{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:24:12Z","timestamp":1792077852228,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES027863"],"award-info":[{"award-number":["R01ES027863"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.taap.2022.116209","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T08:41:04Z","timestamp":1661244064000},"page":"116209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation"],"prefix":"10.1016","volume":"453","author":[{"given":"Yong","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis","family":"Ticiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pearl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Veiga-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2022.116209_bb0005","doi-asserted-by":"crossref","first-page":"16339","DOI":"10.1074\/jbc.273.26.16339","article-title":"The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis","volume":"273","author":"Arakane","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2022.116209_bb0010","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1021\/tx500433r","article-title":"Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells","volume":"28","author":"Baker","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.taap.2022.116209_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146450","article-title":"Phthalates, organotin compounds and per-polyfluoroalkyl substances in semiconfined areas of the Spanish coast: occurrence, sources and risk assessment","volume":"780","author":"Concha-Grana","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2022.116209_bb0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bcp.2010.12.023","article-title":"Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRalpha\/RXR","volume":"81","author":"Cui","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.taap.2022.116209_bb0025","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1095\/biolreprod.110.085910","article-title":"Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation","volume":"84","author":"Forde","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.taap.2022.116209_bb0030","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.chemosphere.2018.08.016","article-title":"In utero exposure to triphenyltin disrupts rat fetal testis development","volume":"211","author":"Ge","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2022.116209_bb0035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ecoenv.2018.10.096","article-title":"Aging and retinoid X receptor agonists on masculinization of female Pomacea canaliculata, with a critical appraisal of imposex evaluation in the Ampullariidae","volume":"169","author":"Giraud-Billoud","year":"2019","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.taap.2022.116209_bb0040","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/humrep\/det033","article-title":"Hypoandrogenism in association with diminished functional ovarian reserve","volume":"28","author":"Gleicher","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.taap.2022.116209_bb0045","first-page":"19","article-title":"Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis","volume":"85","author":"Go","year":"2012","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.taap.2022.116209_bb0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10937400490452705","article-title":"Triphenyltin as a potential human endocrine disruptor","volume":"7","author":"Golub","year":"2004","journal-title":"J. Toxicol. Env. Heal. B."},{"key":"10.1016\/j.taap.2022.116209_bb0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2006.01.008","article-title":"Effects of peripubertal exposure to triphenyltin on female sexual development of the rat","volume":"222","author":"Grote","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2022.116209_bb0060","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/mnfr.201500467","article-title":"Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells","volume":"60","author":"Guillemot","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.taap.2022.116209_bb0065","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1038\/srep08520","article-title":"Structural basis for PPARgamma transactivation by endocrine-disrupting organotin compounds","volume":"5","author":"Harada","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2022.116209_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119800","article-title":"Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles","volume":"10","author":"Hatzirodos","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.taap.2022.116209_bb0075","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cbi.2009.03.006","article-title":"Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) gamma by organotin compounds","volume":"180","author":"Hiromori","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.taap.2022.116209_bb0080","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1039\/c5mt00086f","article-title":"Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation","volume":"7","author":"Hiromori","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.taap.2022.116209_bb0085","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jsbmb.2014.10.010","article-title":"Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells","volume":"155","author":"Hiromori","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.taap.2022.116209_bb0090","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquatox.2017.08.016","article-title":"Effects of triphenyltin on reproduction in Japanese medaka (Oryzias latipes) across two generations","volume":"192","author":"Horie","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.taap.2022.116209_bb0095","first-page":"77","article-title":"Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex","volume":"13","author":"Horiguchi","year":"2006","journal-title":"Environ. Sci."},{"key":"10.1016\/j.taap.2022.116209_bb0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0269-7491(96)00093-0","article-title":"Effects of triphenyltin chloride and five other organotin compounds on the development of imposex in the rock shell, Thais clavigera","volume":"95","author":"Horiguchi","year":"1997","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.taap.2022.116209_bb0105","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00216-009-3230-x","article-title":"Time course of expression of the retinoid X receptor gene and induction of imposex in the rock shell, Thais clavigera, exposed to triphenyltin chloride","volume":"396","author":"Horiguchi","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.taap.2022.116209_bb0110","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2022.116209_bb0115","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1194\/jlr.M600163-JLR200","article-title":"Regulation of ABCA1 expression in human keratinocytes and murine epidermis","volume":"47","author":"Jiang","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.taap.2022.116209_bb0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2005.06.007","article-title":"Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man","volume":"185","author":"Laaksonen","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.taap.2022.116209_bb0125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.aquatox.2016.03.005","article-title":"Triphenyltin induces imposex in Nucella lapillus through an aphallic route","volume":"175","author":"Laranjeiro","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.taap.2022.116209_bb0130","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/molehr\/gat065","article-title":"Involvement of androgens in ovarian health and