{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:46:32Z","timestamp":1793126792970,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570720"],"award-info":[{"award-number":["81570720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","award":["CPU2018GY23"],"award-info":[{"award-number":["CPU2018GY23"]}],"id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.taap.2022.115929","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:17:53Z","timestamp":1645489073000},"page":"115929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H+] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes"],"prefix":"10.1016","volume":"439","author":[{"given":"Yuxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiurui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2022.115929_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070680","article-title":"Mitochondria in health and disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.taap.2022.115929_bb0010","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ceb.2003.10.015","article-title":"Mitochondrial fission in apoptosis, neurodegeneration and aging","volume":"15","author":"Bossy-Wetzel","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.taap.2022.115929_bb0015","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s10545-012-9546-2","article-title":"Ammonia toxicity to the brain","volume":"36","author":"Braissant","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.taap.2022.115929_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122697","article-title":"Analysis of activity-dependent energy metabolism in mice reveals regulation of mitochondrial fission and fusion mRNA by voluntary physical exercise in subcutaneous fat from male Marathon mice (DUhTP)","volume":"9","author":"Brenmoehl","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.taap.2022.115929_bb0025","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","article-title":"Mitochondrial uncoupling, ROS generation and cardioprotection","volume":"1859","author":"Cadenas","year":"2018","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"10.1016\/j.taap.2022.115929_bb0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cbi.2018.12.006","article-title":"Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-\u03b21\/Smad and NOX4\/ROS pathways","volume":"299","author":"Cheng","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2022.115929_bb0035","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1073\/pnas.94.10.4890","article-title":"Parkinson disease: a new link between monoamine oxidase and mitochondrial electron flow","volume":"94","author":"Cohen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2022.115929_bb0040","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12272-017-0990-2","article-title":"Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway","volume":"41","author":"Cui","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.taap.2022.115929_bb0045","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41419-018-1136-2","article-title":"Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.taap.2022.115929_bb0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mc.20583","article-title":"Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling","volume":"49","author":"Deng","year":"2010","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.taap.2022.115929_bb0055","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrneph.2015.214","article-title":"Mitochondrial dysfunction in inherited renal disease and acute kidney injury","volume":"12","author":"Emma","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.taap.2022.115929_bb0060","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1471-4159.2007.04921.x","article-title":"Monoamine oxidase-a modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells","volume":"103","author":"Fitzgerald","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.taap.2022.115929_bb0065","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1159\/000492656","article-title":"Crucial roles of 5-HT and 5-HT2 receptor in diabetes-related lipid accumulation and pro-inflammatory cytokine generation in hepatocytes","volume":"48","author":"Fu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.taap.2022.115929_bb0070","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbadis.2013.11.009","article-title":"Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer\u2019s disease cybrid cell","volume":"1842","author":"Gan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2022.115929_bb0075","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.1201940","article-title":"Mitochondria and the autophagy-inflammation-cell death axis in organismal aging","volume":"333","author":"Green","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.taap.2022.115929_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109662","article-title":"Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules","volume":"349","author":"Guan","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2022.115929_bb0085","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.cellsig.2011.05.008","article-title":"Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases?","volume":"23","author":"Hu","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.taap.2022.115929_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108948","article-title":"Inhibition of the mitochondrial complex-1 protects against carbon tetrachloride-induced acute liver injury","volume":"115","author":"Hua","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.taap.2022.115929_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-203136","article-title":"Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication","volume":"2014","author":"Hydes","year":"2014","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.taap.2022.115929_bb0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5483\/BMBRep.2008.41.1.011","article-title":"The role of mitochondria in apoptosis","volume":"41","author":"Jeong","year":"2008","journal-title":"BMB Rep."