{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:47:22Z","timestamp":1790686042458,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"am","delay-in-days":361,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES005022"],"award-info":[{"award-number":["P30ES005022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54AR055073"],"award-info":[{"award-number":["U54AR055073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.taap.2023.116388","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T17:07:37Z","timestamp":1674234457000},"page":"116388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics"],"prefix":"10.1016","volume":"461","author":[{"given":"Rama","family":"Malaviya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol R.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Rancourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ley Cody","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Abramova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinal N.","family":"Vayas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2023.116388_bb0005","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/15376516.2019.1669244","article-title":"Toxic effects of chlorine gas and potential treatments: a literature review","volume":"31","author":"Achanta","year":"2021","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.taap.2023.116388_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cytogfr.2019.12.001","article-title":"Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants","volume":"51","author":"Andres","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.taap.2023.116388_bb0015","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbagen.2011.12.006","article-title":"S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation","volume":"1820","author":"Atochina-Vasserman","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.taap.2023.116388_bb0020","first-page":"L158","article-title":"TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury","volume":"307","author":"Balakrishna","year":"2014","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/019021490944232","article-title":"Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology","volume":"31","author":"Chakrabarti","year":"2005","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.taap.2023.116388_bb0030","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.taap.2013.06.009","article-title":"Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide","volume":"272","author":"Chen","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020436","article-title":"Macrophages in lung injury, repair, and fibrosis","volume":"10","author":"Cheng","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.taap.2023.116388_bb0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jth.13514","article-title":"Standardization of microparticle enumeration across different flow cytometry platforms: results of a multicenter collaborative workshop","volume":"15","author":"Cointe","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2023.116388_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00281-011-0290-8","article-title":"Fibrinogen as a key regulator of inflammation in disease","volume":"34","author":"Davalos","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.taap.2023.116388_bb0050","first-page":"15","article-title":"Histopathological effects of acute exposure to chlorine gas on Sprague-Dawley rat lungs","volume":"14","author":"Demnati","year":"1995","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.taap.2023.116388_bb0055","first-page":"242","article-title":"Effects of dexamethasone on functional and pathological changes in rat bronchi caused by high acute exposure to chlorine","volume":"45","author":"Demnati","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0060","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.smim.2015.09.001","article-title":"Contribution of metabolic reprogramming to macrophage plasticity and function","volume":"27","author":"El Kasmi","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.taap.2023.116388_bb0065","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/toxsci\/kfw192","article-title":"Editor\u2019s highlight: role of spleen-derived macrophages in ozone-induced lung inflammation and injury","volume":"155","author":"Francis","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0070","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype","volume":"289","author":"Freemerman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2023.116388_bb0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00408-013-9452-x","article-title":"Lung surfactant protein D (SP-D) response and regulation during acute and chronic lung injury","volume":"191","author":"Gaunsbaek","year":"2013","journal-title":"Lung"},{"key":"10.1016\/j.taap.2023.116388_bb0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.toxlet.2018.01.014","article-title":"Civilian exposure to chlorine gas: a systematic review","volume":"293","author":"Govier","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2023.116388_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060266","article-title":"S-nitrosylation of surfactant protein-D controls inflammatory function","volume":"6","author":"Guo","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.taap.2023.116388_bb0090","first-page":"L539","article-title":"Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation","volume":"317","author":"Guo","year":"2019","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0095","first-page":"L512","article-title":"Matrix metalloproteinases: all the RAGE in the acute respiratory distress syndrome","volume":"300","author":"Hergrueter","year":"2011","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0100","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/toxsci\/kfq264","article-title":"Deviations from Haber\u2019s law for multiple measures of acute lung injury in chlorine-exposed mice","volume":"118","author":"Hoyle","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2016.03.001","article-title":"Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation","volume":"298","author":"Hoyle","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-med-041316-085215","article-title":"Targeting RAGE signaling in inflammatory disease","volume":"69","author":"Hudson","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.taap.2023.116388_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/em.20358","article-title":"The \u03b3-H2A.X: is it just a surrogate marker of double-strand breaks or much more?","volume":"49","author":"Ismail","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.taap.2023.116388_bb0120","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2023.116388_bb0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2012.10.022","article-title":"Inhalation of chlorine causes long-standing lung inflammation and airway hyperresponsiveness in a murine model of chemical-induced lung injury","volume":"303","author":"Jonasson","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2023.116388_bb0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3349\/ymj.2009.50.1.68","article-title":"Early and late changes of MMP-2 and MMP-9 in bleomycin-induced pulmonary