{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:27:53Z","timestamp":1788139673678,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["19\/2551\u20130001\u2013873-8"],"award-info":[{"award-number":["19\/2551\u20130001\u2013873-8"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302167\/2022\u20136"],"award-info":[{"award-number":["302167\/2022\u20136"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.taap.2023.116410","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T01:52:00Z","timestamp":1675389120000},"page":"116410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of used and under-used doses of Transfluthrin-based insecticide on Caenorhabditis elegans metabolism"],"prefix":"10.1016","volume":"461","author":[{"given":"Wagner Antonio","family":"Tamagno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Pompermaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9vilin Corr\u00eaa","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Jos\u00e9 Gil","family":"Barcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.taap.2023.116410_bib167","series-title":"In: StatPearls. Study Guide from StatPearls Publishing, Treasure Island (FL)","author":"Adeyinka","year":"2018"},{"key":"10.1016\/j.taap.2023.116410_bb0005","author":"Ag\u00eancia Brasil"},{"key":"10.1016\/j.taap.2023.116410_bb0010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chemosphere.2018.12.026","article-title":"Behavioral, molecular and physiological responses of embryo-larval zebrafish exposed to types I and II pyrethroids","volume":"219","author":"Awoyemi","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2023.116410_bib174","series-title":"Antioxidant categories and mode of action","first-page":"3","author":"Aziz","year":"2019"},{"key":"10.1016\/j.taap.2023.116410_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cbi.2008.05.040","article-title":"Is acetylcholinesterase a pertinent biomarker to detect exposure of pyrethroids? A study case with deltamethrin","volume":"175","author":"Badiou","year":"2008","journal-title":"Chemico-Biological Interactions, Proceedings of the IX International Meeting on Cholinesterases"},{"key":"10.1016\/j.taap.2023.116410_bb0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/diseases9040085","article-title":"Implications of glycosaminoglycans on viral zoonotic diseases","volume":"9","author":"Bauer","year":"2021","journal-title":"Diseases"},{"key":"10.1016\/j.taap.2023.116410_bb0025","series-title":"Pesticides - Updates on Toxicity, Efficacy and Risk Assessment","article-title":"Deleterious effects of banned chemical pesticides on human health in developing countries","author":"Bayoumi","year":"2022"},{"key":"10.1016\/j.taap.2023.116410_bb0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jinorgbio.2017.11.001","article-title":"Ilex paraguariensis: potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer\u2019s disease","volume":"181","author":"Bortoli","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.taap.2023.116410_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.taap.2023.116410_bb0040","article-title":"Elements to increase translation in pyrethroid epidemiology research: a review","volume":"152568","author":"Burns","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.taap.2023.116410_bb0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0302-4598(87)85026-2","article-title":"Induction of selenium-glutathione peroxidase by stimulation of metabolic hydrogen peroxide production in vivo","volume":"18","author":"Chaudiere","year":"1987","journal-title":"Bioelectrochem. Bioenerg."},{"issue":"45","key":"10.1016\/j.taap.2023.116410_bib177","doi-asserted-by":"crossref","first-page":"25456","DOI":"10.1039\/C8RA05042B","article-title":"Dynamics revelation of conformational changes and binding modes of heat shock protein 90 induced by inhibitor associations","volume":"8","author":"Chen","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.taap.2023.116410_bb0050","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.psj.2020.11.029","article-title":"Hydrogen peroxide\u2013induced oxidative stress impairs redox status and damages aerobic metabolism of breast muscle in broilers","volume":"100","author":"Chen","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.taap.2023.116410_bb0055","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.taap.2003.09.013","article-title":"The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity","volume":"194","author":"Cole","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"10","key":"10.1016\/j.taap.2023.116410_bib173","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/ijms20102407","article-title":"Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases","volume":"20","author":"Collin","year":"2019","journal-title":"Int.\u00a0 J. Mole. Sci."