{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:18:13Z","timestamp":1768483093507,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.taap.2022.116246","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T23:25:38Z","timestamp":1663284338000},"page":"116246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Myricetin alleviates the formaldehyde-enhanced Warburg effect in tumor cells through inhibition of HIF-1\u03b1"],"prefix":"10.1016","volume":"454","author":[{"given":"Linyi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.taap.2022.116246_bb0005","doi-asserted-by":"crossref","first-page":"884","DOI":"10.5551\/jat.RV17009","article-title":"The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases","volume":"24","author":"Abe","year":"2017","journal-title":"J. Atheroscler. Thromb."},{"issue":"12","key":"10.1016\/j.taap.2022.116246_bb0010","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.3390\/nu10121962","article-title":"Myricetin exerts anti-obesity effects through upregulation of SIRT3 in adipose tissue","volume":"10","author":"Akindehin","year":"2018","journal-title":"Nutrients."},{"issue":"7","key":"10.1016\/j.taap.2022.116246_bb0015","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/17460441.2019.1613370","article-title":"The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy","volume":"14","author":"Albadari","year":"2019","journal-title":"Expert Opin. Drug Discovery"},{"key":"10.1016\/j.taap.2022.116246_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109576","article-title":"Low concentrations of FA exhibits the Hormesis effect by affecting cell division and the Warburg effect","volume":"183","author":"An","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.taap.2022.116246_bb0025","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41590-020-0666-9","article-title":"Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal","volume":"21","author":"Baumann","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.taap.2022.116246_bb0030","doi-asserted-by":"crossref","first-page":"A), 108740","DOI":"10.1016\/j.envres.2019.108740","article-title":"Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility","volume":"179(Pt","author":"Costa","year":"2019","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.taap.2022.116246_bb0035","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1073\/pnas.082121399","article-title":"Structural basis for Hif-1 alpha \/CBP recognition in the cellular hypoxic response","volume":"99","author":"Dames","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.taap.2022.116246_bb0040","article-title":"Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo","volume":"165127","author":"Duthie","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.taap.2022.116246_bb0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-020-01629-4","article-title":"Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma","volume":"39","author":"Feng","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.taap.2022.116246_bb0050","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/jcb.24390","article-title":"Recent agents targeting HIF-1\u03b1 for cancer therapy","volume":"114","author":"Hu","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.taap.2022.116246_bb0055","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.3390\/ijms22115703","article-title":"Cancer cell metabolism in hypoxia: role of HIF-1 as key regulator and therapeutic target","volume":"22","author":"Infantino","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00280-013-2362-z","article-title":"Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1\u03b1), in patients with refractory solid tumors","volume":"73","author":"Jeong","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.taap.2022.116246_bb0065","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.freeradbiomed.2021.05.019","article-title":"Myricetin prevents high molecular weight A\u03b21-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria","volume":"171","author":"Kimura","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2022.116246_bb0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.coi.2019.05.005","article-title":"HIF-1\u03b1 as a central mediator of cellular resistance to intracellular pathogens","volume":"60","author":"Knight","year":"2019","journal-title":"Curr. Opin. Immunol."},{"issue":"10","key":"10.1016\/j.taap.2022.116246_bb0075","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s12272-011-1021-3","article-title":"A novel approach to cancer therapy using PX-478 as a HIF-1\u03b1 inhibitor","volume":"34","author":"Lee","year":"2011","journal-title":"Arch. Pharm. Res."},{"issue":"6","key":"10.1016\/j.taap.2022.116246_bb0080","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/genes12060913","article-title":"Formaldehyde and De\/methylation in age-related cognitive impairment","volume":"12","author":"Li","year":"2021","journal-title":"Genes (Basel)"},{"issue":"5","key":"10.1016\/j.taap.2022.116246_bb0085","article-title":"Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis","volume":"282","author":"Ma","year":"2021","journal-title":"Chemosphere."},{"key":"10.1016\/j.taap.2022.116246_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115910","article-title":"Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages","volume":"438","author":"Ma","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.taap.2022.116246_bb0095","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.taap.2022.116246_bb0100","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1749-6632.2002.tb04680.x","article-title":"CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2","volume":"973","author":"Piret","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0105","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/nu13020342","article-title":"Myricetin as a promising molecule for the treatment of post-ischemic brain neurodegeneration","volume":"13","author":"Pluta","year":"2021","journal-title":"Nutrients."