},{"key":"10.1016\/j.taap.2022.115929_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120002","article-title":"Renal ischemia\/reperfusion injury in rats is probably due to the activation of the 5-HT degradation system in proximal renal tubular epithelial cells","volume":"285","author":"Jin","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.taap.2022.115929_bb0110","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jpi.12319","article-title":"Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis","volume":"60","author":"Kang","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.taap.2022.115929_bb0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1499-3872(17)60014-6","article-title":"Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance","volume":"16","author":"Khan","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.taap.2022.115929_bb0120","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.taap.2022.115929_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010017","article-title":"Mitochondrial gene expression and beyond-novel aspects of cellular physiology","volume":"9","author":"Kotrys","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.taap.2022.115929_bb0130","doi-asserted-by":"crossref","first-page":"44879","DOI":"10.18632\/oncotarget.9821","article-title":"Mitochondrial dysfunction and oxidative stress in aging and cancer","volume":"7","author":"Kudryavtseva","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.taap.2022.115929_bb0135","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.orcp.2016.03.015","article-title":"5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats","volume":"12","author":"Li","year":"2018","journal-title":"Obes Res. Clin. Pr."},{"key":"10.1016\/j.taap.2022.115929_bb0140","first-page":"755","article-title":"Breviscapine ameliorates CCl4-induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation","volume":"42","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2022.115929_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040837","article-title":"Role and mechanisms of Mitophagy in liver diseases","volume":"9","author":"Ma","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.taap.2022.115929_bb0150","series-title":"Mitochondrial Glutathione: Recent Insights and Role in Disease","first-page":"9","author":"Mar\u00ed","year":"2020"},{"key":"10.1016\/j.taap.2022.115929_bb0155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1139\/y87-028","article-title":"Electrophysiological evidence for ammonium as a substitute for potassium in activating the sodium pump in a crayfish sensory neuron","volume":"65","author":"Moser","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.taap.2022.115929_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062048","article-title":"Indole-3-Carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury in mice by inhibiting inflammatory response, apoptosis and regulating oxidative stress","volume":"21","author":"Munakarmi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.taap.2022.115929_bb0165","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00702-009-0309-7","article-title":"Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival","volume":"116","author":"Naoi","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.taap.2022.115929_bb0170","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrm2434","article-title":"Cytochrome c: functions beyond respiration","volume":"9","author":"Ow","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.taap.2022.115929_bb0175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yexmp.2006.09.008","article-title":"Mitochondrial dysfunction and molecular pathways of disease","volume":"83","author":"Pieczenik","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.taap.2022.115929_bb0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10408447309082019","article-title":"Carbon tetrachloride hepatotoxicity: an example of lethal cleavage","volume":"2","author":"Rechnagel","year":"1973","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2022.115929_bb0185","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jhep.2008.01.006","article-title":"The function of serotonin within the liver","volume":"48","author":"Ruddell","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.taap.2022.115929_bb0190","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0304-4165(90)90092-B","article-title":"Hydrogen peroxide production by monoamine oxidase in isolated rat-brain mitochondria: its effect on glutathione levels and Ca2+ efflux","volume":"1035","author":"Sandri","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2022.115929_bb0195","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41575-018-0065-y","article-title":"Apoptosis and necroptosis in the liver: a matter of life and death","volume":"15","author":"Schwabe","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.taap.2022.115929_bb0200","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2022.115929_bb0205","doi-asserted-by":"crossref","first-page":"F11","DOI":"10.1152\/ajprenal.00554.2010","article-title":"Role of NH3 and NH4+ transporters in renal acid-base transport","volume":"300","author":"Weiner","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.taap.2022.115929_bb0210","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.redox.2013.10.008","article-title":"Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK","volume":"1","author":"Wu","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2022.115929_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12731","article-title":"TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1\/Mitophagy signalling pathway","volume":"53","author":"Wu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.taap.2022.115929_bb0220","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.taap.2022.115929_bb0225","first-page":"394","article-title":"How to increase serotonin in the human brain without drugs","volume":"32(6)","author":"Young","year":"2007","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.taap.2022.115929_bb0230","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4161\/auto.18867","article-title":"Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis","volume":"8","author":"Zhang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.taap.2022.115929_bb0235","first-page":"190","article-title":"Relationship between fatigue caused by type 2 diabetes mellitus and 5-HT degradation in skeletal muscle","volume":"56","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.taap.2022.115929_bb0240","article-title":"Role of 5-HT degradation in acute liver injury induced by carbon tetrachloride","volume":"174355","author":"Zhang","year":"2021","journal-title":"Eur. J. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.taap.2022.116010","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000}},{"DOI":"10.1016\/j.taap.2022.116038","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000}}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X22000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X22000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T09:13:22Z","timestamp":1672478002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X22000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"alternative-id":["S0041008X22000746"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2022.115929","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.taap.2022.116010","asserted-by":"object"},{"id-type":"doi","id":"10.1016\/j.taap.2022.116038","asserted-by":"object"}]},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H+] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2022.115929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115929"}}