bcp.2012.06.007","article-title":"Suppression of Akt\/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNF\u03b1-mediated NF\u03baB activation in piceatannol-treated human leukemia U937 cells","volume":"84","author":"Liu","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0165","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/carcin\/bgs409","article-title":"p38 MAPK\/PP2Ac\u03b1\/TTP pathway on the connection of TNF-\u03b1 and caspases activation on hydroquinone-induced apoptosis","volume":"34","author":"Liu","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.taap.2021.115847_bb0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline chemotherapy and cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.taap.2021.115847_bb0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/17512433.2019.1573668","article-title":"Daunorubicin and cytarabine for certain types of poor-prognosis acute myeloid leukemia: a systematic literature review","volume":"12","author":"Meg\u00edas-Vericat","year":"2019","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.taap.2021.115847_bb0180","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ccell.2018.11.004","article-title":"BH3-mimetic drugs: blazing the trail for new cancer medicines","volume":"34","author":"Merino","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.taap.2021.115847_bb0185","doi-asserted-by":"crossref","first-page":"26176","DOI":"10.1074\/jbc.M313346200","article-title":"Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1\/2 and p38 MAPK","volume":"279","author":"Nishihara","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2021.115847_bb0190","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nature04839","article-title":"CRD-BP mediates stabilization of \u03b2TrCP1 and c-myc mRNA in response to \u03b2-catenin signalling","volume":"441","author":"Noubissi","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.taap.2021.115847_bb0195","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1089\/ars.2013.5374","article-title":"Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis","volume":"20","author":"Peshavariya","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.taap.2021.115847_bb0200","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-018-0624-2","article-title":"Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy","volume":"11","author":"Rossari","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.taap.2021.115847_bb0205","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41418-019-0486-3","article-title":"Saga of mcl-1: regulation from transcription to degradation","volume":"27","author":"Senichkin","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.taap.2021.115847_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055509","article-title":"Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-\u03baB and HSP27\/p38\/AKT pathways and by inhibiting ABCB1","volume":"8","author":"Sims","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2021.115847_bb0215","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2021.115847_bb0220","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-018-0780-6","article-title":"Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy","volume":"17","author":"Soverini","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.taap.2021.115847_bb0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.leu.2403241","article-title":"JAK\/STAT, Raf\/MEK\/ERK, PI3K\/Akt and BCR-ABL in cell cycle progression and leukemogenesis","volume":"18","author":"Steelman","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2021.115847_bb0230","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/jcp.26125","article-title":"TLR4 and NF\u03baB signaling is critical for taxol resistance in ovarian carcinoma cells","volume":"233","author":"Sun","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.taap.2021.115847_bb0235","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/sj.leu.2402498","article-title":"Resistance to daunorubicin-induced apoptosis is not completely reversed in CML blast cells by STI571","volume":"16","author":"Tabrizi","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.taap.2021.115847_bb0240","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1182\/blood.V96.9.3195","article-title":"Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl-positive cells","volume":"96","author":"Thiesing","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.taap.2021.115847_bb0245","doi-asserted-by":"crossref","first-page":"10553","DOI":"10.1038\/ncomms10553","article-title":"Inactivation of nuclear GSK3\u03b2 by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response","volume":"7","author":"Thornton","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.taap.2021.115847_bb0250","first-page":"2822","article-title":"Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation","volume":"13","author":"Wadzinski","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.taap.2021.115847_bb0255","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/jir.2009.0117","article-title":"Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor \u03b22 in cancer cells","volume":"30","author":"Wan","year":"2010","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.taap.2021.115847_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100672","article-title":"Targeting MCL-1 in hematologic malignancies: rationale and progress","volume":"44","author":"Wei","year":"2020","journal-title":"Blood Rev."},{"key":"10.1016\/j.taap.2021.115847_bb0265","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/pharmaceutics8010005","article-title":"Venetoclax (ABT-199) might act as a perpetrator in pharmacokinetic drug-drug interactions","volume":"8","author":"Weiss","year":"2016","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.taap.2021.115847_bb0270","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fonc.2019.00665","article-title":"New approaches and treatment combinations for the management of chronic myeloid leukemia","volume":"9","author":"Westerweel","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.taap.2021.115847_bb0275","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI130809","article-title":"A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia","volume":"130","author":"Williams","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2021.115847_bb0280","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1087057108314610","article-title":"High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent","volume":"13","author":"Winter","year":"2008","journal-title":"J. Biomol. Screen."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21004518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X21004518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:57:19Z","timestamp":1758574639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X21004518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":56,"alternative-id":["S0041008X21004518"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2021.115847","relation":{},"ISSN":["0041-008X"],"issn-type":[{"type":"print","value":"0041-008X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CREB\/Sp1-mediated MCL1 expression and NF\u03baB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2021.115847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115847"}}