},{"key":"10.1016\/j.taap.2022.116246_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145796","article-title":"Up-down regulation of HIF-1\u03b1 in cancer progression","volume":"798","author":"Rashid","year":"2021","journal-title":"Gene."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8+ T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.taap.2022.116246_bb0120","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/ijms20040840","article-title":"Targeting tumor microenvironment for cancer therapy","volume":"20","author":"Roma-Rodrigues","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.taap.2022.116246_bb0125","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1021\/acs.jcim.8b00228","article-title":"Comparative evaluation of covalent docking tools","volume":"58","author":"Scarpino","year":"2018","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/nu8020090","article-title":"Myricetin: a dietary molecule with diverse biological activities","volume":"8","author":"Semwal","year":"2016","journal-title":"Nutrients."},{"key":"10.1016\/j.taap.2022.116246_bb0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.canlet.2020.10.011","article-title":"APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma","volume":"496","author":"Shi","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.taap.2022.116246_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111017","article-title":"Myricetin: a review of the most recent research","volume":"134","author":"Song","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.taap.2022.116246_bb0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12906-020-03033-z","article-title":"Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications","volume":"20","author":"Taheri","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"issue":"6","key":"10.1016\/j.taap.2022.116246_bb0150","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1113\/JP278810","article-title":"Revisiting the Warburg effect: historical dogma versus current understanding","volume":"599","author":"Vaupel","year":"2021","journal-title":"J. Physiol."},{"issue":"7","key":"10.1016\/j.taap.2022.116246_bb0155","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","article-title":"The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression","volume":"95","author":"Vaupel","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0160","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.aca.2011.02.030","article-title":"Determination of trace formaldehyde in blood plasma by resonance fluorescence technology","volume":"690","author":"Wang","year":"2011","journal-title":"Anal. Chim. Acta"},{"issue":"3","key":"10.1016\/j.taap.2022.116246_bb0165","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3233\/JAD-201448","article-title":"Role of hypoxia inducible factor-1\u03b1 in Alzheimer\u2019s disease","volume":"80","author":"Wang","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.taap.2022.116246_bb0170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuint.2010.05.008","article-title":"Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells","volume":"57","author":"Wu","year":"2010","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.taap.2022.116246_bb0175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1389557519666191018112756","article-title":"Molecular mechanisms of the action of Myricetin in cancer","volume":"20","author":"Xie","year":"2020","journal-title":"Mini-Rev. Med. Chem."},{"issue":"20","key":"10.1016\/j.taap.2022.116246_bb0180","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1021\/acs.analchem.0c02447","article-title":"Fluorophore-promoted facile deprotonation and exocyclic five-membered ring cyclization for selective and dynamic tracking of labile Glyoxals","volume":"92","author":"Xu","year":"2020","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.taap.2022.116246_bb0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molcel.2013.11.004","article-title":"Reciprocal regulation of HIF-1\u03b1 and lincRNA-p21 modulates the Warburg effect","volume":"53","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"issue":"D1","key":"10.1016\/j.taap.2022.116246_bb0190","doi-asserted-by":"crossref","first-page":"D1147","DOI":"10.1093\/nar\/gkab905","article-title":"CancerSCEM: a database of single-cell expression map across various human cancers","volume":"50","author":"Zeng","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"35","key":"10.1016\/j.taap.2022.116246_bb0195","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1021\/acs.jafc.0c03471","article-title":"Trapping methylglyoxal by Myricetin and its metabolites in mice","volume":"68","author":"Zhang","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.taap.2022.116246_bb0200","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1111\/jcmm.16556","article-title":"HIF-1\u03b1 is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell. Mol. Med."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2200391X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X2200391X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:00:39Z","timestamp":1758574839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X2200391X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":40,"alternative-id":["S0041008X2200391X"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2022.116246","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myricetin alleviates the formaldehyde-enhanced Warburg effect in tumor cells through inhibition of HIF-1\u03b1","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2022.116246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116246"}}