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A."},{"key":"10.1016\/j.taap.2022.116068_bb0290","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2006.08.005","article-title":"Mice deficient for the vesicular acetylcholine transporter are Myasthenic and have deficits in object and social recognition","volume":"51","author":"Prado","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.taap.2022.116068_bb0295","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbr.2012.03.030","article-title":"Biperiden (M 1 antagonist) impairs the expression of cocaine conditioned place preference but potentiates the expression of cocaine-induced behavioral sensitization","volume":"231","author":"Ramos","year":"2012","journal-title":"Behav. 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Toxicol."},{"key":"10.1016\/j.taap.2022.116068_bb0310","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0006-8993(03)02561-7","article-title":"Acute \u201cbinge\u201d cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL\/6J but not 129\/J mice","volume":"974","author":"Schlussman","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.taap.2022.116068_bb0315","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainresbull.2005.04.018","article-title":"Steady-dose and escalating-dose \u201cbinge\u201d administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats","volume":"67","author":"Schlussman","year":"2005","journal-title":"Brain Res. 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Neurosci."},{"key":"10.1016\/j.taap.2022.116068_bb0380","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0306-4522(00)00542-X","article-title":"Involvement of dopamine D2 receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats","volume":"103","author":"Umegaki","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.taap.2022.116068_bb0385","series-title":"World Drug Report 2020","first-page":"62","article-title":"Executive summary","author":"United Nations Office on Drugs and Crime (UNODC)","year":"2020"},{"key":"10.1016\/j.taap.2022.116068_bb0390","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0022-3565(25)22549-6","article-title":"Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration","volume":"270","author":"Unterwald","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"80","key":"10.1016\/j.taap.2022.116068_bb0395","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.1098975","article-title":"Drug seeking becomes compulsive after prolonged cocaine self-administration","volume":"305","author":"Vanderschuren","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.taap.2022.116068_bb0400","doi-asserted-by":"crossref","first-page":"27229","DOI":"10.1074\/jbc.271.44.27229","article-title":"Active transport of acetylcholine by the human vesicular acetylcholine transporter","volume":"271","author":"Varoqui","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2022.116068_bb0405","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2015.07.046","article-title":"The brain on drugs: from reward to addiction","volume":"162","author":"Volkow","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.taap.2022.116068_bb0410","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMra1511480","article-title":"Neurobiologic advances from the brain disease model of addiction","volume":"374","author":"Volkow","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.taap.2022.116068_bb0415","doi-asserted-by":"crossref","first-page":"26001","DOI":"10.1073\/pnas.1914446116","article-title":"Crystal structure of the M5 muscarinic acetylcholine receptor","volume":"116","author":"Vuckovic","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2022.116068_bb0420","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1111\/ejn.12279","article-title":"Cholinergic control of morphine-induced locomotion in rostromedial tegmental nucleus versus ventral tegmental area sites","volume":"38","author":"Wasserman","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.taap.2022.116068_bb0425","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41386-020-0684-1","article-title":"Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats","volume":"45","author":"Weikop","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.taap.2022.116068_bb0430","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/sj.npp.1301585","article-title":"The role of acetylcholine in cocaine addiction","volume":"33","author":"Williams","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.taap.2022.116068_bb0435","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1523\/JNEUROSCI.0694-08.2008","article-title":"Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation","volume":"28","author":"You","year":"2008","journal-title":"J. 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