fibrosis","volume":"50","author":"Kim","year":"2009","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.taap.2023.116388_bb0135","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1289\/ehp.1002386","article-title":"Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles","volume":"119","author":"Kodavanti","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.taap.2023.116388_bb0140","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","article-title":"Update on the features and measurements of experimental acute lung injury in animals: an official American thoracic society workshop report","volume":"66","author":"Kulkarni","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2023.116388_bb0145","doi-asserted-by":"crossref","first-page":"16246","DOI":"10.1038\/nmicrobiol.2016.246","article-title":"Microbial stimulation of different toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes","volume":"2","author":"Lachmandas","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.taap.2023.116388_bb0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.pharmtox.010909.105812","article-title":"Macrophages and tissue injury: agents of defense or destruction?","volume":"51","author":"Laskin","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.taap.2023.116388_bb0155","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/toxsci\/kfy309","article-title":"Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants","volume":"168","author":"Laskin","year":"2019","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0160","first-page":"L752","article-title":"Macrophages from the upper and lower human respiratory tract are metabolically distinct","volume":"315","author":"Lavrich","year":"2018","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0165","article-title":"The role of macrophages in the development of acute and chronic inflammatory lung diseases","volume":"10","author":"Lee","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.taap.2023.116388_bb0170","first-page":"L733","article-title":"Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants","volume":"295","author":"Leustik","year":"2008","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0175","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2018-07-818211","article-title":"The multifaceted role of fibrinogen in tissue injury and inflammation","volume":"133","author":"Luyendyk","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.taap.2023.116388_bb0180","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/dmp.2014.81","article-title":"Management of chlorine gas-related injuries from the Graniteville, South Carolina, train derailment","volume":"8","author":"Mackie","year":"2014","journal-title":"Disaster Med. Public Health Prep."},{"key":"10.1016\/j.taap.2023.116388_bb0185","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/toxsci\/kfu255","article-title":"Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D","volume":"144","author":"Malaviya","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0190","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/toxsci\/kfaa150","article-title":"Progressive lung injury, inflammation, and fibrosis in rats following inhalation of sulfur mustard","volume":"178","author":"Malaviya","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0195","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1164\/rccm.200201-021OC","article-title":"Chlorine-induced injury to the airways in mice","volume":"168","author":"Martin","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.taap.2023.116388_bb0200","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2014.02.006","article-title":"Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction","volume":"278","author":"Massa","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0205","doi-asserted-by":"crossref","first-page":"40486","DOI":"10.1074\/jbc.M102700200","article-title":"Chlorination of guanosine and other nucleosides by hypochlorous acid and myeloperoxidase of activated human neutrophils. Catalysis by nicotine and trimethylamine","volume":"276","author":"Masuda","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.taap.2023.116388_bb0210","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1096\/fj.08-120568","article-title":"Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo","volume":"23","author":"Matalon","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.taap.2023.116388_bb0215","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.freeradbiomed.2010.12.001","article-title":"AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury","volume":"50","author":"McGovern","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2023.116388_bb0220","first-page":"L802","article-title":"Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres","volume":"310","author":"McVey","year":"2016","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.taap.2023.116388_bb0225","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.freeradbiomed.2019.07.003","article-title":"The myeloperoxidase product, hypochlorous acid, reduces thrombus formation under flow and attenuates clot retraction and fibrinolysis in human blood","volume":"141","author":"Misztal","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.taap.2023.116388_bb0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12931-020-01423-y","article-title":"Extracellular vesicles: novel communicators in lung diseases","volume":"21","author":"Mohan","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2023.116388_bb0235","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.taap.2023.116388_bb0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.taap.2018.08.024","article-title":"Inhibition of chlorine-induced airway fibrosis by budesonide","volume":"363","author":"Musah","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0245","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1183\/16000617.0009-2016","article-title":"Cell-derived microparticles and the lung","volume":"25","author":"Nieri","year":"2016","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.taap.2023.116388_bb0250","first-page":"40","article-title":"All the \u201cRAGE\u201d in lung disease: the receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses","volume":"23","author":"Oczypok","year":"2017","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.taap.2023.116388_bb0255","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fimmu.2017.00609","article-title":"Fatty acid oxidation compensates for lipopolysaccharide-induced Warburg effect in glucose-deprived monocytes","volume":"8","author":"Raulien","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2023.116388_bb0260","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mrfmmm.2005.06.012","article-title":"Oxidative stress-induced DNA damage by particulate air pollution","volume":"592","author":"Risom","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2023.116388_bb0265","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfp179","article-title":"Nitrative and oxidative stress in toxicology and disease","volume":"112","author":"Roberts","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.taap.2023.116388_bb0270","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41598-018-36163-z","article-title":"RAGE is a critical mediator of pulmonary oxidative stress, alveolar macrophage activation and emphysema in