disease","volume":"19","author":"Lebbe","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.taap.2022.116209_bb0135","article-title":"Triphenyltin chloride delays leydig cell maturation during puberty in rats","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.taap.2022.116209_bb0140","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.jenvman.2008.06.008","article-title":"Aquatic organotin pollution in Taiwan","volume":"90","author":"Meng","year":"2009","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.taap.2022.116209_bb0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ogc.2014.10.003","article-title":"Progesterone and the luteal phase: a requisite to reproduction","volume":"42","author":"Mesen","year":"2015","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.taap.2022.116209_bb0150","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.chemosphere.2008.09.004","article-title":"Biomagnification profiles of tributyltin (TBT) and triphenyltin (TPT) in Japanese coastal food webs elucidated by stable nitrogen isotope ratios","volume":"73","author":"Murai","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2022.116209_bb0155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2131\/jts.33.269","article-title":"Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor","volume":"33","author":"Nakanishi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.taap.2022.116209_bb0160","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.steroids.2005.03.005","article-title":"Triphenyltin and tributyltin inhibit pig testicular 17 beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis","volume":"70","author":"Ohno","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.taap.2022.116209_bb0165","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00204-019-02449-y","article-title":"Multispecies study: low-dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species including humans","volume":"93","author":"Pu","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.taap.2022.116209_bb0170","series-title":"Toxicological Profile for Tin and Tin Compounds, U.S. Department of Health and Human Services","first-page":"1","author":"Registry, A.f.T.S.a.D","year":"2005"},{"key":"10.1016\/j.taap.2022.116209_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2017-00164","article-title":"Ovarian follicular Theca cell recruitment, differentiation, and impact on fertility: 2017 update","volume":"39","author":"Richards","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.taap.2022.116209_bb0180","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0147-6513(03)00061-7","article-title":"Case study: bioavailability of tin and tin compounds","volume":"56","author":"Rudel","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.taap.2022.116209_bb0185","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/bbrc.2001.5952","article-title":"Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN","volume":"289","author":"Saitoh","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.taap.2022.116209_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.taap.2022.116209_bb0195","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0045-6535(97)10011-X","article-title":"Distribution pattern of organotin compounds at different trophic levels of aquatic ecosystems","volume":"36","author":"Shawky","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2022.116209_bb0200","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1210\/endo.142.4.8075","article-title":"Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene","volume":"142","author":"Shea-Eaton","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.taap.2022.116209_bb0205","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1071\/RD12332","article-title":"Triphenyltin chloride induces spindle microtubule depolymerisation and inhibits meiotic maturation in mouse oocytes","volume":"26","author":"Shen","year":"2014","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.taap.2022.116209_bb0210","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/jf60227a015","article-title":"Degradation of triphenyltin hydroxide in water","volume":"28","author":"Soderquist","year":"1980","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.taap.2022.116209_bb0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1677\/joe.0.1640247","article-title":"The role of the StAR protein in steroidogenesis: challenges for the future","volume":"164","author":"Stocco","year":"2000","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.taap.2022.116209_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.10.898","article-title":"Regulation of intestinal LDLR by the LXR-IDOL axis","volume":"315","author":"van Loon","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.taap.2022.116209_bb0225","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bpobgyn.2007.08.009","article-title":"Progesterone for recurrent miscarriage: truth and deceptions","volume":"22","author":"Walch","year":"2008","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.taap.2022.116209_bb0230","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.theriogenology.2018.05.042","article-title":"Membrane receptor-independent inhibitory effect of melatonin on androgen production in porcine theca cells","volume":"118","author":"Wang","year":"2018","journal-title":"Theriogenology"},{"key":"10.1016\/j.taap.2022.116209_bb0235","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.etp.2008.03.009","article-title":"Histological alterations in ovaries of pubertal female rats induced by triphenyltin","volume":"60","author":"Watermann","year":"2008","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.taap.2022.116209_bb0240","series-title":"TRIPHENYLTIN COMPOUNDS","first-page":"1999","author":"WHO","year":"1999"},{"key":"10.1016\/j.taap.2022.116209_bb0245","series-title":"Organotins in Drinking-Water","year":"2020"},{"key":"10.1016\/j.taap.2022.116209_bb0250","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mce.2018.01.011","article-title":"The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells","volume":"473","author":"Xu","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.taap.2022.116209_bb0255","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.3168\/jds.2018-15538","article-title":"Activation of liver X receptor promotes fatty acid synthesis in goat mammary epithelial cells via modulation of SREBP1 expression","volume":"102","author":"Xu","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.taap.2022.116209_bb0260","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ecoenv.2018.03.028","article-title":"Organotin exposure stimulates steroidogenesis in H295R cell via cAMP pathway","volume":"156","author":"Yan","year":"2018","journal-title":"Ecotox. Environ. Safe"},{"key":"10.1016\/j.taap.2022.116209_bb0265","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.chemosphere.2012.05.080","article-title":"Review of measured concentrations of triphenyltin compounds in marine ecosystems and meta-analysis of their risks to humans and the environment","volume":"89","author":"Yi","year":"2012","journal-title":"Chemosphere"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X22003544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X22003544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:59:19Z","timestamp":1758574759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X22003544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":53,"alternative-id":["S0041008X22003544"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2022.116209","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2022.116209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116209"}}