},{"key":"10.1016\/j.taap.2023.116410_bb0060","first-page":"297","article-title":"Focus: zoonotic disease: biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic Zoonoses","volume":"94","author":"Cong","year":"2021","journal-title":"The Yale Journal of Biology and Medicine"},{"issue":"2","key":"10.1016\/j.taap.2023.116410_bib178","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/ptr.6871","article-title":"N\u2010butanol extract of Hedyotis diffusa protects transgenic Caenorhabditis elegans from A\u03b2\u2010induced toxicity","volume":"35","author":"DanQing","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.taap.2023.116410_bb0065","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0092-8674(00)81609-8","article-title":"Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans","volume":"94","author":"De Bono","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.taap.2023.116410_bb0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuro.2017.03.004","article-title":"Acute exposure to chlorpyrifos caused NADPH oxidase mediated oxidative stress and neurotoxicity in a striatal cell model of Huntington\u2019s disease","volume":"60","author":"Dominah","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.taap.2023.116410_bb0075","series-title":"Veterinary Toxicology","first-page":"515","article-title":"Pyrethrins and pyrethroids","author":"Ensley","year":"2018"},{"key":"10.1016\/j.taap.2023.116410_bb0080","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1432-1033.1991.tb15776.x","article-title":"Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni","volume":"195","author":"Espinoza","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.taap.2023.116410_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature02714","article-title":"Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue","volume":"430","author":"Gray","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.taap.2023.116410_bb0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0531-5565(80)90032-7","article-title":"Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans","volume":"15","author":"Hosono","year":"1980","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.taap.2023.116410_bb0095","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.neuro.2004.01.002","article-title":"The modulatory effect of pyrethroids on acetylcholine release in the Hippocampus of freely moving rats","volume":"25","author":"Hossain","year":"2004","journal-title":"NeuroToxicology"},{"issue":"4","key":"10.1016\/j.taap.2023.116410_bib175","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alexandria J. Med."},{"key":"10.1016\/j.taap.2023.116410_bb0100","doi-asserted-by":"crossref","first-page":"E1263","DOI":"10.1073\/pnas.1621274114","article-title":"Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans","volume":"114","author":"Jang","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.taap.2023.116410_bib166","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1007\/s11064-008-9725-6","article-title":"Effect of Long-Term Exposure to Aluminum on the Acetylcholinesterase Activity in the Central Nervous System and Erythrocytes","volume":"33","author":"Kaizer","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.taap.2023.116410_bb0105","doi-asserted-by":"crossref","unstructured":"Lednicky, J.A., Tagliamonte, M.S., White, S.K., Elbadry, M.A., Alam, M.M., Stephenson, C.J., Bonny, T.S., Loeb, J.C., Telisma, T., Chavannes, S., 2021. Emergence of porcine delta-coronavirus pathogenic infections among children in Haiti through independent zoonoses and convergent evolution. MedRxiv. [Preprint]. 2021 Mar 25:2021.03.19.21253391. doi: 10.1101\/2021.03.19.21253391. Update in: Nature. 2021 Dec;600(7887):133-137.","DOI":"10.1038\/s41586-021-04111-z"},{"key":"10.1016\/j.taap.2023.116410_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-14-291","article-title":"Alterations in gene expression in Caenorhabditis elegans associated with organophosphate pesticide intoxication and recovery","volume":"14","author":"Lewis","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.taap.2023.116410_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2021.648171","article-title":"Neurobehavioral, neuromotor, and neurocognitive effects in agricultural workers and their children exposed to pyrethroid pesticides: a review","volume":"15","author":"Lucero","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.taap.2023.116410_bb0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2116\/analsci.26.461","article-title":"Pressurized liquid extraction and cleanup procedure for the determination of Pyrethroids in soils using gas chromatography\/tandem mass spectrometry","volume":"26","author":"Luo","year":"2010","journal-title":"Anal. Sci."