response to cigarette smoke","volume":"9","author":"Sanders","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.taap.2023.116388_bb0275","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1165\/rcmb.2010-0226OC","article-title":"Postexposure administration of a \u03b22-agonist decreases chlorine-induced airway hyperreactivity in mice","volume":"45","author":"Song","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2023.116388_bb0280","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fmed.2018.00018","article-title":"Surfactant protein D in respiratory and non-respiratory diseases","volume":"5","author":"Sorensen","year":"2018","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.taap.2023.116388_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/v11020168","article-title":"Myeloid cells during viral infections and inflammation","volume":"11","author":"Stegelmeier","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.taap.2023.116388_bb0290","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1165\/rcmb.2013-0013OC","article-title":"Conditional overexpression of receptors for advanced glycation end-products in the adult murine lung causes airspace enlargement and induces inflammation","volume":"49","author":"Stogsdill","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2023.116388_bb0295","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.taap.2015.02.002","article-title":"Regulation of ozone-induced lung inflammation and injury by the \u03b2-galactoside-binding lectin galectin-3","volume":"284","author":"Sunil","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0300","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/08958370802007841","article-title":"Acute lung injury induced by chlorine inhalation in C57BL\/6 and FVB\/N mice","volume":"20","author":"Tian","year":"2008","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2023.116388_bb0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1465-9921-9-61","article-title":"Time course of airway remodelling after an acute chlorine gas exposure in mice","volume":"9","author":"Tuck","year":"2008","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2023.116388_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115569","article-title":"Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression","volume":"423","author":"Venosa","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0315","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.taap.2023.116388_bb0320","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1172\/JCI200419569","article-title":"Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness","volume":"114","author":"Wagers","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.taap.2023.116388_bb0325","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/SHK.0000000000001032","article-title":"Role of receptor for advanced glycation end products in regulating lung fluid balance in lipopolysaccharide-induced acute lung injury and infection-related acute respiratory distress syndrome","volume":"50","author":"Wang","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.taap.2023.116388_bb0330","first-page":"61","article-title":"HMGB1 participates in LPS-induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE\/NF-\u03baB signaling pathways","volume":"45","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.taap.2023.116388_bb0335","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tox.2014.12.008","article-title":"N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury","volume":"328","author":"Wigenstam","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.taap.2023.116388_bib391","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1513\/pats.201001-008SM","article-title":"Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models","volume":"7","author":"White","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.taap.2023.116388_bb0340","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.taap.2016.08.027","article-title":"Acute respiratory changes and pulmonary inflammation involving a pathway of TGF-\u03b21 induction in a rat model of chlorine-induced lung injury","volume":"309","author":"Wigenstam","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0345","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1465-9921-12-29","article-title":"Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD","volume":"12","author":"Winkler","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.taap.2023.116388_bb0350","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1165\/rcmb.2019-0244OC","article-title":"Tissue-resident alveolar macrophages do not rely on glycolysis for LPS-induced inflammation","volume":"62","author":"Woods","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.taap.2023.116388_bb0355","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1160\/TH07-11-0666","article-title":"Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases","volume":"99","author":"Wygrecka","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.taap.2023.116388_bb0360","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.taap.2023.116388_bb0365","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.mrgentox.2005.06.002","article-title":"Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells","volume":"586","author":"Xie","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.taap.2023.116388_bb0370","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1513\/pats.201001-009SM","article-title":"Mechanisms and modification of chlorine-induced lung injury in animals","volume":"7","author":"Yadav","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.taap.2023.116388_bb0375","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/08958370490520749","article-title":"Long-term pulmonary histopathologic changes in rats following acute experimental exposure to chlorine gas","volume":"16","author":"Yildirim","year":"2004","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.taap.2023.116388_bb0380","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2019.12.005","article-title":"Choking agents and chlorine gas - history, pathophysiology, clinical effects and treatment","volume":"320","author":"Zellner","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.taap.2023.116388_bb0385","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.etap.2009.04.013","article-title":"Up-regulation of RAGE and S100A6 in rats exposed to cigarette smoke","volume":"28","author":"Zhang","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.taap.2023.116388_bb0390","first-page":"1","article-title":"Heterogeneity of T cells and macrophages in chlorine-induced acute lung injury in mice using single-cell RNA sequencing","author":"Zhao","year":"2022","journal-title":"Inhal. Toxicol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23000261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23000261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:13:13Z","timestamp":1736385193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X23000261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":79,"alternative-id":["S0041008X23000261"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2023.116388","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2023.116388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116388"}}