},{"key":"10.1016\/j.taap.2023.116410_bib170","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.copbio.2019.12.011","article-title":"Caenorhabditis elegans as a model system for human diseases","volume":"63","author":"Markaki","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.taap.2023.116410_bb0125","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.chemosphere.2008.05.070","article-title":"Chronic exposure to pyrethroid-based allethrin and prallethrin mosquito repellents alters plasma biochemical profile","volume":"73","author":"Narendra","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.taap.2023.116410_bb0130","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/acs.jafc.5b05812","article-title":"An anthocyanin-rich extract of acai (Euterpe precatoria Mart.) increases stress resistance and retards aging-related markers in Caenorhabditis elegans","volume":"64","author":"Peixoto","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.taap.2023.116410_bib169","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1002\/jcb.28338","article-title":"Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths","volume":"120","author":"Priya","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.taap.2023.116410_bb0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/10408444.2021.1879007","article-title":"Pyrethroid based pesticides\u2013chemical and biological aspects","volume":"51","author":"Ravula","year":"2021","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.taap.2023.116410_bb0140","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/gerona\/glw248","article-title":"Assessing health span in Caenorhabditis elegans: lessons from short-lived mutants","volume":"72","author":"Rollins","year":"2017","journal-title":"Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences"},{"key":"10.1016\/j.taap.2023.116410_bb0145","article-title":"Fruit extract of red pitaya (Hylocereus undatus) prevents and reverses stress-induced impairments in the cholinergic and antioxidant systems of Caenorhabditis elegans","volume":"e13981","author":"Tamagno","year":"2021","journal-title":"J. Food Biochem."},{"issue":"10","key":"10.1016\/j.taap.2023.116410_bib171","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41582-020-0389-4","article-title":"Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities","volume":"16","author":"Tabrizi","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.taap.2023.116410_bb0150","article-title":"Pitaya fruit extract ameliorates the healthspan on copper-induced toxicity of Caenorhabditis elegans","volume":"e14050","author":"Tamagno","year":"2022","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.taap.2023.116410_bb0155","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13139","article-title":"Buti\u00e1 fruit extract (Butia eriospatha) protects against oxidative damage and increases lifespan on Caenorhabditis elegans","volume":"44","author":"Tambara","year":"2020","journal-title":"J. Food Biochem."},{"issue":"11","key":"10.1016\/j.taap.2023.116410_bib172","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/mp.2015.81","article-title":"Huntington\u2019s disease cerebrospinal fluid seeds aggregation of mutant huntingtin","volume":"20","author":"Tan","year":"2015","journal-title":"Mole. Psychiat."},{"key":"10.1016\/j.taap.2023.116410_bb0160","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/neu.10245","article-title":"Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans","volume":"56","author":"Tsalik","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.taap.2023.116410_bib176","first-page":"1","article-title":"Glutathione S-transferase: A versatile protein family. 3","volume":"10","author":"Vaish","year":"2020","journal-title":"Biotech"},{"key":"10.1016\/j.taap.2023.116410_bb0165","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.1162011","article-title":"Fat metabolism links germline stem cells and longevity in C. elegans","volume":"322","author":"Wang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.taap.2023.116410_bib168","doi-asserted-by":"crossref","first-page":"126779","DOI":"10.1016\/j.chemosphere.2020.126779","article-title":"Synthesis, insecticidal activity, resistance, photodegradation and toxicity of pyrethroids (A review)","volume":"254","author":"Zhu","year":"2020","journal-title":"Chemosphere"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23000480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X23000480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T20:13:35Z","timestamp":1736367215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X23000480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":46,"alternative-id":["S0041008X23000480"],"URL":"https:\/\/doi.org\/10.1016\/j.taap.2023.116410","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of used and under-used doses of Transfluthrin-based insecticide on Caenorhabditis elegans metabolism","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.taap.2023.116410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116410"}}